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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX19B-KCTD19 (FusionGDB2 ID:HG11269TG146212)

Fusion Gene Summary for DDX19B-KCTD19

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX19B-KCTD19
Fusion gene ID: hg11269tg146212
HgeneTgene
Gene symbol

DDX19B

KCTD19

Gene ID

11269

146212

Gene nameDEAD-box helicase 19Bpotassium channel tetramerization domain containing 19
SynonymsDBP5|DDX19|RNAh-
Cytomap('DDX19B')('KCTD19')

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX19BATP-dependent RNA helicase DDX19DEAD (Asp-Glu-Ala-As) box polypeptide 19BDEAD (Asp-Glu-Ala-Asp) box polypeptide 19BDEAD box protein 19BDEAD-box RNA helicase DEAD5DEAD-box protein 5DEAD/H (Asp-Glu-Ala-Asp/His) box poBTB/POZ domain-containing protein KCTD19potassium channel tetramerisation domain containing 19testicular tissue protein Li 101
Modification date2020031320200313
UniProtAcc.

Q17RG1

Ensembl transtripts involved in fusion geneENST00000288071, ENST00000355992, 
ENST00000393657, ENST00000451014, 
ENST00000563206, ENST00000563392, 
ENST00000568625, ENST00000570055, 
Fusion gene scores* DoF score5 X 4 X 3=605 X 3 X 4=60
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX19B [Title/Abstract] AND KCTD19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX19B(70333257)-KCTD19(67354788), # samples:2
Anticipated loss of major functional domain due to fusion event.DDX19B-KCTD19 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX19B-KCTD19 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX19B-KCTD19 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX19B-KCTD19 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX19B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KCTD19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-5192-01ADDX19Bchr16

70333257

-KCTD19chr16

67354788

-
ChimerDB4KIRCTCGA-BP-5192-01ADDX19Bchr16

70333257

+KCTD19chr16

67354788

-


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Fusion Gene ORF analysis for DDX19B-KCTD19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288071ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
5CDS-intronENST00000355992ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
5UTR-3CDSENST00000393657ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
5UTR-intronENST00000393657ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
In-frameENST00000288071ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
In-frameENST00000355992ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-3CDSENST00000451014ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-3CDSENST00000563206ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-3CDSENST00000563392ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-3CDSENST00000568625ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-3CDSENST00000570055ENST00000304372DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-intronENST00000451014ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-intronENST00000563206ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-intronENST00000563392ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-intronENST00000568625ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-
intron-intronENST00000570055ENST00000562860DDX19Bchr16

70333257

+KCTD19chr16

67354788

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288071DDX19Bchr1670333257+ENST00000304372KCTD19chr1667354788-32013021130791022
ENST00000355992DDX19Bchr1670333257+ENST00000304372KCTD19chr1667354788-30601611042938944

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288071ENST00000304372DDX19Bchr1670333257+KCTD19chr1667354788-0.0038105390.99618953
ENST00000355992ENST00000304372DDX19Bchr1670333257+KCTD19chr1667354788-0.0043520660.99564797

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Fusion Genomic Features for DDX19B-KCTD19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DDX19B-KCTD19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70333257/chr16:67354788)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCTD19

Q17RG1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCTD19chr16:70333257chr16:67354788ENST0000030437201618_721927.0DomainNote=BTB 1
TgeneKCTD19chr16:70333257chr16:67354788ENST00000304372016398_4851927.0DomainNote=BTB 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+112125_29519480.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+112306_47419480.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+111125_29519449.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+111306_47419449.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+110125_2950371.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+110306_4740371.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+111125_2950454.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+111306_4740454.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+110125_2950371.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+110306_4740371.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+111125_2950371.0DomainHelicase ATP-binding
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+111306_4740371.0DomainHelicase C-terminal
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+112242_24519480.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+11292_12019480.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+111242_24519449.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+11192_12019449.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+110242_2450371.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+11092_1200371.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+111242_2450454.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+11192_1200454.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+110242_2450371.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+11092_1200371.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+111242_2450371.0MotifNote=DEAD box
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+11192_1200371.0MotifNote=Q motif
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+112138_14519480.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+111138_14519449.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+110138_1450371.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+111138_1450454.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+110138_1450371.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+111138_1450371.0Nucleotide bindingNote=ATP
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+1122_30019480.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+112301_47919480.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000288071+11255_6819480.0RegionNote=N-terminal helix
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+1112_30019449.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+111301_47919449.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000355992+11155_6819449.0RegionNote=N-terminal helix
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+1102_3000371.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+110301_4790371.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000393657+11055_680371.0RegionNote=N-terminal helix
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+1112_3000454.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+111301_4790454.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000451014+11155_680454.0RegionNote=N-terminal helix
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+1102_3000371.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+110301_4790371.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000563392+11055_680371.0RegionNote=N-terminal helix
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+1112_3000371.0RegionNote=N-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+111301_4790371.0RegionNote=C-terminal lobe
HgeneDDX19Bchr16:70333257chr16:67354788ENST00000568625+11155_680371.0RegionNote=N-terminal helix


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Fusion Gene Sequence for DDX19B-KCTD19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21919_21919_1_DDX19B-KCTD19_DDX19B_chr16_70333257_ENST00000288071_KCTD19_chr16_67354788_ENST00000304372_length(transcript)=3201nt_BP=302nt
GATAGGAAAGCTTGCTCTGCCCGGGGTTGAGGGGTACGGGTCTGAGGGCAACAGAATCGACAGCCTCAAGTGGGCAAAGGGTGGCCAAAC
AGGAGTGGCCTCCGACGTCACTGTGGCGCGCCGCTTCCGGTCTGCAGCCTTGTAGTGGGGCTGGAGCAGAGCCTGCCGCGAACCCCCGGA
GCCCACGATCCCTCGTGCCATCCCTCGAATCCACCAGCACGAGCGTCCCACCCGCGCCTGGGACCATGGCCACTGACTCATGGGCCCTGG
CGGTGGACGAGCAGGAAGCTGCGGCTGAGTCGGAGGAGTCTGGCATGGCTCATGAATCAGCAGAGGACTTGTTTCATTTCAACGTAGGGG
GCTGGCATTTCTCAGTTCCCAGAAGCAAACTCTCTCAGTTTCCAGACTCCCTGCTGTGGAAAGAGGCTTCAGCCTTGACCTCTTCAGAAA
GCCAGAGGCTATTTATCGACAGAGATGGTTCCACATTTAGGCACGTGCACTATTACCTCTACACCTCCAAACTCTCCTTCTCCAGTTGTG
CAGAACTGAACTTGCTGTATGAGCAAGCATTGGGTTTGCAGCTGATGCCTTTGCTGCAGACTCTAGATAACCTGAAGGAAGGGAAACACC
ATCTACGCGTACGGCCTGCAGACCTACCTGTTGCTGAGAGAGCATCTCTGAACTACTGGCGTACATGGAAGTGTATTAGCAAACCCTCAG
AATTTCCAATTAAAAGCCCAGCCTTTACAGGCCTACATGATAAGGCACCTCTGGGGCTCATGGACACACCCCTGTTAGACACAGAAGAGG
AGGTGCACTACTGCTTCCTGCCCCTAGACCTGGTGGCCAAATATCCCAGCCTAGTGACTGAAGACAACCTGCTGTGGCTGGCTGAGACGG
TGGCCCTCATCGAGTGCGAGTGCAGCGAGTTCCGCTTCATTGTGAATTTTCTTCGCTCACAGAAGATTTTACTACCGGATAATTTCTCCA
ACATTGATGTATTAGAAGCAGAAGTGGAAATTCTGGAAATCCCTGCACTCACTGAAGCCGTAAGGTGGTACCGGATGAACATGGGTGGCT
GTTCCCCGACCACCTGTTCTCCCCTGAGCCCCGGGAAGGGGGCCCGCACAGCCAGCCTGGAGTCCGTGAAACCGCTCTACACAATGGCCC
TGGGTCTGCTGGTCAAGTACCCGGACTCTGCGCTGGGCCAGCTTCGCATCGAGAGCACGCTAGACGGAAGCCGACTGTACATCACAGGGA
ATGGCGTCCTCTTTCAGCACGTCAAGAACTGGCTGGGGACTTGCCGGCTGCCCCTGACAGAGACCATTTCCGAGGTATATGAGCTCTGTG
CCTTCCTAGACAAAAGGGACATCACCTACGAGCCAATCAAAGTTGCTTTGAAGACTCATCTGGAGCCAAGGACTTTGGCACCCATGGATG
TGCTCAATGAGTGGACGGCAGAGATCACTGTGTATTCCCCACAACAGATCATCAAAGTGTATGTTGGAAGCCACTGGTACGCAACCACCC
TGCAGACACTGCTGAAGTATCCAGAACTGCTGTCCAACCCTCAGAGAGTGTACTGGATCACATATGGACAAACCCTGCTCATCCACGGGG
ATGGCCAGATGTTCCGACACATTCTCAACTTCCTGAGACTTGGCAAACTGTTTTTACCATCTGAATTTAAGGAATGGCCCCTCTTCTGCC
AGGAGGTGGAGGAATACCACATTCCATCCCTCTCAGAAGCCCTTGCACAATGTGAAGCATACAAGTCATGGACTCAGGAGAAAGAATCTG
AAAATGAAGAAGCTTTTTCCATCAGGAGGCTGCATGTGGTGACAGAAGGGCCAGGGTCACTGGTGGAGTTCAGTAGAGACACTAAAGAAA
CCACAGCCTACATGCCTGTGGACTTCGAAGACTGCAGTGACAGGACTCCATGGAACAAGGCTAAGGGAAACCTGGTCAGGTCCAACCAGA
TGGATGAGGCTGAGCAGTACACTCGGCCCATCCAGGTGTCCCTATGCCGAAATGCCAAGAGGGCTGGCAACCCTAGCACATACTCACACT
GCCGTGGCTTGTGTACCAATCCTGGACACTGGGGGAGCCACCCTGAGAGCCCCCCAAAGAAGAAATGCACCACAATCAACCTCACACAGA
AATCTGAAACCAAAGACCCTCCCGCCACTCCCATGCAAAAACTCATCTCCCTGGTGAGAGAATGGGACATGGTCAATTGCAAACAGTGGG
AATTCCAGCCACTGACAGCCACACGGAGCAGCCCCTTGGAGGAGGCCACCCTGCAGCTCCCCTTGGGAAGCGAGGCTGCTTCCCAGCCCA
GCACCTCAGCTGCCTGGAAAGCCCATTCCACAGCCTCAGAGAAGGATCCAGGACCACAGGCAGGGGCTGGAGCTGGAGCGAAAGACAAGG
GGCCAGAGCCAACCTTCAAGCCATACTTACCCCCAAAAAGAGCTGGCACCCTGAAGGACTGGAGCAAGCAGAGGACCAAGGAGAGAGAAA
GCCCTGCCCCTGAGCAGCCTCTGCCCGAGGCCAGTGAGGTGGACAGCCTAGGGGTTATCCTCAAAGTGACTCACCCCCCCGTGGTGGGCA
GCGATGGCTTCTGCATGTTCTTTGAGGACAGCATCATCTATACCACGGAGATGGACAACCTCAGGCACACAACACCCACAGCCAGTCCCC
AGCCCCAAGAAGTGACTTTCCTGAGTTTCTCTCTGTCCTGGGAAGAGATGTTTTATGCACAGAAATGTCACTGCTTCCTGGCTGACATCA
TCATGGATTCCATCAGGCAAAAGGACCCCAAAGCCATCACAGCCAAGGTGGTCTCCCTGGCCAATCGGCTGTGGACCCTGCACATCAGCC
CCAAGCAGTTTGTGGTAGATTTGCTGGCCATCACCGGCTTCAAGGATGACCGGCACACCCAGGAGCGCCTGTACAGCTGGGTGGAGCTTA
CACTGCCCTTCGCCAGGAAATATGGCCGATGCATGGACCTGCTCATCCAGAGGGGCCTGTCTAGGTCTGTCTCTTACTCCATCCTGGGAA
AGTACCTACAAGAGGACTAGGGTGCCCAGAGATGCAGCCCCTCATGCCCCACCCGCCAAGTCTCATTTTAATTGGAGATAGCCCAGAATG
CATGTGCCCATCAGAGGGTACATATCAGTCTATTTTTTATTATAAACAAAT

>21919_21919_1_DDX19B-KCTD19_DDX19B_chr16_70333257_ENST00000288071_KCTD19_chr16_67354788_ENST00000304372_length(amino acids)=1022AA_BP=97
MLCPGLRGTGLRATESTASSGQRVAKQEWPPTSLWRAASGLQPCSGAGAEPAANPRSPRSLVPSLESTSTSVPPAPGTMATDSWALAVDE
QEAAAESEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELN
LLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADLPVAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHY
CFLPLDLVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVRWYRMNMGGCSPT
TCSPLSPGKGARTASLESVKPLYTMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETISEVYELCAFLD
KRDITYEPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITYGQTLLIHGDGQM
FRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLVEFSRDTKETTAY
MPVDFEDCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHCRGLCTNPGHWGSHPESPPKKKCTTINLTQKSET
KDPPATPMQKLISLVREWDMVNCKQWEFQPLTATRSSPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAGAGAGAKDKGPEP
TFKPYLPPKRAGTLKDWSKQRTKERESPAPEQPLPEASEVDSLGVILKVTHPPVVGSDGFCMFFEDSIIYTTEMDNLRHTTPTASPQPQE
VTFLSFSLSWEEMFYAQKCHCFLADIIMDSIRQKDPKAITAKVVSLANRLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPF
ARKYGRCMDLLIQRGLSRSVSYSILGKYLQED

--------------------------------------------------------------
>21919_21919_2_DDX19B-KCTD19_DDX19B_chr16_70333257_ENST00000355992_KCTD19_chr16_67354788_ENST00000304372_length(transcript)=3060nt_BP=161nt
GTAGTGGGGCTGGAGCAGAGCCTGCCGCGAACCCCCGGAGCCCACGATCCCTCGTGCCATCCCTCGAATCCACCAGCACGAGCGTCCCAC
CCGCGCCTGGGACCATGGCCACTGACTCATGGGCCCTGGCGGTGGACGAGCAGGAAGCTGCGGCTGAGTCGGAGGAGTCTGGCATGGCTC
ATGAATCAGCAGAGGACTTGTTTCATTTCAACGTAGGGGGCTGGCATTTCTCAGTTCCCAGAAGCAAACTCTCTCAGTTTCCAGACTCCC
TGCTGTGGAAAGAGGCTTCAGCCTTGACCTCTTCAGAAAGCCAGAGGCTATTTATCGACAGAGATGGTTCCACATTTAGGCACGTGCACT
ATTACCTCTACACCTCCAAACTCTCCTTCTCCAGTTGTGCAGAACTGAACTTGCTGTATGAGCAAGCATTGGGTTTGCAGCTGATGCCTT
TGCTGCAGACTCTAGATAACCTGAAGGAAGGGAAACACCATCTACGCGTACGGCCTGCAGACCTACCTGTTGCTGAGAGAGCATCTCTGA
ACTACTGGCGTACATGGAAGTGTATTAGCAAACCCTCAGAATTTCCAATTAAAAGCCCAGCCTTTACAGGCCTACATGATAAGGCACCTC
TGGGGCTCATGGACACACCCCTGTTAGACACAGAAGAGGAGGTGCACTACTGCTTCCTGCCCCTAGACCTGGTGGCCAAATATCCCAGCC
TAGTGACTGAAGACAACCTGCTGTGGCTGGCTGAGACGGTGGCCCTCATCGAGTGCGAGTGCAGCGAGTTCCGCTTCATTGTGAATTTTC
TTCGCTCACAGAAGATTTTACTACCGGATAATTTCTCCAACATTGATGTATTAGAAGCAGAAGTGGAAATTCTGGAAATCCCTGCACTCA
CTGAAGCCGTAAGGTGGTACCGGATGAACATGGGTGGCTGTTCCCCGACCACCTGTTCTCCCCTGAGCCCCGGGAAGGGGGCCCGCACAG
CCAGCCTGGAGTCCGTGAAACCGCTCTACACAATGGCCCTGGGTCTGCTGGTCAAGTACCCGGACTCTGCGCTGGGCCAGCTTCGCATCG
AGAGCACGCTAGACGGAAGCCGACTGTACATCACAGGGAATGGCGTCCTCTTTCAGCACGTCAAGAACTGGCTGGGGACTTGCCGGCTGC
CCCTGACAGAGACCATTTCCGAGGTATATGAGCTCTGTGCCTTCCTAGACAAAAGGGACATCACCTACGAGCCAATCAAAGTTGCTTTGA
AGACTCATCTGGAGCCAAGGACTTTGGCACCCATGGATGTGCTCAATGAGTGGACGGCAGAGATCACTGTGTATTCCCCACAACAGATCA
TCAAAGTGTATGTTGGAAGCCACTGGTACGCAACCACCCTGCAGACACTGCTGAAGTATCCAGAACTGCTGTCCAACCCTCAGAGAGTGT
ACTGGATCACATATGGACAAACCCTGCTCATCCACGGGGATGGCCAGATGTTCCGACACATTCTCAACTTCCTGAGACTTGGCAAACTGT
TTTTACCATCTGAATTTAAGGAATGGCCCCTCTTCTGCCAGGAGGTGGAGGAATACCACATTCCATCCCTCTCAGAAGCCCTTGCACAAT
GTGAAGCATACAAGTCATGGACTCAGGAGAAAGAATCTGAAAATGAAGAAGCTTTTTCCATCAGGAGGCTGCATGTGGTGACAGAAGGGC
CAGGGTCACTGGTGGAGTTCAGTAGAGACACTAAAGAAACCACAGCCTACATGCCTGTGGACTTCGAAGACTGCAGTGACAGGACTCCAT
GGAACAAGGCTAAGGGAAACCTGGTCAGGTCCAACCAGATGGATGAGGCTGAGCAGTACACTCGGCCCATCCAGGTGTCCCTATGCCGAA
ATGCCAAGAGGGCTGGCAACCCTAGCACATACTCACACTGCCGTGGCTTGTGTACCAATCCTGGACACTGGGGGAGCCACCCTGAGAGCC
CCCCAAAGAAGAAATGCACCACAATCAACCTCACACAGAAATCTGAAACCAAAGACCCTCCCGCCACTCCCATGCAAAAACTCATCTCCC
TGGTGAGAGAATGGGACATGGTCAATTGCAAACAGTGGGAATTCCAGCCACTGACAGCCACACGGAGCAGCCCCTTGGAGGAGGCCACCC
TGCAGCTCCCCTTGGGAAGCGAGGCTGCTTCCCAGCCCAGCACCTCAGCTGCCTGGAAAGCCCATTCCACAGCCTCAGAGAAGGATCCAG
GACCACAGGCAGGGGCTGGAGCTGGAGCGAAAGACAAGGGGCCAGAGCCAACCTTCAAGCCATACTTACCCCCAAAAAGAGCTGGCACCC
TGAAGGACTGGAGCAAGCAGAGGACCAAGGAGAGAGAAAGCCCTGCCCCTGAGCAGCCTCTGCCCGAGGCCAGTGAGGTGGACAGCCTAG
GGGTTATCCTCAAAGTGACTCACCCCCCCGTGGTGGGCAGCGATGGCTTCTGCATGTTCTTTGAGGACAGCATCATCTATACCACGGAGA
TGGACAACCTCAGGCACACAACACCCACAGCCAGTCCCCAGCCCCAAGAAGTGACTTTCCTGAGTTTCTCTCTGTCCTGGGAAGAGATGT
TTTATGCACAGAAATGTCACTGCTTCCTGGCTGACATCATCATGGATTCCATCAGGCAAAAGGACCCCAAAGCCATCACAGCCAAGGTGG
TCTCCCTGGCCAATCGGCTGTGGACCCTGCACATCAGCCCCAAGCAGTTTGTGGTAGATTTGCTGGCCATCACCGGCTTCAAGGATGACC
GGCACACCCAGGAGCGCCTGTACAGCTGGGTGGAGCTTACACTGCCCTTCGCCAGGAAATATGGCCGATGCATGGACCTGCTCATCCAGA
GGGGCCTGTCTAGGTCTGTCTCTTACTCCATCCTGGGAAAGTACCTACAAGAGGACTAGGGTGCCCAGAGATGCAGCCCCTCATGCCCCA
CCCGCCAAGTCTCATTTTAATTGGAGATAGCCCAGAATGCATGTGCCCATCAGAGGGTACATATCAGTCTATTTTTTATTATAAACAAAT


>21919_21919_2_DDX19B-KCTD19_DDX19B_chr16_70333257_ENST00000355992_KCTD19_chr16_67354788_ENST00000304372_length(amino acids)=944AA_BP=19
MATDSWALAVDEQEAAAESEESGMAHESAEDLFHFNVGGWHFSVPRSKLSQFPDSLLWKEASALTSSESQRLFIDRDGSTFRHVHYYLYT
SKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADLPVAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMD
TPLLDTEEEVHYCFLPLDLVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPALTEAVR
WYRMNMGGCSPTTCSPLSPGKGARTASLESVKPLYTMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTET
ISEVYELCAFLDKRDITYEPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITY
GQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLV
EFSRDTKETTAYMPVDFEDCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHCRGLCTNPGHWGSHPESPPKKK
CTTINLTQKSETKDPPATPMQKLISLVREWDMVNCKQWEFQPLTATRSSPLEEATLQLPLGSEAASQPSTSAAWKAHSTASEKDPGPQAG
AGAGAKDKGPEPTFKPYLPPKRAGTLKDWSKQRTKERESPAPEQPLPEASEVDSLGVILKVTHPPVVGSDGFCMFFEDSIIYTTEMDNLR
HTTPTASPQPQEVTFLSFSLSWEEMFYAQKCHCFLADIIMDSIRQKDPKAITAKVVSLANRLWTLHISPKQFVVDLLAITGFKDDRHTQE
RLYSWVELTLPFARKYGRCMDLLIQRGLSRSVSYSILGKYLQED

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Fusion Gene PPI Analysis for DDX19B-KCTD19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX19B-KCTD19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX19B-KCTD19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource