Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AGAP1-IFIH1 (FusionGDB2 ID:HG116987TG64135)

Fusion Gene Summary for AGAP1-IFIH1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP1-IFIH1
Fusion gene ID: hg116987tg64135
HgeneTgene
Gene symbol

AGAP1

IFIH1

Gene ID

116987

64135

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 1interferon induced with helicase C domain 1
SynonymsAGAP-1|CENTG2|GGAP1|cnt-g2AGS7|Hlcd|IDDM19|MDA-5|MDA5|RLR-2|SGMRT1
Cytomap('AGAP1')('IFIH1')

2q37.2

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2interferon-induced helicase C domain-containing protein 1CADM-140 autoantigenDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRIG-I-like receptor 2RNA helicase-DEAD box protein 116clinically amyopathic dermatomyositis autoantigen 140 kDahelicardhelicase
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304032, ENST00000336665, 
ENST00000409457, ENST00000409538, 
ENST00000428334, 
Fusion gene scores* DoF score49 X 18 X 17=149947 X 7 X 4=196
# samples 487
** MAII scorelog2(48/14994*10)=-4.96520709119934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGAP1 [Title/Abstract] AND IFIH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP1(236403493)-IFIH1(163167443), # samples:2
Anticipated loss of major functional domain due to fusion event.AGAP1-IFIH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-IFIH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-IFIH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-IFIH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-IFIH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AGAP1-IFIH1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFIH1

GO:0016925

protein sumoylation

21156324

TgeneIFIH1

GO:0032728

positive regulation of interferon-beta production

17600090

TgeneIFIH1

GO:0039530

MDA-5 signaling pathway

17600090

TgeneIFIH1

GO:0051607

defense response to virus

21478870


check buttonFusion gene breakpoints across AGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IFIH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2298-01AAGAP1chr2

236403493

+IFIH1chr2

163167443

-


Top

Fusion Gene ORF analysis for AGAP1-IFIH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000304032ENST00000263642AGAP1chr2

236403493

+IFIH1chr2

163167443

-
Frame-shiftENST00000336665ENST00000263642AGAP1chr2

236403493

+IFIH1chr2

163167443

-
Frame-shiftENST00000409457ENST00000263642AGAP1chr2

236403493

+IFIH1chr2

163167443

-
In-frameENST00000304032ENST00000421365AGAP1chr2

236403493

+IFIH1chr2

163167443

-
In-frameENST00000336665ENST00000421365AGAP1chr2

236403493

+IFIH1chr2

163167443

-
In-frameENST00000409457ENST00000421365AGAP1chr2

236403493

+IFIH1chr2

163167443

-
intron-3CDSENST00000409538ENST00000263642AGAP1chr2

236403493

+IFIH1chr2

163167443

-
intron-3CDSENST00000409538ENST00000421365AGAP1chr2

236403493

+IFIH1chr2

163167443

-
intron-3CDSENST00000428334ENST00000263642AGAP1chr2

236403493

+IFIH1chr2

163167443

-
intron-3CDSENST00000428334ENST00000421365AGAP1chr2

236403493

+IFIH1chr2

163167443

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000336665AGAP1chr2236403493+ENST00000421365IFIH1chr2163167443-1530743762202186
ENST00000304032AGAP1chr2236403493+ENST00000421365IFIH1chr2163167443-1530743762202186
ENST00000409457AGAP1chr2236403493+ENST00000421365IFIH1chr2163167443-1548761780220186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336665ENST00000421365AGAP1chr2236403493+IFIH1chr2163167443-0.09772560.90227437
ENST00000304032ENST00000421365AGAP1chr2236403493+IFIH1chr2163167443-0.09772560.90227437
ENST00000409457ENST00000421365AGAP1chr2236403493+IFIH1chr2163167443-0.157045990.84295404

Top

Fusion Genomic Features for AGAP1-IFIH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for AGAP1-IFIH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:236403493/chr2:163167443)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIFIH1chr2:236403493chr2:163167443ENST00000263642016316_5091511026.0DomainHelicase ATP-binding
TgeneIFIH1chr2:236403493chr2:163167443ENST00000263642016700_8821511026.0DomainHelicase C-terminal
TgeneIFIH1chr2:236403493chr2:163167443ENST00000263642016893_10201511026.0DomainRLR CTR
TgeneIFIH1chr2:236403493chr2:163167443ENST0000042136502316_509151222.0DomainHelicase ATP-binding
TgeneIFIH1chr2:236403493chr2:163167443ENST0000042136502700_882151222.0DomainHelicase C-terminal
TgeneIFIH1chr2:236403493chr2:163167443ENST0000042136502893_1020151222.0DomainRLR CTR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118346_58854858.0DomainPH
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118609_72954858.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117346_58854805.0DomainPH
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117609_72954805.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110346_58854406.0DomainPH
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110609_72954406.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118122_12654858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118178_18154858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+11878_8554858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117122_12654805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117178_18154805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+11778_8554805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110122_12654406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110178_18154406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+11078_8554406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+11866_27654858.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+11766_27654805.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+11066_27654406.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118768_79754858.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118801_83054858.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117768_79754805.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117801_83054805.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110768_79754406.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110801_83054406.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr2:163167443ENST00000304032+118624_64754858.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr2:163167443ENST00000336665+117624_64754805.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr2:163167443ENST00000409457+110624_64754406.0Zinc fingerC4-type
TgeneIFIH1chr2:236403493chr2:163167443ENST00000263642016110_1901511026.0DomainNote=CARD 2
TgeneIFIH1chr2:236403493chr2:163167443ENST000002636420167_971511026.0DomainNote=CARD 1
TgeneIFIH1chr2:236403493chr2:163167443ENST0000042136502110_190151222.0DomainNote=CARD 2
TgeneIFIH1chr2:236403493chr2:163167443ENST00000421365027_97151222.0DomainNote=CARD 1


Top

Fusion Gene Sequence for AGAP1-IFIH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2772_2772_1_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000304032_IFIH1_chr2_163167443_ENST00000421365_length(transcript)=1530nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTGCTGCTGCAGAAAACAATGGAAATGAATCAGGTGTAAGAGAGCTACTAAAAAGGATTGTGCAGA
AAGAAAACTGGTTCTCTGCATTTCTGAATGTTCTTCGTCAAACAGGAAACAATGAACTTGTCCAAGAGTTAACAGGCTCTGATTGCTCAG
AAAGCAATGCAGGTATTTGTAATTTTACTGAGGAAGATTCTTCAAATTCTGCCTAGTGATTGAGAATTCAATAAAGCAGAAAGACACAAT
GCTAAACACCAAGATTTTTAGAATCAAAATTTTAAGAGTGGAACATATGTGATAGATCATCTATTTTATCACCTTAACAAATGAGGAAAT
TGATGCCTGGGAAAATATCAACTGATCAAAGACCATTTTTCATCCAACCAACACTCTTTCTACTACCTTATTTTAAAAACAATATGACTA
CCAGAAATTTTATCAAGATTATGTAACATTAAATATACACAAATACATTGGAAGAAAGTATTTTAGTGGTTATAAAAAATCTGCTGCATA
TTCTTCTGAACATTTTTATACATTTTAAGCAATGTATTAAGCATTTGATAAAAGGATTGTTTTGTCAATATATCTCAACCTTACCTAATG
TGAGATTTTAAACAGCATTCAATAATAGTAATAACATAACATTTTATAGCTCCTTCTCCTACATTATTTGTAAATCTCACTTAAACTGCT
ATCTTATTTTTCTTTTCGTAGTATGCATCCTATGTTTCCAAAAATATCATATGAAAGACAAATTGAAAGTTAACTATTAATTAATTATAA

>2772_2772_1_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000304032_IFIH1_chr2_163167443_ENST00000421365_length(amino acids)=186AA_BP=
MFSAAAIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGA
AAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGA

--------------------------------------------------------------
>2772_2772_2_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000336665_IFIH1_chr2_163167443_ENST00000421365_length(transcript)=1530nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATTGCTGCTGCAGAAAACAATGGAAATGAATCAGGTGTAAGAGAGCTACTAAAAAGGATTGTGCAGA
AAGAAAACTGGTTCTCTGCATTTCTGAATGTTCTTCGTCAAACAGGAAACAATGAACTTGTCCAAGAGTTAACAGGCTCTGATTGCTCAG
AAAGCAATGCAGGTATTTGTAATTTTACTGAGGAAGATTCTTCAAATTCTGCCTAGTGATTGAGAATTCAATAAAGCAGAAAGACACAAT
GCTAAACACCAAGATTTTTAGAATCAAAATTTTAAGAGTGGAACATATGTGATAGATCATCTATTTTATCACCTTAACAAATGAGGAAAT
TGATGCCTGGGAAAATATCAACTGATCAAAGACCATTTTTCATCCAACCAACACTCTTTCTACTACCTTATTTTAAAAACAATATGACTA
CCAGAAATTTTATCAAGATTATGTAACATTAAATATACACAAATACATTGGAAGAAAGTATTTTAGTGGTTATAAAAAATCTGCTGCATA
TTCTTCTGAACATTTTTATACATTTTAAGCAATGTATTAAGCATTTGATAAAAGGATTGTTTTGTCAATATATCTCAACCTTACCTAATG
TGAGATTTTAAACAGCATTCAATAATAGTAATAACATAACATTTTATAGCTCCTTCTCCTACATTATTTGTAAATCTCACTTAAACTGCT
ATCTTATTTTTCTTTTCGTAGTATGCATCCTATGTTTCCAAAAATATCATATGAAAGACAAATTGAAAGTTAACTATTAATTAATTATAA

>2772_2772_2_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000336665_IFIH1_chr2_163167443_ENST00000421365_length(amino acids)=186AA_BP=
MFSAAAIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGA
AAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGA

--------------------------------------------------------------
>2772_2772_3_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000409457_IFIH1_chr2_163167443_ENST00000421365_length(transcript)=1548nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTGCTGCTGCAGAAAACAATGGAAATGAATCAGGTGTAAGAGAGCTAC
TAAAAAGGATTGTGCAGAAAGAAAACTGGTTCTCTGCATTTCTGAATGTTCTTCGTCAAACAGGAAACAATGAACTTGTCCAAGAGTTAA
CAGGCTCTGATTGCTCAGAAAGCAATGCAGGTATTTGTAATTTTACTGAGGAAGATTCTTCAAATTCTGCCTAGTGATTGAGAATTCAAT
AAAGCAGAAAGACACAATGCTAAACACCAAGATTTTTAGAATCAAAATTTTAAGAGTGGAACATATGTGATAGATCATCTATTTTATCAC
CTTAACAAATGAGGAAATTGATGCCTGGGAAAATATCAACTGATCAAAGACCATTTTTCATCCAACCAACACTCTTTCTACTACCTTATT
TTAAAAACAATATGACTACCAGAAATTTTATCAAGATTATGTAACATTAAATATACACAAATACATTGGAAGAAAGTATTTTAGTGGTTA
TAAAAAATCTGCTGCATATTCTTCTGAACATTTTTATACATTTTAAGCAATGTATTAAGCATTTGATAAAAGGATTGTTTTGTCAATATA
TCTCAACCTTACCTAATGTGAGATTTTAAACAGCATTCAATAATAGTAATAACATAACATTTTATAGCTCCTTCTCCTACATTATTTGTA
AATCTCACTTAAACTGCTATCTTATTTTTCTTTTCGTAGTATGCATCCTATGTTTCCAAAAATATCATATGAAAGACAAATTGAAAGTTA

>2772_2772_3_AGAP1-IFIH1_AGAP1_chr2_236403493_ENST00000409457_IFIH1_chr2_163167443_ENST00000421365_length(amino acids)=186AA_BP=
MFSAAAIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGA
AAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AGAP1-IFIH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AGAP1-IFIH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AGAP1-IFIH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGAP1C0004352Autistic Disorder1CTD_human
TgeneC3888244AICARDI-GOUTIERES SYNDROME 76GENOMICS_ENGLAND;UNIPROT
TgeneC0393591AICARDI-GOUTIERES SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4225427SINGLETON-MERTEN SYNDROME 13GENOMICS_ENGLAND;UNIPROT
TgeneC0024141Lupus Erythematosus, Systemic2CTD_human
TgeneC0162538Immunoglobulin A deficiency (disorder)2CTD_human
TgeneC0242380Libman-Sacks Disease2CTD_human
TgeneC0432254Singleton Merten syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0018213Graves Disease1CTD_human
TgeneC0021400Influenza1CTD_human
TgeneC0030246Pustulosis of Palms and Soles1CTD_human
TgeneC0033860Psoriasis1CTD_human
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0042900Vitiligo1CTD_human
TgeneC0796126AICARDI-GOUTIERES SYNDROME 11CTD_human
TgeneC3489724Aicardi-Goutieres Syndrome 21CTD_human
TgeneC3489725Pseudo-TORCH syndrome1CTD_human
TgeneC3860213Autoinflammatory disorder1GENOMICS_ENGLAND