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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:AP2M1-MAP3K13 (FusionGDB2 ID:HG1173TG9175)

Fusion Gene Summary for AP2M1-MAP3K13

check button Fusion gene summary
Fusion gene informationFusion gene name: AP2M1-MAP3K13
Fusion gene ID: hg1173tg9175
HgeneTgene
Gene symbol

AP2M1

MAP3K13

Gene ID

1173

9175

Gene nameadaptor related protein complex 2 subunit mu 1mitogen-activated protein kinase kinase kinase 13
SynonymsAP50|CLAPM1|MRD60|mu2LZK|MEKK13|MLK
Cytomap('AP2M1')('MAP3K13')

3q27.1

3q27.2

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit muAP-2 mu 2 chainHA2 50 kDA subunitadaptin-mu2adaptor protein complex AP-2 subunit muadaptor related protein complex 2 mu 1 subunitadaptor-related protein complex 2 subunit muclathrin adaptor complex AP2, mu subunitclathrin asmitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000461733, ENST00000292807, 
ENST00000382456, ENST00000411763, 
ENST00000439647, 
Fusion gene scores* DoF score8 X 11 X 6=52812 X 14 X 9=1512
# samples 1214
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1512*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP2M1 [Title/Abstract] AND MAP3K13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP2M1(183898772)-MAP3K13(185046412), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2M1

GO:0072583

clathrin-dependent endocytosis

23676497|31104773

TgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

TgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

TgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

TgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

TgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8628-01AAP2M1chr3

183898771

+MAP3K13chr3

185046411

+
ChimerDB4LUSCTCGA-56-8628-01AAP2M1chr3

183898772

+MAP3K13chr3

185046412

+
ChimerDB4LUSCTCGA-56-8628AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
ChimerDB4LUSCTCGA-56-8628AP2M1chr3

183898772

+MAP3K13chr3

185146284

+


Top

Fusion Gene ORF analysis for AP2M1-MAP3K13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000461733ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-5UTRENST00000461733ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000265026AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000424227AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000438798AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000443863AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000446828AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000448876AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000454237AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
3UTR-intronENST00000461733ENST00000535426AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
3UTR-intronENST00000461733ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
3UTR-intronENST00000461733ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000292807ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000292807ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000382456ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000382456ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000411763ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000411763ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000439647ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-5UTRENST00000439647ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000265026AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000424227AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000438798AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000443863AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000446828AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000448876AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000454237AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000292807ENST00000535426AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000292807ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000292807ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000265026AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000424227AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000438798AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000443863AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000446828AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000448876AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000454237AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000382456ENST00000535426AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000382456ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000382456ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000265026AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000424227AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000438798AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000443863AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000446828AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000448876AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000454237AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000411763ENST00000535426AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000411763ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000411763ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000265026AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000265026AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000424227AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000424227AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000438798AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000438798AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000443863AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000443863AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000446828AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000446828AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000448876AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000448876AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000454237AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000454237AP2M1chr3

183898772

+MAP3K13chr3

185146284

+
5CDS-intronENST00000439647ENST00000535426AP2M1chr3

183898771

+MAP3K13chr3

185046411

+
5CDS-intronENST00000439647ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185046412

+
5CDS-intronENST00000439647ENST00000535426AP2M1chr3

183898772

+MAP3K13chr3

185146284

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for AP2M1-MAP3K13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AP2M1chr3183898772+MAP3K13chr3185146284+0.0865314160.9134686
AP2M1chr3183898772+MAP3K13chr3185146284+0.0865314160.9134686


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for AP2M1-MAP3K13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:183898772/:185046412)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AP2M1-MAP3K13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AP2M1-MAP3K13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP2M1-MAP3K13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP2M1-MAP3K13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP2M1C0004134Ataxia1GENOMICS_ENGLAND
HgeneAP2M1C0036572Seizures1GENOMICS_ENGLAND
HgeneAP2M1C0393702Myoclonic Astatic Epilepsy1ORPHANET
HgeneAP2M1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneAP2M1C0856975Autistic behavior1GENOMICS_ENGLAND
HgeneAP2M1C1858120Generalized hypotonia1GENOMICS_ENGLAND
HgeneAP2M1C3714756Intellectual Disability1GENOMICS_ENGLAND