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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TADA1-CADM3 (FusionGDB2 ID:HG117143TG57863)

Fusion Gene Summary for TADA1-CADM3

check button Fusion gene summary
Fusion gene informationFusion gene name: TADA1-CADM3
Fusion gene ID: hg117143tg57863
HgeneTgene
Gene symbol

TADA1

CADM3

Gene ID

117143

57863

Gene nametranscriptional adaptor 1cell adhesion molecule 3
SynonymsADA1|HFI1|STAF42|TADA1L|hADA1BIgR|IGSF4B|NECL1|Necl-1|TSLL1|synCAM3
Cytomap('TADA1')('CADM3')

1q24.1

1q23.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional adapter 1SPT3-associated factor 42 (STAF42)transcriptional adapter 1-like proteintranscriptional adaptor 1 (HFI1 homolog, yeast)cell adhesion molecule 3TSLC1-like 1brain immunoglobulin receptordendritic cell nectin-like protein 1 short isoformimmunoglobulin superfamily member 4Bsynaptic cell adhesion molecule 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367874, ENST00000467021, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 4 X 3=36
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TADA1 [Title/Abstract] AND CADM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTADA1(166838682)-CADM3(159169541), # samples:3
Anticipated loss of major functional domain due to fusion event.TADA1-CADM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TADA1-CADM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTADA1

GO:0043966

histone H3 acetylation

11564863


check buttonFusion gene breakpoints across TADA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CADM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4432-01ATADA1chr1

166838681

-CADM3chr1

159169540

+
ChimerDB4LUADTCGA-05-4432-01ATADA1chr1

166838682

-CADM3chr1

159169541

+
ChimerDB4LUADTCGA-05-4432TADA1chr1

166838681

-CADM3chr1

159169540

+


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Fusion Gene ORF analysis for TADA1-CADM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367874ENST00000497636TADA1chr1

166838682

-CADM3chr1

159169541

+
5CDS-3UTRENST00000367874ENST00000497636TADA1chr1

166838681

-CADM3chr1

159169540

+
In-frameENST00000367874ENST00000368124TADA1chr1

166838682

-CADM3chr1

159169541

+
In-frameENST00000367874ENST00000368124TADA1chr1

166838681

-CADM3chr1

159169540

+
In-frameENST00000367874ENST00000368125TADA1chr1

166838682

-CADM3chr1

159169541

+
In-frameENST00000367874ENST00000368125TADA1chr1

166838681

-CADM3chr1

159169540

+
intron-3CDSENST00000467021ENST00000368124TADA1chr1

166838682

-CADM3chr1

159169541

+
intron-3CDSENST00000467021ENST00000368124TADA1chr1

166838681

-CADM3chr1

159169540

+
intron-3CDSENST00000467021ENST00000368125TADA1chr1

166838682

-CADM3chr1

159169541

+
intron-3CDSENST00000467021ENST00000368125TADA1chr1

166838681

-CADM3chr1

159169540

+
intron-3UTRENST00000467021ENST00000497636TADA1chr1

166838682

-CADM3chr1

159169541

+
intron-3UTRENST00000467021ENST00000497636TADA1chr1

166838681

-CADM3chr1

159169540

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367874TADA1chr1166838682-ENST00000368124CADM3chr1159169541+16613261538822238
ENST00000367874TADA1chr1166838682-ENST00000368125CADM3chr1159169541+29623261538822238
ENST00000367874TADA1chr1166838681-ENST00000368124CADM3chr1159169540+16613261538822238
ENST00000367874TADA1chr1166838681-ENST00000368125CADM3chr1159169540+29623261538822238

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367874ENST00000368124TADA1chr1166838682-CADM3chr1159169541+0.0051722690.9948277
ENST00000367874ENST00000368125TADA1chr1166838682-CADM3chr1159169541+0.0077495390.9922504
ENST00000367874ENST00000368124TADA1chr1166838681-CADM3chr1159169540+0.0051722690.9948277
ENST00000367874ENST00000368125TADA1chr1166838681-CADM3chr1159169540+0.0077495390.9922504

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Fusion Genomic Features for TADA1-CADM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TADA1chr1166838681-CADM3chr1159169540+1.71E-081
TADA1chr1166838681-CADM3chr1159169540+1.71E-081
TADA1chr1166838681-CADM3chr1159169540+1.71E-081
TADA1chr1166838681-CADM3chr1159169540+1.71E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TADA1-CADM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:166838682/chr1:159169541)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCADM3chr1:166838681chr1:159169540ENST00000368124710352_398351433.0Topological domainCytoplasmic
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812569352_398317399.0Topological domainCytoplasmic
TgeneCADM3chr1:166838682chr1:159169541ENST00000368124710352_398351433.0Topological domainCytoplasmic
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812569352_398317399.0Topological domainCytoplasmic
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812569331_351317399.0TransmembraneHelical
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812569331_351317399.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCADM3chr1:166838681chr1:159169540ENST00000368124710130_228351433.0DomainNote=Ig-like C2-type 1
TgeneCADM3chr1:166838681chr1:159169540ENST00000368124710233_315351433.0DomainNote=Ig-like C2-type 2
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812471025_126351433.0DomainNote=Ig-like V-type
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812569130_228317399.0DomainNote=Ig-like C2-type 1
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812569233_315317399.0DomainNote=Ig-like C2-type 2
TgeneCADM3chr1:166838681chr1:159169540ENST000003681256925_126317399.0DomainNote=Ig-like V-type
TgeneCADM3chr1:166838682chr1:159169541ENST00000368124710130_228351433.0DomainNote=Ig-like C2-type 1
TgeneCADM3chr1:166838682chr1:159169541ENST00000368124710233_315351433.0DomainNote=Ig-like C2-type 2
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812471025_126351433.0DomainNote=Ig-like V-type
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812569130_228317399.0DomainNote=Ig-like C2-type 1
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812569233_315317399.0DomainNote=Ig-like C2-type 2
TgeneCADM3chr1:166838682chr1:159169541ENST000003681256925_126317399.0DomainNote=Ig-like V-type
TgeneCADM3chr1:166838681chr1:159169540ENST0000036812471025_330351433.0Topological domainExtracellular
TgeneCADM3chr1:166838681chr1:159169540ENST000003681256925_330317399.0Topological domainExtracellular
TgeneCADM3chr1:166838682chr1:159169541ENST0000036812471025_330351433.0Topological domainExtracellular
TgeneCADM3chr1:166838682chr1:159169541ENST000003681256925_330317399.0Topological domainExtracellular
TgeneCADM3chr1:166838681chr1:159169540ENST00000368124710331_351351433.0TransmembraneHelical
TgeneCADM3chr1:166838682chr1:159169541ENST00000368124710331_351351433.0TransmembraneHelical


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Fusion Gene Sequence for TADA1-CADM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88684_88684_1_TADA1-CADM3_TADA1_chr1_166838681_ENST00000367874_CADM3_chr1_159169540_ENST00000368124_length(transcript)=1661nt_BP=326nt
AGCTTCCAGAGCCAAGGCCTTCCGCCGAGTTGGTTTTTGGGTTGTTGATCGCGGTGGCCGGGCGGTCTGCGGTCGGGCTGAGACACGCGG
AGCAATGGCGACCTTTGTGAGCGAGCTGGAGGCGGCCAAGAAGAACTTAAGCGAGGCCCTGGGGGACAACGTGAAACAATACTGGGCTAA
CCTAAAGCTGTGGTTCAAGCAGAAGATCAGCAAAGAGGAGTTTGACCTTGAAGCTCATAGACTTCTCACACAGGATAATGTCCATTCTCA
CAATGATTTCCTCCTGGCCATTCTCACGCGTTGTCAGATTTTGGTTTCTACACCAGACCCCAGTCCGGTGCCCTCCTCCTCCAGCACCTA
CCACGCCATCATCGGTGGGATCGTGGCTTTCATTGTCTTCCTGCTGCTCATCATGCTCATCTTCCTTGGCCACTACTTGATCCGGCACAA
AGGAACCTACCTGACACATGAGGCAAAAGGCTCCGACGATGCTCCAGACGCGGACACGGCCATCATCAATGCAGAAGGCGGGCAGTCAGG
AGGGGACGACAAGAAGGAATATTTCATCTAGAGGCGCCTGCCCACTTCCTGCGCCCCCCAGGGGCCCTGTGGGGACTGCTGGGGCCGTCA
CCAACCCGGACTTGTACAGAGCAACCGCAGGGCCGCCCCTCCCGCTTGCTCCCCAGCCCACCCACCCCCCTGTACAGAATGTCTGCTTTG
GGTGCGGTTTTGTACTCGGTTTGGAATGGGGAGGGAGGAGGGCGGGGGGAGGGGAGGGTTGCCCTCAGCCCTTTCCGTGGCTTCTCTGCA
TTTGGGTTATTATTATTTTTGTAACAATCCCAAATCAAATCTGTCTCCAGGCTGGAGAGGCAGGAGCCCTGGGGTGAGAAAAGCAAAAAA
CAAACAAAAAACAAAACCCTGGAGTGTTAGGAGGAGAGTGAAGGTAGAGGGGTGAGGAAGGGTAAGGGGCAGGGCTGGTTTCAGCTGGGG
GCTCTCACCAGCCCTCCTTTCAGCCTCTACAACAGAGCAGCTTCCCAGACTTCTCCAGGAACCCAGAAACGGGATGGTTGTCGGCAAAGG
TTGGGAGTGGCTTTTCCTCTGGTAGCCACACACCTGAGCACTACGGACAGGGAGGCAGGTGCCACCTTGACACCTCTCTTCCATAGCAAT
GGGAAAGTGATGAGTGCGGGAGTCCTGAGGAGATGTGGCCTGCAGACAACATGCAGCCATGCAGGGACCCAGGACTGTAACCTGGGGAGG
ACGCGGGTCCCTGCAAGGAAGAGTAGATTTGGAGAGGAAGGATGGAGGTGGACTCTCACCCCATTCCCCCCGGAAATGAACAAAGCCGGG
CCCTTTCCATAGGAACTGCCCTTGGAGATAGCAGAGTGTGGCTGCCCCTCCTTGCTCCAGCAGCAGTGGGAGAGGCACTGCTCTGGGGCC
TGAACTGCCTCTGCTTCCCCCCCTGAGGGGCCCCTCACTCTTACCCAAGACTCTGGATTGTTGCACGGCAACCACTCCTCCCATGGCATT
GCTCAGCAACTACTTCTCCCTTCCCGGCCACCCTGTGCCCCCTTCCTGGTCCCAACGCCAGCCCTTCATCCTTCCTCCCTCAGCAGCCAG

>88684_88684_1_TADA1-CADM3_TADA1_chr1_166838681_ENST00000367874_CADM3_chr1_159169540_ENST00000368124_length(amino acids)=238AA_BP=
MLSNAMGGVVAVQQSRVLGKSEGPLRGGSRGSSGPRAVPLPLLLEQGGAATLCYLQGQFLWKGPGFVHFRGEWGESPPPSFLSKSTLPCR
DPRPPQVTVLGPCMAACCLQATSPQDSRTHHFPIAMEERCQGGTCLPVRSAQVCGYQRKSHSQPLPTTIPFLGSWRSLGSCSVVEAERRA

--------------------------------------------------------------
>88684_88684_2_TADA1-CADM3_TADA1_chr1_166838681_ENST00000367874_CADM3_chr1_159169540_ENST00000368125_length(transcript)=2962nt_BP=326nt
AGCTTCCAGAGCCAAGGCCTTCCGCCGAGTTGGTTTTTGGGTTGTTGATCGCGGTGGCCGGGCGGTCTGCGGTCGGGCTGAGACACGCGG
AGCAATGGCGACCTTTGTGAGCGAGCTGGAGGCGGCCAAGAAGAACTTAAGCGAGGCCCTGGGGGACAACGTGAAACAATACTGGGCTAA
CCTAAAGCTGTGGTTCAAGCAGAAGATCAGCAAAGAGGAGTTTGACCTTGAAGCTCATAGACTTCTCACACAGGATAATGTCCATTCTCA
CAATGATTTCCTCCTGGCCATTCTCACGCGTTGTCAGATTTTGGTTTCTACACCAGACCCCAGTCCGGTGCCCTCCTCCTCCAGCACCTA
CCACGCCATCATCGGTGGGATCGTGGCTTTCATTGTCTTCCTGCTGCTCATCATGCTCATCTTCCTTGGCCACTACTTGATCCGGCACAA
AGGAACCTACCTGACACATGAGGCAAAAGGCTCCGACGATGCTCCAGACGCGGACACGGCCATCATCAATGCAGAAGGCGGGCAGTCAGG
AGGGGACGACAAGAAGGAATATTTCATCTAGAGGCGCCTGCCCACTTCCTGCGCCCCCCAGGGGCCCTGTGGGGACTGCTGGGGCCGTCA
CCAACCCGGACTTGTACAGAGCAACCGCAGGGCCGCCCCTCCCGCTTGCTCCCCAGCCCACCCACCCCCCTGTACAGAATGTCTGCTTTG
GGTGCGGTTTTGTACTCGGTTTGGAATGGGGAGGGAGGAGGGCGGGGGGAGGGGAGGGTTGCCCTCAGCCCTTTCCGTGGCTTCTCTGCA
TTTGGGTTATTATTATTTTTGTAACAATCCCAAATCAAATCTGTCTCCAGGCTGGAGAGGCAGGAGCCCTGGGGTGAGAAAAGCAAAAAA
CAAACAAAAAACAAAACCCTGGAGTGTTAGGAGGAGAGTGAAGGTAGAGGGGTGAGGAAGGGTAAGGGGCAGGGCTGGTTTCAGCTGGGG
GCTCTCACCAGCCCTCCTTTCAGCCTCTACAACAGAGCAGCTTCCCAGACTTCTCCAGGAACCCAGAAACGGGATGGTTGTCGGCAAAGG
TTGGGAGTGGCTTTTCCTCTGGTAGCCACACACCTGAGCACTACGGACAGGGAGGCAGGTGCCACCTTGACACCTCTCTTCCATAGCAAT
GGGAAAGTGATGAGTGCGGGAGTCCTGAGGAGATGTGGCCTGCAGACAACATGCAGCCATGCAGGGACCCAGGACTGTAACCTGGGGAGG
ACGCGGGTCCCTGCAAGGAAGAGTAGATTTGGAGAGGAAGGATGGAGGTGGACTCTCACCCCATTCCCCCCGGAAATGAACAAAGCCGGG
CCCTTTCCATAGGAACTGCCCTTGGAGATAGCAGAGTGTGGCTGCCCCTCCTTGCTCCAGCAGCAGTGGGAGAGGCACTGCTCTGGGGCC
TGAACTGCCTCTGCTTCCCCCCCTGAGGGGCCCCTCACTCTTACCCAAGACTCTGGATTGTTGCACGGCAACCACTCCTCCCATGGCATT
GCTCAGCAACTACTTCTCCCTTCCCGGCCACCCTGTGCCCCCTTCCTGGTCCCAACGCCAGCCCTTCATCCTTCCTCCCTCAGCAGCCAG
GCAGACATAACAACAAAACTACTAAAAGGAGCTTCACTGCAGTGAGCTGTTTCCTGCCCAAACTAAGGGAATAATGTGAACTGTGTGCAT
GTGTGTGGTGTGTATGCATGTGTGCATGTGTGTGTGTGTGTGTGCATGTGTGTGAGTGAGTGAGAGGCAGAGCGAGGAACTGAGGAGGAG
GGCTAAGAGCCAGGGGTCCTGGGCAAGTGGACAGGGCTGTGGGACATGTTGGGGAGGCTTTGGGAATGGGGTATTCCTAGTCAGGGTTCA
CACCTCACCTGGGATGTTGTTCCATGCTGGTATTTCCTCTGCCACCCCCAATGCCCATCGGTCTTGGAGAAAGGAGTCCCCGGGTGTGTG
TTTGCCCAGCTGTCCATTCTATCTCTCCCTTAAACACAGAGCATTCAGCCCTTCCCTGGATTTCCCTCCTCTGAGCCATGGAGTCAGTGC
CACAGCCTTTGCTATGCACCTCTCAGGCCTCTCCTTGGCGTTGACCCTGGAAAGACCTACCACCACCTATTTTTTCCCATAGTCTGTACC
CAGTGAGTTGAAGGCTGGGTCCCCACCCTTCCTTTTGATTTCCTGTCTTCCTTCTCGTGGCCCCAGCTGGTTGCTGTGGAGATGAGGTTC
CTGGTCCTCCCTGTCCTGGCTGGACTGCCCCGCCTCAGATCCAGGATGCCCTTGGCATCGCTCCCACCCTCCCCCAGCTTTTCCTCCCTG
GTCTGACAATGGGCATGCAAAAAGGGGCAGCTGCAATCTAGCAGGCCTGCCCACCCCCTTCAGTTCAGGTAATACAGTTGTGAATCTTCC
AGCCGCTGGTTAGGGCCTTGGGCACCACAGGCAGCCCCTCACCTAAGCCGGGGCCTACTCCTCTTACAACAGCAAGAGAGCCCTGGGGCC
CCAGGCCTGTTGAGCTTCTTGTCTCCCAGCACCCGCTTTTGGGAAAATGACTTTTCCTCTTCAAGCTGAACCACTCTGTCCATATTACAC
AGAAGCCATATTTGTACGGGGGGGTGGGAGGGAGAGGGGCTGTTGTGCTGTGTGTGTCTGTCCAGGGGTGGGGGGGTGGGGGAAGGGAGC
AGGGAGGGGACCGTGTATCTTTATAATCTTTCTAACTCTCCTGTGCTAATCTCAGAGGGGTCACCCTCAATATATCTGGATTATCCGTGT
CATTCAGCTGCCTCCTTTCTGGTCCTCTTGCTGCTGCTGGGATGTGTGTATGTGAGGGTCTTCTTCCCATACCCCTTGCACCTGGTGCCT

>88684_88684_2_TADA1-CADM3_TADA1_chr1_166838681_ENST00000367874_CADM3_chr1_159169540_ENST00000368125_length(amino acids)=238AA_BP=
MLSNAMGGVVAVQQSRVLGKSEGPLRGGSRGSSGPRAVPLPLLLEQGGAATLCYLQGQFLWKGPGFVHFRGEWGESPPPSFLSKSTLPCR
DPRPPQVTVLGPCMAACCLQATSPQDSRTHHFPIAMEERCQGGTCLPVRSAQVCGYQRKSHSQPLPTTIPFLGSWRSLGSCSVVEAERRA

--------------------------------------------------------------
>88684_88684_3_TADA1-CADM3_TADA1_chr1_166838682_ENST00000367874_CADM3_chr1_159169541_ENST00000368124_length(transcript)=1661nt_BP=326nt
AGCTTCCAGAGCCAAGGCCTTCCGCCGAGTTGGTTTTTGGGTTGTTGATCGCGGTGGCCGGGCGGTCTGCGGTCGGGCTGAGACACGCGG
AGCAATGGCGACCTTTGTGAGCGAGCTGGAGGCGGCCAAGAAGAACTTAAGCGAGGCCCTGGGGGACAACGTGAAACAATACTGGGCTAA
CCTAAAGCTGTGGTTCAAGCAGAAGATCAGCAAAGAGGAGTTTGACCTTGAAGCTCATAGACTTCTCACACAGGATAATGTCCATTCTCA
CAATGATTTCCTCCTGGCCATTCTCACGCGTTGTCAGATTTTGGTTTCTACACCAGACCCCAGTCCGGTGCCCTCCTCCTCCAGCACCTA
CCACGCCATCATCGGTGGGATCGTGGCTTTCATTGTCTTCCTGCTGCTCATCATGCTCATCTTCCTTGGCCACTACTTGATCCGGCACAA
AGGAACCTACCTGACACATGAGGCAAAAGGCTCCGACGATGCTCCAGACGCGGACACGGCCATCATCAATGCAGAAGGCGGGCAGTCAGG
AGGGGACGACAAGAAGGAATATTTCATCTAGAGGCGCCTGCCCACTTCCTGCGCCCCCCAGGGGCCCTGTGGGGACTGCTGGGGCCGTCA
CCAACCCGGACTTGTACAGAGCAACCGCAGGGCCGCCCCTCCCGCTTGCTCCCCAGCCCACCCACCCCCCTGTACAGAATGTCTGCTTTG
GGTGCGGTTTTGTACTCGGTTTGGAATGGGGAGGGAGGAGGGCGGGGGGAGGGGAGGGTTGCCCTCAGCCCTTTCCGTGGCTTCTCTGCA
TTTGGGTTATTATTATTTTTGTAACAATCCCAAATCAAATCTGTCTCCAGGCTGGAGAGGCAGGAGCCCTGGGGTGAGAAAAGCAAAAAA
CAAACAAAAAACAAAACCCTGGAGTGTTAGGAGGAGAGTGAAGGTAGAGGGGTGAGGAAGGGTAAGGGGCAGGGCTGGTTTCAGCTGGGG
GCTCTCACCAGCCCTCCTTTCAGCCTCTACAACAGAGCAGCTTCCCAGACTTCTCCAGGAACCCAGAAACGGGATGGTTGTCGGCAAAGG
TTGGGAGTGGCTTTTCCTCTGGTAGCCACACACCTGAGCACTACGGACAGGGAGGCAGGTGCCACCTTGACACCTCTCTTCCATAGCAAT
GGGAAAGTGATGAGTGCGGGAGTCCTGAGGAGATGTGGCCTGCAGACAACATGCAGCCATGCAGGGACCCAGGACTGTAACCTGGGGAGG
ACGCGGGTCCCTGCAAGGAAGAGTAGATTTGGAGAGGAAGGATGGAGGTGGACTCTCACCCCATTCCCCCCGGAAATGAACAAAGCCGGG
CCCTTTCCATAGGAACTGCCCTTGGAGATAGCAGAGTGTGGCTGCCCCTCCTTGCTCCAGCAGCAGTGGGAGAGGCACTGCTCTGGGGCC
TGAACTGCCTCTGCTTCCCCCCCTGAGGGGCCCCTCACTCTTACCCAAGACTCTGGATTGTTGCACGGCAACCACTCCTCCCATGGCATT
GCTCAGCAACTACTTCTCCCTTCCCGGCCACCCTGTGCCCCCTTCCTGGTCCCAACGCCAGCCCTTCATCCTTCCTCCCTCAGCAGCCAG

>88684_88684_3_TADA1-CADM3_TADA1_chr1_166838682_ENST00000367874_CADM3_chr1_159169541_ENST00000368124_length(amino acids)=238AA_BP=
MLSNAMGGVVAVQQSRVLGKSEGPLRGGSRGSSGPRAVPLPLLLEQGGAATLCYLQGQFLWKGPGFVHFRGEWGESPPPSFLSKSTLPCR
DPRPPQVTVLGPCMAACCLQATSPQDSRTHHFPIAMEERCQGGTCLPVRSAQVCGYQRKSHSQPLPTTIPFLGSWRSLGSCSVVEAERRA

--------------------------------------------------------------
>88684_88684_4_TADA1-CADM3_TADA1_chr1_166838682_ENST00000367874_CADM3_chr1_159169541_ENST00000368125_length(transcript)=2962nt_BP=326nt
AGCTTCCAGAGCCAAGGCCTTCCGCCGAGTTGGTTTTTGGGTTGTTGATCGCGGTGGCCGGGCGGTCTGCGGTCGGGCTGAGACACGCGG
AGCAATGGCGACCTTTGTGAGCGAGCTGGAGGCGGCCAAGAAGAACTTAAGCGAGGCCCTGGGGGACAACGTGAAACAATACTGGGCTAA
CCTAAAGCTGTGGTTCAAGCAGAAGATCAGCAAAGAGGAGTTTGACCTTGAAGCTCATAGACTTCTCACACAGGATAATGTCCATTCTCA
CAATGATTTCCTCCTGGCCATTCTCACGCGTTGTCAGATTTTGGTTTCTACACCAGACCCCAGTCCGGTGCCCTCCTCCTCCAGCACCTA
CCACGCCATCATCGGTGGGATCGTGGCTTTCATTGTCTTCCTGCTGCTCATCATGCTCATCTTCCTTGGCCACTACTTGATCCGGCACAA
AGGAACCTACCTGACACATGAGGCAAAAGGCTCCGACGATGCTCCAGACGCGGACACGGCCATCATCAATGCAGAAGGCGGGCAGTCAGG
AGGGGACGACAAGAAGGAATATTTCATCTAGAGGCGCCTGCCCACTTCCTGCGCCCCCCAGGGGCCCTGTGGGGACTGCTGGGGCCGTCA
CCAACCCGGACTTGTACAGAGCAACCGCAGGGCCGCCCCTCCCGCTTGCTCCCCAGCCCACCCACCCCCCTGTACAGAATGTCTGCTTTG
GGTGCGGTTTTGTACTCGGTTTGGAATGGGGAGGGAGGAGGGCGGGGGGAGGGGAGGGTTGCCCTCAGCCCTTTCCGTGGCTTCTCTGCA
TTTGGGTTATTATTATTTTTGTAACAATCCCAAATCAAATCTGTCTCCAGGCTGGAGAGGCAGGAGCCCTGGGGTGAGAAAAGCAAAAAA
CAAACAAAAAACAAAACCCTGGAGTGTTAGGAGGAGAGTGAAGGTAGAGGGGTGAGGAAGGGTAAGGGGCAGGGCTGGTTTCAGCTGGGG
GCTCTCACCAGCCCTCCTTTCAGCCTCTACAACAGAGCAGCTTCCCAGACTTCTCCAGGAACCCAGAAACGGGATGGTTGTCGGCAAAGG
TTGGGAGTGGCTTTTCCTCTGGTAGCCACACACCTGAGCACTACGGACAGGGAGGCAGGTGCCACCTTGACACCTCTCTTCCATAGCAAT
GGGAAAGTGATGAGTGCGGGAGTCCTGAGGAGATGTGGCCTGCAGACAACATGCAGCCATGCAGGGACCCAGGACTGTAACCTGGGGAGG
ACGCGGGTCCCTGCAAGGAAGAGTAGATTTGGAGAGGAAGGATGGAGGTGGACTCTCACCCCATTCCCCCCGGAAATGAACAAAGCCGGG
CCCTTTCCATAGGAACTGCCCTTGGAGATAGCAGAGTGTGGCTGCCCCTCCTTGCTCCAGCAGCAGTGGGAGAGGCACTGCTCTGGGGCC
TGAACTGCCTCTGCTTCCCCCCCTGAGGGGCCCCTCACTCTTACCCAAGACTCTGGATTGTTGCACGGCAACCACTCCTCCCATGGCATT
GCTCAGCAACTACTTCTCCCTTCCCGGCCACCCTGTGCCCCCTTCCTGGTCCCAACGCCAGCCCTTCATCCTTCCTCCCTCAGCAGCCAG
GCAGACATAACAACAAAACTACTAAAAGGAGCTTCACTGCAGTGAGCTGTTTCCTGCCCAAACTAAGGGAATAATGTGAACTGTGTGCAT
GTGTGTGGTGTGTATGCATGTGTGCATGTGTGTGTGTGTGTGTGCATGTGTGTGAGTGAGTGAGAGGCAGAGCGAGGAACTGAGGAGGAG
GGCTAAGAGCCAGGGGTCCTGGGCAAGTGGACAGGGCTGTGGGACATGTTGGGGAGGCTTTGGGAATGGGGTATTCCTAGTCAGGGTTCA
CACCTCACCTGGGATGTTGTTCCATGCTGGTATTTCCTCTGCCACCCCCAATGCCCATCGGTCTTGGAGAAAGGAGTCCCCGGGTGTGTG
TTTGCCCAGCTGTCCATTCTATCTCTCCCTTAAACACAGAGCATTCAGCCCTTCCCTGGATTTCCCTCCTCTGAGCCATGGAGTCAGTGC
CACAGCCTTTGCTATGCACCTCTCAGGCCTCTCCTTGGCGTTGACCCTGGAAAGACCTACCACCACCTATTTTTTCCCATAGTCTGTACC
CAGTGAGTTGAAGGCTGGGTCCCCACCCTTCCTTTTGATTTCCTGTCTTCCTTCTCGTGGCCCCAGCTGGTTGCTGTGGAGATGAGGTTC
CTGGTCCTCCCTGTCCTGGCTGGACTGCCCCGCCTCAGATCCAGGATGCCCTTGGCATCGCTCCCACCCTCCCCCAGCTTTTCCTCCCTG
GTCTGACAATGGGCATGCAAAAAGGGGCAGCTGCAATCTAGCAGGCCTGCCCACCCCCTTCAGTTCAGGTAATACAGTTGTGAATCTTCC
AGCCGCTGGTTAGGGCCTTGGGCACCACAGGCAGCCCCTCACCTAAGCCGGGGCCTACTCCTCTTACAACAGCAAGAGAGCCCTGGGGCC
CCAGGCCTGTTGAGCTTCTTGTCTCCCAGCACCCGCTTTTGGGAAAATGACTTTTCCTCTTCAAGCTGAACCACTCTGTCCATATTACAC
AGAAGCCATATTTGTACGGGGGGGTGGGAGGGAGAGGGGCTGTTGTGCTGTGTGTGTCTGTCCAGGGGTGGGGGGGTGGGGGAAGGGAGC
AGGGAGGGGACCGTGTATCTTTATAATCTTTCTAACTCTCCTGTGCTAATCTCAGAGGGGTCACCCTCAATATATCTGGATTATCCGTGT
CATTCAGCTGCCTCCTTTCTGGTCCTCTTGCTGCTGCTGGGATGTGTGTATGTGAGGGTCTTCTTCCCATACCCCTTGCACCTGGTGCCT

>88684_88684_4_TADA1-CADM3_TADA1_chr1_166838682_ENST00000367874_CADM3_chr1_159169541_ENST00000368125_length(amino acids)=238AA_BP=
MLSNAMGGVVAVQQSRVLGKSEGPLRGGSRGSSGPRAVPLPLLLEQGGAATLCYLQGQFLWKGPGFVHFRGEWGESPPPSFLSKSTLPCR
DPRPPQVTVLGPCMAACCLQATSPQDSRTHHFPIAMEERCQGGTCLPVRSAQVCGYQRKSHSQPLPTTIPFLGSWRSLGSCSVVEAERRA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TADA1-CADM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TADA1-CADM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TADA1-CADM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource