Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHKA-PC (FusionGDB2 ID:HG1119TG5091)

Fusion Gene Summary for CHKA-PC

check button Fusion gene summary
Fusion gene informationFusion gene name: CHKA-PC
Fusion gene ID: hg1119tg5091
HgeneTgene
Gene symbol

CHKA

PC

Gene ID

1119

5091

Gene namecholine kinase alphapyruvate carboxylase
SynonymsCHK|CK|CKI|EKPCB
Cytomap('CHKA')('PC')

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptioncholine kinase alphaCHETK-alphaethanolamine kinasepyruvate carboxylase, mitochondrialpyruvic carboxylase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265689, ENST00000356135, 
ENST00000533728, 
Fusion gene scores* DoF score12 X 7 X 5=42013 X 8 X 7=728
# samples 1313
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHKA [Title/Abstract] AND PC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHKA(67864486)-PC(66639630), # samples:3
Anticipated loss of major functional domain due to fusion event.CHKA-PC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHKA-PC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHKA

GO:0006646

phosphatidylethanolamine biosynthetic process

19915674

HgeneCHKA

GO:0006656

phosphatidylcholine biosynthetic process

19915674


check buttonFusion gene breakpoints across CHKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A440-01ACHKAchr11

67864486

-PCchr11

66639630

-


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Fusion Gene ORF analysis for CHKA-PC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265689ENST00000524491CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-5UTRENST00000356135ENST00000524491CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000265689ENST00000393955CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000265689ENST00000528224CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000265689ENST00000529047CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000356135ENST00000393955CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000356135ENST00000528224CHKAchr11

67864486

-PCchr11

66639630

-
5CDS-intronENST00000356135ENST00000529047CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000265689ENST00000355677CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000265689ENST00000393958CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000265689ENST00000393960CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000356135ENST00000355677CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000356135ENST00000393958CHKAchr11

67864486

-PCchr11

66639630

-
In-frameENST00000356135ENST00000393960CHKAchr11

67864486

-PCchr11

66639630

-
intron-3CDSENST00000533728ENST00000355677CHKAchr11

67864486

-PCchr11

66639630

-
intron-3CDSENST00000533728ENST00000393958CHKAchr11

67864486

-PCchr11

66639630

-
intron-3CDSENST00000533728ENST00000393960CHKAchr11

67864486

-PCchr11

66639630

-
intron-5UTRENST00000533728ENST00000524491CHKAchr11

67864486

-PCchr11

66639630

-
intron-intronENST00000533728ENST00000393955CHKAchr11

67864486

-PCchr11

66639630

-
intron-intronENST00000533728ENST00000528224CHKAchr11

67864486

-PCchr11

66639630

-
intron-intronENST00000533728ENST00000529047CHKAchr11

67864486

-PCchr11

66639630

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265689CHKAchr1167864486-ENST00000393958PCchr1166639630-44004891840251335
ENST00000265689CHKAchr1167864486-ENST00000393960PCchr1166639630-43994891840251335
ENST00000265689CHKAchr1167864486-ENST00000355677PCchr1166639630-2109489182078686
ENST00000356135CHKAchr1167864486-ENST00000393958PCchr1166639630-464072921042651351
ENST00000356135CHKAchr1167864486-ENST00000393960PCchr1166639630-463972921042651351
ENST00000356135CHKAchr1167864486-ENST00000355677PCchr1166639630-23497292102318702

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265689ENST00000393958CHKAchr1167864486-PCchr1166639630-0.0016793280.99832064
ENST00000265689ENST00000393960CHKAchr1167864486-PCchr1166639630-0.0016744630.9983255
ENST00000265689ENST00000355677CHKAchr1167864486-PCchr1166639630-0.0289141350.9710859
ENST00000356135ENST00000393958CHKAchr1167864486-PCchr1166639630-0.0022868480.9977132
ENST00000356135ENST00000393960CHKAchr1167864486-PCchr1166639630-0.0022787440.99772125
ENST00000356135ENST00000355677CHKAchr1167864486-PCchr1166639630-0.0306123550.9693877

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Fusion Genomic Features for CHKA-PC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHKA-PC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:67864486/chr11:66639630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67864486chr11:66639630ENST00000265689-21250_85154458.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67864486chr11:66639630ENST00000356135-21150_85154440.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67864486chr11:66639630ENST00000265689-212117_123154458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:66639630ENST00000356135-211117_123154440.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:66639630ENST00000265689-212119_121154458.0RegionNote=Substrate binding
HgeneCHKAchr11:67864486chr11:66639630ENST00000356135-211119_121154440.0RegionNote=Substrate binding
TgenePCchr11:67864486chr11:66639630ENST000003939550211109_117801179.0DomainBiotinyl-binding
TgenePCchr11:67864486chr11:66639630ENST00000393955021156_35301179.0DomainATP-grasp
TgenePCchr11:67864486chr11:66639630ENST0000039395502136_48601179.0DomainNote=Biotin carboxylation
TgenePCchr11:67864486chr11:66639630ENST00000393955021563_83201179.0DomainPyruvate carboxyltransferase
TgenePCchr11:67864486chr11:66639630ENST000003939581221109_117801179.0DomainBiotinyl-binding
TgenePCchr11:67864486chr11:66639630ENST00000393958122156_35301179.0DomainATP-grasp
TgenePCchr11:67864486chr11:66639630ENST0000039395812236_48601179.0DomainNote=Biotin carboxylation
TgenePCchr11:67864486chr11:66639630ENST00000393958122563_83201179.0DomainPyruvate carboxyltransferase
TgenePCchr11:67864486chr11:66639630ENST000003939602231109_117801179.0DomainBiotinyl-binding
TgenePCchr11:67864486chr11:66639630ENST00000393960223156_35301179.0DomainATP-grasp
TgenePCchr11:67864486chr11:66639630ENST0000039396022336_48601179.0DomainNote=Biotin carboxylation
TgenePCchr11:67864486chr11:66639630ENST00000393960223563_83201179.0DomainPyruvate carboxyltransferase
TgenePCchr11:67864486chr11:66639630ENST00000393955021571_57501179.0RegionNote=Substrate binding
TgenePCchr11:67864486chr11:66639630ENST00000393958122571_57501179.0RegionNote=Substrate binding
TgenePCchr11:67864486chr11:66639630ENST00000393960223571_57501179.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67864486chr11:66639630ENST00000265689-212207_213154458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:66639630ENST00000356135-211207_213154440.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for CHKA-PC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16501_16501_1_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000355677_length(transcript)=2109nt_BP=489nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGC
CGAACCTCCACCGCCCCCGCTGCCTCCCCAAATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAG
ATTGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGG
CAGAAAGCAGATGAAGCCTATCTCATCGGCCGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAG
GAGAACAACGTAGATGCAGTGCACCCTGGCTACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGG
TTTATTGGGCCAAGCCCAGAAGTGGTCCGCAAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTC
CCTGGCACAGATGCCCCCATCACGTCCCTGCATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTAT
GGGGGTGGAGGGCGTGGCATGAGGGTGGTGCACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCC
TTTGGGAATGGGGCGCTGTTTGTGGAGAAGTTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATC
CTGCACCTGTACGAGCGAGACTGCTCCATCCAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTT
CGGACTCGGCTCACCAGCGACTCTGTGAAACTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCAC
GGCAAGCACTACTTCATCGAGGTCAACTCCCGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCT
CAGATCCACGTGGCTGAGGGCAGGAGCCTACCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGG
GTCACCACCGAGGACCCCGCGCGCAGCTTCCAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTG
GATAATGCTTCCGCCTTCCAAGGAGCCGTCATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCC
ACGGCCGCCACCAAGATGAGCAGGGCCCTTGCGGAGTTCCGCGTCCGAGGTGTGAAGGTCAGAAGACACCAGGCACAGCCCTTGGCCGCA
GCCCTGGGCCGCCCCTGTGGACAGGAAGCCAGGAGGCCCCAGGCTGCTGTGACTGCCCCCACCGGCCCTGGTAGCCCCACCCTTGTCCGT
GTGCCACCAGCGGCCCGTGTCCTGTCCTCCCGTCTCGGGGGACCTAGCCAGACAACACCAGAGACTAGCACTGAGGTGTCCCCAACAATT
TTATTATAAATAAAAACAAGACTCCCAGTGGGTGGCTGC

>16501_16501_1_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000355677_length(amino acids)=686AA_BP=27
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTVHGGLRLLGIRRTSTAP
AASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDA
VHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRG
MRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTS
DSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDP
ARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKVRRHQAQPLAAALGRPC
GQEARRPQAAVTAPTGPGSPTLVRVPPAARVLSSRLGGPSQTTPETSTEVSPTILL

--------------------------------------------------------------
>16501_16501_2_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000393958_length(transcript)=4400nt_BP=489nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGC
CGAACCTCCACCGCCCCCGCTGCCTCCCCAAATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAG
ATTGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGG
CAGAAAGCAGATGAAGCCTATCTCATCGGCCGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAG
GAGAACAACGTAGATGCAGTGCACCCTGGCTACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGG
TTTATTGGGCCAAGCCCAGAAGTGGTCCGCAAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTC
CCTGGCACAGATGCCCCCATCACGTCCCTGCATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTAT
GGGGGTGGAGGGCGTGGCATGAGGGTGGTGCACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCC
TTTGGGAATGGGGCGCTGTTTGTGGAGAAGTTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATC
CTGCACCTGTACGAGCGAGACTGCTCCATCCAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTT
CGGACTCGGCTCACCAGCGACTCTGTGAAACTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCAC
GGCAAGCACTACTTCATCGAGGTCAACTCCCGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCT
CAGATCCACGTGGCTGAGGGCAGGAGCCTACCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGG
GTCACCACCGAGGACCCCGCGCGCAGCTTCCAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTG
GATAATGCTTCCGCCTTCCAAGGAGCCGTCATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCC
ACGGCCGCCACCAAGATGAGCAGGGCCCTTGCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCCTTCCTGCAGAATGTGCTCAAC
AACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCC
CAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCC
GTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTG
CGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTC
AAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGC
TTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAAT
GCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTT
GACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACG
GGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATC
CTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCA
CTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCA
GCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCC
ATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGC
AACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTC
AAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTG
GCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTC
CTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGG
CCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTG
CTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTC
TTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGAC
CTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAG
ATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCA
GGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTC
CGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGG
CCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTC
CTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATG
TTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGT
CCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGCC

>16501_16501_2_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000393958_length(amino acids)=1335AA_BP=27
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTVHGGLRLLGIRRTSTAP
AASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDA
VHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRG
MRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTS
DSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDP
ARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLA
GTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGL
LLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTN
YPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDM
AGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFD
YSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQ
NGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMY
PDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPK
ALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE

--------------------------------------------------------------
>16501_16501_3_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000393960_length(transcript)=4399nt_BP=489nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGC
CGAACCTCCACCGCCCCCGCTGCCTCCCCAAATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAG
ATTGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGG
CAGAAAGCAGATGAAGCCTATCTCATCGGCCGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAG
GAGAACAACGTAGATGCAGTGCACCCTGGCTACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGG
TTTATTGGGCCAAGCCCAGAAGTGGTCCGCAAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTC
CCTGGCACAGATGCCCCCATCACGTCCCTGCATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTAT
GGGGGTGGAGGGCGTGGCATGAGGGTGGTGCACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCC
TTTGGGAATGGGGCGCTGTTTGTGGAGAAGTTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATC
CTGCACCTGTACGAGCGAGACTGCTCCATCCAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTT
CGGACTCGGCTCACCAGCGACTCTGTGAAACTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCAC
GGCAAGCACTACTTCATCGAGGTCAACTCCCGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCT
CAGATCCACGTGGCTGAGGGCAGGAGCCTACCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGG
GTCACCACCGAGGACCCCGCGCGCAGCTTCCAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTG
GATAATGCTTCCGCCTTCCAAGGAGCCGTCATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCC
ACGGCCGCCACCAAGATGAGCAGGGCCCTTGCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCCTTCCTGCAGAATGTGCTCAAC
AACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCC
CAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCC
GTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTG
CGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTC
AAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGC
TTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAAT
GCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTT
GACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACG
GGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATC
CTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCA
CTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCA
GCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCC
ATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGC
AACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTC
AAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTG
GCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTC
CTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGG
CCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTG
CTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTC
TTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGAC
CTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAG
ATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCA
GGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTC
CGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGG
CCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTC
CTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATG
TTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGT
CCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGC

>16501_16501_3_CHKA-PC_CHKA_chr11_67864486_ENST00000265689_PC_chr11_66639630_ENST00000393960_length(amino acids)=1335AA_BP=27
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTVHGGLRLLGIRRTSTAP
AASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDA
VHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRG
MRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTS
DSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDP
ARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLA
GTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGL
LLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTN
YPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDM
AGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFD
YSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQ
NGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMY
PDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPK
ALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE

--------------------------------------------------------------
>16501_16501_4_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000355677_length(transcript)=2349nt_BP=729nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGCCGAACCTCCACCGCCCCCGCTGCCTCCCCA
AATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAGATTGCCATCCGTGTGTTCCGGGCCTGCACG
GAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGGCAGAAAGCAGATGAAGCCTATCTCATCGGC
CGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAGGAGAACAACGTAGATGCAGTGCACCCTGGC
TACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGGTTTATTGGGCCAAGCCCAGAAGTGGTCCGC
AAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTCCCTGGCACAGATGCCCCCATCACGTCCCTG
CATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTATGGGGGTGGAGGGCGTGGCATGAGGGTGGTG
CACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCCTTTGGGAATGGGGCGCTGTTTGTGGAGAAG
TTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATCCTGCACCTGTACGAGCGAGACTGCTCCATC
CAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTTCGGACTCGGCTCACCAGCGACTCTGTGAAA
CTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCACTACTTCATCGAGGTCAACTCC
CGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCTCAGATCCACGTGGCTGAGGGCAGGAGCCTA
CCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGGGTCACCACCGAGGACCCCGCGCGCAGCTTC
CAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTGGATAATGCTTCCGCCTTCCAAGGAGCCGTC
ATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCCACGGCCGCCACCAAGATGAGCAGGGCCCTT
GCGGAGTTCCGCGTCCGAGGTGTGAAGGTCAGAAGACACCAGGCACAGCCCTTGGCCGCAGCCCTGGGCCGCCCCTGTGGACAGGAAGCC
AGGAGGCCCCAGGCTGCTGTGACTGCCCCCACCGGCCCTGGTAGCCCCACCCTTGTCCGTGTGCCACCAGCGGCCCGTGTCCTGTCCTCC
CGTCTCGGGGGACCTAGCCAGACAACACCAGAGACTAGCACTGAGGTGTCCCCAACAATTTTATTATAAATAAAAACAAGACTCCCAGTG
GGTGGCTGC

>16501_16501_4_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000355677_length(amino acids)=702AA_BP=43
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTV
HGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYL
HIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTY
GFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEI
APAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENI
RINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKV
RRHQAQPLAAALGRPCGQEARRPQAAVTAPTGPGSPTLVRVPPAARVLSSRLGGPSQTTPETSTEVSPTILL

--------------------------------------------------------------
>16501_16501_5_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000393958_length(transcript)=4640nt_BP=729nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGCCGAACCTCCACCGCCCCCGCTGCCTCCCCA
AATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAGATTGCCATCCGTGTGTTCCGGGCCTGCACG
GAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGGCAGAAAGCAGATGAAGCCTATCTCATCGGC
CGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAGGAGAACAACGTAGATGCAGTGCACCCTGGC
TACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGGTTTATTGGGCCAAGCCCAGAAGTGGTCCGC
AAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTCCCTGGCACAGATGCCCCCATCACGTCCCTG
CATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTATGGGGGTGGAGGGCGTGGCATGAGGGTGGTG
CACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCCTTTGGGAATGGGGCGCTGTTTGTGGAGAAG
TTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATCCTGCACCTGTACGAGCGAGACTGCTCCATC
CAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTTCGGACTCGGCTCACCAGCGACTCTGTGAAA
CTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCACTACTTCATCGAGGTCAACTCC
CGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCTCAGATCCACGTGGCTGAGGGCAGGAGCCTA
CCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGGGTCACCACCGAGGACCCCGCGCGCAGCTTC
CAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTGGATAATGCTTCCGCCTTCCAAGGAGCCGTC
ATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCCACGGCCGCCACCAAGATGAGCAGGGCCCTT
GCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGAC
ACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTC
ATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCC
CCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGAC
ACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAAC
TTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTG
CAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAAC
GTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTG
CTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAG
TACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTG
AAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGG
GCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAG
CCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTAC
TGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCA
GGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCC
AACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGC
CGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGG
GGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTG
CAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTT
GCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAG
TTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTC
TTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGAC
GTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTG
TGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACA
CTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGC
TGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGC
CTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCC
TCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAG
ATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGCC

>16501_16501_5_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000393958_length(amino acids)=1351AA_BP=43
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTV
HGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYL
HIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTY
GFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEI
APAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENI
RINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKT
NIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLR
EGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNI
PFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLA
EELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACT
RGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKV
TPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDR
HGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSI
LVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI
E

--------------------------------------------------------------
>16501_16501_6_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000393960_length(transcript)=4639nt_BP=729nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGCCGAACCTCCACCGCCCCCGCTGCCTCCCCA
AATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTCATGGTGGCCAACAGAGGTGAGATTGCCATCCGTGTGTTCCGGGCCTGCACG
GAGCTGGGCATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGGCAGAAAGCAGATGAAGCCTATCTCATCGGC
CGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCAGACATCATCAAGGTGGCCAAGGAGAACAACGTAGATGCAGTGCACCCTGGC
TACGGGTTCCTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGGTTTATTGGGCCAAGCCCAGAAGTGGTCCGC
AAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATTGCTGCGGGTGTTCCCGTTGTCCCTGGCACAGATGCCCCCATCACGTCCCTG
CATGAGGCCCACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTATGGGGGTGGAGGGCGTGGCATGAGGGTGGTG
CACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCCTACTCAGAGGCTCTGGCCGCCTTTGGGAATGGGGCGCTGTTTGTGGAGAAG
TTCATCGAGAAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATCCTGCACCTGTACGAGCGAGACTGCTCCATC
CAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCCGCCCACCTGGACCCGCAGCTTCGGACTCGGCTCACCAGCGACTCTGTGAAA
CTCGCTAAACAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCACTACTTCATCGAGGTCAACTCC
CGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACCGACGTAGACCTGGTCCATGCTCAGATCCACGTGGCTGAGGGCAGGAGCCTA
CCCGACCTGGGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGGGTCACCACCGAGGACCCCGCGCGCAGCTTC
CAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGAGAGGGCATGGGCATCCGCCTGGATAATGCTTCCGCCTTCCAAGGAGCCGTC
ATCTCGCCCCACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCCACGGCCGCCACCAAGATGAGCAGGGCCCTT
GCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGAC
ACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTC
ATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCC
CCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGAC
ACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAAC
TTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTG
CAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAAC
GTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTG
CTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAG
TACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTG
AAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGG
GCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAG
CCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTAC
TGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCA
GGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCC
AACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGC
CGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGG
GGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTG
CAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTT
GCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAG
TTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTC
TTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGAC
GTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTG
TGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACA
CTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGC
TGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGC
CTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCC
TCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAG
ATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGC

>16501_16501_6_CHKA-PC_CHKA_chr11_67864486_ENST00000356135_PC_chr11_66639630_ENST00000393960_length(amino acids)=1351AA_BP=43
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMMLKFRTV
HGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYL
HIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTY
GFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEI
APAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENI
RINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKT
NIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLR
EGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNI
PFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLA
EELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACT
RGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKV
TPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDR
HGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSI
LVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI
E

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHKA-PC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CHKA-PC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHKA-PC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHKAC0038219Status Dysraphicus1CTD_human
HgeneCHKAC0080178Spina Bifida1CTD_human
HgeneCHKAC0266508Rachischisis1CTD_human
TgeneC0034341Pyruvate Carboxylase Deficiency Disease2CTD_human;GENOMICS_ENGLAND
TgeneC0005586Bipolar Disorder1CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0006413Burkitt Lymphoma1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0338831Manic1CTD_human
TgeneC0343640African Burkitt's lymphoma1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4721444Burkitt Leukemia1CTD_human