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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BTBD9-CDC5L (FusionGDB2 ID:HG114781TG988) |
Fusion Gene Summary for BTBD9-CDC5L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BTBD9-CDC5L | Fusion gene ID: hg114781tg988 | Hgene | Tgene | Gene symbol | BTBD9 | CDC5L | Gene ID | 114781 | 988 |
| Gene name | BTB domain containing 9 | cell division cycle 5 like | |
| Synonyms | dJ322I12.1 | CDC5|CDC5-LIKE|CEF1|PCDC5RP|dJ319D22.1 | |
| Cytomap | ('BTBD9')('CDC5L') 6p21.2 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BTB/POZ domain-containing protein 9BTB (POZ) domain containing 9 | cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000403056, ENST00000408958, ENST00000314100, ENST00000419706, ENST00000481247, | ||
| Fusion gene scores | * DoF score | 18 X 16 X 9=2592 | 8 X 6 X 6=288 |
| # samples | 21 | 8 | |
| ** MAII score | log2(21/2592*10)=-3.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BTBD9 [Title/Abstract] AND CDC5L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BTBD9(38224185)-CDC5L(44413392), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BTBD9-CDC5L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BTBD9-CDC5L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BTBD9-CDC5L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BTBD9-CDC5L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BTBD9-CDC5L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. BTBD9-CDC5L seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDC5L | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Tgene | CDC5L | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11082045 |
| Fusion gene breakpoints across BTBD9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CDC5L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-4R-AA8I-01A | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
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Fusion Gene ORF analysis for BTBD9-CDC5L |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000403056 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
| Frame-shift | ENST00000408958 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
| In-frame | ENST00000314100 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
| In-frame | ENST00000419706 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
| In-frame | ENST00000481247 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000314100 | BTBD9 | chr6 | 38224185 | - | ENST00000371477 | CDC5L | chr6 | 44413392 | + | 5708 | 1675 | 317 | 1678 | 453 |
| ENST00000481247 | BTBD9 | chr6 | 38224185 | - | ENST00000371477 | CDC5L | chr6 | 44413392 | + | 5747 | 1714 | 152 | 1717 | 521 |
| ENST00000419706 | BTBD9 | chr6 | 38224185 | - | ENST00000371477 | CDC5L | chr6 | 44413392 | + | 5764 | 1731 | 229 | 1734 | 501 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000314100 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + | 0.000161393 | 0.9998386 |
| ENST00000481247 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + | 0.000245129 | 0.99975485 |
| ENST00000419706 | ENST00000371477 | BTBD9 | chr6 | 38224185 | - | CDC5L | chr6 | 44413392 | + | 0.00020657 | 0.99979347 |
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Fusion Genomic Features for BTBD9-CDC5L |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| BTBD9 | chr6 | 38224184 | - | CDC5L | chr6 | 44413391 | + | 0.000531609 | 0.9994684 |
| BTBD9 | chr6 | 38224184 | - | CDC5L | chr6 | 44413391 | + | 0.000531609 | 0.9994684 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for BTBD9-CDC5L |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:38224185/chr6:44413392) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000314100 | - | 8 | 10 | 142_240 | 452 | 545.0 | Domain | Note=BACK |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000314100 | - | 8 | 10 | 36_104 | 452 | 545.0 | Domain | BTB |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000403056 | - | 8 | 10 | 142_240 | 520 | 613.0 | Domain | Note=BACK |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000403056 | - | 8 | 10 | 36_104 | 520 | 613.0 | Domain | BTB |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000408958 | - | 7 | 9 | 142_240 | 452 | 545.0 | Domain | Note=BACK |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000408958 | - | 7 | 9 | 36_104 | 452 | 545.0 | Domain | BTB |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000419706 | - | 9 | 11 | 142_240 | 490 | 583.0 | Domain | Note=BACK |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000419706 | - | 9 | 11 | 36_104 | 490 | 583.0 | Domain | BTB |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000481247 | - | 9 | 11 | 142_240 | 520 | 613.0 | Domain | Note=BACK |
| Hgene | BTBD9 | chr6:38224185 | chr6:44413392 | ENST00000481247 | - | 9 | 11 | 36_104 | 520 | 613.0 | Domain | BTB |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 764_802 | 697 | 803.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 142_245 | 697 | 803.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 676_701 | 697 | 803.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 31_54 | 697 | 803.0 | DNA binding | H-T-H motif | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 82_104 | 697 | 803.0 | DNA binding | H-T-H motif | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 1_56 | 697 | 803.0 | Domain | HTH myb-type 1 | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 57_108 | 697 | 803.0 | Domain | HTH myb-type 2 | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 165_271 | 697 | 803.0 | Motif | Nuclear localization signal |
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Fusion Gene Sequence for BTBD9-CDC5L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >10490_10490_1_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000314100_CDC5L_chr6_44413392_ENST00000371477_length(transcript)=5708nt_BP=1675nt AGATAAGGAATTGTATAGGAGGAAACTTCATAGTAAACATTGAACCTCTGTGCTTGTCTCCTTGTTGAAGTTGGGGGTTCATGTTTATTG TTCCAAGGGAGCCTCATCAAAACCACTTTTAAAGCATTGAGAATCCAAATAAATACCATGGATCATACAGGATTGGGGATAAGTCTTGAG GTCTCCCCGAGAAGGAGAAGTTCTTTAATTTGGTAATTTTAGGGTAATGGTTGGATGCTCTCTGGATTAATGGAAACCTTCAGGGGTACT TTTAGGCAGAGTATAACCCAGTGAAGAGAGCATTATTATATGGTGGAATGCGAGAGTCTCAGCCTGAAGCAGAAATTCCTCTCCAAGACA CCACTGCAGAAGCATTCACAATGCTACTCAAATATATCTACACTGGGCGGGCAACGCTGACAGATGAGAAGGAGGAGGTGCTGCTGGACT TTTTGAGCCTGGCTCATAAATATGGATTTCCAGAGCTAGAGGATTCTACCTCTGAGTATCTCTGCACCATACTTAACATTCAGAATGTCT GCATGACTTTTGATGTTGCCAGTCTCTACTCACTTCCCAAGTTAACTTGTATGTGCTGCATGTTTATGGATAGGAATGCTCAGGAAGTCC TCTCAAGTGAAGGTTTCCTCTCCCTTTCTAAGACAGCACTTTTAAACATCGTGTTAAGAGACTCATTTGCAGCTCCCGAAAAAGATATTT TCCTAGCCTTATTAAACTGGTGTAAGCACAATTCAAAGGAGAATCATGCTGAAATCATGCAGGCTGTGCGTTTACCTCTCATGAGCCTCA CAGAGCTTCTGAATGTTGTGAGGCCTTCAGGACTGCTGTCTCCTGATGCCATCCTGGATGCCATTAAAGTGCGATCTGAGAGCCGGGATA TGGACCTCAATTATAGAGGCATGCTCATACCAGAAGAAAACATTGCAACTATGAAGTATGGAGCCCAAGTTGTAAAGGGGGAGCTGAAAT CAGCCTTATTAGATGGTGATACTCAAAATTATGATTTGGATCATGGATTTTCAAGGCACCCAATTGATGATGACTGCCGTTCCGGCATCG AGATTAAGCTAGGTCAGCCATCCATTATCAATCACATACGGATACTCTTGTGGGACCGAGATAGCCGGTCTTACTCATACTTCATTGAAG TGTCAATGGATGAACTTGATTGGGTCAGAGTGATAGATCATTCACAATATCTGTGTCGTTCTTGGCAGAAATTATATTTTCCAGCCCGTG TCTGCAGGTATATTCGAATTGTTGGGACTCACAACACAGTGAACAAGATTTTTCACATTGTGGCTTTTGAATGTATGTTTACAAACAAAA CCTTCACTCTTGAGAAGGGGCTGATAGTTCCCATGGAGAATGTTGCAACAATTGCTGATTGTGCCAGTGTGATTGAAGGAGTCAGTCGGA GCCGAAATGCCTTGCTGAATGGGGACACTAAGAATTATGACTGGGATTCTGGCTACACATGTCACCAGCTAGGAAGTGGTGCGATTGTGG TTCAGTTGGCACAACCGTACATGATTGGGTCAATACGGTTACTACTTTGGGATTGTGATGATCGAAGCTATAGCTACTACGTTGAGGTTT CTACCAACCAGCAACAGTGGACCATGGTTGCTGACAGAACTAAAGTCTCCTGCAAATAAACAGGGGTCACATGACGACAGAAGCCAAGAG GGCTGCAAAGATGGAAAAGAAGATGAAAATTTTGCTTGGGGGTTACCAGTCTCGTGCTATGGGGCTCATGAAACAGTTGAATGACTTATG GGACCAAATTGAACAGGCTCACTTGGAGTTACGCACTTTTGAAGAACTCAAGAAACATGAAGATTCTGCTATTCCCCGGAGGCTAGAGTG TCTAAAAGAAGACGTTCAGCGACAACAAGAAAGAGAAAAGGAACTTCAACATAGATATGCTGATTTGCTGCTGGAGAAAGAGACTTTAAA GTCAAAATTCTGAAGTACAGTTTATATTCTGTCACAGGATTAATTAATTGCCGGTTTTCATACTCTAGAAGGCTGAAACTGATGTTTATC TTCATTGACAAATTTACCCACCATCTGTGGTTTTTCAGTTGTTTATTTTAAATGATATCGATCTTACACATTCTGTGTATAAAGACCTTA ACTCCACAGGACGGACATTTTAGAGTTTAAATTATTAAGGCTATCATTCTTTTAGTAATGTCATATTTGCAAACTTTTTTAGTTTTGGCC TTTAATTTAAAAAGCCTAATTTTAAAGTGCTGCCTGTGAGTAACTCTTGAATAAAAACAAAATATAAAAAATTGAGAATGTAGCCTTTTG TTTGAAGTAATTAGATACTTAAGAGTGCCTGCAAACCAGCAGCTATGTACTCTGTGTCATATTTAATGAGTAACTCTTGGGTAATCAAAA TGGTGATGCAGTATCTTAAACACTTAAGAGGCAGTTCTTTGTGGCTTTGTTAGTTTCAGCAAAGAGTGGTCATTTCTGTATACACTGACA AGTTAGATTAACTTTTTAGTACCTCAAATTTTTTTTTTGTTAATATCACTTTAAAGAAGGTCTCTTGTCTGCCAGCTACTTAAATAATTT ATGGGTCAGGGCTTAAAAGATTTAACTTCCTTGCCCCATTATTTTCTTATAAGTATTTTTTGACAAAGGCATTTTAAAAGTTAATTTCAA GAAGGCCATCAAACTTAAAGCTCTATGTTTAGCCTAAGAAGTCAGTTACATCAGTGTAGAATTTGGGGAATGGATAGAGGTGGAGATATT TAATTTTATATAATTCATATAAATTGATTTAGTTACAGTATCAGTTGGCTACAAGCTCATTATAGACTAGCAATGTTTTGACATCACCAA AAACGTTTGCCCAGTCTTAGAATACTAGGGACTATAGGAAGGGAAGGGATTCATTCATTCATTCGATATTGAATGTATACCCTGTGCCAG AGTCTTAGAGAGAGAACAACAAACAAAATAGGCCTAGTTCTTGTTTAGTAGAGCTTATAGTCTTTTGAGAATGACAGACAATTAAAATCC AAATGTTTATTTGGTGATTCTTATGTGTCAGACACTTAAGTGTTGGGAGATAAGCAGTTATTAAGACAGAGTTCTTGCTCTCATGGAGGT GACATTAGTGGGGAGGAGATACTAAGTATGTCCAGGGAAAGTATCAGACCATGAGTTTTAGATTCTGTGGAGGAAATTAAAGTAGGGTGA TTATGAGATAGTGAATGAGTGGCTATTTTAGACTGGACGATCAAAGAGACCTCTTGGAAGGCAGCTATGCTCACCACTATACCACTGCAC TGTGCCGCACCGTACCACTATAAGCTGCACGGCCAAAGAGACCTCTTAAAGAAGTAACATTTAAGATAACATGTGATTGACATTTTAGAA TGGGCTATCCTTGTGAGATTCAAGGAAAGAACATCCTAGGTGGAGTGAATAGCAAACATAAAGCCTCTTTTGTATGTTTGAGGAACAAAA AGGACAATGCAGCTAGAGTGTCAAGAATGGCATTTCTGTATATAAGACCTCGTTGTATAGAGCCACATAAATAAGGCTATAATAAGGAAT TTGGATCTTACTTTAAATATGATAAGAATCGATGAGAAGATCTAAGCAAAGGAATGACATGATCAGATTTGGTTTTAGAAACATCACTAT CTCCTTAGTGTGTAAAATCTCACCAGGCTGGAGATAGGGAAGCCAGTCCAATTAGGAGCCTGATGCAGTGATCCAGACAAAAAAATAATA GTGATTCTAACTAGAGTCCAGGTAATAGTAGTGGAGATATGTGGAGAGACATGATAGGTATATACTTAATAGTCTTATCAGACGATAAAT TGATATTTTCCTGGTGTGTAGTCACTTAATTCAAATACTTTTTTCAGTAAGTTCTGGGTTTTCTAGGAAAAACTTCAGTATCATCAGTGA ATAATGATAGTGTTTCTTCTGATAGTTTTATTTCACTTTTATTGCATGTTTTGTTATCTGAAATGTTTAGGACAATGTTAACAATAATGA TGTTAGACATTTTTTTTTCTTATTTTAATGGGAATGTCCATAGTTTTAAGTTTGCTGTTGGGAGTTAGATAGTCTTTATCTGAAAGACAG TGTCTCTCTTTTAGTTTTTAAAGAGTTTGAATTAGAAATGGCTCTGGAACTTTAAACAGTATACCATTTGGGCATCTATTAAAGCATTCA TATAATTGTTCTCATTTGATGTTTTGATGAGGTATATTAATAGATTTTCCCACATTAAATCATCTTTGCACTCCTGGAATCAGGTAGATT AATTTTTAAAAGAAATTTTAAAGGATTTATAGTTTATTTGCACTTTTTGTAGACTTGAATTATATGGATTTAAAAGTTGATCTAATATTA ATAAAGGCTCACTTTGTTTTCAAAATTTGAAGTAATTCACATACTTATAGCCTAAAAAAATCGGCAGGAATTACAAAATTTCAAAACTGG CACATTGTAAACTGCATATGCATTTGCCAGGTAGTGGTGCCACTTGAAATGGTGAACAGACACACTGTTATCCTTTGTCAGTATCCTGTA AAGCCCAGGATTCTTTACCAGCACCATACAGCGATTTTGGTGACTATTTTAACATTCACACTGAGGCCAGGGGTGGTGAGTCATGCCTGT AATCCTAGCACTTTGGGAGGCCAAGGTGGGAGGATCATTTGAGCTCAGGAGTTCAAGATTAGCCTGGGTAACATAGTGAGACCCTGTCTC TATTAAAAAATAATAATAAAAATAACATTCACATTGGTATTGTTCACTAAGGTATTGGTTGTTAAGGCATTCATTAAGGTATTGTTAAAA CTTGTGTTAAGCATGTTAAAGTCTCAGTAACTTTGGGATAGAAATAAAATGTGATAAAAAGCTGAAAGAAACCACCACAAGGGAGAGTCC TTTTTGAAATATTAGAGACATAATGCTGTCTAATAAAAAACGACATCAAAGAAAAACTACACTACAGTGACTGCAGACTTAATGTTGGCC AACCATGCATCCTCCCTAGAAATGCATTTGAATTTGATTTACTAATCTTTTATTTAGGAAATTTACATTTTTACATTAGTGAGATTGGTC TTTTGGGCTATTGTACTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTCTCACCCAGGCTGGAGTGCAGTAGTGCAATCTTGGCCC ACTGCAACCTCTGCCTCCTGGGCTCGAGTGATTCTCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGGCATGTGCCACCGCACCTGGCT AATTTTTGTGTTTTTAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGGTCTTGAATTCCTGACCTCAGGTGATCCACCTACCTCGGC CTCCCAAAGTGCTAGAATTACAGGTGTGAGCCACCATGCCCAGCCTGGTTATTGTATTTTGATATTGGGATTTTGCTAGCTCTCTAAAGT AAATAGGATAACTGTATATCTTTTTCTGTGCATTAAGCAGTTATAACATGGGAATGATTTGTTCATGAAAGGTTGAAAGTCTGTACTTAC AGAACTTTTGAGTTCACAGTGCTTTCTGGAAATAATTTCTTTATAACTGTCAGTTTCTTTTGTGACTATTATGTTACCTATTTTTAAATT >10490_10490_1_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000314100_CDC5L_chr6_44413392_ENST00000371477_length(amino acids)=453AA_BP= MRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLT CMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPD AILDAIKVRSESRDMDLNYRGMLIPEENIATMKYGAQVVKGELKSALLDGDTQNYDLDHGFSRHPIDDDCRSGIEIKLGQPSIINHIRIL LWDRDSRSYSYFIEVSMDELDWVRVIDHSQYLCRSWQKLYFPARVCRYIRIVGTHNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVA TIADCASVIEGVSRSRNALLNGDTKNYDWDSGYTCHQLGSGAIVVQLAQPYMIGSIRLLLWDCDDRSYSYYVEVSTNQQQWTMVADRTKV -------------------------------------------------------------- >10490_10490_2_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000419706_CDC5L_chr6_44413392_ENST00000371477_length(transcript)=5764nt_BP=1731nt CATGTTTATTGTTCCAAGGGAGCCTCATCAAAACCACTTTTAAAGCATTGAGAATCCAAATAAATACCATGGATCATACAGGATTGGGGA TAAGTCTTGAGGTCTCCCCGAGAAGGAGAAGTTCTTTAATTTGGTAATTTTAGGGTAATGGTTGGATGCTCTCTGGATTAATGGAAACCT TCAGGGGTACTTTTAGGCAGAGTATAACCCAGTGAAGAGCAAATCCTATTTGAGGGTTTCTTCATGTGTTTCTTCCCTGATGTGCAGAGC ATTATTATATGGTGGAATGCGAGAGTCTCAGCCTGAAGCAGAAATTCCTCTCCAAGACACCACTGCAGAAGCATTCACAATGCTACTCAA ATATATCTACACTGGGCGGGCAACGCTGACAGATGAGAAGGAGGAGGTGCTGCTGGACTTTTTGAGCCTGGCTCATAAATATGGATTTCC AGAGCTAGAGGATTCTACCTCTGAGTATCTCTGCACCATACTTAACATTCAGAATGTCTGCATGACTTTTGATGTTGCCAGTCTCTACTC ACTTCCCAAGTTAACTTGTATGTGCTGCATGTTTATGGATAGGAATGCTCAGGAAGTCCTCTCAAGTGAAGGTTTCCTCTCCCTTTCTAA GACAGCACTTTTAAACATCGTGTTAAGAGACTCATTTGCAGCTCCCGAAAAAGATATTTTCCTAGCCTTATTAAACTGGTGTAAGCACAA TTCAAAGGAGAATCATGCTGAAATCATGCAGGCTGTGCGTTTACCTCTCATGAGCCTCACAGAGCTTCTGAATGTTGTGAGGCCTTCAGG ACTGCTGTCTCCTGATGCCATCCTGGATGCCATTAAAGTGCGATCTGAGAGCCGGGATATGGACCTCAATTATAGAGGCATGCTCATACC AGAAGAAAACATTGCAACTATGAAGTATGGAGCCCAAGTTGTAAAGGGGGAGCTGAAATCAGCCTTATTAGATGGTGATACTCAAAATTA TGATTTGGATCATGGATTTTCAAGGCACCCAATTGATGATGACTGCCGTTCCGGCATCGAGATTAAGCTAGGTCAGCCATCCATTATCAA TCACATACGGATACTCTTGTGGGACCGAGATAGCCGGTCTTACTCATACTTCATTGAAGTGTCAATGGATGAACTTGATTGGGTCAGAGT GATAGATCATTCACAATATCTGTGTCGTTCTTGGCAGAAATTATATTTTCCAGCCCGTGTCTGCAGTGGAGATGGAGTCTCACTATGGTG CCCACTCTGGTCTCGAACTCCTGAGCTCAAGCAATCCTCCCTCCTTGGCCTTCCAAAGTGCAGGTATATTCGAATTGTTGGGACTCACAA CACAGTGAACAAGATTTTTCACATTGTGGCTTTTGAATGTATGTTTACAAACAAAACCTTCACTCTTGAGAAGGGGCTGATAGTTCCCAT GGAGAATGTTGCAACAATTGCTGATTGTGCCAGTGTGATTGAAGGAGTCAGTCGGAGCCGAAATGCCTTGCTGAATGGGGACACTAAGAA TTATGACTGGGATTCTGGCTACACATGTCACCAGCTAGGAAGTGGTGCGATTGTGGTTCAGTTGGCACAACCGTACATGATTGGGTCAAT ACGGTTACTACTTTGGGATTGTGATGATCGAAGCTATAGCTACTACGTTGAGGTTTCTACCAACCAGCAACAGTGGACCATGGTTGCTGA CAGAACTAAAGTCTCCTGCAAATAAACAGGGGTCACATGACGACAGAAGCCAAGAGGGCTGCAAAGATGGAAAAGAAGATGAAAATTTTG CTTGGGGGTTACCAGTCTCGTGCTATGGGGCTCATGAAACAGTTGAATGACTTATGGGACCAAATTGAACAGGCTCACTTGGAGTTACGC ACTTTTGAAGAACTCAAGAAACATGAAGATTCTGCTATTCCCCGGAGGCTAGAGTGTCTAAAAGAAGACGTTCAGCGACAACAAGAAAGA GAAAAGGAACTTCAACATAGATATGCTGATTTGCTGCTGGAGAAAGAGACTTTAAAGTCAAAATTCTGAAGTACAGTTTATATTCTGTCA CAGGATTAATTAATTGCCGGTTTTCATACTCTAGAAGGCTGAAACTGATGTTTATCTTCATTGACAAATTTACCCACCATCTGTGGTTTT TCAGTTGTTTATTTTAAATGATATCGATCTTACACATTCTGTGTATAAAGACCTTAACTCCACAGGACGGACATTTTAGAGTTTAAATTA TTAAGGCTATCATTCTTTTAGTAATGTCATATTTGCAAACTTTTTTAGTTTTGGCCTTTAATTTAAAAAGCCTAATTTTAAAGTGCTGCC TGTGAGTAACTCTTGAATAAAAACAAAATATAAAAAATTGAGAATGTAGCCTTTTGTTTGAAGTAATTAGATACTTAAGAGTGCCTGCAA ACCAGCAGCTATGTACTCTGTGTCATATTTAATGAGTAACTCTTGGGTAATCAAAATGGTGATGCAGTATCTTAAACACTTAAGAGGCAG TTCTTTGTGGCTTTGTTAGTTTCAGCAAAGAGTGGTCATTTCTGTATACACTGACAAGTTAGATTAACTTTTTAGTACCTCAAATTTTTT TTTTGTTAATATCACTTTAAAGAAGGTCTCTTGTCTGCCAGCTACTTAAATAATTTATGGGTCAGGGCTTAAAAGATTTAACTTCCTTGC CCCATTATTTTCTTATAAGTATTTTTTGACAAAGGCATTTTAAAAGTTAATTTCAAGAAGGCCATCAAACTTAAAGCTCTATGTTTAGCC TAAGAAGTCAGTTACATCAGTGTAGAATTTGGGGAATGGATAGAGGTGGAGATATTTAATTTTATATAATTCATATAAATTGATTTAGTT ACAGTATCAGTTGGCTACAAGCTCATTATAGACTAGCAATGTTTTGACATCACCAAAAACGTTTGCCCAGTCTTAGAATACTAGGGACTA TAGGAAGGGAAGGGATTCATTCATTCATTCGATATTGAATGTATACCCTGTGCCAGAGTCTTAGAGAGAGAACAACAAACAAAATAGGCC TAGTTCTTGTTTAGTAGAGCTTATAGTCTTTTGAGAATGACAGACAATTAAAATCCAAATGTTTATTTGGTGATTCTTATGTGTCAGACA CTTAAGTGTTGGGAGATAAGCAGTTATTAAGACAGAGTTCTTGCTCTCATGGAGGTGACATTAGTGGGGAGGAGATACTAAGTATGTCCA GGGAAAGTATCAGACCATGAGTTTTAGATTCTGTGGAGGAAATTAAAGTAGGGTGATTATGAGATAGTGAATGAGTGGCTATTTTAGACT GGACGATCAAAGAGACCTCTTGGAAGGCAGCTATGCTCACCACTATACCACTGCACTGTGCCGCACCGTACCACTATAAGCTGCACGGCC AAAGAGACCTCTTAAAGAAGTAACATTTAAGATAACATGTGATTGACATTTTAGAATGGGCTATCCTTGTGAGATTCAAGGAAAGAACAT CCTAGGTGGAGTGAATAGCAAACATAAAGCCTCTTTTGTATGTTTGAGGAACAAAAAGGACAATGCAGCTAGAGTGTCAAGAATGGCATT TCTGTATATAAGACCTCGTTGTATAGAGCCACATAAATAAGGCTATAATAAGGAATTTGGATCTTACTTTAAATATGATAAGAATCGATG AGAAGATCTAAGCAAAGGAATGACATGATCAGATTTGGTTTTAGAAACATCACTATCTCCTTAGTGTGTAAAATCTCACCAGGCTGGAGA TAGGGAAGCCAGTCCAATTAGGAGCCTGATGCAGTGATCCAGACAAAAAAATAATAGTGATTCTAACTAGAGTCCAGGTAATAGTAGTGG AGATATGTGGAGAGACATGATAGGTATATACTTAATAGTCTTATCAGACGATAAATTGATATTTTCCTGGTGTGTAGTCACTTAATTCAA ATACTTTTTTCAGTAAGTTCTGGGTTTTCTAGGAAAAACTTCAGTATCATCAGTGAATAATGATAGTGTTTCTTCTGATAGTTTTATTTC ACTTTTATTGCATGTTTTGTTATCTGAAATGTTTAGGACAATGTTAACAATAATGATGTTAGACATTTTTTTTTCTTATTTTAATGGGAA TGTCCATAGTTTTAAGTTTGCTGTTGGGAGTTAGATAGTCTTTATCTGAAAGACAGTGTCTCTCTTTTAGTTTTTAAAGAGTTTGAATTA GAAATGGCTCTGGAACTTTAAACAGTATACCATTTGGGCATCTATTAAAGCATTCATATAATTGTTCTCATTTGATGTTTTGATGAGGTA TATTAATAGATTTTCCCACATTAAATCATCTTTGCACTCCTGGAATCAGGTAGATTAATTTTTAAAAGAAATTTTAAAGGATTTATAGTT TATTTGCACTTTTTGTAGACTTGAATTATATGGATTTAAAAGTTGATCTAATATTAATAAAGGCTCACTTTGTTTTCAAAATTTGAAGTA ATTCACATACTTATAGCCTAAAAAAATCGGCAGGAATTACAAAATTTCAAAACTGGCACATTGTAAACTGCATATGCATTTGCCAGGTAG TGGTGCCACTTGAAATGGTGAACAGACACACTGTTATCCTTTGTCAGTATCCTGTAAAGCCCAGGATTCTTTACCAGCACCATACAGCGA TTTTGGTGACTATTTTAACATTCACACTGAGGCCAGGGGTGGTGAGTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGAGGA TCATTTGAGCTCAGGAGTTCAAGATTAGCCTGGGTAACATAGTGAGACCCTGTCTCTATTAAAAAATAATAATAAAAATAACATTCACAT TGGTATTGTTCACTAAGGTATTGGTTGTTAAGGCATTCATTAAGGTATTGTTAAAACTTGTGTTAAGCATGTTAAAGTCTCAGTAACTTT GGGATAGAAATAAAATGTGATAAAAAGCTGAAAGAAACCACCACAAGGGAGAGTCCTTTTTGAAATATTAGAGACATAATGCTGTCTAAT AAAAAACGACATCAAAGAAAAACTACACTACAGTGACTGCAGACTTAATGTTGGCCAACCATGCATCCTCCCTAGAAATGCATTTGAATT TGATTTACTAATCTTTTATTTAGGAAATTTACATTTTTACATTAGTGAGATTGGTCTTTTGGGCTATTGTACTTTTTTTTTTTTTTTTTT GAGATGGAGTCTTGCTCTCTCACCCAGGCTGGAGTGCAGTAGTGCAATCTTGGCCCACTGCAACCTCTGCCTCCTGGGCTCGAGTGATTC TCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGGCATGTGCCACCGCACCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTTGC TATGTTGGCCAGGCTGGTCTTGAATTCCTGACCTCAGGTGATCCACCTACCTCGGCCTCCCAAAGTGCTAGAATTACAGGTGTGAGCCAC CATGCCCAGCCTGGTTATTGTATTTTGATATTGGGATTTTGCTAGCTCTCTAAAGTAAATAGGATAACTGTATATCTTTTTCTGTGCATT AAGCAGTTATAACATGGGAATGATTTGTTCATGAAAGGTTGAAAGTCTGTACTTACAGAACTTTTGAGTTCACAGTGCTTTCTGGAAATA ATTTCTTTATAACTGTCAGTTTCTTTTGTGACTATTATGTTACCTATTTTTAAATTTAAGCAACTTTAAATTAAAAAAATTGTTTTTAAA >10490_10490_2_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000419706_CDC5L_chr6_44413392_ENST00000371477_length(amino acids)=501AA_BP= MRVSSCVSSLMCRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNI QNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENHAEIMQAVRLPL MSLTELLNVVRPSGLLSPDAILDAIKVRSESRDMDLNYRGMLIPEENIATMKYGAQVVKGELKSALLDGDTQNYDLDHGFSRHPIDDDCR SGIEIKLGQPSIINHIRILLWDRDSRSYSYFIEVSMDELDWVRVIDHSQYLCRSWQKLYFPARVCSGDGVSLWCPLWSRTPELKQSSLLG LPKCRYIRIVGTHNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVATIADCASVIEGVSRSRNALLNGDTKNYDWDSGYTCHQLGSGA -------------------------------------------------------------- >10490_10490_3_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000481247_CDC5L_chr6_44413392_ENST00000371477_length(transcript)=5747nt_BP=1714nt AGCCGGGGCGGCGGCGAGGACGGCGGCCACGGAAGCGGCCAAGGGGGCGGTGGCGCAGAGAGGGGTGCGGAGCGGGCGGAAGAGGCGTCT GTGTCGCAGCTTGGTCTCAGAGGAGCATCGCTGGGAACAACGACTATCGTCTATTCCACAAGATGAGTAACAGCCACCCTCTTCGCCCCT TTACTGCAGTGGGGGAAATTGATCATGTGCACATTTTGTCTGAACATATTGGTGCCTTGTTGATTGGGGAAGAATATGGCGACGTCACAT TCGTGGTGGAAAAGAAACGTTTTCCTGCCCACAGGGTAATTTTAGCAGCCAGGTGCCAATATTTTCGAGCATTATTATATGGTGGAATGC GAGAGTCTCAGCCTGAAGCAGAAATTCCTCTCCAAGACACCACTGCAGAAGCATTCACAATGCTACTCAAATATATCTACACTGGGCGGG CAACGCTGACAGATGAGAAGGAGGAGGTGCTGCTGGACTTTTTGAGCCTGGCTCATAAATATGGATTTCCAGAGCTAGAGGATTCTACCT CTGAGTATCTCTGCACCATACTTAACATTCAGAATGTCTGCATGACTTTTGATGTTGCCAGTCTCTACTCACTTCCCAAGTTAACTTGTA TGTGCTGCATGTTTATGGATAGGAATGCTCAGGAAGTCCTCTCAAGTGAAGGTTTCCTCTCCCTTTCTAAGACAGCACTTTTAAACATCG TGTTAAGAGACTCATTTGCAGCTCCCGAAAAAGATATTTTCCTAGCCTTATTAAACTGGTGTAAGCACAATTCAAAGGAGAATCATGCTG AAATCATGCAGGCTGTGCGTTTACCTCTCATGAGCCTCACAGAGCTTCTGAATGTTGTGAGGCCTTCAGGACTGCTGTCTCCTGATGCCA TCCTGGATGCCATTAAAGTGCGATCTGAGAGCCGGGATATGGACCTCAATTATAGAGGCATGCTCATACCAGAAGAAAACATTGCAACTA TGAAGTATGGAGCCCAAGTTGTAAAGGGGGAGCTGAAATCAGCCTTATTAGATGGTGATACTCAAAATTATGATTTGGATCATGGATTTT CAAGGCACCCAATTGATGATGACTGCCGTTCCGGCATCGAGATTAAGCTAGGTCAGCCATCCATTATCAATCACATACGGATACTCTTGT GGGACCGAGATAGCCGGTCTTACTCATACTTCATTGAAGTGTCAATGGATGAACTTGATTGGGTCAGAGTGATAGATCATTCACAATATC TGTGTCGTTCTTGGCAGAAATTATATTTTCCAGCCCGTGTCTGCAGGTATATTCGAATTGTTGGGACTCACAACACAGTGAACAAGATTT TTCACATTGTGGCTTTTGAATGTATGTTTACAAACAAAACCTTCACTCTTGAGAAGGGGCTGATAGTTCCCATGGAGAATGTTGCAACAA TTGCTGATTGTGCCAGTGTGATTGAAGGAGTCAGTCGGAGCCGAAATGCCTTGCTGAATGGGGACACTAAGAATTATGACTGGGATTCTG GCTACACATGTCACCAGCTAGGAAGTGGTGCGATTGTGGTTCAGTTGGCACAACCGTACATGATTGGGTCAATACGGTTACTACTTTGGG ATTGTGATGATCGAAGCTATAGCTACTACGTTGAGGTTTCTACCAACCAGCAACAGTGGACCATGGTTGCTGACAGAACTAAAGTCTCCT GCAAATAAACAGGGGTCACATGACGACAGAAGCCAAGAGGGCTGCAAAGATGGAAAAGAAGATGAAAATTTTGCTTGGGGGTTACCAGTC TCGTGCTATGGGGCTCATGAAACAGTTGAATGACTTATGGGACCAAATTGAACAGGCTCACTTGGAGTTACGCACTTTTGAAGAACTCAA GAAACATGAAGATTCTGCTATTCCCCGGAGGCTAGAGTGTCTAAAAGAAGACGTTCAGCGACAACAAGAAAGAGAAAAGGAACTTCAACA TAGATATGCTGATTTGCTGCTGGAGAAAGAGACTTTAAAGTCAAAATTCTGAAGTACAGTTTATATTCTGTCACAGGATTAATTAATTGC CGGTTTTCATACTCTAGAAGGCTGAAACTGATGTTTATCTTCATTGACAAATTTACCCACCATCTGTGGTTTTTCAGTTGTTTATTTTAA ATGATATCGATCTTACACATTCTGTGTATAAAGACCTTAACTCCACAGGACGGACATTTTAGAGTTTAAATTATTAAGGCTATCATTCTT TTAGTAATGTCATATTTGCAAACTTTTTTAGTTTTGGCCTTTAATTTAAAAAGCCTAATTTTAAAGTGCTGCCTGTGAGTAACTCTTGAA TAAAAACAAAATATAAAAAATTGAGAATGTAGCCTTTTGTTTGAAGTAATTAGATACTTAAGAGTGCCTGCAAACCAGCAGCTATGTACT CTGTGTCATATTTAATGAGTAACTCTTGGGTAATCAAAATGGTGATGCAGTATCTTAAACACTTAAGAGGCAGTTCTTTGTGGCTTTGTT AGTTTCAGCAAAGAGTGGTCATTTCTGTATACACTGACAAGTTAGATTAACTTTTTAGTACCTCAAATTTTTTTTTTGTTAATATCACTT TAAAGAAGGTCTCTTGTCTGCCAGCTACTTAAATAATTTATGGGTCAGGGCTTAAAAGATTTAACTTCCTTGCCCCATTATTTTCTTATA AGTATTTTTTGACAAAGGCATTTTAAAAGTTAATTTCAAGAAGGCCATCAAACTTAAAGCTCTATGTTTAGCCTAAGAAGTCAGTTACAT CAGTGTAGAATTTGGGGAATGGATAGAGGTGGAGATATTTAATTTTATATAATTCATATAAATTGATTTAGTTACAGTATCAGTTGGCTA CAAGCTCATTATAGACTAGCAATGTTTTGACATCACCAAAAACGTTTGCCCAGTCTTAGAATACTAGGGACTATAGGAAGGGAAGGGATT CATTCATTCATTCGATATTGAATGTATACCCTGTGCCAGAGTCTTAGAGAGAGAACAACAAACAAAATAGGCCTAGTTCTTGTTTAGTAG AGCTTATAGTCTTTTGAGAATGACAGACAATTAAAATCCAAATGTTTATTTGGTGATTCTTATGTGTCAGACACTTAAGTGTTGGGAGAT AAGCAGTTATTAAGACAGAGTTCTTGCTCTCATGGAGGTGACATTAGTGGGGAGGAGATACTAAGTATGTCCAGGGAAAGTATCAGACCA TGAGTTTTAGATTCTGTGGAGGAAATTAAAGTAGGGTGATTATGAGATAGTGAATGAGTGGCTATTTTAGACTGGACGATCAAAGAGACC TCTTGGAAGGCAGCTATGCTCACCACTATACCACTGCACTGTGCCGCACCGTACCACTATAAGCTGCACGGCCAAAGAGACCTCTTAAAG AAGTAACATTTAAGATAACATGTGATTGACATTTTAGAATGGGCTATCCTTGTGAGATTCAAGGAAAGAACATCCTAGGTGGAGTGAATA GCAAACATAAAGCCTCTTTTGTATGTTTGAGGAACAAAAAGGACAATGCAGCTAGAGTGTCAAGAATGGCATTTCTGTATATAAGACCTC GTTGTATAGAGCCACATAAATAAGGCTATAATAAGGAATTTGGATCTTACTTTAAATATGATAAGAATCGATGAGAAGATCTAAGCAAAG GAATGACATGATCAGATTTGGTTTTAGAAACATCACTATCTCCTTAGTGTGTAAAATCTCACCAGGCTGGAGATAGGGAAGCCAGTCCAA TTAGGAGCCTGATGCAGTGATCCAGACAAAAAAATAATAGTGATTCTAACTAGAGTCCAGGTAATAGTAGTGGAGATATGTGGAGAGACA TGATAGGTATATACTTAATAGTCTTATCAGACGATAAATTGATATTTTCCTGGTGTGTAGTCACTTAATTCAAATACTTTTTTCAGTAAG TTCTGGGTTTTCTAGGAAAAACTTCAGTATCATCAGTGAATAATGATAGTGTTTCTTCTGATAGTTTTATTTCACTTTTATTGCATGTTT TGTTATCTGAAATGTTTAGGACAATGTTAACAATAATGATGTTAGACATTTTTTTTTCTTATTTTAATGGGAATGTCCATAGTTTTAAGT TTGCTGTTGGGAGTTAGATAGTCTTTATCTGAAAGACAGTGTCTCTCTTTTAGTTTTTAAAGAGTTTGAATTAGAAATGGCTCTGGAACT TTAAACAGTATACCATTTGGGCATCTATTAAAGCATTCATATAATTGTTCTCATTTGATGTTTTGATGAGGTATATTAATAGATTTTCCC ACATTAAATCATCTTTGCACTCCTGGAATCAGGTAGATTAATTTTTAAAAGAAATTTTAAAGGATTTATAGTTTATTTGCACTTTTTGTA GACTTGAATTATATGGATTTAAAAGTTGATCTAATATTAATAAAGGCTCACTTTGTTTTCAAAATTTGAAGTAATTCACATACTTATAGC CTAAAAAAATCGGCAGGAATTACAAAATTTCAAAACTGGCACATTGTAAACTGCATATGCATTTGCCAGGTAGTGGTGCCACTTGAAATG GTGAACAGACACACTGTTATCCTTTGTCAGTATCCTGTAAAGCCCAGGATTCTTTACCAGCACCATACAGCGATTTTGGTGACTATTTTA ACATTCACACTGAGGCCAGGGGTGGTGAGTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGAGGATCATTTGAGCTCAGGAG TTCAAGATTAGCCTGGGTAACATAGTGAGACCCTGTCTCTATTAAAAAATAATAATAAAAATAACATTCACATTGGTATTGTTCACTAAG GTATTGGTTGTTAAGGCATTCATTAAGGTATTGTTAAAACTTGTGTTAAGCATGTTAAAGTCTCAGTAACTTTGGGATAGAAATAAAATG TGATAAAAAGCTGAAAGAAACCACCACAAGGGAGAGTCCTTTTTGAAATATTAGAGACATAATGCTGTCTAATAAAAAACGACATCAAAG AAAAACTACACTACAGTGACTGCAGACTTAATGTTGGCCAACCATGCATCCTCCCTAGAAATGCATTTGAATTTGATTTACTAATCTTTT ATTTAGGAAATTTACATTTTTACATTAGTGAGATTGGTCTTTTGGGCTATTGTACTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTC TCTCACCCAGGCTGGAGTGCAGTAGTGCAATCTTGGCCCACTGCAACCTCTGCCTCCTGGGCTCGAGTGATTCTCTGCCTCAGCCTTCCA AGTAGCTGGGACTACAGGCATGTGCCACCGCACCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGG TCTTGAATTCCTGACCTCAGGTGATCCACCTACCTCGGCCTCCCAAAGTGCTAGAATTACAGGTGTGAGCCACCATGCCCAGCCTGGTTA TTGTATTTTGATATTGGGATTTTGCTAGCTCTCTAAAGTAAATAGGATAACTGTATATCTTTTTCTGTGCATTAAGCAGTTATAACATGG GAATGATTTGTTCATGAAAGGTTGAAAGTCTGTACTTACAGAACTTTTGAGTTCACAGTGCTTTCTGGAAATAATTTCTTTATAACTGTC >10490_10490_3_BTBD9-CDC5L_BTBD9_chr6_38224185_ENST00000481247_CDC5L_chr6_44413392_ENST00000371477_length(amino acids)=521AA_BP= MSNSHPLRPFTAVGEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTM LLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLS LSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSESRDMDLNYRGM LIPEENIATMKYGAQVVKGELKSALLDGDTQNYDLDHGFSRHPIDDDCRSGIEIKLGQPSIINHIRILLWDRDSRSYSYFIEVSMDELDW VRVIDHSQYLCRSWQKLYFPARVCRYIRIVGTHNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVATIADCASVIEGVSRSRNALLNG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BTBD9-CDC5L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 706_800 | 697.0 | 803.0 | PLRG1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 501_659 | 697.0 | 803.0 | DAPK3 | |
| Tgene | CDC5L | chr6:38224185 | chr6:44413392 | ENST00000371477 | 13 | 16 | 260_606 | 697.0 | 803.0 | PPP1R8 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BTBD9-CDC5L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BTBD9-CDC5L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BTBD9 | C0035258 | Restless Legs Syndrome | 1 | CTD_human |
| Hgene | BTBD9 | C0036341 | Schizophrenia | 1 | PSYGENET |
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