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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGD4-MRPS35 (FusionGDB2 ID:HG121512TG60488)

Fusion Gene Summary for FGD4-MRPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD4-MRPS35
Fusion gene ID: hg121512tg60488
HgeneTgene
Gene symbol

FGD4

MRPS35

Gene ID

121512

60488

Gene nameFYVE, RhoGEF and PH domain containing 4mitochondrial ribosomal protein S35
SynonymsCMT4H|FRABP|ZFYVE6HDCMD11P|MDS023|MRP-S28|MRPS28
Cytomap('FGD4')('MRPS35')

12p11.21

12p11.22

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 628S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000534526, ENST00000266482, 
ENST00000381025, ENST00000427716, 
ENST00000472289, ENST00000473513, 
ENST00000525053, ENST00000531134, 
ENST00000546442, 
Fusion gene scores* DoF score19 X 13 X 13=321115 X 8 X 7=840
# samples 2220
** MAII scorelog2(22/3211*10)=-3.86744723620111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/840*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGD4 [Title/Abstract] AND MRPS35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGD4(32552893)-MRPS35(27867713), # samples:3
Anticipated loss of major functional domain due to fusion event.FGD4-MRPS35 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGD4-MRPS35 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MRPS35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XK-AAJ3-01AFGD4chr12

32552893

-MRPS35chr12

27867713

+
ChimerDB4PRADTCGA-XK-AAJ3-01AFGD4chr12

32552893

+MRPS35chr12

27867713

+
ChimerDB4PRADTCGA-XK-AAJ3FGD4chr12

32552893

+MRPS35chr12

27867713

+
ChimerDB4PRADTCGA-XK-AAJ3FGD4chr12

32552893

+MRPS35chr12

27908114

+


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Fusion Gene ORF analysis for FGD4-MRPS35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000534526ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
In-frameENST00000534526ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
In-frameENST00000534526ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
In-frameENST00000534526ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000266482ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000266482ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000266482ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000381025ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000381025ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000381025ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000427716ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000427716ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000427716ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000472289ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000472289ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000472289ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000473513ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000473513ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000473513ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000525053ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000525053ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000525053ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000531134ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000531134ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000531134ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000546442ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3CDSENST00000546442ENST00000081029FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3CDSENST00000546442ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27867713

+
intron-3UTRENST00000266482ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000381025ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000427716ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000472289ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000473513ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000525053ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000531134ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+
intron-3UTRENST00000546442ENST00000538315FGD4chr12

32552893

+MRPS35chr12

27908114

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534526FGD4chr1232552893+ENST00000081029MRPS35chr1227867713+21364311781290370
ENST00000534526FGD4chr1232552893+ENST00000538315MRPS35chr1227867713+2025431178903241
ENST00000534526FGD4chr1232552893+ENST00000081029MRPS35chr1227908114+154643127536169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534526ENST00000081029FGD4chr1232552893+MRPS35chr1227867713+0.0010140440.99898595
ENST00000534526ENST00000538315FGD4chr1232552893+MRPS35chr1227867713+0.0634841840.9365158
ENST00000534526ENST00000081029FGD4chr1232552893+MRPS35chr1227908114+0.88877520.111224756

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Fusion Genomic Features for FGD4-MRPS35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGD4chr1232552893+MRPS35chr1227867712+5.88E-101
FGD4chr1232552893+MRPS35chr1227867712+5.88E-101
FGD4chr1232552893+MRPS35chr1227908113+5.02E-111
FGD4chr1232552893+MRPS35chr1227867712+5.88E-101
FGD4chr1232552893+MRPS35chr1227867712+5.88E-101
FGD4chr1232552893+MRPS35chr1227908113+5.02E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGD4-MRPS35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:32552893/chr12:27867713)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMRPS35chr12:32552893chr12:27867713ENST0000008102908257_32137324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr12:32552893chr12:27867713ENST0000053831507257_32137526.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr12:32552893chr12:27908114ENST0000008102968257_321234324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr12:32552893chr12:27908114ENST0000053831557257_321197526.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGD4chr12:32552893chr12:27867713ENST00000381025+19206_3930281.0DomainDH
HgeneFGD4chr12:32552893chr12:27867713ENST00000381025+19422_5210281.0DomainPH 1
HgeneFGD4chr12:32552893chr12:27867713ENST00000381025+19643_7400281.0DomainPH 2
HgeneFGD4chr12:32552893chr12:27867713ENST00000427716+117206_3930767.0DomainDH
HgeneFGD4chr12:32552893chr12:27867713ENST00000427716+117422_5210767.0DomainPH 1
HgeneFGD4chr12:32552893chr12:27867713ENST00000427716+117643_7400767.0DomainPH 2
HgeneFGD4chr12:32552893chr12:27908114ENST00000381025+19206_3930281.0DomainDH
HgeneFGD4chr12:32552893chr12:27908114ENST00000381025+19422_5210281.0DomainPH 1
HgeneFGD4chr12:32552893chr12:27908114ENST00000381025+19643_7400281.0DomainPH 2
HgeneFGD4chr12:32552893chr12:27908114ENST00000427716+117206_3930767.0DomainDH
HgeneFGD4chr12:32552893chr12:27908114ENST00000427716+117422_5210767.0DomainPH 1
HgeneFGD4chr12:32552893chr12:27908114ENST00000427716+117643_7400767.0DomainPH 2
HgeneFGD4chr12:32552893chr12:27867713ENST00000381025+191_1500281.0RegionActin filament-binding
HgeneFGD4chr12:32552893chr12:27867713ENST00000427716+1171_1500767.0RegionActin filament-binding
HgeneFGD4chr12:32552893chr12:27908114ENST00000381025+191_1500281.0RegionActin filament-binding
HgeneFGD4chr12:32552893chr12:27908114ENST00000427716+1171_1500767.0RegionActin filament-binding
HgeneFGD4chr12:32552893chr12:27867713ENST00000381025+19559_6190281.0Zinc fingerFYVE-type
HgeneFGD4chr12:32552893chr12:27867713ENST00000427716+117559_6190767.0Zinc fingerFYVE-type
HgeneFGD4chr12:32552893chr12:27908114ENST00000381025+19559_6190281.0Zinc fingerFYVE-type
HgeneFGD4chr12:32552893chr12:27908114ENST00000427716+117559_6190767.0Zinc fingerFYVE-type


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Fusion Gene Sequence for FGD4-MRPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30170_30170_1_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27867713_ENST00000081029_length(transcript)=2136nt_BP=431nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGCGGAAAGAACACCCGGAAA
TGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACAGAGAAAATGGCTGTTGACCAGGACTGGCCTAGTGTTTACCCAGTTGCAGC
ACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATGGGTTATCCAGTAAAAAAGGGCGTGCCCATGGCAAAGGAGGGAAATCTAGA
ACTTTTAAAGATTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCC
AGCCGCACTGGACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCG
GAACCCCAGAGCACGAGTAGTAGTCTTAAGAGTAAAGCTTTCCAGTTTGAATTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGT
AGGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTA
TCTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGA
AAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCT
TGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGA
ATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATC
TAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATG
ATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTT
CTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTT
CAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCAC
ATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCT
AAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGA
AGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATG
TAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCA

>30170_30170_1_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27867713_ENST00000081029_length(amino acids)=370AA_BP=83
MGMQATPPRGRSRLDGSGRSRGAAVEPGRMSDEGGSNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATAERTPG
NERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEW
PAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAV
YLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYK

--------------------------------------------------------------
>30170_30170_2_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27867713_ENST00000538315_length(transcript)=2025nt_BP=431nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGCGGAAAGAACACCCGGAAA
TGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACAGAGAAAATGGCTGTTGACCAGGACTGGCCTAGTGTTTACCCAGTTGCAGC
ACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATGGGTTATCCAGTAAAAAAGGGCGTGCCCATGGCAAAGGAGGGAAATCTAGA
ACTTTTAAAGATTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCC
AGCCGCACTGGACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCG
GAACCCCAGAGCACGAGTAGTAGTCTTAAGAGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACC
ATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAA
ATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAG
AGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAA
ATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAA
AATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAA
TTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTAT
TCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAA
TGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGAT
GCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAA
CTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATG
TATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAA
ATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGA

>30170_30170_2_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27867713_ENST00000538315_length(amino acids)=241AA_BP=83
MGMQATPPRGRSRLDGSGRSRGAAVEPGRMSDEGGSNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATAERTPG
NERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEW

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>30170_30170_3_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27908114_ENST00000081029_length(transcript)=1546nt_BP=431nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGAATACTGAAGAATGGGAAA
AAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAG
CTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAA
ATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATC
TGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGA
GTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGT
CTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATT
TTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCA
GAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAG
AAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGT
GGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGC
CACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTC
AATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAA

>30170_30170_3_FGD4-MRPS35_FGD4_chr12_32552893_ENST00000534526_MRPS35_chr12_27908114_ENST00000081029_length(amino acids)=169AA_BP=134
MQIPRRCDCRRSRRSQTRRDAGRERTGKERERRHSLRRRRSRGRPRSRAEPGHAGDAPQGPLAAGREREESGSGGRARQDERRGRLQLQA

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Fusion Gene PPI Analysis for FGD4-MRPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGD4-MRPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGD4-MRPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGD4C1836336CHARCOT-MARIE-TOOTH DISEASE, TYPE 4H3CTD_human;GENOMICS_ENGLAND;UNIPROT