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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:RMI2-CLEC16A (FusionGDB2 ID:HG116028TG23274)

Fusion Gene Summary for RMI2-CLEC16A

check button Fusion gene summary
Fusion gene informationFusion gene name: RMI2-CLEC16A
Fusion gene ID: hg116028tg23274
HgeneTgene
Gene symbol

RMI2

CLEC16A

Gene ID

116028

23274

Gene nameRecQ mediated genome instability 2C-type lectin domain containing 16A
SynonymsBLAP18|C16orf75Gop-1|KIAA0350
Cytomap('RMI2')('CLEC16A')

16p13.13

16p13.13

Type of geneprotein-codingprotein-coding
DescriptionrecQ-mediated genome instability protein 2BLM-associated protein of 18 kDaRMI2, RecQ mediated genome instability 2, homologprotein CLEC16AC-type lectin domain family 16 member A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312499, ENST00000572173, 
ENST00000381820, ENST00000572992, 
ENST00000576027, 		ENST00000312499, 
ENST00000381820, ENST00000572992, 
ENST00000576027, ENST00000572173, 
Fusion gene scores* DoF score1 X 2 X 1=214 X 13 X 10=1820
# samples 217
** MAII scorelog2(2/2*10)=3.32192809488736log2(17/1820*10)=-3.42033179894836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RMI2 [Title/Abstract] AND CLEC16A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRMI2(11439623)-CLEC16A(11214472), # samples:3
Anticipated loss of major functional domain due to fusion event.CLEC16A-RMI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLEC16A-RMI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RMI2-CLEC16A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RMI2-CLEC16A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RMI2-CLEC16A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RMI2-CLEC16A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RMI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLEC16A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A56S-01ARMI2chr16

11439623

-CLEC16Achr16

11214472

+
ChimerDB4UCSTCGA-N8-A56S-01ARMI2chr16

11439623

+CLEC16Achr16

11214472

+
ChimerDB4UCSTCGA-N8-A56SRMI2chr16

11343635

+CLEC16Achr16

11214472

+
ChimerDB4UCSTCGA-N8-A56SRMI2chr16

11439623

+CLEC16Achr16

11214472

+


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Fusion Gene ORF analysis for RMI2-CLEC16A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000312499ENST00000465491RMI2chr16

11439623

+CLEC16Achr16

11214472

+
5CDS-intronENST00000312499ENST00000381822RMI2chr16

11439623

+CLEC16Achr16

11214472

+
5UTR-3CDSENST00000572173ENST00000409552RMI2chr16

11343635

+CLEC16Achr16

11214472

+
5UTR-3CDSENST00000572173ENST00000409790RMI2chr16

11343635

+CLEC16Achr16

11214472

+
5UTR-3UTRENST00000572173ENST00000465491RMI2chr16

11343635

+CLEC16Achr16

11214472

+
5UTR-intronENST00000572173ENST00000381822RMI2chr16

11343635

+CLEC16Achr16

11214472

+
In-frameENST00000312499ENST00000409552RMI2chr16

11439623

+CLEC16Achr16

11214472

+
In-frameENST00000312499ENST00000409790RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000312499ENST00000409552RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000312499ENST00000409790RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000381820ENST00000409552RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000381820ENST00000409552RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000381820ENST00000409790RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000381820ENST00000409790RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572173ENST00000409552RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572173ENST00000409790RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572992ENST00000409552RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572992ENST00000409552RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572992ENST00000409790RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000572992ENST00000409790RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000576027ENST00000409552RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000576027ENST00000409552RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3CDSENST00000576027ENST00000409790RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3CDSENST00000576027ENST00000409790RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3UTRENST00000312499ENST00000465491RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3UTRENST00000381820ENST00000465491RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3UTRENST00000381820ENST00000465491RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3UTRENST00000572173ENST00000465491RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3UTRENST00000572992ENST00000465491RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3UTRENST00000572992ENST00000465491RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-3UTRENST00000576027ENST00000465491RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-3UTRENST00000576027ENST00000465491RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-intronENST00000312499ENST00000381822RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-intronENST00000381820ENST00000381822RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-intronENST00000381820ENST00000381822RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-intronENST00000572173ENST00000381822RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-intronENST00000572992ENST00000381822RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-intronENST00000572992ENST00000381822RMI2chr16

11343635

+CLEC16Achr16

11214472

+
intron-intronENST00000576027ENST00000381822RMI2chr16

11439623

+CLEC16Achr16

11214472

+
intron-intronENST00000576027ENST00000381822RMI2chr16

11343635

+CLEC16Achr16

11214472

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312499RMI2chr1611439623+ENST00000409790CLEC16Achr1611214472+4881336411381446
ENST00000312499RMI2chr1611439623+ENST00000409552CLEC16Achr1611214472+105933641994317

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312499ENST00000409790RMI2chr1611439623+CLEC16Achr1611214472+0.047949310.9520507
ENST00000312499ENST00000409552RMI2chr1611439623+CLEC16Achr1611214472+0.163310920.8366891

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Fusion Genomic Features for RMI2-CLEC16A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RMI2chr1611343635+CLEC16Achr1611214471+8.08E-070.99999917
RMI2chr1611439623+CLEC16Achr1611214471+1.59E-081
RMI2chr1611439623+CLEC16Achr1611214471+1.59E-081
RMI2chr1611343635+CLEC16Achr1611214471+8.08E-070.99999917
RMI2chr1611439623+CLEC16Achr1611214471+1.59E-081
RMI2chr1611439623+CLEC16Achr1611214471+1.59E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RMI2-CLEC16A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:11439623/chr16:11214472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLEC16Achr16:11439623chr16:11214472ENST0000038182204892_9330141.0Compositional biasNote=Ser-rich
TgeneCLEC16Achr16:11439623chr16:11214472ENST000004095521721892_933687907.0Compositional biasNote=Ser-rich
TgeneCLEC16Achr16:11439623chr16:11214472ENST000004097901824892_9337051054.0Compositional biasNote=Ser-rich
TgeneCLEC16Achr16:11439623chr16:11214472ENST000003818220451_1980141.0DomainFPL

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRMI2chr16:11439623chr16:11214472ENST00000312499+1244_11498148.0DNA bindingNote=OB
HgeneRMI2chr16:11439623chr16:11214472ENST00000381820+1244_114085.0DNA bindingNote=OB
HgeneRMI2chr16:11439623chr16:11214472ENST00000572173+1544_114085.0DNA bindingNote=OB
TgeneCLEC16Achr16:11439623chr16:11214472ENST00000409552172151_198687907.0DomainFPL
TgeneCLEC16Achr16:11439623chr16:11214472ENST00000409790182451_1987051054.0DomainFPL


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Fusion Gene Sequence for RMI2-CLEC16A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74254_74254_1_RMI2-CLEC16A_RMI2_chr16_11439623_ENST00000312499_CLEC16A_chr16_11214472_ENST00000409552_length(transcript)=1059nt_BP=336nt
CGGGAAAGCGGAGGCGGGGCGGAAGGGTGCGGCGAGGCGGAATGGCGGCGGCTGCGGACTCGTTCTCAGGCGGCCCCGCGGGGGTGCGGC
TTCCGAGGTCGCCGCCACTCAAGGTGCTGGCGGAGCAGCTGCGGCGCGACGCGGAGGGCGGCCCGGGCGCGTGGCGGCTGTCACGGGCGG
CGGCGGGCCGCGGGCCGCTGGACCTGGCGGCCGTGTGGATGCAGGGCAGGGTAGTGATGGCGGACCGCGGCGAGGCTCGGCTGAGGGACC
CGAGCGGGGACTTCTCGGTCCGCGGCCTGGAGCGGGTGCCGCGCGGGCGGCCCTGTCTAGTCCCAGATAACAGCGACTTGATTGCATGTA
CAGTGATCACCAAGGATGGCGGCATGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGATGAGTTTGGTGGAGCCTGATGTGTCCAGGC
TTGGCTGGGGAGTGGTCAAGTTTGCAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGGAGGACGACAGCCGTGCCCTGAACATCACCA
TCCACAAGCCTGCGTCCAGCCCCCATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCATCTTCTCAGACCACATCCGCTGCATCATCG
CCAAGCAGCGCCTGGCCAAAGGCCGCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAGCTGCCCTCCTGGACCTCCCAATCCAGCCCA
CCACTGAAGTCCTGGGGTTTGGACTCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCCGCTTCTACGACCAGGGGCGCCGGGGCAGCA
GCGACCCCACAGTGCAGCGCTCCGTGTTTGCATCGGTGGACAAGGTGCCAGGTGAGCCAGCCCCCCGCCCTGCGCCACAGCTCGTTCATC
ATGGTGGGCGTTCAAGGTCTTTCTCTCTGTGGAGCCTGTGTGAGCTGCCCTTCCTCTCTCAGAAGCCCCGTCGGCTGGCAGCACCAGCTT
CTTAGAATTTGTCAAAGCACAGCGCAAGATTAAACACAGCCCCCAAAATAAATTTTGGCTTTCCCTTTA

>74254_74254_1_RMI2-CLEC16A_RMI2_chr16_11439623_ENST00000312499_CLEC16A_chr16_11214472_ENST00000409552_length(amino acids)=317AA_BP=95
MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVP
RGRPCLVPDNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFP
ILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVD
KVPGEPAPRPAPQLVHHGGRSRSFSLWSLCELPFLSQKPRRLAAPAS

--------------------------------------------------------------
>74254_74254_2_RMI2-CLEC16A_RMI2_chr16_11439623_ENST00000312499_CLEC16A_chr16_11214472_ENST00000409790_length(transcript)=4881nt_BP=336nt
CGGGAAAGCGGAGGCGGGGCGGAAGGGTGCGGCGAGGCGGAATGGCGGCGGCTGCGGACTCGTTCTCAGGCGGCCCCGCGGGGGTGCGGC
TTCCGAGGTCGCCGCCACTCAAGGTGCTGGCGGAGCAGCTGCGGCGCGACGCGGAGGGCGGCCCGGGCGCGTGGCGGCTGTCACGGGCGG
CGGCGGGCCGCGGGCCGCTGGACCTGGCGGCCGTGTGGATGCAGGGCAGGGTAGTGATGGCGGACCGCGGCGAGGCTCGGCTGAGGGACC
CGAGCGGGGACTTCTCGGTCCGCGGCCTGGAGCGGGTGCCGCGCGGGCGGCCCTGTCTAGTCCCAGATAACAGCGACTTGATTGCATGTA
CAGTGATCACCAAGGATGGCGGCATGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGATGAGTTTGGTGGAGCCTGATGTGTCCAGGC
TTGGCTGGGGAGTGGTCAAGTTTGCAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGGAGGACGACAGCCGTGCCCTGAACATCACCA
TCCACAAGCCTGCGTCCAGCCCCCATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCATCTTCTCAGACCACATCCGCTGCATCATCG
CCAAGCAGCGCCTGGCCAAAGGCCGCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAGCTGCCCTCCTGGACCTCCCAATCCAGCCCA
CCACTGAAGTCCTGGGGTTTGGACTCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCCGCTTCTACGACCAGGGGCGCCGGGGCAGCA
GCGACCCCACAGTGCAGCGCTCCGTGTTTGCATCGGTGGACAAGGTGCCAGGCTTCGCCGTGGCCCAGTGCATAAACCAGCACAGCTCCC
CGTCCCTGTCCTCACAGTCGCCACCCTCCGCCAGCGGGAGCCCCAGCGGCAGCGGGAGCACCAGCCACTGCGACTCTGGAGGCACCAGCT
CGTCCTCCACCCCCTCCACAGCCCAGAGTCCAGCAGATGCCCCCATGAGTCCAGAACTGCCTAAGCCTCACCTTCCTGACCAGTTGGTAA
TCGTCAACGAAACGGAAGCAGACTCTAAGCCCAGCAAGAACGTGGCCAGGAGCGCAGCCGTGGAGACAGCCAGCCTGTCCCCCAGCCTCG
TCCCTGCCCGGCAGCCCACCATTTCCCTGCTCTGCGAGGACACGGCTGACACGCTGAGCGTCGAATCGCTGACCCTTGTCCCCCCAGTTG
ACCCCCACAGCCTCCGCAGCCTCACCGGCATGCCCCCGCTGTCCACGCCGGCTGCCGCCTGCACAGAGCCCGTGGGCGAAGAGGCTGCAT
GTGCTGAGCCTGTGGGCACCGCTGAGGACTGAGTCAGTGCCGGGGCCTCCCTTTGTGTGTGTGGCCCCGCTGGTAGGGACCCCAGTGCCG
CTGACTGGCAAGACACACTGGGAGCACCCACCATTCTGTGCGGCCCCCAGCAGCCATCTCAACCACCTATCCCTGCGCTCCCTTGAATGG
GAAGAAGCCCCACGTTGTCCTTGAATTCCTTTTTCACTTTGCATCTCTTCACGTGCAGGCTGGGACCAGCGGAGACACCGCGGCGAATGC
AGATGACTGCACCGGCCACTCAGGGAGCTGCCTGGGCTCCGTGTCTCTGAGCCCCGGGTGGCAGGACCCACCGGCACCTCTTTCTTCCTC
TGTCATATGGCTCCTCTGTCACCAGCCCCAGTGTGCACAGAAGAATTGGACCAGGTCACTGTACGTAGAAATTTGTAGAAAAGCAGACTT
AGATAAACATCTCCTTTGGATATTTATTTCCGCTTTTGGCAGCAGGTGAACATTTATTTTTAAAACTTCTATTTAAAAGAAGTCCAAAAA
CATCAACACTAAGGTTTGATGTCATGTGAAAAGTGTAATAATAACAGTTAAGATTTCATGATCATTTTCACTGGACCTTTCCTGATATTT
TGTTTCAGAGTTCTTAGTGTGGCTTTTTCCATTTATTTAAGTGATTCTTTGTTACTCACTAACTCTGCAAGCCTGTGGAATAATGAAGTA
CCTTCCTGGAAAGTTTGGATTATTTTTTAAACAAAAACAAGGGAGATACATGTATTCTCAGGTACACACAGAGCTGAGAGGGCTGAATGG
TTTTCTGCTATAGCAGCCGAGAGGCCTCCCATCATGGAAAGATTTCTCCAGGAAAAGGAGGAATGTAGCCAGCTCCCCACTCAGGACGCT
TCCTCATTTCTCTTCACCAAAACCAAACAGAGACAGCTTCCAGCACCTTCTTCAGTGTTACCATCTCTAAGAAGGAACCAGTTGGGACCG
TGAAGACTCCCGACCCTGTGGCCATGATGGAAATCAAAGGAAGACACCCTCTACGTCACCTGCCCTCGACTGTGTGTGCCCACATGTGCC
GAGAGATGGCCCAGAGCCAGTTCCCCTCCAGCTGCAAGGGCATGGTGTCCCCAGAGCTCTGAGTCTGTCACTCTCCCTCTGCTACTGCTG
CTGATCTGAATATGGAAACCCCATGGTTCCCTTCCCCATTCGGACTGGGTGTGTACAAGCAAGGACCCAGATGCATCAGACACAGCCCCC
AAGATGTTCCTTTCTACTCGGCCAGCTCGGGAGCCAGACACAGCACTCACAGCCCAGGCCGTGATCCACCCTCCCCAAGTCCACCAGGGC
CAGCGGCCCCTCACCTCTCTGGTCACTGGTGAGACCTTCCACAACTTTCCTCCAGACCTGCCAGCAGATGTGCCCACCAGGGGCATTAGG
TATCCGCCGGAGCCTGGCCATAGGGTAGTCTCGGGAGCCGCGCTGAGATCTTTTGCCACCTGCATTTTAGAAGAACATGGTCTCTGTCTC
CTCGGCCCAGCCAGCTGTCCCGGCAAGGCCTGCCGAGGGCAGTTTTCAACCTCATGAAGGAAACACAGTCCTGCCAAGGAGGGGGAGTGG
CGCCCATGGGGACAGGCCTCAGTCCTTAGAAGCCCTCTGGGTAGCTGTGCCCACCCAGCCTTCATGGCTGCAGGTACAAGGACCTTTGCT
TCCATAGAGAAAACGCACAGCTCAGAAAGGGGGCCACATGGGCAGAAACCCAAAGGAAGGACAAACCACGACCACCGTGGCCATCTGCAG
AATCCCTGGAAGAGAAGGAAGGCAGGGTGGAGCGGGGGGAAGACCATCATGGAGAGAAGGACCACAGCATCAGGAGACGGGACACGCCAC
ACCCAGCAGGCAGCCTGTGTGTTGCTTAATTTTTTAAGAGCAAGAGGGGTAGAGAGGATCAAGCTGGCCCTGGCTGGAGATGGCTAGCCC
CTGAGACATGCACTTCTGGTTTTGAAATGACTCTGTCTGTGGGGCAGCAGAAACTAGAGAAGGCAAGTGGCTGCCCCACCCCAAGGCGTG
ACCAGGAGGAACAGCCTGCAGCTCACTCCATGCCACACGGGTGGGCCACCAGCCTGCTGTCAGAAGTCTCTGGGCTCCAACTGGTCTTGT
AACCACTGAGCACTGAAGGAGAGAGGTCTTGGTCAGGGCTGGACAGCATGCCCGGGAGGACCAGCAGAGGATTAAAGGTGACTGGGAGGA
CCAGCGGAGGATAAAAGACACTGCTCAGGGCAGGGCTTCTACCCTGCATCCCTGGCCAAGAAAAGGGCAGTCCCCATGTGGGCTTGCAGG
GTCACTCTCAGGGGCCTCTTTCAGCTGGGGCTGGCAACTTGCGTCTGGGGGACACCTCCAGGTGTGTGGGGTGAGGATTTCCTATAACCA
GGGCTCCCAGAAGCTTTGCTTATGTAAGGAGGTCTGGGAGCCAGCCCATTGGAGGCCACCAGCCATTTTGGCTTCAAAGGACCCCACCTC
ACCCAGGTCTCAGCGGCAGTGGGCACAGCTATGTCTTCAGGAGCTCCCGTCAAACCTCATAGCTGGGGCGCTCCCAGACAGGCCAGTCCA
GACAGGACACGCTGGGCCCCTGGCATCCAGAGGAAGAGCCAGGAGTGTGGGAAGGCCCACAGTGGGGGCTGTGGCTTCTGACACTCAGGT
CATAGCCTCAGAGGTCTGAGGTCAGCCCCCACAGACCCATCCGGCCCGCCCCCCAAGTCCCTGCAGAGAGCACTTAGAGTTATGGCCCAG
GCCCTGGTCCACCCTTCCCCTGTGCACCTCCGGCTGGGTTTGCCAAGTCAGGGAGCAGGGCTGGCCGCAGGAACTCCCAAACCTTGGCTT
TGAATATTGTTGTGGAGGTGTGCTCGTCCCTTTCTGGACGTGCAAGGTACCTGTCCCAGCAGGTCAGATGGGGCCAGCTGAGGCGCTCCC
CCAGGCAGGAAGGGCCAGCCTTCACCATCGCGTGGGATTGGGAGGAGGGGCCTCCGTGAGCAGCCCCTCCTCTGCCGCTGTCCCAGCCCA
GTCCCTCTCCCGGAGCCTTGGCAGCCTCCCACAACCCAGACACTTGCGTTCACAAGCAACCTAAGGGGCAGGTGAAGAAGCGCAGCCCTG
CCAGACGCGCTAGATTCCTCTAAGGTCTCTGAGATGCACCGTTTTTTAAAAAGGCGTGGGGTGAACTGATTTTGATCTTCTTGTCTAGAT
GCAATAAATAAATCTGAAGCATTTAATGTAGTCATCTTGACATTGGGCCTACACTGTACGAGTTCCTTATGTTTCCTTGAGCTAAAAATA
TGTAAATAATTTTTGTCCCAGTGAGAACCGAGGGTTAGAAAACCTCGATGCCTCTGAGCCTCGGGACCGCTCTAGGGAAGTACCTGCTTT
CGCCAGCATGACTCATGCTTCGTGGGTACTGAACACGAGGGTGGAAATGAAAACTGGAACTTCCTTGTAAATTTAAACTTGGCAATAAAA
GAGAAAAAAAGTTACCAAGAA

>74254_74254_2_RMI2-CLEC16A_RMI2_chr16_11439623_ENST00000312499_CLEC16A_chr16_11214472_ENST00000409790_length(amino acids)=446AA_BP=95
MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVP
RGRPCLVPDNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFP
ILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVD
KVPGFAVAQCINQHSSPSLSSQSPPSASGSPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEADSKPSKN
VARSAAVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRSLTGMPPLSTPAAACTEPVGEEAACAEPVGTAED

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Fusion Gene PPI Analysis for RMI2-CLEC16A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RMI2-CLEC16A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RMI2-CLEC16A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011854Diabetes Mellitus, Insulin-Dependent2CTD_human
TgeneC0026769Multiple Sclerosis2CTD_human
TgeneC0162538Immunoglobulin A deficiency (disorder)2CTD_human
TgeneC0205734Diabetes, Autoimmune2CTD_human
TgeneC0342302Brittle diabetes2CTD_human
TgeneC0751324Multiple Sclerosis, Acute Fulminating2CTD_human
TgeneC3837958Diabetes Mellitus, Ketosis-Prone2CTD_human
TgeneC4554117Diabetes Mellitus, Sudden-Onset2CTD_human
TgeneC0001403Addison Disease1CTD_human
TgeneC0008312Primary biliary cirrhosis1CTD_human
TgeneC0023892Biliary cirrhosis1CTD_human
TgeneC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneC0238065Secondary Biliary Cholangitis1CTD_human
TgeneC0242380Libman-Sacks Disease1CTD_human
TgeneC4551595Biliary Cirrhosis, Primary, 11CTD_human