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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY9-CREBBP (FusionGDB2 ID:HG115TG1387)

Fusion Gene Summary for ADCY9-CREBBP

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY9-CREBBP
Fusion gene ID: hg115tg1387
HgeneTgene
Gene symbol

ADCY9

CREBBP

Gene ID

115

1387

Gene nameadenylate cyclase 9CREB binding protein
SynonymsAC9|ACIXCBP|KAT3A|MKHK1|RSTS|RSTS1
Cytomap('ADCY9')('CREBBP')

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyaseCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP
Modification date2020031320200329
UniProtAcc.

Q92793

Ensembl transtripts involved in fusion geneENST00000294016, ENST00000571889, 
ENST00000571889, ENST00000294016, 
Fusion gene scores* DoF score27 X 12 X 11=356418 X 30 X 8=4320
# samples 2728
** MAII scorelog2(27/3564*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4320*10)=-3.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY9 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY9(4163751)-CREBBP(3901010), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

HgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827

TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CREBBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26I-01AADCY9chr16

4163751

-CREBBPchr16

3901010

-
ChimerDB4BRCATCGA-A7-A26I-01BADCY9chr16

4163751

-CREBBPchr16

3901010

-


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Fusion Gene ORF analysis for ADCY9-CREBBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000294016ENST00000262367ADCY9chr16

4163751

-CREBBPchr16

3901010

-
In-frameENST00000294016ENST00000382070ADCY9chr16

4163751

-CREBBPchr16

3901010

-
intron-3CDSENST00000571889ENST00000262367ADCY9chr16

4163751

-CREBBPchr16

3901010

-
intron-3CDSENST00000571889ENST00000382070ADCY9chr16

4163751

-CREBBPchr16

3901010

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294016ADCY9chr164163751-ENST00000262367CREBBPchr163901010-12140223253994752978
ENST00000294016ADCY9chr164163751-ENST00000382070CREBBPchr163901010-9541223253993612940

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294016ENST00000262367ADCY9chr164163751-CREBBPchr163901010-0.0040745130.99592555
ENST00000294016ENST00000382070ADCY9chr164163751-CREBBPchr163901010-0.0107578080.98924226

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Fusion Genomic Features for ADCY9-CREBBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADCY9-CREBBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4163751/chr16:3901010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CREBBP

Q92793

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211394_5215641354.0DomainGuanylate cyclase 1
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211399_4045641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211441_4435641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211139_1415641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211163_1715641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211193_2155641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-2111_1175641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211236_2415641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211260_2805641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211118_1385641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211142_1625641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211172_1925641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211216_2355641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211242_2595641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211281_3015641354.0TransmembraneHelical
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311061_1064282443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311199_1487282443.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311555_1562282443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311943_1948282443.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311967_1970282443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670312081_2085282443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670312199_2216282443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670312245_2248282443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670312297_2300282443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301061_1064282405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301199_1487282405.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301555_1562282405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301943_1948282405.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301967_1970282405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700302081_2085282405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700302199_2216282405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700302245_2248282405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700302297_2300282405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311103_1175282443.0DomainBromo
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311323_1700282443.0DomainCBP/p300-type HAT
TgeneCREBBPchr16:4163751chr16:3901010ENST00000262367031587_666282443.0DomainKIX
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301103_1175282405.0DomainBromo
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301323_1700282405.0DomainCBP/p300-type HAT
TgeneCREBBPchr16:4163751chr16:3901010ENST00000382070030587_666282405.0DomainKIX
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311434_1436282443.0RegionAcetyl-CoA binding
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311446_1447282443.0RegionAcetyl-CoA binding
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301434_1436282405.0RegionAcetyl-CoA binding
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301446_1447282405.0RegionAcetyl-CoA binding
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311701_1744282443.0Zinc fingerZZ-type
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311765_1846282443.0Zinc fingerTAZ-type 2
TgeneCREBBPchr16:4163751chr16:3901010ENST00000262367031347_433282443.0Zinc fingerTAZ-type 1
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301701_1744282405.0Zinc fingerZZ-type
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301765_1846282405.0Zinc fingerTAZ-type 2
TgeneCREBBPchr16:4163751chr16:3901010ENST00000382070030347_433282405.0Zinc fingerTAZ-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-2111058_11985641354.0DomainGuanylate cyclase 2
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-2111185_11875641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-2111192_11965641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211302_7865641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211808_8185641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211840_8675641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211889_8915641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211913_9205641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211942_9755641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211997_13535641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211787_8075641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211819_8395641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211868_8885641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211892_9125641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211921_9415641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:3901010ENST00000294016-211976_9965641354.0TransmembraneHelical


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Fusion Gene Sequence for ADCY9-CREBBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2253_2253_1_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000262367_length(transcript)=12140nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGATTTTGGATCATTGTTTG
ACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTT
CCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCG
TGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCC
AGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAG
CACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAACTTTAACCAGACCC
ACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGG
CTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGC
AGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACTGGGAACACAAGTC
CATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCA
ACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACATCAGTGGGAATTG
TACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTC
ATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAACGTTTTGAATCACA
TGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAGAACTGCACACGAC
ATGACTGTCCTGTTTGCCTCCCTTTGAAAAATGCCAGTGACAAGCGAAACCAACAAACCATCCTGGGGTCTCCAGCTAGTGGAATTCAAA
ACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCCATGCAGCGAGCCT
ATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCACAGCCTCAAACCC
ACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAGCAGCCCCCAAACT
TGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAACATTGGAACCCTCA
GCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTGCGGAGCCATCTAG
TGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTAGCCTATGCTAAGA
AAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAGATACAAAAAGAAC
TAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCTCAGCCCCCTGTGA
TTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGGATGAATTCATTTA
ACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCTGTCCAGATGAACA
GCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACCAACAACATGATGG
CCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATGGGGCAGCCGCCAG
CCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCCAGCCAGCTACCTT
GCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAGCACACGACACCAC
CTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACCCCGACTCCTGGCT
CAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCTCAAACCCCAGTTC
AGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCGCTTTCCCAGGCAG
CAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCTGACGTACCTGTGC
TGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAGATGATGGAGGAGG
ATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAAAAGAAACCTGAAG
TGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCGCGCAAAAAAATCT
TTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCTTTCCGGCAGCCTG
TAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGGAAGCTGGACACAG
GGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAGACATCCCGAGTCT
ATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGTGGACGCAAGTATG
AGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTATCAGAATAGGTATC
ATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACGACAATTTCAAAGG
ATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATGCATCAGATTTGCG
TTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAAGAAAACAAATTCA
GTGCTAAGAGGCTGCAGACCACAAGACTGGGAAACCACTTGGAAGACCGAGTGAACAAATTTTTGCGGCGCCAGAATCACCCTGAAGCCG
GGGAGGTTTTTGTCCGAGTGGTGGCCAGCTCAGACAAGACGGTGGAGGTCAAGCCCGGGATGAAGTCACGGTTTGTGGATTCTGGGGAAA
TGTCTGAATCTTTCCCATATCGAACCAAAGCTCTGTTTGCTTTTGAGGAAATTGACGGCGTGGATGTCTGCTTTTTTGGAATGCACGTCC
AAGAATACGGCTCTGATTGCCCCCCTCCAAACACGAGGCGTGTGTACATTTCTTATCTGGATAGTATTCATTTCTTCCGGCCACGTTGCC
TCCGCACAGCCGTTTACCATGAGATCCTTATTGGATATTTAGAGTATGTGAAGAAATTAGGGTATGTGACAGGGCACATCTGGGCCTGTC
CTCCAAGTGAAGGAGATGATTACATCTTCCATTGCCACCCACCTGATCAAAAAATACCCAAGCCAAAACGACTGCAGGAGTGGTACAAAA
AGATGCTGGACAAGGCGTTTGCAGAGCGGATCATCCATGACTACAAGGATATTTTCAAACAAGCAACTGAAGACAGGCTCACCAGTGCCA
AGGAACTGCCCTATTTTGAAGGTGATTTCTGGCCCAATGTGTTAGAAGAGAGCATTAAGGAACTAGAACAAGAAGAAGAGGAGAGGAAAA
AGGAAGAGAGCACTGCAGCCAGTGAAACCACTGAGGGCAGTCAGGGCGACAGCAAGAATGCCAAGAAGAAGAACAACAAGAAAACCAACA
AGAACAAAAGCAGCATCAGCCGCGCCAACAAGAAGAAGCCCAGCATGCCCAACGTGTCCAATGACCTGTCCCAGAAGCTGTATGCCACCA
TGGAGAAGCACAAGGAGGTCTTCTTCGTGATCCACCTGCACGCTGGGCCTGTCATCAACACCCTGCCCCCCATCGTCGACCCCGACCCCC
TGCTCAGCTGTGACCTCATGGATGGGCGCGACGCCTTCCTCACCCTCGCCAGAGACAAGCACTGGGAGTTCTCCTCCTTGCGCCGCTCCA
AGTGGTCCACGCTCTGCATGCTGGTGGAGCTGCACACCCAGGGCCAGGACCGCTTTGTCTACACCTGCAACGAGTGCAAGCACCACGTGG
AGACGCGCTGGCACTGCACTGTGTGCGAGGACTACGACCTCTGCATCAACTGCTATAACACGAAGAGCCATGCCCATAAGATGGTGAAGT
GGGGGCTGGGCCTGGATGACGAGGGCAGCAGCCAGGGCGAGCCACAGTCAAAGAGCCCCCAGGAGTCACGCCGGCTGAGCATCCAGCGCT
GCATCCAGTCGCTGGTGCACGCGTGCCAGTGCCGCAACGCCAACTGCTCGCTGCCATCCTGCCAGAAGATGAAGCGGGTGGTGCAGCACA
CCAAGGGCTGCAAACGCAAGACCAACGGGGGCTGCCCGGTGTGCAAGCAGCTCATCGCCCTCTGCTGCTACCACGCCAAGCACTGCCAAG
AAAACAAATGCCCCGTGCCCTTCTGCCTCAACATCAAACACAAGCTCCGCCAGCAGCAGATCCAGCACCGCCTGCAGCAGGCCCAGCTCA
TGCGCCGGCGGATGGCCACCATGAACACCCGCAACGTGCCTCAGCAGAGTCTGCCTTCTCCTACCTCAGCACCGCCCGGGACCCCCACAC
AGCAGCCCAGCACACCCCAGACGCCGCAGCCCCCTGCCCAGCCCCAACCCTCACCCGTGAGCATGTCACCAGCTGGCTTCCCCAGCGTGG
CCCGGACTCAGCCCCCCACCACGGTGTCCACAGGGAAGCCTACCAGCCAGGTGCCGGCCCCCCCACCCCCGGCCCAGCCCCCTCCTGCAG
CGGTGGAAGCGGCTCGGCAGATCGAGCGTGAGGCCCAGCAGCAGCAGCACCTGTACCGGGTGAACATCAACAACAGCATGCCCCCAGGAC
GCACGGGCATGGGGACCCCGGGGAGCCAGATGGCCCCCGTGAGCCTGAATGTGCCCCGACCCAACCAGGTGAGCGGGCCCGTCATGCCCA
GCATGCCTCCCGGGCAGTGGCAGCAGGCGCCCCTTCCCCAGCAGCAGCCCATGCCAGGCTTGCCCAGGCCTGTGATATCCATGCAGGCCC
AGGCGGCCGTGGCTGGGCCCCGGATGCCCAGCGTGCAGCCACCCAGGAGCATCTCACCCAGCGCTCTGCAAGACCTGCTGCGGACCCTGA
AGTCGCCCAGCTCCCCTCAGCAGCAACAGCAGGTGCTGAACATTCTCAAATCAAACCCGCAGCTAATGGCAGCTTTCATCAAACAGCGCA
CAGCCAAGTACGTGGCCAATCAGCCCGGCATGCAGCCCCAGCCTGGCCTCCAGTCCCAGCCCGGCATGCAACCCCAGCCTGGCATGCACC
AGCAGCCCAGCCTGCAGAACCTGAATGCCATGCAGGCTGGCGTGCCGCGGCCCGGTGTGCCTCCACAGCAGCAGGCGATGGGAGGCCTGA
ACCCCCAGGGCCAGGCCTTGAACATCATGAACCCAGGACACAACCCCAACATGGCGAGTATGAATCCACAGTACCGAGAAATGTTACGGA
GGCAGCTGCTGCAGCAGCAGCAGCAACAGCAGCAGCAACAACAGCAGCAACAGCAGCAGCAGCAAGGGAGTGCCGGCATGGCTGGGGGCA
TGGCGGGGCACGGCCAGTTCCAGCAGCCTCAAGGACCCGGAGGCTACCCACCGGCCATGCAGCAGCAGCAGCGCATGCAGCAGCATCTCC
CCCTCCAGGGCAGCTCCATGGGCCAGATGGCGGCTCAGATGGGACAGCTTGGCCAGATGGGGCAGCCGGGGCTGGGGGCAGACAGCACCC
CCAACATCCAGCAAGCCCTGCAGCAGCGGATTCTGCAGCAACAGCAGATGAAGCAGCAGATTGGGTCCCCAGGCCAGCCGAACCCCATGA
GCCCCCAGCAACACATGCTCTCAGGACAGCCACAGGCCTCGCATCTCCCTGGCCAGCAGATCGCCACGTCCCTTAGTAACCAGGTGCGGT
CTCCAGCCCCTGTCCAGTCTCCACGGCCCCAGTCCCAGCCTCCACATTCCAGCCCGTCACCACGGATACAGCCCCAGCCTTCGCCACACC
ACGTCTCACCCCAGACTGGTTCCCCCCACCCCGGACTCGCAGTCACCATGGCCAGCTCCATAGATCAGGGACACTTGGGGAACCCCGAAC
AGAGTGCAATGCTCCCCCAGCTGAACACCCCCAGCAGGAGTGCGCTGTCCAGCGAACTGTCCCTGGTCGGGGACACCACGGGGGACACGC
TAGAGAAGTTTGTGGAGGGCTTGTAGCATTGTGAGAGCATCACCTTTTCCCTTTCATGTTCTTGGACCTTTTGTACTGAAAATCCAGGCA
TCTAGGTTCTTTTTATTCCTAGATGGAACTGCGACTTCCGAGCCATGGAAGGGTGGATTGATGTTTAAAGAAACAATACAAAGAATATAT
TTTTTTGTTAAAAACCAGTTGATTTAAATATCTGGTCTCTCTCTTTGGTTTTTTTTTGGCGGGGGGGTGGGGGGGGTTCTTTTTTTTCCG
TTTTGTTTTTGTTTGGGGGGAGGGGGGTTTTGTTTGGATTCTTTTTGTCGTCATTGCTGGTGACTCATGCCTTTTTTTAACGGGAAAAAC
AAGTTCATTATATTCATATTTTTTATTTGTATTTTCAAGACTTTAAACATTTATGTTTAAAAGTAAGAAGAAAAATAATATTCAGAACTG
ATTCCTGAAATAATGCAAGCTTATAATGTATCCCGATAACTTTGTGATGTTTCGGGAAGATTTTTTTCTATAGTGAACTCTGTGGGCGTC
TCCCAGTATTACCCTGGATGATAGGAATTGACTCCGGCGTGCACACACGTACACACCCACACACATCTATCTATACATAATGGCTGAAGC
CAAACTTGTCTTGCAGATGTAGAAATTGTTGCTTTGTTTCTCTGATAAAACTGGTTTTAGACAAAAAATAGGGATGATCACTCTTAGACC
ATGCTAATGTTACTAGAGAAGAAGCCTTCTTTTCTTTCTTCTATGTGAAACTTGAAATGAGGAAAAGCAATTCTAGTGTAAATCATGCAA
GCGCTCTAATTCCTATAAATACGAAACTCGAGAAGATTCAATCACTGTATAGAATGGTAAAATACCAACTCATTTCTTATATCATATTGT
TAAATAAACTGTGTGCAACAGACAAAAAGGGTGGTCCTTCTTGAATTCATGTACATGGTATTAACACTTAGTGTTCGGGGTTTTTTGTTA
TGAAAATGCTGTTTTCAACATTGTATTTGGACTATGCATGTGTTTTTTCCCCATTGTATATAAAGTACCGCTTAAAATTGATATAAATTA
CTGAGGTTTTTAACATGTATTCTGTTCTTTAAGATCCCTGTAAGAATGTTTAAGGTTTTTATTTATTTATATATATTTTTTGAGTCTGTT
CTTTGTAAGACATGGTTCTGGTTGTTCGCTCATAGCGGAGAGGCTGGGGCTGCGGTTGTGGTTGTGGCGGCGTGGGTGGTGGCTGGGAAC
TGTGGCCCAGGCTTAGCGGCCGCCCGGAGGCTTTTCTTCCCGGAGACTGAGGTGGGCGACTGAGGTGGGCGGCTCAGCGTTGGCCCCACA
CATTCGAGGCTCACAGGTGATTGTCGCTCACACAGTTAGGGTCGTCAGTTGGTCTGAAACTGCATTTGGCCCACTCCTCCATCCTCCCTG
TCCGTCGTAGCTGCCACCCCCAGAGGCGGCGCTTCTTCCCGTGTTCAGGCGGCTCCCCCCCCCCGTACACGACTCCCAGAATCTGAGGCA
GAGAGTGCTCCAGGCTCGCGAGGTGCTTTCTGACTTCCCCCCAAATCCTGCCGCTGCCGCGCAGCATGTCCCGTGTGGCGTTTGAGGAAA
TGCTGAGGGACAGACACCTTGGAGCACCAGCTCCGGTCCCTGTTACAGTGAGAAAGGTCCCCCACTTCGGGGGATACTTGCACTTAGCCA
CATGGTCCTGCCTCCCTTGGAGTCCAGTTCCAGGCTCCCTTACTGAGTGGGTGAGACAAGTTCACAAAAACCGTAAAACTGAGAGGAGGA
CCATGGGCAGGGGAGCTGAAGTTCATCCCCTAAGTCTACCACCCCCAGCACCCAGAGAACCCACTTTATCCCTAGTCCCCCAACAAAGGC
TGGTCTAGGTGGGGGTGATGGTAATTTTAGAAATCACGCCCCAAATAGCTTCCGTTTGGGCCCTTACATTCACAGATAGGTTTTAAATAG
CTGAATACTTGGTTTGGGAATCTGAATTCGAGGAACCTTTCTAAGAAGTTGGAAAGGTCCGATCTAGTTTTAGCACAGAGCTTTGAACCT
TGAGTTATAAAATGCAGAATAATTCAAGTAAAAATAAGACCACCATCTGGCACCCCTGACCAGCCCCCATTCACCCCATCCCAGGAGGGG
AAGCACAGGCCGGGCCTCCGGTGGAGATTGCTGCCACTGCTCGGCCTGCTGGGTTCTTAACCTCCAGTGTCCTCTTCATCTTTTCCACCC
GTAGGGAAACCTTGAGCCATGTGTTCAAACAAGAAGTGGGGCTAGAGCCCGAGAGCAGCAGCTCTAAGCCCACACTCAGAAAGTGGCGCC
CTCCTGGTTGTGCAGCCTTTTAATGTGGGCAGTGGAGGGGCCTCTGTTTCAGGTTATCCTGGAATTCAAAACGTTATGTACCAACCTCAT
CCTCTTTGGAGTCTGCATCCTGTGCAACCGTCTTGGGCAATCCAGATGTCGAAGGATGTGACCGAGAGCATGGTCTGTGGATGCTAACCC
TAAGTTTGTCGTAAGGAAATTTCTGTAAGAAACCTGGAAAGCCCCAACGCTGTGTCTCATGCTGTATACTTAAGAGGAGAAGAAAAAGTC

>2253_2253_1_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000262367_length(amino acids)=2978AA_BP=0
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSP
VQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQT
HPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTS
PFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHA
HKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQ
NTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPN
LISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAK
KVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSF
NPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPP
AQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPG
SVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPV
LEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKI
FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISK
DQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEA
GEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRC
LRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSA
KELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYAT
MEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHV
ETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQH
TKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPT
QQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPG
RTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTL
KSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGL
NPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHL
PLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVR
SPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDT

--------------------------------------------------------------
>2253_2253_2_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000382070_length(transcript)=9541nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGATTTTGGATCATTGTTTG
ACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTT
CCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCG
TGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCC
AGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAG
CACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAACTTTAACCAGACCC
ACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGG
CTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGC
AGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACTGGGAACACAAGTC
CATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCA
ACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACATCAGTGGGAATTG
TACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTC
ATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAACGTTTTGAATCACA
TGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGCCATCCTGGGGTCTCCAGCTAGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAG
GGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCCATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACA
TGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCACAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACC
CCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAGCAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGA
CTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAACATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTC
CTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTGCGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCT
TCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTAGCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGT
CTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAGATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTT
TACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCTCAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGAC
CTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGGATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCC
AGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCTGTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGG
CCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACCAACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGT
TTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATGGGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGAC
AGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCCAGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCAC
TGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAGCACACGACACCACCTGGGATGACTCCTCCCCAGCCAG
CAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACCCCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCC
AGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCTCAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTC
AGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCGCTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCC
CTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCTGACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAG
CAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAGATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTA
AAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAAAAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAG
AAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCGCGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGG
CCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCTTTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTC
CAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGGAAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGT
ACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAGACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAG
AGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGTGGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCT
GCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTATCAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAG
AGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACGACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATG
ATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATGCATCAGATTTGCGTTCTGCACTATGACATCATTTGGC
CTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAAGAAAACAAATTCAGTGCTAAGAGGCTGCAGACCACAA
GACTGGGAAACCACTTGGAAGACCGAGTGAACAAATTTTTGCGGCGCCAGAATCACCCTGAAGCCGGGGAGGTTTTTGTCCGAGTGGTGG
CCAGCTCAGACAAGACGGTGGAGGTCAAGCCCGGGATGAAGTCACGGTTTGTGGATTCTGGGGAAATGTCTGAATCTTTCCCATATCGAA
CCAAAGCTCTGTTTGCTTTTGAGGAAATTGACGGCGTGGATGTCTGCTTTTTTGGAATGCACGTCCAAGAATACGGCTCTGATTGCCCCC
CTCCAAACACGAGGCGTGTGTACATTTCTTATCTGGATAGTATTCATTTCTTCCGGCCACGTTGCCTCCGCACAGCCGTTTACCATGAGA
TCCTTATTGGATATTTAGAGTATGTGAAGAAATTAGGGTATGTGACAGGGCACATCTGGGCCTGTCCTCCAAGTGAAGGAGATGATTACA
TCTTCCATTGCCACCCACCTGATCAAAAAATACCCAAGCCAAAACGACTGCAGGAGTGGTACAAAAAGATGCTGGACAAGGCGTTTGCAG
AGCGGATCATCCATGACTACAAGGATATTTTCAAACAAGCAACTGAAGACAGGCTCACCAGTGCCAAGGAACTGCCCTATTTTGAAGGTG
ATTTCTGGCCCAATGTGTTAGAAGAGAGCATTAAGGAACTAGAACAAGAAGAAGAGGAGAGGAAAAAGGAAGAGAGCACTGCAGCCAGTG
AAACCACTGAGGGCAGTCAGGGCGACAGCAAGAATGCCAAGAAGAAGAACAACAAGAAAACCAACAAGAACAAAAGCAGCATCAGCCGCG
CCAACAAGAAGAAGCCCAGCATGCCCAACGTGTCCAATGACCTGTCCCAGAAGCTGTATGCCACCATGGAGAAGCACAAGGAGGTCTTCT
TCGTGATCCACCTGCACGCTGGGCCTGTCATCAACACCCTGCCCCCCATCGTCGACCCCGACCCCCTGCTCAGCTGTGACCTCATGGATG
GGCGCGACGCCTTCCTCACCCTCGCCAGAGACAAGCACTGGGAGTTCTCCTCCTTGCGCCGCTCCAAGTGGTCCACGCTCTGCATGCTGG
TGGAGCTGCACACCCAGGGCCAGGACCGCTTTGTCTACACCTGCAACGAGTGCAAGCACCACGTGGAGACGCGCTGGCACTGCACTGTGT
GCGAGGACTACGACCTCTGCATCAACTGCTATAACACGAAGAGCCATGCCCATAAGATGGTGAAGTGGGGGCTGGGCCTGGATGACGAGG
GCAGCAGCCAGGGCGAGCCACAGTCAAAGAGCCCCCAGGAGTCACGCCGGCTGAGCATCCAGCGCTGCATCCAGTCGCTGGTGCACGCGT
GCCAGTGCCGCAACGCCAACTGCTCGCTGCCATCCTGCCAGAAGATGAAGCGGGTGGTGCAGCACACCAAGGGCTGCAAACGCAAGACCA
ACGGGGGCTGCCCGGTGTGCAAGCAGCTCATCGCCCTCTGCTGCTACCACGCCAAGCACTGCCAAGAAAACAAATGCCCCGTGCCCTTCT
GCCTCAACATCAAACACAAGCTCCGCCAGCAGCAGATCCAGCACCGCCTGCAGCAGGCCCAGCTCATGCGCCGGCGGATGGCCACCATGA
ACACCCGCAACGTGCCTCAGCAGAGTCTGCCTTCTCCTACCTCAGCACCGCCCGGGACCCCCACACAGCAGCCCAGCACACCCCAGACGC
CGCAGCCCCCTGCCCAGCCCCAACCCTCACCCGTGAGCATGTCACCAGCTGGCTTCCCCAGCGTGGCCCGGACTCAGCCCCCCACCACGG
TGTCCACAGGGAAGCCTACCAGCCAGGTGCCGGCCCCCCCACCCCCGGCCCAGCCCCCTCCTGCAGCGGTGGAAGCGGCTCGGCAGATCG
AGCGTGAGGCCCAGCAGCAGCAGCACCTGTACCGGGTGAACATCAACAACAGCATGCCCCCAGGACGCACGGGCATGGGGACCCCGGGGA
GCCAGATGGCCCCCGTGAGCCTGAATGTGCCCCGACCCAACCAGGTGAGCGGGCCCGTCATGCCCAGCATGCCTCCCGGGCAGTGGCAGC
AGGCGCCCCTTCCCCAGCAGCAGCCCATGCCAGGCTTGCCCAGGCCTGTGATATCCATGCAGGCCCAGGCGGCCGTGGCTGGGCCCCGGA
TGCCCAGCGTGCAGCCACCCAGGAGCATCTCACCCAGCGCTCTGCAAGACCTGCTGCGGACCCTGAAGTCGCCCAGCTCCCCTCAGCAGC
AACAGCAGGTGCTGAACATTCTCAAATCAAACCCGCAGCTAATGGCAGCTTTCATCAAACAGCGCACAGCCAAGTACGTGGCCAATCAGC
CCGGCATGCAGCCCCAGCCTGGCCTCCAGTCCCAGCCCGGCATGCAACCCCAGCCTGGCATGCACCAGCAGCCCAGCCTGCAGAACCTGA
ATGCCATGCAGGCTGGCGTGCCGCGGCCCGGTGTGCCTCCACAGCAGCAGGCGATGGGAGGCCTGAACCCCCAGGGCCAGGCCTTGAACA
TCATGAACCCAGGACACAACCCCAACATGGCGAGTATGAATCCACAGTACCGAGAAATGTTACGGAGGCAGCTGCTGCAGCAGCAGCAGC
AACAGCAGCAGCAACAACAGCAGCAACAGCAGCAGCAGCAAGGGAGTGCCGGCATGGCTGGGGGCATGGCGGGGCACGGCCAGTTCCAGC
AGCCTCAAGGACCCGGAGGCTACCCACCGGCCATGCAGCAGCAGCAGCGCATGCAGCAGCATCTCCCCCTCCAGGGCAGCTCCATGGGCC
AGATGGCGGCTCAGATGGGACAGCTTGGCCAGATGGGGCAGCCGGGGCTGGGGGCAGACAGCACCCCCAACATCCAGCAAGCCCTGCAGC
AGCGGATTCTGCAGCAACAGCAGATGAAGCAGCAGATTGGGTCCCCAGGCCAGCCGAACCCCATGAGCCCCCAGCAACACATGCTCTCAG
GACAGCCACAGGCCTCGCATCTCCCTGGCCAGCAGATCGCCACGTCCCTTAGTAACCAGGTGCGGTCTCCAGCCCCTGTCCAGTCTCCAC
GGCCCCAGTCCCAGCCTCCACATTCCAGCCCGTCACCACGGATACAGCCCCAGCCTTCGCCACACCACGTCTCACCCCAGACTGGTTCCC
CCCACCCCGGACTCGCAGTCACCATGGCCAGCTCCATAGATCAGGGACACTTGGGGAACCCCGAACAGAGTGCAATGCTCCCCCAGCTGA
ACACCCCCAGCAGGAGTGCGCTGTCCAGCGAACTGTCCCTGGTCGGGGACACCACGGGGGACACGCTAGAGAAGTTTGTGGAGGGCTTGT
AGCATTGTGAGAGCATCACCTTTTCCCTTTCATGTTCTTGGACCTTTTGTACTGAAAATCCAGGCATCTAGGTTCTTTTTATTCCTAGAT
GGAACTGCGACTTCCGAGCCATGGAAGGGTGGATTGATGTTTAAAGAAACAATACAAAGAATATATTTTTTTGTTAAAAACCAGTTGATT

>2253_2253_2_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000382070_length(amino acids)=2940AA_BP=0
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSP
VQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQT
HPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTS
PFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHA
HKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPY
MNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAP
PSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSR
LHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGM
AISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSP
LHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATP
QSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQV
KEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI
PDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLC
CYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIW
PSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYR
TKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDY
IFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAAS
ETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMD
GRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDE
GSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF
CLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTT
VSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQ
QAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQ
PGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQ
QQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQ
QRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADCY9-CREBBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311162_118028.3333333333333322443.0ASF1A
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301162_118028.3333333333333322405.0ASF1A
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311433_143528.3333333333333322443.0histone
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301433_143528.3333333333333322405.0histone
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311124_117028.3333333333333322443.0histone
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301124_117028.3333333333333322405.0histone
TgeneCREBBPchr16:4163751chr16:3901010ENST00000262367031227_41028.3333333333333322443.0SRCAP
TgeneCREBBPchr16:4163751chr16:3901010ENST00000382070030227_41028.3333333333333322405.0SRCAP
TgeneCREBBPchr16:4163751chr16:3901010ENST000002623670311460_189128.3333333333333322443.0TRERF1
TgeneCREBBPchr16:4163751chr16:3901010ENST000003820700301460_189128.3333333333333322405.0TRERF1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY9-CREBBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY9-CREBBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007138Carcinoma, Transitional Cell1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0011573Endogenous depression1PSYGENET
TgeneC0024301Lymphoma, Follicular1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0079745Lymphoma, Large-Cell, Follicular1CTD_human
TgeneC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
TgeneC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
TgeneC0149925Small cell carcinoma of lung1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC1956130Lymphoma, Follicular, Grade 11CTD_human
TgeneC1956131Lymphoma, Follicular, Grade 31CTD_human
TgeneC1956132Lymphoma, Follicular, Grade 21CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human