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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACOT7-PLEKHG5 (FusionGDB2 ID:HG11332TG57449)

Fusion Gene Summary for ACOT7-PLEKHG5

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOT7-PLEKHG5
Fusion gene ID: hg11332tg57449
HgeneTgene
Gene symbol

ACOT7

PLEKHG5

Gene ID

11332

57449

Gene nameacyl-CoA thioesterase 7pleckstrin homology and RhoGEF domain containing G5
SynonymsACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACHCMTRIC|DSMA4|GEF720|Syx|Tech
Cytomap('ACOT7')('PLEKHG5')

1p36.31

1p36.31

Type of geneprotein-codingprotein-coding
Descriptioncytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolasepleckstrin homology domain-containing family G member 5NFkB activating proteinPH domain-containing family G member 5guanine nucleotide exchange factor 720novel PH domain-containing proteinpleckstrin homology domain containing, family G (with RhoGef d
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361521, ENST00000377842, 
ENST00000377845, ENST00000377855, 
ENST00000545482, ENST00000608083, 
ENST00000541130, 
Fusion gene scores* DoF score15 X 10 X 10=15004 X 3 X 4=48
# samples 206
** MAII scorelog2(20/1500*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACOT7 [Title/Abstract] AND PLEKHG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOT7(6341162)-PLEKHG5(6556629), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

HgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

HgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OS-01AACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
ChimerDB4ESCATCGA-L5-A4OSACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
ChimerDB4ESCATCGA-L5-A4OSACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
ChimerDB4STADTCGA-VQ-A925-01AACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
ChimerDB4STADTCGA-VQ-A925ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-


Top

Fusion Gene ORF analysis for ACOT7-PLEKHG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361521ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000361521ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377842ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377845ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000377855ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000545482ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-5UTRENST00000608083ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000361521ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377842ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377845ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000377855ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000545482ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
5CDS-intronENST00000608083ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000361521ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000361521ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377842ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377842ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377845ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377845ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377855ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000377855ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000545482ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000545482ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000608083ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
Frame-shiftENST00000608083ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-3CDSENST00000541130ENST00000377748ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-3CDSENST00000541130ENST00000377748ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377732ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377732ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377737ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377737ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377740ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000377740ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000400915ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000400915ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000537245ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000537245ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000544978ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-5UTRENST00000541130ENST00000544978ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000340850ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000340850ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000377725ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000377725ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000377728ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000377728ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000400913ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000400913ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000535355ACOT7chr1

6341162

-PLEKHG5chr1

6556629

-
intron-intronENST00000541130ENST00000535355ACOT7chr1

6341161

-PLEKHG5chr1

6556629

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACOT7-PLEKHG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ACOT7-PLEKHG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6341162/:6556629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACOT7-PLEKHG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACOT7-PLEKHG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACOT7-PLEKHG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACOT7-PLEKHG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3809309CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE C3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0393541Distal Spinal Muscular Atrophy1GENOMICS_ENGLAND
TgeneC1136382Sclerocystic Ovaries1CTD_human
TgeneC1970211Spinal Muscular Atrophy, Distal, Autosomal Recessive, 41CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT