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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHRM1-SARNP (FusionGDB2 ID:HG1128TG84324)

Fusion Gene Summary for CHRM1-SARNP

check button Fusion gene summary
Fusion gene informationFusion gene name: CHRM1-SARNP
Fusion gene ID: hg1128tg84324
HgeneTgene
Gene symbol

CHRM1

SARNP

Gene ID

1128

84324

Gene namecholinergic receptor muscarinic 1SAP domain containing ribonucleoprotein
SynonymsHM1|M1|M1RCIP29|HCC1|HSPC316|THO1
Cytomap('CHRM1')('SARNP')

11q12.3

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionmuscarinic acetylcholine receptor M1acetylcholine receptor, muscarinic 1SAP domain-containing ribonucleoproteincytokine induced protein 29 kDacytokine-induced protein of 29 kDahepatocellular carcinoma 1nuclear protein Hcc-1proliferation associated cytokine-inducible protein CIP29
Modification date2020031320200313
UniProtAcc

P11229

.
Ensembl transtripts involved in fusion geneENST00000306960, 
Fusion gene scores* DoF score3 X 2 X 1=621 X 11 X 10=2310
# samples 323
** MAII scorelog2(3/6*10)=2.32192809488736log2(23/2310*10)=-3.32818708535904
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHRM1 [Title/Abstract] AND SARNP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHRM1(62676153)-SARNP(56193377), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSARNP

GO:0006406

mRNA export from nucleus

20844015



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CHRM1-SARNP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHRM1-SARNP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CHRM1-SARNP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62676153/:56193377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHRM1

P11229

.
FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHRM1-SARNP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHRM1-SARNP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHRM1-SARNP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCHRM1P11229DB00185CevimelineAgonistSmall moleculeApproved
HgeneCHRM1P11229DB00202SuccinylcholineAgonistSmall moleculeApproved
HgeneCHRM1P11229DB00209TrospiumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00219OxyphenoniumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00245BenzatropineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00246ZiprasidoneAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00280DisopyramideAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00354BuclizineAntagonist|Weak inhibitorSmall moleculeApproved
HgeneCHRM1P11229DB00363ClozapineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00376TrihexyphenidylAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00383OxyphencyclimineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00387ProcyclidineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00392ProfenamineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00408LoxapineBinderSmall moleculeApproved
HgeneCHRM1P11229DB00411CarbamoylcholineAgonistSmall moleculeApproved
HgeneCHRM1P11229DB00424HyoscyamineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00434CyproheptadineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00458ImipramineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00462Methscopolamine bromideAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00483Gallamine triethiodideSmall moleculeApproved
HgeneCHRM1P11229DB00517Anisotropine methylbromideAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00543AmoxapineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00670PirenzepineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00725Homatropine methylbromideAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00771ClidiniumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00782PropanthelineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00804DicyclomineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00805MinaprineAgonistSmall moleculeApproved
HgeneCHRM1P11229DB00835BrompheniramineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00942CycrimineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00979CyclopentolateAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB01019BethanecholSmall moleculeApproved
HgeneCHRM1P11229DB01148FlavoxateAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB01175EscitalopramInhibitorSmall moleculeApproved
HgeneCHRM1P11229DB01224QuetiapineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB01409TiotropiumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB01591SolifenacinAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB01618MolindoneOther/unknownSmall moleculeApproved
HgeneCHRM1P11229DB04843MepenzolateAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB06153PizotifenAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB06702FesoterodineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB06787HexocycliumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB08897AclidiniumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB09076UmeclidiniumAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB09089TrimebutineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB09167DosulepinAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB11181HomatropineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB11235ThonzylamineAntagonistSmall moleculeApproved
HgeneCHRM1P11229DB00332IpratropiumAntagonistSmall moleculeApproved|Experimental
HgeneCHRM1P11229DB01239ChlorprothixeneAntagonistSmall moleculeApproved|Experimental|Investigational|Withdrawn
HgeneCHRM1P11229DB00907CocaineAntagonistSmall moleculeApproved|Illicit
HgeneCHRM1P11229DB00193TramadolAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00334OlanzapineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00496DarifenacinAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00622NicardipineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00747ScopolamineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00809TropicamideAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00810BiperidenAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00934MaprotilineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00940MethanthelineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01036TolterodineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01062OxybutyninAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01069PromethazineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01085PilocarpineAgonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01142DoxepinAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01151DesipramineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01233MetoclopramideAgonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01238AripiprazoleLigandSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB01403MethotrimeprazineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB03128AcetylcholineSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB14185Aripiprazole lauroxilSmall moleculeApproved|Investigational
HgeneCHRM1P11229DB00477ChlorpromazineAntagonistSmall moleculeApproved|Investigational|Vet_approved
HgeneCHRM1P11229DB00986GlycopyrroniumAntagonistSmall moleculeApproved|Investigational|Vet_approved
HgeneCHRM1P11229DB00875FlupentixolAntagonistSmall moleculeApproved|Investigational|Withdrawn
HgeneCHRM1P11229DB01231DiphenidolAntagonistSmall moleculeApproved|Investigational|Withdrawn
HgeneCHRM1P11229DB00420PromazineAntagonistSmall moleculeApproved|Vet_approved
HgeneCHRM1P11229DB00508TriflupromazineAntagonistSmall moleculeApproved|Vet_approved
HgeneCHRM1P11229DB00572AtropineAntagonistSmall moleculeApproved|Vet_approved
HgeneCHRM1P11229DB11156PyrantelAgonist|AntagonistSmall moleculeApproved|Vet_approved
HgeneCHRM1P11229DB00342TerfenadineBinderSmall moleculeApproved|Withdrawn

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Related Diseases for CHRM1-SARNP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHRM1C0022333Jacksonian Seizure5CTD_human
HgeneCHRM1C0036572Seizures5CTD_human
HgeneCHRM1C0149958Complex partial seizures5CTD_human
HgeneCHRM1C0234533Generalized seizures5CTD_human
HgeneCHRM1C0234535Clonic Seizures5CTD_human
HgeneCHRM1C0270824Visual seizure5CTD_human
HgeneCHRM1C0270844Tonic Seizures5CTD_human
HgeneCHRM1C0270846Epileptic drop attack5CTD_human
HgeneCHRM1C0422850Seizures, Somatosensory5CTD_human
HgeneCHRM1C0422852Seizures, Auditory5CTD_human
HgeneCHRM1C0422853Olfactory seizure5CTD_human
HgeneCHRM1C0422854Gustatory seizure5CTD_human
HgeneCHRM1C0422855Vertiginous seizure5CTD_human
HgeneCHRM1C0494475Tonic - clonic seizures5CTD_human
HgeneCHRM1C0751056Non-epileptic convulsion5CTD_human
HgeneCHRM1C0751110Single Seizure5CTD_human
HgeneCHRM1C0751123Atonic Absence Seizures5CTD_human
HgeneCHRM1C0751494Convulsive Seizures5CTD_human
HgeneCHRM1C0751495Seizures, Focal5CTD_human
HgeneCHRM1C0751496Seizures, Sensory5CTD_human
HgeneCHRM1C3495874Nonepileptic Seizures5CTD_human
HgeneCHRM1C4048158Convulsions5CTD_human
HgeneCHRM1C4316903Absence Seizures5CTD_human
HgeneCHRM1C4317109Epileptic Seizures5CTD_human
HgeneCHRM1C4317123Myoclonic Seizures5CTD_human
HgeneCHRM1C4505436Generalized Absence Seizures5CTD_human
HgeneCHRM1C0036341Schizophrenia4PSYGENET
HgeneCHRM1C0007786Brain Ischemia1CTD_human
HgeneCHRM1C0014544Epilepsy1CTD_human
HgeneCHRM1C0025261Memory Disorders1CTD_human
HgeneCHRM1C0086237Epilepsy, Cryptogenic1CTD_human
HgeneCHRM1C0233794Memory impairment1CTD_human
HgeneCHRM1C0236018Aura1CTD_human
HgeneCHRM1C0751111Awakening Epilepsy1CTD_human
HgeneCHRM1C0751292Age-Related Memory Disorders1CTD_human
HgeneCHRM1C0751293Memory Disorder, Semantic1CTD_human
HgeneCHRM1C0751294Memory Disorder, Spatial1CTD_human
HgeneCHRM1C0751295Memory Loss1CTD_human
HgeneCHRM1C0917798Cerebral Ischemia1CTD_human