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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:AGAP1-PINX1 (FusionGDB2 ID:HG116987TG54984)

Fusion Gene Summary for AGAP1-PINX1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP1-PINX1
Fusion gene ID: hg116987tg54984
HgeneTgene
Gene symbol

AGAP1

PINX1

Gene ID

116987

54984

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 1PIN2 (TERF1) interacting telomerase inhibitor 1
SynonymsAGAP-1|CENTG2|GGAP1|cnt-g2Gno1|LPTL|LPTS|Pxr1
Cytomap('AGAP1')('PINX1')

2q37.2

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2PIN2/TERF1-interacting telomerase inhibitor 167-11-3 proteinPIN2-interacting protein 1TRF1-interacting protein 1hepatocellular carcinoma-related putative tumor suppressorliver-related putative tumor suppressorpin2-interacting protein X1protein 67-1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304032, ENST00000336665, 
ENST00000409457, ENST00000409538, 
ENST00000428334, 
Fusion gene scores* DoF score49 X 18 X 17=149946 X 4 X 5=120
# samples 486
** MAII scorelog2(48/14994*10)=-4.96520709119934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGAP1 [Title/Abstract] AND PINX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP1(236403493)-PINX1(10683754), # samples:3
Anticipated loss of major functional domain due to fusion event.AGAP1-PINX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-PINX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-PINX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-PINX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePINX1

GO:0007004

telomere maintenance via telomerase

11701125

TgenePINX1

GO:0010972

negative regulation of G2/M transition of mitotic cell cycle

11701125

TgenePINX1

GO:0032211

negative regulation of telomere maintenance via telomerase

11701125

TgenePINX1

GO:0051974

negative regulation of telomerase activity

11701125

TgenePINX1

GO:1902570

protein localization to nucleolus

24415760

TgenePINX1

GO:1904744

positive regulation of telomeric DNA binding

19265708|24415760

TgenePINX1

GO:1904751

positive regulation of protein localization to nucleolus

19265708


check buttonFusion gene breakpoints across AGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PINX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1544-01AAGAP1chr2

236403493

+PINX1chr8

10683754

-
ChimerDB4OVTCGA-24-1544AGAP1chr2

236403493

+PINX1chr8

10683754

-


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Fusion Gene ORF analysis for AGAP1-PINX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304032ENST00000520018AGAP1chr2

236403493

+PINX1chr8

10683754

-
5CDS-intronENST00000336665ENST00000520018AGAP1chr2

236403493

+PINX1chr8

10683754

-
5CDS-intronENST00000409457ENST00000520018AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000304032ENST00000314787AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000304032ENST00000426190AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000304032ENST00000519088AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000336665ENST00000314787AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000336665ENST00000426190AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000336665ENST00000519088AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000409457ENST00000314787AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000409457ENST00000426190AGAP1chr2

236403493

+PINX1chr8

10683754

-
In-frameENST00000409457ENST00000519088AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000409538ENST00000314787AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000409538ENST00000426190AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000409538ENST00000519088AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000428334ENST00000314787AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000428334ENST00000426190AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-3CDSENST00000428334ENST00000519088AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-intronENST00000409538ENST00000520018AGAP1chr2

236403493

+PINX1chr8

10683754

-
intron-intronENST00000428334ENST00000520018AGAP1chr2

236403493

+PINX1chr8

10683754

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336665AGAP1chr2236403493+ENST00000314787PINX1chr810683754-18677434211428335
ENST00000336665AGAP1chr2236403493+ENST00000426190PINX1chr810683754-1788743969202255
ENST00000336665AGAP1chr2236403493+ENST00000519088PINX1chr810683754-1594743969202255
ENST00000304032AGAP1chr2236403493+ENST00000314787PINX1chr810683754-18677434211428335
ENST00000304032AGAP1chr2236403493+ENST00000426190PINX1chr810683754-1788743969202255
ENST00000304032AGAP1chr2236403493+ENST00000519088PINX1chr810683754-1594743969202255
ENST00000409457AGAP1chr2236403493+ENST00000314787PINX1chr810683754-18857614391446335
ENST00000409457AGAP1chr2236403493+ENST00000426190PINX1chr810683754-1806761987220255
ENST00000409457AGAP1chr2236403493+ENST00000519088PINX1chr810683754-1612761987220255

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336665ENST00000314787AGAP1chr2236403493+PINX1chr810683754-0.004009090.99599093
ENST00000336665ENST00000426190AGAP1chr2236403493+PINX1chr810683754-0.0072897850.99271023
ENST00000336665ENST00000519088AGAP1chr2236403493+PINX1chr810683754-0.0064794230.99352056
ENST00000304032ENST00000314787AGAP1chr2236403493+PINX1chr810683754-0.004009090.99599093
ENST00000304032ENST00000426190AGAP1chr2236403493+PINX1chr810683754-0.0072897850.99271023
ENST00000304032ENST00000519088AGAP1chr2236403493+PINX1chr810683754-0.0064794230.99352056
ENST00000409457ENST00000314787AGAP1chr2236403493+PINX1chr810683754-0.0043747080.99562526
ENST00000409457ENST00000426190AGAP1chr2236403493+PINX1chr810683754-0.008724860.9912751
ENST00000409457ENST00000519088AGAP1chr2236403493+PINX1chr810683754-0.007161120.9928389

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Fusion Genomic Features for AGAP1-PINX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AGAP1-PINX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:236403493/chr8:10683754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePINX1chr2:236403493chr8:10683754ENST0000031478737287_297100329.0MotifNote=TBM
TgenePINX1chr2:236403493chr8:10683754ENST0000051908836287_297100175.0MotifNote=TBM
TgenePINX1chr2:236403493chr8:10683754ENST0000031478737254_328100329.0RegionNote=Telomerase inhibitory domain (TID)
TgenePINX1chr2:236403493chr8:10683754ENST0000051908836254_328100175.0RegionNote=Telomerase inhibitory domain (TID)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118346_58854858.0DomainPH
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118609_72954858.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117346_58854805.0DomainPH
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117609_72954805.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110346_58854406.0DomainPH
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110609_72954406.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118122_12654858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118178_18154858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+11878_8554858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117122_12654805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117178_18154805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+11778_8554805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110122_12654406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110178_18154406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+11078_8554406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+11866_27654858.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+11766_27654805.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+11066_27654406.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118768_79754858.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118801_83054858.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117768_79754805.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117801_83054805.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110768_79754406.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110801_83054406.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr8:10683754ENST00000304032+118624_64754858.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr8:10683754ENST00000336665+117624_64754805.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr8:10683754ENST00000409457+110624_64754406.0Zinc fingerC4-type
TgenePINX1chr2:236403493chr8:10683754ENST000003147873726_72100329.0DomainG-patch
TgenePINX1chr2:236403493chr8:10683754ENST000005190883626_72100175.0DomainG-patch


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Fusion Gene Sequence for AGAP1-PINX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2778_2778_1_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000314787_length(transcript)=1867nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA
GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGC
CAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAA
GAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGC
CGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTC
TGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA
AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAG
CCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCT
GGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAA
TGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAAT
ACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT
CCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA

>2778_2778_1_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000314787_length(amino acids)=335AA_BP=107
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTT
SAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRG
PCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK

--------------------------------------------------------------
>2778_2778_2_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000426190_length(transcript)=1788nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC
AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC
GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA
AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA
GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA
AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT
GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA
CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG
AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTAT
AATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCG
TTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGC

>2778_2778_2_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000426190_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------
>2778_2778_3_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000519088_length(transcript)=1594nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC
AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC
GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA
AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA
GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA
AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT
GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA
CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG
AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA

>2778_2778_3_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000304032_PINX1_chr8_10683754_ENST00000519088_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------
>2778_2778_4_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000314787_length(transcript)=1867nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA
GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGC
CAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAA
GAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGC
CGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTC
TGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA
AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAG
CCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCT
GGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAA
TGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAAT
ACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT
CCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA

>2778_2778_4_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000314787_length(amino acids)=335AA_BP=107
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTT
SAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRG
PCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK

--------------------------------------------------------------
>2778_2778_5_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000426190_length(transcript)=1788nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC
AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC
GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA
AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA
GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA
AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT
GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA
CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG
AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTAT
AATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCG
TTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGC

>2778_2778_5_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000426190_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------
>2778_2778_6_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000519088_length(transcript)=1594nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG
TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC
AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC
GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA
AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA
GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA
AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT
GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA
CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG
AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA

>2778_2778_6_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000336665_PINX1_chr8_10683754_ENST00000519088_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------
>2778_2778_7_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000314787_length(transcript)=1885nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC
CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTT
TGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCAC
CATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGT
GGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGA
GGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGA
CCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAG
AGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTC
CAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGA
GTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTC
CCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTA
ATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTAT
CTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA

>2778_2778_7_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000314787_length(amino acids)=335AA_BP=107
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTT
SAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRG
PCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK

--------------------------------------------------------------
>2778_2778_8_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000426190_length(transcript)=1806nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC
CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA
CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTT
CTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCA
AGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAG
GCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGC
CCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA
AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTG
AAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCC
CCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCA
GCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTG
TGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTA
AGAGGC

>2778_2778_8_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000426190_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------
>2778_2778_9_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000519088_length(transcript)=1612nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC
CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA
CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTT
CTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCA
AGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAG
GCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGC
CCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA
AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTG
AAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCC
CCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA

>2778_2778_9_AGAP1-PINX1_AGAP1_chr2_236403493_ENST00000409457_PINX1_chr8_10683754_ENST00000519088_length(amino acids)=255AA_BP=0
MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQH
RLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKAR
AEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AGAP1-PINX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGAP1-PINX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGAP1-PINX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGAP1C0004352Autistic Disorder1CTD_human