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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLTA-RIN2 (FusionGDB2 ID:HG1211TG54453)

Fusion Gene Summary for CLTA-RIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CLTA-RIN2
Fusion gene ID: hg1211tg54453
HgeneTgene
Gene symbol

CLTA

RIN2

Gene ID

1211

54453

Gene nameclathrin light chain ARas and Rab interactor 2
SynonymsLCAMACS|RASSF4
Cytomap('CLTA')('RIN2')

9p13.3

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionclathrin light chain Aclathrin, light polypeptide (Lca)ras and Rab interactor 2RAB5 interacting protein 2RAS association (RalGDS/AF-6) domain containing protein JC265RAS association domain family 4RAS inhibitor JC265RAS interaction/interference protein 2
Modification date2020031320200313
UniProtAcc

P09496

.
Ensembl transtripts involved in fusion geneENST00000242285, ENST00000345519, 
ENST00000396603, ENST00000433436, 
ENST00000466396, ENST00000470744, 
ENST00000538225, ENST00000540080, 
Fusion gene scores* DoF score11 X 10 X 7=77013 X 13 X 5=845
# samples 1314
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/845*10)=-2.59352451422458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLTA [Title/Abstract] AND RIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLTA(36205689)-RIN2(19981391), # samples:2
Anticipated loss of major functional domain due to fusion event.CLTA-RIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTA-RIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTA-RIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTA-RIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTA-RIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CLTA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8535-01ACLTAchr9

36204176

+RIN2chr20

19981397

+
ChimerDB4STADTCGA-CD-8535-01ACLTAchr9

36205689

+RIN2chr20

19981391

+


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Fusion Gene ORF analysis for CLTA-RIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000242285ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000345519ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000396603ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000433436ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000466396ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000470744ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000538225ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
5CDS-3UTRENST00000540080ENST00000484638CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000242285ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000345519ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000396603ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000433436ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000466396ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000470744ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000538225ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
Frame-shiftENST00000540080ENST00000255006CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000242285ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000345519ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000396603ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000433436ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000466396ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000470744ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000538225ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
In-frameENST00000540080ENST00000440354CLTAchr9

36204176

+RIN2chr20

19981397

+
intron-3CDSENST00000242285ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000242285ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000345519ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000345519ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000396603ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000396603ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000433436ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000433436ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000466396ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000466396ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000470744ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000470744ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000538225ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000538225ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000540080ENST00000255006CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3CDSENST00000540080ENST00000440354CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000242285ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000345519ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000396603ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000433436ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000466396ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000470744ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000538225ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+
intron-3UTRENST00000540080ENST00000484638CLTAchr9

36205689

+RIN2chr20

19981391

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540080CLTAchr936204176+ENST00000440354RIN2chr2019981397+1125530192872226
ENST00000433436CLTAchr936204176+ENST00000440354RIN2chr2019981397+12816861921028278
ENST00000538225CLTAchr936204176+ENST00000440354RIN2chr2019981397+12816861921028278
ENST00000345519CLTAchr936204176+ENST00000440354RIN2chr2019981397+1214619125961278
ENST00000470744CLTAchr936204176+ENST00000440354RIN2chr2019981397+1205610116952278
ENST00000242285CLTAchr936204176+ENST00000440354RIN2chr2019981397+1200605111947278
ENST00000466396CLTAchr936204176+ENST00000440354RIN2chr2019981397+101842385765226
ENST00000396603CLTAchr936204176+ENST00000440354RIN2chr2019981397+117457985921278

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540080ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0198256860.9801743
ENST00000433436ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0069857310.9930143
ENST00000538225ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0069857310.9930143
ENST00000345519ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.005706670.99429333
ENST00000470744ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0044028310.9955972
ENST00000242285ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0047733780.9952266
ENST00000466396ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0133588440.9866412
ENST00000396603ENST00000440354CLTAchr936204176+RIN2chr2019981397+0.0047743020.99522567

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Fusion Genomic Features for CLTA-RIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLTA-RIN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36205689/chr20:19981391)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTA

P09496

.
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTAchr9:36204176chr20:19981397ENST00000242285+47100_162161249.0RegionNote=Involved in binding clathrin heavy chain
HgeneCLTAchr9:36204176chr20:19981397ENST00000345519+45100_162161219.0RegionNote=Involved in binding clathrin heavy chain
HgeneCLTAchr9:36204176chr20:19981397ENST00000396603+46100_162161237.0RegionNote=Involved in binding clathrin heavy chain
HgeneCLTAchr9:36204176chr20:19981397ENST00000433436+47100_162161249.0RegionNote=Involved in binding clathrin heavy chain
HgeneCLTAchr9:36204176chr20:19981397ENST00000470744+46100_162161231.0RegionNote=Involved in binding clathrin heavy chain
HgeneCLTAchr9:36204176chr20:19981397ENST00000538225+46100_162161231.0RegionNote=Involved in binding clathrin heavy chain
TgeneRIN2chr9:36204176chr20:19981397ENST00000255006012307_3140945.0Compositional biasNote=Poly-Pro
TgeneRIN2chr9:36204176chr20:19981397ENST00000255006012618_7570945.0DomainVPS9
TgeneRIN2chr9:36204176chr20:19981397ENST00000255006012787_8780945.0DomainRas-associating
TgeneRIN2chr9:36204176chr20:19981397ENST0000025500601297_1900945.0DomainSH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTAchr9:36204176chr20:19981397ENST00000540080+23100_162109167.0RegionNote=Involved in binding clathrin heavy chain


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Fusion Gene Sequence for CLTA-RIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17372_17372_1_CLTA-RIN2_CLTA_chr9_36204176_ENST00000242285_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1200nt_BP=605nt
CCTCCTGGCGCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACC
GTTGGTGTCCGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGG
AACGGAGTGGCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAG
GCCTTCGCCATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTGATGGAGTAATGAAT
GGTGAATACTACCAGGAAAGTAATGGTCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAGAGCCTGAAAGTATC
CGTAAATGGAGAGAAGAACAAATGGAACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGGCAATA
AAGGAGCTAGAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGAGACAT
GGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACA
AACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGT
GGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGT
GTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCT
TTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGT
ATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCAC
TCCTGTGGATGGCTTCATCCCTGCCTTCCT

>17372_17372_1_CLTA-RIN2_CLTA_chr9_36204176_ENST00000242285_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

--------------------------------------------------------------
>17372_17372_2_CLTA-RIN2_CLTA_chr9_36204176_ENST00000345519_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1214nt_BP=619nt
GCTTTACCCGTCTCCCTCCTGGCGCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTG
GTTTTTGTCTCACCGTTGGTGTCCGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCG
GTCCCGCGCTGGGGAACGGAGTGGCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCA
TCGAGAACGACGAGGCCTTCGCCATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTG
ATGGAGTAATGAATGGTGAATACTACCAGGAAAGTAATGGTCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAG
AGCCTGAAAGTATCCGTAAATGGAGAGAAGAACAAATGGAACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGA
AAGAAAAGGCAATAAAGGAGCTAGAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTT
CGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTT
CCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGG
CGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTC
GGGGACCCCTCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAA
CAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAG
GTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGT
CAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGCCTTCCT

>17372_17372_2_CLTA-RIN2_CLTA_chr9_36204176_ENST00000345519_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

--------------------------------------------------------------
>17372_17372_3_CLTA-RIN2_CLTA_chr9_36204176_ENST00000396603_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1174nt_BP=579nt
AGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACCGTTGGTGTCCGTGCCGTTCAGTTGCC
CGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGGAACGGAGTGGCCGGCGCCGGCGAAGA
AGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAGGCCTTCGCCATCCTGGACGGCGGCGC
CCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTGATGGAGTAATGAATGGTGAATACTACCAGGAAAGTAATGG
TCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAGAGCCTGAAAGTATCCGTAAATGGAGAGAAGAACAAATGGA
ACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGGCAATAAAGGAGCTAGAAGAATGGTATGCAAG
ACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTAC
CCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGC
ATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGC
CTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGTAGTGACTAAGCCATCCACAGGCCA
ACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGAT
GGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTA
AGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGCCT
TCCT

>17372_17372_3_CLTA-RIN2_CLTA_chr9_36204176_ENST00000396603_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

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>17372_17372_4_CLTA-RIN2_CLTA_chr9_36204176_ENST00000433436_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1281nt_BP=686nt
GATTGGTTGTTCCCTTTTCGGCTCTGCAACACCGCCTAGACCGACCGGATACACGGGTAGGGCTTCCGCTTTACCCGTCTCCCTCCTGGC
GCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACCGTTGGTGTC
CGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGGAACGGAGTG
GCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAGGCCTTCGCC
ATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTGATGGAGTAATGAATGGTGAATAC
TACCAGGAAAGTAATGGTCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAGAGCCTGAAAGTATCCGTAAATGG
AGAGAAGAACAAATGGAACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGGCAATAAAGGAGCTA
GAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGC
TGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCA
AGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCC
AAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGTAGTGACT
AAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAAT
GGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATG
TGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGA
TGGCTTCATCCCTGCCTTCCT

>17372_17372_4_CLTA-RIN2_CLTA_chr9_36204176_ENST00000433436_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

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>17372_17372_5_CLTA-RIN2_CLTA_chr9_36204176_ENST00000466396_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1018nt_BP=423nt
AGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACCGTTGGTGTCCGTGCCGTTCAGTTGCC
CGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGGAACGGAGTGGCCGGCGCCGGCGAAGA
AGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAGGCCTTCGCCATCCTGGACGGCGGCGC
CCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGGCAATAAA
GGAGCTAGAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGAGACATGG
CAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAA
CGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGG
TGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGT
AGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTT
TGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTAT
GTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTC
CTGTGGATGGCTTCATCCCTGCCTTCCT

>17372_17372_5_CLTA-RIN2_CLTA_chr9_36204176_ENST00000466396_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=226AA_BP=113
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDANSRKQEAEWKEKA
IKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRTLTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLP
SGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPSTGQLGQGQL

--------------------------------------------------------------
>17372_17372_6_CLTA-RIN2_CLTA_chr9_36204176_ENST00000470744_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1205nt_BP=610nt
GTCTCCCTCCTGGCGCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTC
TCACCGTTGGTGTCCGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGC
TGGGGAACGGAGTGGCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACG
ACGAGGCCTTCGCCATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTGATGGAGTAA
TGAATGGTGAATACTACCAGGAAAGTAATGGTCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAGAGCCTGAAA
GTATCCGTAAATGGAGAGAAGAACAAATGGAACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGG
CAATAAAGGAGCTAGAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGA
GACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGT
CTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTC
CCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCC
TCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGAT
TCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTA
CAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATT
CTCACTCCTGTGGATGGCTTCATCCCTGCCTTCCT

>17372_17372_6_CLTA-RIN2_CLTA_chr9_36204176_ENST00000470744_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

--------------------------------------------------------------
>17372_17372_7_CLTA-RIN2_CLTA_chr9_36204176_ENST00000538225_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1281nt_BP=686nt
GATTGGTTGTTCCCTTTTCGGCTCTGCAACACCGCCTAGACCGACCGGATACACGGGTAGGGCTTCCGCTTTACCCGTCTCCCTCCTGGC
GCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACCGTTGGTGTC
CGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGGAACGGAGTG
GCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAGGCCTTCGCC
ATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCTGTTGATGGAGTAATGAATGGTGAATAC
TACCAGGAAAGTAATGGTCCAACAGACAGTTATGCAGCTATTTCACAAGTGGATCGATTGCAGTCAGAGCCTGAAAGTATCCGTAAATGG
AGAGAAGAACAAATGGAACGCTTGGAAGCCCTTGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGGAAAGAAAAGGCAATAAAGGAGCTA
GAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGC
TGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCA
AGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCC
AAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGTAGTGACT
AAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAAT
GGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATG
TGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGA
TGGCTTCATCCCTGCCTTCCT

>17372_17372_7_CLTA-RIN2_CLTA_chr9_36204176_ENST00000538225_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=278AA_BP=165
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQES
NGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRT
LTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLPSGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPST
GQLGQGQL

--------------------------------------------------------------
>17372_17372_8_CLTA-RIN2_CLTA_chr9_36204176_ENST00000540080_RIN2_chr20_19981397_ENST00000440354_length(transcript)=1125nt_BP=530nt
GATTGGTTGTTCCCTTTTCGGCTCTGCAACACCGCCTAGACCGACCGGATACACGGGTAGGGCTTCCGCTTTACCCGTCTCCCTCCTGGC
GCTTGTCCTCCTCTCCCAGTCGGCACCACAGCGGTGGCTGCCGGGCGTGGTGTCGGTGGGTCGGTTGGTTTTTGTCTCACCGTTGGTGTC
CGTGCCGTTCAGTTGCCCGCCATGGCTGAGCTGGATCCGTTCGGCGCCCCTGCCGGCGCCCCTGGCGGTCCCGCGCTGGGGAACGGAGTG
GCCGGCGCCGGCGAAGAAGACCCGGCTGCGGCCTTCTTGGCGCAGCAAGAGAGCGAGATTGCGGGCATCGAGAACGACGAGGCCTTCGCC
ATCCTGGACGGCGGCGCCCCCGGGCCCCAGCCGCACGGCGAGCCGCCGGGGGGTCCGGATGCCAATTCTCGGAAGCAAGAAGCAGAGTGG
AAAGAAAAGGCAATAAAGGAGCTAGAAGAATGGTATGCAAGACAGGACGAGCAGCTACAGAAAACAAAAGCAAACAACAGCTCTTTCTCT
TCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCT
TCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAG
GCGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCT
CGGGGACCCCTCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAA
ACAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTA
GGTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCG
TCAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGCCTTCCT

>17372_17372_8_CLTA-RIN2_CLTA_chr9_36204176_ENST00000540080_RIN2_chr20_19981397_ENST00000440354_length(amino acids)=226AA_BP=113
MPAMAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDANSRKQEAEWKEKA
IKELEEWYARQDEQLQKTKANNSSFSSLTRHGSSWQRTLTLKKSRRSCTADHSPTSSTLSTNASRTILMASFSRTGKKTSPPPRRQAGLP
SGASKGELEALPSRFYMLELEKQSPPRGPLSVVTKPSTGQLGQGQL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CLTA-RIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLTA-RIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLTA-RIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2751321Macrocephaly, Alopecia, Cutis Laxa, and Scoliosis3CTD_human;GENOMICS_ENGLAND;ORPHANET