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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AEBP2-PRLR (FusionGDB2 ID:HG121536TG5618)

Fusion Gene Summary for AEBP2-PRLR

check button Fusion gene summary
Fusion gene informationFusion gene name: AEBP2-PRLR
Fusion gene ID: hg121536tg5618
HgeneTgene
Gene symbol

AEBP2

PRLR

Gene ID

121536

5618

Gene nameAE binding protein 2prolactin receptor
Synonyms-HPRL|MFAB|RI-PRLR|hPRLrI
Cytomap('AEBP2')('PRLR')

12p12.3

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2prolactin receptorhPRL receptorsecreted prolactin binding protein
Modification date2020031320200329
UniProtAcc

Q6ZN18

.
Ensembl transtripts involved in fusion geneENST00000266508, ENST00000360995, 
ENST00000398864, ENST00000541908, 
Fusion gene scores* DoF score10 X 9 X 8=7208 X 7 X 5=280
# samples 128
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AEBP2 [Title/Abstract] AND PRLR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAEBP2(19646920)-PRLR(35118224), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRLR

GO:0007171

activation of transmembrane receptor protein tyrosine kinase activity

10585417

TgenePRLR

GO:0042976

activation of Janus kinase activity

10585417

TgenePRLR

GO:0043066

negative regulation of apoptotic process

10585417



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3CC-06AAEBP2chr12

19646920

-PRLRchr5

35118224

-
ChimerDB4SKCMTCGA-D3-A3CC-06AAEBP2chr12

19646920

+PRLRchr5

35118224

-


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Fusion Gene ORF analysis for AEBP2-PRLR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000266508ENST00000342362AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000266508ENST00000382002AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000360995ENST00000342362AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000360995ENST00000382002AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000398864ENST00000342362AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000398864ENST00000382002AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000541908ENST00000342362AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-5UTRENST00000541908ENST00000382002AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000231423AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000310101AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000348262AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000397391AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000509934AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000511486AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000513753AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000266508ENST00000542609AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000231423AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000310101AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000348262AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000397391AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000509934AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000511486AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000513753AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000360995ENST00000542609AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000231423AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000310101AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000348262AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000397391AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000509934AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000511486AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000513753AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000398864ENST00000542609AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000231423AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000310101AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000348262AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000397391AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000509934AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000511486AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000513753AEBP2chr12

19646920

+PRLRchr5

35118224

-
5CDS-intronENST00000541908ENST00000542609AEBP2chr12

19646920

+PRLRchr5

35118224

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AEBP2-PRLR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for AEBP2-PRLR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19646920/:35118224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AEBP2

Q6ZN18

.
FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AEBP2-PRLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AEBP2-PRLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AEBP2-PRLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AEBP2-PRLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007097Carcinoma2CTD_human
TgeneC0024667Animal Mammary Neoplasms2CTD_human
TgeneC0205696Anaplastic carcinoma2CTD_human
TgeneC0205697Carcinoma, Spindle-Cell2CTD_human
TgeneC0205698Undifferentiated carcinoma2CTD_human
TgeneC0205699Carcinomatosis2CTD_human
TgeneC1257925Mammary Carcinoma, Animal2CTD_human
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0014175Endometriosis1CTD_human
TgeneC0020514Hyperprolactinemia1CTD_human;ORPHANET;UNIPROT
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0269102Endometrioma1CTD_human
TgeneC3809918MULTIPLE FIBROADENOMAS OF THE BREAST1CTD_human;UNIPROT
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human