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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY9-NMRAL1 (FusionGDB2 ID:HG115TG57407)

Fusion Gene Summary for ADCY9-NMRAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY9-NMRAL1
Fusion gene ID: hg115tg57407
HgeneTgene
Gene symbol

ADCY9

NMRAL1

Gene ID

115

57407

Gene nameadenylate cyclase 9NmrA like redox sensor 1
SynonymsAC9|ACIXHSCARG|SDR48A1
Cytomap('ADCY9')('NMRAL1')

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyasenmrA-like family domain-containing protein 1NmrA-like family domain containing 1epididymis secretory sperm binding proteinshort chain dehydrogenase/reductase family 48A, member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000294016, ENST00000571889, 
Fusion gene scores* DoF score27 X 12 X 11=35644 X 3 X 4=48
# samples 274
** MAII scorelog2(27/3564*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY9 [Title/Abstract] AND NMRAL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY9(4163751)-NMRAL1(4519466), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCY9-NMRAL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-NMRAL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-NMRAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-NMRAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

HgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827


check buttonFusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NMRAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-A64L-01AADCY9chr16

4163751

-NMRAL1chr16

4519466

-


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Fusion Gene ORF analysis for ADCY9-NMRAL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294016ENST00000572391ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
In-frameENST00000294016ENST00000283429ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
In-frameENST00000294016ENST00000404295ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
In-frameENST00000294016ENST00000574425ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
In-frameENST00000294016ENST00000574733ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
intron-3CDSENST00000571889ENST00000283429ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
intron-3CDSENST00000571889ENST00000404295ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
intron-3CDSENST00000571889ENST00000574425ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
intron-3CDSENST00000571889ENST00000574733ADCY9chr16

4163751

-NMRAL1chr16

4519466

-
intron-intronENST00000571889ENST00000572391ADCY9chr16

4163751

-NMRAL1chr16

4519466

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000294016ADCY9chr164163751-ENST00000283429NMRAL1chr164519466-319222325393091850
ENST00000294016ADCY9chr164163751-ENST00000574733NMRAL1chr164519466-318122325393091850
ENST00000294016ADCY9chr164163751-ENST00000404295NMRAL1chr164519466-317822325393091850
ENST00000294016ADCY9chr164163751-ENST00000574425NMRAL1chr164519466-317722325393091850

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294016ENST00000283429ADCY9chr164163751-NMRAL1chr164519466-0.0076825420.99231744
ENST00000294016ENST00000574733ADCY9chr164163751-NMRAL1chr164519466-0.0075884520.99241155
ENST00000294016ENST00000404295ADCY9chr164163751-NMRAL1chr164519466-0.0075587110.9924413
ENST00000294016ENST00000574425ADCY9chr164163751-NMRAL1chr164519466-0.0076580220.992342

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Fusion Genomic Features for ADCY9-NMRAL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADCY9-NMRAL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4163751/chr16:4519466)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211394_5215641354.0DomainGuanylate cyclase 1
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211399_4045641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211441_4435641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211139_1415641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211163_1715641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211193_2155641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-2111_1175641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211236_2415641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211260_2805641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211118_1385641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211142_1625641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211172_1925641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211216_2355641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211242_2595641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211281_3015641354.0TransmembraneHelical
TgeneNMRAL1chr16:4163751chr16:4519466ENST000002834291611_1613300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000028342916155_15813300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000002834291637_4113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000002834291658_5913300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000002834291679_8113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000004042951611_1613300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000040429516155_15813300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000004042951637_4113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000004042951658_5913300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000004042951679_8113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005744251611_1613300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000057442516155_15813300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005744251637_4113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005744251658_5913300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005744251679_8113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005747331611_1613300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000057473316155_15813300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005747331637_4113300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005747331658_5913300.0Nucleotide bindingNADP
TgeneNMRAL1chr16:4163751chr16:4519466ENST000005747331679_8113300.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-2111058_11985641354.0DomainGuanylate cyclase 2
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-2111185_11875641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-2111192_11965641354.0Nucleotide bindingATP
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211302_7865641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211808_8185641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211840_8675641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211889_8915641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211913_9205641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211942_9755641354.0Topological domainExtracellular
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211997_13535641354.0Topological domainCytoplasmic
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211787_8075641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211819_8395641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211868_8885641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211892_9125641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211921_9415641354.0TransmembraneHelical
HgeneADCY9chr16:4163751chr16:4519466ENST00000294016-211976_9965641354.0TransmembraneHelical


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Fusion Gene Sequence for ADCY9-NMRAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2263_2263_1_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000283429_length(transcript)=3192nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_1_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000283429_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_2_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000404295_length(transcript)=3178nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_2_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000404295_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_3_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574425_length(transcript)=3177nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_3_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574425_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_4_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574733_length(transcript)=3181nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_4_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574733_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADCY9-NMRAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000028342916153_18913.333333333333334300.0ASS1
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000040429516153_18913.333333333333334300.0ASS1
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000057442516153_18913.333333333333334300.0ASS1
TgeneNMRAL1chr16:4163751chr16:4519466ENST0000057473316153_18913.333333333333334300.0ASS1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY9-NMRAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY9-NMRAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource