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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLTA-ZCCHC7 (FusionGDB2 ID:HG1211TG84186)

Fusion Gene Summary for CLTA-ZCCHC7

check button Fusion gene summary
Fusion gene informationFusion gene name: CLTA-ZCCHC7
Fusion gene ID: hg1211tg84186
HgeneTgene
Gene symbol

CLTA

ZCCHC7

Gene ID

1211

84186

Gene nameclathrin light chain Azinc finger CCHC-type containing 7
SynonymsLCAAIR1|HSPC086
Cytomap('CLTA')('ZCCHC7')

9p13.3

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionclathrin light chain Aclathrin, light polypeptide (Lca)zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7
Modification date2020031320200320
UniProtAcc

P09496

Q8N3Z6

Ensembl transtripts involved in fusion geneENST00000242285, ENST00000345519, 
ENST00000396603, ENST00000433436, 
ENST00000466396, ENST00000470744, 
ENST00000538225, ENST00000540080, 
Fusion gene scores* DoF score11 X 10 X 7=77020 X 16 X 8=2560
# samples 1322
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2560*10)=-3.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLTA [Title/Abstract] AND ZCCHC7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLTA(36204176)-ZCCHC7(37302185), # samples:1
Anticipated loss of major functional domain due to fusion event.CLTA-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CLTA-ZCCHC7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08I-01ACLTAchr9

36204176

+ZCCHC7chr9

37302185

+


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Fusion Gene ORF analysis for CLTA-ZCCHC7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000242285ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000345519ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000396603ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000433436ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000466396ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000470744ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000538225ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000540080ENST00000461038CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000242285ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000345519ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000396603ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000433436ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000466396ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000470744ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000538225ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000540080ENST00000534928CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000242285ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000345519ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000396603ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000433436ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000466396ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000470744ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000538225ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000540080ENST00000322831CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000242285ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000345519ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000396603ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000433436ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000466396ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000470744ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000538225ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+
Frame-shiftENST00000540080ENST00000336755CLTAchr9

36204176

+ZCCHC7chr9

37302185

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CLTA-ZCCHC7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLTAchr936204176+ZCCHC7chr937302184+0.001067710.9989323
CLTAchr936204176+ZCCHC7chr937302184+0.001067710.9989323


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CLTA-ZCCHC7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36204176/:37302185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTA

P09496

ZCCHC7

Q8N3Z6

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CLTA-ZCCHC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CLTA-ZCCHC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLTA-ZCCHC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLTA-ZCCHC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource