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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACOT7-CHD5 (FusionGDB2 ID:HG11332TG26038) |
Fusion Gene Summary for ACOT7-CHD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACOT7-CHD5 | Fusion gene ID: hg11332tg26038 | Hgene | Tgene | Gene symbol | ACOT7 | CHD5 | Gene ID | 11332 | 26038 |
| Gene name | acyl-CoA thioesterase 7 | chromodomain helicase DNA binding protein 5 | |
| Synonyms | ACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACH | CHD-5 | |
| Cytomap | ('ACOT7')('CHD5') 1p36.31 | 1p36.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase | chromodomain-helicase-DNA-binding protein 5ATP-dependent helicase CHD5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000361521, ENST00000377842, ENST00000377845, ENST00000377855, ENST00000541130, ENST00000545482, ENST00000608083, | ||
| Fusion gene scores | * DoF score | 15 X 10 X 10=1500 | 2 X 2 X 2=8 |
| # samples | 20 | 2 | |
| ** MAII score | log2(20/1500*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ACOT7 [Title/Abstract] AND CHD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACOT7(6378552)-CHD5(6228337), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ACOT7-CHD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACOT7-CHD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACOT7-CHD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACOT7-CHD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACOT7-CHD5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ACOT7-CHD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ACOT7-CHD5 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACOT7 | GO:0015937 | coenzyme A biosynthetic process | 10578051 |
| Hgene | ACOT7 | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process | 10578051 |
| Hgene | ACOT7 | GO:0036116 | long-chain fatty-acyl-CoA catabolic process | 10578051 |
| Hgene | ACOT7 | GO:0051792 | medium-chain fatty acid biosynthetic process | 10578051 |
| Hgene | ACOT7 | GO:1900535 | palmitic acid biosynthetic process | 10578051 |
| Fusion gene breakpoints across ACOT7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CHD5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CG-4441-01A | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
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Fusion Gene ORF analysis for ACOT7-CHD5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000361521 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000377842 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000377845 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000377855 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000541130 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000545482 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| 5CDS-5UTR | ENST00000608083 | ENST00000378021 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000361521 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000377842 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000377845 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000377855 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000541130 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| Frame-shift | ENST00000608083 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| In-frame | ENST00000545482 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000545482 | ACOT7 | chr1 | 6378552 | - | ENST00000262450 | CHD5 | chr1 | 6228337 | - | 10036 | 569 | 136 | 6354 | 2072 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000545482 | ENST00000262450 | ACOT7 | chr1 | 6378552 | - | CHD5 | chr1 | 6228337 | - | 0.003025102 | 0.99697495 |
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Fusion Genomic Features for ACOT7-CHD5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ACOT7-CHD5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6378552/chr1:6228337) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000361521 | - | 6 | 9 | 50_168 | 237 | 371.0 | Domain | HotDog ACOT-type 1 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377842 | - | 6 | 9 | 50_168 | 196 | 330.0 | Domain | HotDog ACOT-type 1 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377845 | - | 6 | 9 | 50_168 | 217 | 351.0 | Domain | HotDog ACOT-type 1 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377855 | - | 6 | 9 | 50_168 | 247 | 381.0 | Domain | HotDog ACOT-type 1 |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 49_116 | 26 | 3082.3333333333335 | Compositional bias | Note=Lys-rich | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 1028_1193 | 26 | 3082.3333333333335 | Domain | Helicase C-terminal | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 497_554 | 26 | 3082.3333333333335 | Domain | Chromo 1 | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 592_653 | 26 | 3082.3333333333335 | Domain | Chromo 2 | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 712_896 | 26 | 3082.3333333333335 | Domain | Helicase ATP-binding | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 847_850 | 26 | 3082.3333333333335 | Motif | Note=DEAH box | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 725_732 | 26 | 3082.3333333333335 | Nucleotide binding | ATP | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 343_653 | 26 | 3082.3333333333335 | Region | Note=Histone-binding | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 343_390 | 26 | 3082.3333333333335 | Zinc finger | PHD-type 1 | |
| Tgene | CHD5 | chr1:6378552 | chr1:6228337 | ENST00000262450 | 0 | 42 | 416_463 | 26 | 3082.3333333333335 | Zinc finger | PHD-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000361521 | - | 6 | 9 | 224_338 | 237 | 371.0 | Domain | HotDog ACOT-type 2 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377842 | - | 6 | 9 | 224_338 | 196 | 330.0 | Domain | HotDog ACOT-type 2 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377845 | - | 6 | 9 | 224_338 | 217 | 351.0 | Domain | HotDog ACOT-type 2 |
| Hgene | ACOT7 | chr1:6378552 | chr1:6228337 | ENST00000377855 | - | 6 | 9 | 224_338 | 247 | 381.0 | Domain | HotDog ACOT-type 2 |
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Fusion Gene Sequence for ACOT7-CHD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1378_1378_1_ACOT7-CHD5_ACOT7_chr1_6378552_ENST00000545482_CHD5_chr1_6228337_ENST00000262450_length(transcript)=10036nt_BP=569nt CATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGAC GTCGAGACGCCGTCCGCCATCCAGATCTGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCAT CGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCT CACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCC TGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAA CGGGGACATCGTCCAGCCAGTCCTCAACCCAGAGCCGAACACTGTCAGCTACAGCCAGTCCAGCTTGATCCACCTGGTGGGGCCTTCAGA CTGCACCCTGCACGGCTTTGTGCACGGAGAAGAAGAAGATGGTGGTCTTGAAGCCTTCGATGACTTTTTCCCTGTGGAGCCCGTGAGCCT TCCTAAGAAGAAGAAACCCAAGAAGCTCAAGGAAAACAAGTGTAAAGGGAAGCGGAAGAAGAAAGAGGGGAGCAATGATGAGCTATCAGA GAATGAAGAGGATCTGGAAGAGAAGTCGGAGAGTGAAGGCAGTGACTACTCCCCGAATAAAAAGAAGAAGAAGAAACTCAAGGACAAGAA GGAGAAAAAAGCCAAGCGAAAAAAGAAGGATGAGGATGAGGATGATAATGATGATGGATGCTTAAAGGAGCCCAAGTCCTCGGGGCAGCT CATGGCCGAGTGGGGCCTGGACGACGTGGACTACCTGTTCTCGGAGGAGGATTACCACACGCTGACCAACTACAAGGCCTTCAGCCAGTT CCTCAGGCCACTCATTGCCAAGAAGAACCCGAAGATCCCCATGTCCAAAATGATGACCGTCCTGGGTGCCAAGTGGCGGGAGTTCAGCGC CAACAACCCCTTCAAGGGCAGCTCCGCGGCAGCAGCGGCGGCGGCGGTGGCTGCGGCTGTAGAGACGGTCACCATCTCCCCTCCGCTAGC CGTCAGCCCCCCGCAGGTGCCCCAGCCTGTGCCTATCCGCAAGGCCAAGACCAAGGAGGGCAAAGGGCCTGGAGTGAGGAAGAAGATCAA AGGCTCCAAAGATGGGAAGAAAAAGGGCAAAGGGAAAAAGACGGCCGGGCTCAAGTTCCGCTTCGGGGGGATCAGCAACAAGAGGAAGAA AGGCTCCTCGAGTGAAGAAGATGAGAGGGAGGAGTCGGACTTCGACAGCGCCAGCATCCACAGTGCCTCCGTGCGCTCCGAATGCTCTGC AGCCCTGGGCAAGAAGAGCAAGAGGAGGCGCAAGAAGAAGAGGATTGATGATGGTGACGGCTATGAGACAGACCACCAGGATTACTGTGA GGTGTGCCAGCAGGGTGGGGAGATCATCCTGTGCGACACCTGCCCGAGGGCCTACCATCTCGTATGCCTGGACCCAGAGCTGGAGAAGGC TCCCGAGGGCAAGTGGAGCTGCCCCCACTGTGAGAAGGAGGGGATCCAGTGGGAGCCGAAGGACGACGACGATGAAGAGGAGGAGGGCGG CTGCGAGGAGGAGGAGGACGACCACATGGAGTTCTGCCGCGTGTGCAAGGACGGGGGCGAGCTGCTCTGCTGCGACGCCTGCCCCTCCTC CTACCACCTGCATTGCCTCAACCCGCCGCTGCCCGAGATCCCAAACGGTGAATGGCTCTGCCCGCGCTGTACTTGCCCCCCACTGAAGGG CAAAGTCCAGCGGATTCTACACTGGAGGTGGACGGAGCCCCCTGCCCCCTTCATGGTGGGGCTGCCGGGGCCTGACGTGGAGCCCAGCCT CCCTCCACCTAAGCCCCTGGAGGGCATCCCTGAGAGAGAGTTCTTTGTCAAGTGGGCAGGGCTGTCCTACTGGCATTGCTCCTGGGTGAA GGAGCTACAGCTGGAGCTGTACCACACGGTGATGTATCGCAACTACCAAAGAAAGAACGACATGGATGAGCCGCCCCCCTTTGACTACGG CTCTGGGGATGAAGACGGCAAGAGCGAGAAGAGGAAGAACAAGGACCCCCTCTATGCCAAGATGGAGGAGCGCTTCTACCGCTATGGCAT CAAGCCAGAGTGGATGATGATTCACCGAATCCTGAACCATAGCTTTGACAAGAAGGGGGATGTGCACTACCTGATCAAGTGGAAAGACCT GCCCTACGACCAGTGCACCTGGGAGATCGATGACATCGACATCCCCTACTACGACAACCTCAAGCAGGCCTACTGGGGCCACAGGGAGCT GATGCTGGGAGAAGACACCAGGCTGCCCAAGAGGCTGCTCAAGAAGGGCAAGAAGCTGAGGGACGACAAGCAGGAGAAGCCGCCGGACAC GCCCATTGTGGACCCCACGGTCAAGTTCGACAAGCAGCCATGGTACATCGACTCCACAGGCGGCACACTGCACCCGTACCAGCTGGAGGG CCTCAACTGGCTGCGCTTCTCTTGGGCCCAGGGCACTGACACCATCCTGGCCGATGAGATGGGTCTGGGCAAGACGGTGCAGACCATCGT GTTCCTTTACTCCCTCTACAAGGAGGGCCACTCCAAAGGGCCCTACCTGGTTAGCGCGCCCCTCTCCACCATCATCAACTGGGAACGCGA GTTTGAGATGTGGGCGCCCGACTTCTACGTGGTCACCTACACGGGGGACAAGGAGAGCCGCTCGGTGATTCGGGAGAACGAGTTTTCCTT TGAGGACAACGCCATTCGGAGTGGGAAGAAGGTATTCCGTATGAAGAAAGAAGTGCAGATCAAATTCCACGTGCTGCTCACCTCCTATGA GCTCATCACCATTGACCAGGCCATCCTGGGCTCCATCGAGTGGGCCTGCCTGGTGGTAGATGAGGCCCACCGCCTCAAGAACAACCAGTC CAAGTTTTTTAGGGTCTTAAACAGCTACAAGATTGATTACAAGCTGCTGCTGACAGGGACCCCCCTTCAGAACAACCTGGAGGAGCTGTT CCATCTCCTCAACTTCCTGACTCCAGAGAGGTTCAACAACCTGGAGGGCTTCCTGGAGGAGTTTGCTGACATCTCCAAGGAAGACCAGAT CAAGAAGCTGCATGACCTGCTGGGGCCGCACATGCTCAGGCGGCTCAAGGCTGACGTGTTCAAGAACATGCCGGCCAAGACCGAGCTCAT TGTCCGGGTGGAGCTGAGCCAGATGCAGAAGAAGTACTACAAGTTCATCCTCACACGGAACTTTGAGGCACTGAACTCCAAGGGGGGCGG GAACCAAGTATCGCTGCTCAACATCATGATGGACCTGAAAAAGTGCTGCAACCACCCCTACCTCTTCCCTGTGGCTGCCGTGGAGGCCCC TGTCTTGCCCAATGGCTCCTACGATGGAAGCTCCCTGGTCAAGTCTTCAGGGAAGCTCATGCTGCTACAGAAGATGCTGAAGAAACTGCG GGATGAGGGGCACCGTGTGCTCATCTTCTCCCAGATGACCAAGATGCTGGACCTCCTGGAGGACTTCCTGGAGTACGAAGGCTACAAGTA TGAGCGGATTGATGGTGGCATCACCGGGGGCCTCCGGCAGGAGGCAATCGACAGATTCAATGCCCCCGGGGCCCAGCAGTTCTGCTTCCT CCTCTCAACCCGGGCAGGTGGTCTGGGCATCAACCTGGCCACGGCGGACACTGTCATCATCTACGACTCGGACTGGAACCCGCACAATGA CATCCAGGCCTTCAGCCGCGCCCACCGCATCGGCCAGAACAAGAAGGTGATGATCTACCGCTTCGTGACTCGGGCCTCGGTGGAGGAGCG CATCACGCAGGTGGCCAAGCGCAAGATGATGCTCACCCACCTGGTGGTGCGGCCCGGCCTCGGCTCCAAGTCGGGGTCCATGACCAAGCA GGAGCTGGACGACATCCTCAAGTTCGGCACGGAGGAACTCTTCAAGGACGACGTGGAGGGCATGATGTCTCAGGGCCAGAGGCCGGTCAC ACCCATCCCTGATGTCCAGTCCTCCAAAGGGGGGAACTTGGCCGCCAGTGCAAAGAAGAAGCACGGTAGCACCCCGCCAGGTGACAACAA GGACGTGGAGGACAGCAGTGTGATCCACTATGACGATGCGGCCATCTCCAAGCTGCTGGACCGGAACCAGGACGCTACAGATGACACGGA GCTACAGAACATGAACGAGTACCTGAGCTCCTTCAAGGTGGCGCAGTACGTGGTGCGCGAGGAGGACGGCGTGGAGGAGGTGGAGCGGGA AATCATCAAGCAGGAGGAGAACGTGGACCCCGACTACTGGGAGAAGCTGCTGCGGCACCACTATGAGCAGCAGCAGGAGGACCTGGCCCG CAACCTGGGCAAGGGCAAGCGCATCCGCAAGCAGGTCAACTACAACGATGCCTCCCAGGAGGACCAGGAGTGGCAGGATGAGCTCTCTGA TAACCAGTCAGAATATTCCATTGGCTCTGAGGATGAGGATGAGGACTTTGAAGAGAGGCCGGAAGGGCAGAGTGGACGACGACAATCCCG GAGGCAGCTGAAGAGTGACAGGGACAAGCCCCTGCCCCCGCTTCTCGCCCGAGTTGGTGGCAACATCGAGGTGCTGGGCTTCAATGCCCG ACAGCGGAAGGCCTTTCTGAACGCCATCATGCGCTGGGGCATGCCCCCGCAGGACGCCTTCAACTCCCACTGGCTGGTGCGGGACCTTCG AGGGAAGAGCGAGAAGGAGTTTAGAGCCTATGTGTCCCTCTTCATGCGGCACCTGTGTGAGCCGGGGGCGGATGGTGCAGAGACCTTCGC AGACGGCGTGCCCCGGGAGGGCCTCTCCAGGCAGCACGTGCTGACCCGCATCGGGGTCATGTCACTAGTTAGGAAGAAGGTTCAGGAGTT TGAGCATGTCAACGGGAAGTACAGCACCCCAGACTTGATCCCTGAGGGGCCCGAGGGGAAGAAGTCGGGCGAGGTGATCTCCTCGGACCC CAACACACCAGTGCCCGCCAGCCCTGCCCACCTCCTGCCAGCCCCGCTGGGCCTGCCAGACAAAATGGAAGCCCAGCTGGGCTACATGGA TGAGAAAGACCCCGGGGCACAGAAGCCAAGGCAGCCCCTGGAAGTCCAGGCCCTTCCAGCCGCCTTGGATAGAGTGGAGAGTGAGGACAA GCACGAGAGCCCAGCCAGCAAGGAGAGAGCCCGAGAGGAGCGGCCAGAGGAGACGGAGAAGGCCCCGCCCTCCCCGGAGCAGCTGCCGAG AGAGGAGGTGCTTCCTGAGAAGGAGAAGATCCTGGACAAGCTGGAGCTGAGCTTGATCCACAGCAGAGGGGACAGTTCCGAACTCAGGCC AGATGACACCAAGGCTGAGGAGAAGGAGCCCATTGAAACACAGCAAAATGGTGACAAAGAGGAAGATGACGAGGGGAAGAAGGAGGACAA GAAGGGGAAATTCAAGTTCATGTTCAACATCGCGGACGGGGGCTTCACGGAGTTGCACACGCTGTGGCAGAACGAGGAGCGGGCTGCTGT ATCCTCTGGGAAAATCTACGACATCTGGCACCGGCGCCATGACTACTGGCTGCTGGCGGGCATCGTGACGCACGGCTACGCCCGCTGGCA GGACATCCAGAATGACCCACGGTACATGATCCTCAACGAGCCCTTCAAGTCTGAGGTCCACAAGGGCAACTACCTGGAGATGAAGAACAA GTTCCTGGCCCGCAGGTTTAAGCTGCTGGAGCAGGCGTTGGTCATTGAGGAGCAGCTCCGGAGGGCCGCGTACCTGAACATGACGCAGGA CCCCAACCACCCCGCCATGGCCCTCAACGCCCGCCTGGCTGAAGTGGAGTGCCTCGCCGAGAGCCACCAGCACCTGTCCAAGGAGTCCCT TGCTGGGAACAAGCCTGCCAATGCCGTCCTGCACAAGGTCCTGAACCAGCTGGAGGAGCTGCTGAGCGACATGAAGGCCGACGTGACCCG GCTGCCATCCATGCTGTCCCGCATCCCCCCGGTGGCCGCCCGGCTGCAGATGTCGGAGCGCAGCATCCTGAGCCGCCTGACCAACCGCGC CGGGGACCCCACCATCCAGCAGGGCGCTTTCGGCTCCTCCCAGATGTACAGCAACAACTTTGGGCCCAACTTCCGGGGCCCTGGACCGGG AGGGATTGTCAACTACAACCAGATGCCCCTGGGGCCCTATGTGACCGATATCTAGCCGTCCTCGAGACTTCCCTGTGTTGCAGCGCTCAT TTCCAGCTGAGCCACGCCTGCCGGGCCACCTGCCCGACCCACATGGGAGAGAAAAGCTGCCACCTTTTTAGGAGCCAGCGCCACCTTGGG ACAAAAAGGGAAACCTAGTAATGCCATCACATGGAGGACGAGGCCCAGCTCAGCTGGGCCAGAGCCCAGAAGTGCCACCTCATCATAATT CAAGTGTTCTTCCACACAGCGTTGCCCCCACAACCACGCCGGACGTGCCCCCTCGCCACCTTTTCCAGACGACTTCTTAGAAGAGATTTC ATTTATTTGTACATCTTTTGCACTTTCCTATTGAAGACTTGAACACGTTTGTCTTGATAAAAGTTGGATGACGTATGGAAGATTCGAACC TGCAGCACTGATGTCTCTTTACCGATGGGTTCCAGACCCAAGGTAGTCCTGGCACTGCCCTGTGGACTCAGCCCAGCTGGGGAGGACATG GCGCCCGGTGCCCTAGGAGCCCTCAGTGTCCCCTACCTGACCTGTCTGCACCTGTGTGACAGCCCCTTCTGATTTGGCCCCCTGCCCGCT TGGAGCCTCCCAGCACCAGACAGGGCAGGTTTGGGGAGCCGCTGTCCAGCCCTATGGTGAGACCCTGGCTGACATTTCCCCTCCTTCCTG CCAAGGCTGGAGGCCGCCAGGTGTTTGCTCTCTCCTTGTGGGGAGGTGGATCCTCTGCCAGCAGGTGTCTGTCCCCGGCCCAGCGCATCT TGAAGGCCCTGGACTCTGTTACCAGTGGGGGGCCTGTGGCCCCGGCTCTTCACAGCAGGCAGAAGCGTATGATCCCAGGGAGGGTGGGCT GGGGGGGGGGCAGCACTTGCCTCGGAGCCACTGCTGCGTTGGGTTTGCCTTCTGCCAGAGGTGTGGTTAAGGGCAGTGATAGCTGCGCCC CAGCAAGGAGGGTCATGGGCCCTGAGCTGGCCCAGGAGACCCTGGCCCTGCCCTGTGCCCTGGGATGCCTACCCTGCCCACCTCCGGAGG TGGAACCGGGCTGCCCCTGGGGGCCTGGACTTGTCCCATTCCCCTGTCCCTGGAAAGGCCTTCCCGGGGGCTTTTTGCCTGAGGCTGCAC TCTTGGAAGGCGTGGGGAGAGTTCTGCCTGGAGGGGGACTGGACCCAGTGCCCTCTGCAGACCCCTCCCAGCCGCAGCACCAAGGGCTTG CTGCCTTGTTTCCTGCCAGGAGCGCCCTGACATCCCAAAACCATCTTCCCACATGTGGGTTGTTGGAATCCCACCCACTCCCCCGGACCC TGCCCCTCCAAGTTGGGGACGGAGATGGGGAGCAGGTCAGGCCCTCCCTAGGCCTGTTTGTGTGTGATCCTTCTCCTGGCCCCAGGTCGA CCTGGAAGGCGTTTCTGAGTCTTGTACTGGGACCTTCCCAGGGAAGGTGCCTTGGGGTGCAGAATCCTGGGAATGTTAGGAAAGGGCTGC GTGAAAAACCCAGCTGGGCCTGGGGTGGAGGTGCACACGGGCTGGGGCTCAGCTCCTTGGAGAGGGCCTGCCTGGGACTGAGGGGGCCAG GGCTGGGTCAGGATTCACCAGCTTGTGTTGCAGACACTGGAGCGATTGCCTGGCCCTCCCTAAGCCCTATATGCCTCACTCATAATGAGG CTGTCTCTGAACCCCGGAGGGCGGGACCTACAAGTCCTTCCTCTTGGCGCATTCCCACACTCCAGTCTGGATCCAGGTCTGCAAGGCCAG CCCGACCCTGACACTGCACGTGGGCGTAGTGGGGAGCACCCTGGAGTGGAGATGATTGTCAGCGGGCTCACATGTTATGGTTCATCCACA TGCGTGTTGTGTGCTCTGCGGTGCCTCCTGGCAAAGGGTCCTGGCTCGGGTCAGAAGCTCACTCCCGTGCCCTCGTCCCCAAACAAGCAG TGGCAAGCACTGGGGTTGGCCCTCGTTGGGAGCAGTGCCCACCTTCCTTGGCCCACAGCAGATAGGTCCCGAGCAGCAGGACTGGAGGCC TGTGGCGGTCAGGGCAGGGGTCTGTGTCTCCACCCCAAGGGCTGATGGTCCCTCCCCTGTGCGCCTTCCTCTCAGGCAGGCTTGCTCTGT CCCTTCCTCTCTGCTTCCCTCCCAGGCCTCGCCAGGGCTCCCTTCTCCTCTGCCTGGTTAGACTCGGGCACCCAGGAAAGCCTGGCCAGG GCTCCTTTGGGCCTGGGCCCCCTGCACTGCCTGGTCCAGAAGGGGTGGTGCTGTCCGTGGCCAGCACCCCGGGGCCCGGGAGGGGTGGGC TACTAGAGTCAGAGCGGGTTTGGGGCTGACCAGTTTGGGAGAGGAGAAAAGATCTGAGAATGTCCTTCTTGGTTTGTCAGTCATCTCTGC CAAAAGTGGTGATGGTGGTGTCCGTATGTTTGGCGTCTTTGGGCTGGGTTTGGTTTTTGCTGCTGGTAGAATCAGGGTCCTCGGGCATGA ACGCGAGCCCAAAGTGCCAGTCTGCGATTGGAAATTTCCAGCCACTTTAAGCCAGTGCTGAGTAGGGCTTCTGCAGAGCCATGTTTGAGC CAAGGTCTTGGAAGGCATTGCCCCATGGGCTCAGGTGACTCGGGGTGGAGTGAGCACGTCTGCAGGGCCCTCTCATACACGCCTGAGGCA GAAGCAGCGTCCCCCGTGAAAGCCACCTTCCGAAGCTCCTGCGTTTTTTGCAAACTTGGCTTCCCCCAGGGGCAGGCTGGACTTTCCCTG CCCCCTATGATTGAAGTCCTCCTGCTTTTGGGGGCTGCCTTCCCAGAGTCCCCCGGGTGCTCCCCTGCCGAGGTCAGGAGCTGACCAAGC CTTGGCCCGGTGACACCTGCAGCCCTCACTCCTGTCATCCCAGGACACTTGAGGCCCAAGGAGGTGGAGTGGAGAGTGGGCTCGGGTACA TGGGAGCCAGAAGCCAGATGGACTTGGTCAAGTGTCGGTCACTTGGAGCCTCCAGTGTGCGTCAGGGTCTGTGGGCAGGGGACAGGGCGT GGGTGGGGGCCGAGGCTGGCACGCCCCTCTGCCCTCACCGTCTTGGTGACCTGGCCTCGGCCCCTCCCCCAAGTCTCTTCTGTGCAAGGC CCGCCTCGGCCTCGGCAGCTGGTTCCTGTCCTGTTTTCTGTGTCTGAAAGTTTACAGGTTGTGGTGCATCAGCCCAAACTCACTGGCGTT GTGTTTTTTTTTTCTTTAATTTTCAGATTTTTTTTTTAAACAAAGTATTTTTTTAGGTGCGATAACCCAGAAAGGGCCCGTTGGGTGTGT GTGTGTGTCCTGAACTCCTCAAGCAGCGATTGGAGCCCAAGCACCCCTGGAGAGGAAGGGAGGGTCCCCACTGGCCCGTGGGGTCTGAGT TCAGGGGTGTGGAGGGAGCAGACTCCACCGGCCCAGGCCCAGCTAAGAGGGGGCCGACCCCTTTCCCCAGGCACAGCCCCAGGCTGGCAA AGGGAGGGCCCTGGGCTGGGTGCAAGGCGCGCCAGGAGTCCCAGCCAGGGTGGCCCCGGCGGGGGCGGGTCCAGCTTTGGAAGCCAGGCT CCCCTGTGAGCCGTGGCTTGTCTGGTCTTCGCCCACGGGAGGCTGGACAGAGGCTGTAGCCAACACAATCACCTTTACTTTGTACTCTGT GTGTATGTTTTGGTTTTCTGTGTTTTAATAAATCCTTTGGGAAAGG >1378_1378_1_ACOT7-CHD5_ACOT7_chr1_6378552_ENST00000545482_CHD5_chr1_6228337_ENST00000262450_length(amino acids)=2072AA_BP=1 MARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKR YEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGEEEDGGLEAFDDFFPVEPVSLPKKKKPKKLKENKCK GKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKKAKRKKKDEDEDDNDDGCLKEPKSSGQLMAEWGLDDVDYLFSE EDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTISPPLAVSPPQVPQPVPIRKA KTKEGKGPGVRKKIKGSKDGKKKGKGKKTAGLKFRFGGISNKRKKGSSSEEDEREESDFDSASIHSASVRSECSAALGKKSKRRRKKKRI DDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVC KDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPDVEPSLPPPKPLEGIPEREFF VKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMIHRILNHSF DKKGDVHYLIKWKDLPYDQCTWEIDDIDIPYYDNLKQAYWGHRELMLGEDTRLPKRLLKKGKKLRDDKQEKPPDTPIVDPTVKFDKQPWY IDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTG DKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKL LLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKF ILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKM LDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKK VMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPVTPIPDVQSSKGGNLAA SAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREIIKQEENVDPDYWEK LLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLL ARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLT RIGVMSLVRKKVQEFEHVNGKYSTPDLIPEGPEGKKSGEVISSDPNTPVPASPAHLLPAPLGLPDKMEAQLGYMDEKDPGAQKPRQPLEV QALPAALDRVESEDKHESPASKERAREERPEETEKAPPSPEQLPREEVLPEKEKILDKLELSLIHSRGDSSELRPDDTKAEEKEPIETQQ NGDKEEDDEGKKEDKKGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPF KSEVHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLN QLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSSQMYSNNFGPNFRGPGPGGIVNYNQMPLGPYVT DI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACOT7-CHD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACOT7-CHD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACOT7-CHD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
| Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
| Tgene | C0027819 | Neuroblastoma | 1 | CTD_human |
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