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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKS3-GLYR1 (FusionGDB2 ID:HG124401TG84656)

Fusion Gene Summary for ANKS3-GLYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKS3-GLYR1
Fusion gene ID: hg124401tg84656
HgeneTgene
Gene symbol

ANKS3

GLYR1

Gene ID

124401

84656

Gene nameankyrin repeat and sterile alpha motif domain containing 3glyoxylate reductase 1 homolog
Synonyms-BM045|HIBDL|N-PAC|NP60|hNDF
Cytomap('ANKS3')('GLYR1')

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and SAM domain-containing protein 3putative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDanucleosome-destabilizing factor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304283, ENST00000446014, 
ENST00000585773, ENST00000592711, 
ENST00000450067, 
Fusion gene scores* DoF score4 X 4 X 4=649 X 6 X 7=378
# samples 610
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKS3 [Title/Abstract] AND GLYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKS3(4779980)-GLYR1(4882913), # samples:1
ANKS3(4774751)-GLYR1(4882913), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKS3-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ANKS3-GLYR1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLYR1

GO:0035066

positive regulation of histone acetylation

29759984

TgeneGLYR1

GO:0045944

positive regulation of transcription by RNA polymerase II

29759984


check buttonFusion gene breakpoints across ANKS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GLYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8286-01AANKS3chr16

4774751

-GLYR1chr16

4882913

-
ChimerDB4STADTCGA-BR-8286ANKS3chr16

4779980

-GLYR1chr16

4882913

-


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Fusion Gene ORF analysis for ANKS3-GLYR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000304283ENST00000586901ANKS3chr16

4774751

-GLYR1chr16

4882913

-
5CDS-5UTRENST00000304283ENST00000586901ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5CDS-5UTRENST00000446014ENST00000586901ANKS3chr16

4774751

-GLYR1chr16

4882913

-
5CDS-5UTRENST00000585773ENST00000586901ANKS3chr16

4774751

-GLYR1chr16

4882913

-
5CDS-5UTRENST00000592711ENST00000586901ANKS3chr16

4774751

-GLYR1chr16

4882913

-
5CDS-5UTRENST00000592711ENST00000586901ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000446014ENST00000321919ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000446014ENST00000381983ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000446014ENST00000436648ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000446014ENST00000591451ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000450067ENST00000321919ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000450067ENST00000381983ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000450067ENST00000436648ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-3CDSENST00000450067ENST00000591451ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-5UTRENST00000446014ENST00000586901ANKS3chr16

4779980

-GLYR1chr16

4882913

-
5UTR-5UTRENST00000450067ENST00000586901ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000321919ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000321919ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000381983ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000381983ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000436648ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000436648ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000591451ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000304283ENST00000591451ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000446014ENST00000321919ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000446014ENST00000381983ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000446014ENST00000436648ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000446014ENST00000591451ANKS3chr16

4774751

-GLYR1chr16

4882913

-
Frame-shiftENST00000592711ENST00000321919ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000592711ENST00000381983ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000592711ENST00000436648ANKS3chr16

4779980

-GLYR1chr16

4882913

-
Frame-shiftENST00000592711ENST00000591451ANKS3chr16

4779980

-GLYR1chr16

4882913

-
In-frameENST00000585773ENST00000321919ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000585773ENST00000381983ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000585773ENST00000436648ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000585773ENST00000591451ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000592711ENST00000321919ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000592711ENST00000381983ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000592711ENST00000436648ANKS3chr16

4774751

-GLYR1chr16

4882913

-
In-frameENST00000592711ENST00000591451ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-3CDSENST00000450067ENST00000321919ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-3CDSENST00000450067ENST00000381983ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-3CDSENST00000450067ENST00000436648ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-3CDSENST00000450067ENST00000591451ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-3CDSENST00000585773ENST00000321919ANKS3chr16

4779980

-GLYR1chr16

4882913

-
intron-3CDSENST00000585773ENST00000381983ANKS3chr16

4779980

-GLYR1chr16

4882913

-
intron-3CDSENST00000585773ENST00000436648ANKS3chr16

4779980

-GLYR1chr16

4882913

-
intron-3CDSENST00000585773ENST00000591451ANKS3chr16

4779980

-GLYR1chr16

4882913

-
intron-5UTRENST00000450067ENST00000586901ANKS3chr16

4774751

-GLYR1chr16

4882913

-
intron-5UTRENST00000585773ENST00000586901ANKS3chr16

4779980

-GLYR1chr16

4882913

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585773ANKS3chr164774751-ENST00000436648GLYR1chr164882913-37944975191760413
ENST00000585773ANKS3chr164774751-ENST00000321919GLYR1chr164882913-40374975192003494
ENST00000585773ANKS3chr164774751-ENST00000381983GLYR1chr164882913-39834975191952477
ENST00000585773ANKS3chr164774751-ENST00000591451GLYR1chr164882913-21734975191985488
ENST00000592711ANKS3chr164774751-ENST00000436648GLYR1chr164882913-37414444661707413
ENST00000592711ANKS3chr164774751-ENST00000321919GLYR1chr164882913-39844444661950494
ENST00000592711ANKS3chr164774751-ENST00000381983GLYR1chr164882913-39304444661899477
ENST00000592711ANKS3chr164774751-ENST00000591451GLYR1chr164882913-21204444661932488

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585773ENST00000436648ANKS3chr164774751-GLYR1chr164882913-0.0024141830.9975858
ENST00000585773ENST00000321919ANKS3chr164774751-GLYR1chr164882913-0.001194780.99880517
ENST00000585773ENST00000381983ANKS3chr164774751-GLYR1chr164882913-0.0016330490.998367
ENST00000585773ENST00000591451ANKS3chr164774751-GLYR1chr164882913-0.003829650.99617034
ENST00000592711ENST00000436648ANKS3chr164774751-GLYR1chr164882913-0.0021248150.9978752
ENST00000592711ENST00000321919ANKS3chr164774751-GLYR1chr164882913-0.0010087580.9989912
ENST00000592711ENST00000381983ANKS3chr164774751-GLYR1chr164882913-0.0013750950.9986249
ENST00000592711ENST00000591451ANKS3chr164774751-GLYR1chr164882913-0.0031659790.996834

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Fusion Genomic Features for ANKS3-GLYR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKS3-GLYR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4779980/chr16:4882913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618101_130191717.0RepeatNote=ANK 3
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618134_163191717.0RepeatNote=ANK 4
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-61834_64191717.0RepeatNote=ANK 1
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-61868_97191717.0RepeatNote=ANK 2
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-41634_64118529.0RepeatNote=ANK 1
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-41668_97118529.0RepeatNote=ANK 2
TgeneGLYR1chr16:4774751chr16:4882913ENST00000321919216168_18051554.0DNA bindingA.T hook
TgeneGLYR1chr16:4774751chr16:4882913ENST00000381983215168_18051537.0DNA bindingA.T hook
TgeneGLYR1chr16:4774751chr16:4882913ENST00000436648215168_18051473.0DNA bindingA.T hook
TgeneGLYR1chr16:4774751chr16:4882913ENST00000591451216168_18051548.0DNA bindingA.T hook
TgeneGLYR1chr16:4774751chr16:4882913ENST00000321919216271_28551554.0Nucleotide bindingNAD
TgeneGLYR1chr16:4774751chr16:4882913ENST00000381983215271_28551537.0Nucleotide bindingNAD
TgeneGLYR1chr16:4774751chr16:4882913ENST00000436648215271_28551473.0Nucleotide bindingNAD
TgeneGLYR1chr16:4774751chr16:4882913ENST00000591451216271_28551548.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618501_526191717.0Coiled coilOntology_term=ECO:0000255
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416501_526118529.0Coiled coilOntology_term=ECO:0000255
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618329_382191717.0Compositional biasNote=Ser-rich
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416329_382118529.0Compositional biasNote=Ser-rich
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618425_488191717.0DomainSAM
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416425_488118529.0DomainSAM
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618168_197191717.0RepeatNote=ANK 5
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-618201_220191717.0RepeatNote=ANK 6
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416101_130118529.0RepeatNote=ANK 3
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416134_163118529.0RepeatNote=ANK 4
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416168_197118529.0RepeatNote=ANK 5
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-416201_220118529.0RepeatNote=ANK 6
TgeneGLYR1chr16:4774751chr16:4882913ENST000003219192168_6651554.0DomainPWWP
TgeneGLYR1chr16:4774751chr16:4882913ENST000003819832158_6651537.0DomainPWWP
TgeneGLYR1chr16:4774751chr16:4882913ENST000004366482158_6651473.0DomainPWWP
TgeneGLYR1chr16:4774751chr16:4882913ENST000005914512168_6651548.0DomainPWWP


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Fusion Gene Sequence for ANKS3-GLYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4819_4819_1_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000321919_length(transcript)=4037nt_BP=497nt
GCGGTGCCCCGGCGAGGGAGCGTGGCGGCGAGCTGTTTGGGGGGGGTTGGCGACGGCAGCCCGAGGGCGGCGCAAGGCCTGAGGCCCAGC
ACAGGAGAGAGTTAGATTTGAATAAGAAGAATGGTGGTGGCTGGACCCCGCTGATGTATGCCTCCTACATTGGCCACGACACAATCGTGC
ACCTGCTGCTTGAGGCGGGGGTGAGTGTGAATGTGCCGACCCCAGAAGGGCAGACTCCACTGATGCTGGCCTCCAGCTGTGGCAACGAGA
GCATCGCCTACTTTCTTCTCCAGCAAGGTGCAGAGCTAGAAATGAAAGACATCCAGGGCTGGACAGCCCTCTTCCACTGTACCAGCGCCG
GGCACCAGCACATGGTCAGGTTCCTCTTGGACAGTGGAGCCAATGCCAACGTGAGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAG
CAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTGGATCAAAGTGGAACAGCTGAAGCCATATCATGCTCAT
AAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGATGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAA
GACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAGTGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAG
CGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAAGAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCC
AAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCCCCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCT
AGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCCAACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCAT
TTCCATCATTTCCTGCTAAGCCAAACAGAGAAGCCAGCTGTCTGTTACCAGGCAATCACGAAGAAGTTGAAAATATGTGAAGAGGAAACT
GGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCACACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGT
CTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGACTGTCTGGAACCGCACTGCAGAGAAATGTGATTTGTTC
ATCCAGGAGGGGGCCCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCG
GCCAAGGACCTGGTGCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTACGTGGACATGTCAACAGTGGACGCTGAC
ACCGTCACTGAGCTGGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGAC
GGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTC
CTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACC
CTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATCAGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGC
CAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTCAGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCG
GTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCC
GTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCG
GGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTATACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCA
GCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGCGTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGG
ACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACACACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAAC
TGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAGTCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTT
CCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCACTGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAG
CCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGATGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGT
GCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGTCCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAG
CAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAAGCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGC
TCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGGAGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGG
GGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGGCTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTG
GTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCTCCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACA
GTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGAGCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTG
TCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCTGTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAAC
TGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTCCTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAA
AAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGGATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCA
TTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTCCTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAG
AAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATGCCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATT
TTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACACTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACC
GGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTTATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTG
AAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAGAAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACA
AATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAACATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTA
AATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAAAAATAAAACACTTCTTGGTAACACA

>4819_4819_1_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000321919_length(amino acids)=494AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKL
KICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFA
CVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQA
MGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRL
AIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_2_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000381983_length(transcript)=3983nt_BP=497nt
GCGGTGCCCCGGCGAGGGAGCGTGGCGGCGAGCTGTTTGGGGGGGGTTGGCGACGGCAGCCCGAGGGCGGCGCAAGGCCTGAGGCCCAGC
ACAGGAGAGAGTTAGATTTGAATAAGAAGAATGGTGGTGGCTGGACCCCGCTGATGTATGCCTCCTACATTGGCCACGACACAATCGTGC
ACCTGCTGCTTGAGGCGGGGGTGAGTGTGAATGTGCCGACCCCAGAAGGGCAGACTCCACTGATGCTGGCCTCCAGCTGTGGCAACGAGA
GCATCGCCTACTTTCTTCTCCAGCAAGGTGCAGAGCTAGAAATGAAAGACATCCAGGGCTGGACAGCCCTCTTCCACTGTACCAGCGCCG
GGCACCAGCACATGGTCAGGTTCCTCTTGGACAGTGGAGCCAATGCCAACGTGAGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAG
CAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTGGATCAAAGTGGAACAGCTGAAGCCATATCATGCTCAT
AAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGATGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAA
GACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAGTGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAG
CGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAAGAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCC
AAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCCCCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCT
AGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCCAACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCAT
TTCCATCATTTCCTGCTAAGCCAAACAGAGAAGGAAACTGGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATC
ACACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTG
ACTGTCTGGAACCGCACTGCAGAGAAATGTGATTTGTTCATCCAGGAGGGGGCCCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACC
TGCGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCT
GGGAAGTGCTACGTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTG
GAAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGC
AGCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTC
CAAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAAT
CAGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATT
CAGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGA
GCCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTC
CAATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTA
TACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGG
CGTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACAC
ACACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCA
GTCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCA
CTGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTG
ATGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAG
TCCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGA
AGCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGG
GAGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTG
GCTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTC
TCCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATG
AGCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTC
TGTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGT
CCTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTG
GATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGT
CCTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGAT
GCCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACAC
ACTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTT
TATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAA
GAAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGA
ACATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGA
AAAATAAAACACTTCTTGGTAAC

>4819_4819_2_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000381983_length(amino acids)=477AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKETGSTSIQAADS
TAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSG
VLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKM
MLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAA
ANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_3_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000436648_length(transcript)=3794nt_BP=497nt
GCGGTGCCCCGGCGAGGGAGCGTGGCGGCGAGCTGTTTGGGGGGGGTTGGCGACGGCAGCCCGAGGGCGGCGCAAGGCCTGAGGCCCAGC
ACAGGAGAGAGTTAGATTTGAATAAGAAGAATGGTGGTGGCTGGACCCCGCTGATGTATGCCTCCTACATTGGCCACGACACAATCGTGC
ACCTGCTGCTTGAGGCGGGGGTGAGTGTGAATGTGCCGACCCCAGAAGGGCAGACTCCACTGATGCTGGCCTCCAGCTGTGGCAACGAGA
GCATCGCCTACTTTCTTCTCCAGCAAGGTGCAGAGCTAGAAATGAAAGACATCCAGGGCTGGACAGCCCTCTTCCACTGTACCAGCGCCG
GGCACCAGCACATGGTCAGGTTCCTCTTGGACAGTGGAGCCAATGCCAACGTGAGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAG
CAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTGGATCAAAGTGGAACAGCTGAAGCCATATCATGCTCAT
AAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGATGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAA
GACCAGGATCTCACCATCCCGGAGTCTAGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCCAACCGCAAGC
GAGCCTGTTAAAGATGCAGATCCTCATTTCCATCATTTCCTGCTAAGCCAAACAGAGAAGCCAGCTGTCTGTTACCAGGCAATCACGAAG
AAGTTGAAAATATGTGAAGAGGAAACTGGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCACACCCACAGAC
AAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGACTGTCTGGAAC
CGCACTGCAGAGAAATGTGATTTGTTCATCCAGGAGGGGGCCCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACT
TTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTAC
GTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTC
TCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTC
CAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTC
ATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATCAGGGACAGTTG
GCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTCAGAAGGATCTC
CGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTG
GACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTC
TGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTATACAGACTTTGA
GACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGCGTGTGGGAAAG
CTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACACACAGGCTCTC
GCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAGTCAAGGAACTA
GAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCACTGGATTCCCTA
CAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGATGAGCTGAGAA
AGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGTCCCGAGAAGAT
GGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAAGCCATGCCCCA
GATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGGAGTCCTCAGGG
CCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGGCTCTGAAGAGC
CACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCTCCATCCTCCCT
CCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGAGCATTTCTTAG
GCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCTGTCGGGAGGGA
AGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTCCTTGGATAGGG
GACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGGATTTTCCAAAA
TCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTCCTTCCCCCCTC
ACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATGCCTGTCGGGTT
TTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACACTGGGGGTGGG
GGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTTATGAATATTTC
TGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAGAAAGCCCCTCC
CTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAACATTTGTCTTT
CAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAAAAATAAAACAC
TTCTTGGTAACACA

>4819_4819_3_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000436648_length(amino acids)=413AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAV
CYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEV
VSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLY
EDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYL
KYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_4_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000591451_length(transcript)=2173nt_BP=497nt
GCGGTGCCCCGGCGAGGGAGCGTGGCGGCGAGCTGTTTGGGGGGGGTTGGCGACGGCAGCCCGAGGGCGGCGCAAGGCCTGAGGCCCAGC
ACAGGAGAGAGTTAGATTTGAATAAGAAGAATGGTGGTGGCTGGACCCCGCTGATGTATGCCTCCTACATTGGCCACGACACAATCGTGC
ACCTGCTGCTTGAGGCGGGGGTGAGTGTGAATGTGCCGACCCCAGAAGGGCAGACTCCACTGATGCTGGCCTCCAGCTGTGGCAACGAGA
GCATCGCCTACTTTCTTCTCCAGCAAGGTGCAGAGCTAGAAATGAAAGACATCCAGGGCTGGACAGCCCTCTTCCACTGTACCAGCGCCG
GGCACCAGCACATGGTCAGGTTCCTCTTGGACAGTGGAGCCAATGCCAACGTGAGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAG
CAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTGGATCAAAGTGGAACAGCTGAAGCCATATCATGCTCAT
AAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGATGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAA
GACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAGTGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAG
CGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAAGAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCC
AAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCCCCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCT
AGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCCAACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCAT
TTCCATCATTTCCTGCTAAGCCAAACAGAGAAGCCAGCTGTCTGTTACCAGGCAATCACGAAGAAGTTGAAAATATGTGAAGAGGAAACT
GGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCACACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGT
CTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGACTGTCTGGAACCGCACTGCAGAGAAAGAGGGGGCCCGT
CTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTG
GGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTACGTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCC
CAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTA
GCGGCTGGAGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAAT
GCAGCCAAGATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGC
CAGTCCCAGCAGACACTCTTGGACATCCTCAATCAGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGA
AACTTTAAGCCTGATTTCTACCTGAAATACATTCAGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCC
ATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATA
CACTAAGCTGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATT
CTGGACCAGCCCACCTATCTCCATTTCCTTTTATACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGC
CGGTGGGGAGGGG

>4819_4819_4_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000585773_GLYR1_chr16_4882913_ENST00000591451_length(amino acids)=488AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKL
KICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKEGARLGRTPAEVVSTCDITFACVSDPK
AAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSF
FLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGD
AVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_5_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000321919_length(transcript)=3984nt_BP=444nt
ACTTGCCGGCACCTGCAGCCCGCCTAGACCCGGCGCTCGGGCGTCCCGCGCTGCACTTGCTCGCCGCGTGACTGGAGGACCGAGCCCCCA
CATTTTCTTTATGTGGTTGTGGTGGGGGCACAGTAATGCCCTGTGCGCCGTAGCGTTCCTGTGGGGATGTGGCCGGGGGGCGTCGGGAAG
CGTCACTGCTTGATGTCCGAGCTCAGCGATGAAGCCAGCGAGCCGGAACTCCTGAACCGCAGCTTGTCCATGTGGCACGGGCTCGGGACA
CAGGTCAGCGGGGAGGAGCTGGATGTCCCCCTGGATCTTCACACAGCTGCTTCCATTGGCCAGTATGAAGTGGTGAAGGAGTGTGTGCAG
CGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAGCAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTG
GATCAAAGTGGAACAGCTGAAGCCATATCATGCTCATAAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGA
TGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAAGACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAG
TGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAGCGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAA
GAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCCAAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCC
CCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCTAGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCC
AACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCATTTCCATCATTTCCTGCTAAGCCAAACAGAGAAGCCAGCTGTCTGTTACCAGGC
AATCACGAAGAAGTTGAAAATATGTGAAGAGGAAACTGGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCAC
ACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGAC
TGTCTGGAACCGCACTGCAGAGAAATGTGATTTGTTCATCCAGGAGGGGGCCCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTG
CGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGG
GAAGTGCTACGTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGA
AGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCAG
CAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCCA
AGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATCA
GGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTCA
GAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGC
CAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCCA
ATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTATA
CAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGCG
TGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACAC
ACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAGT
CAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCACT
GGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGAT
GAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGTC
CCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAAG
CCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGGA
GTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGGC
TCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCTC
CATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGAG
CATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCTG
TCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTCC
TTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGGA
TTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTCC
TTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATGC
CTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACAC
TGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTTA
TGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAGA
AAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAAC
ATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAAA
AATAAAACACTTCTTGGTAACACA

>4819_4819_5_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000321919_length(amino acids)=494AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKL
KICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFA
CVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQA
MGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRL
AIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_6_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000381983_length(transcript)=3930nt_BP=444nt
ACTTGCCGGCACCTGCAGCCCGCCTAGACCCGGCGCTCGGGCGTCCCGCGCTGCACTTGCTCGCCGCGTGACTGGAGGACCGAGCCCCCA
CATTTTCTTTATGTGGTTGTGGTGGGGGCACAGTAATGCCCTGTGCGCCGTAGCGTTCCTGTGGGGATGTGGCCGGGGGGCGTCGGGAAG
CGTCACTGCTTGATGTCCGAGCTCAGCGATGAAGCCAGCGAGCCGGAACTCCTGAACCGCAGCTTGTCCATGTGGCACGGGCTCGGGACA
CAGGTCAGCGGGGAGGAGCTGGATGTCCCCCTGGATCTTCACACAGCTGCTTCCATTGGCCAGTATGAAGTGGTGAAGGAGTGTGTGCAG
CGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAGCAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTG
GATCAAAGTGGAACAGCTGAAGCCATATCATGCTCATAAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGA
TGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAAGACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAG
TGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAGCGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAA
GAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCCAAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCC
CCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCTAGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCC
AACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCATTTCCATCATTTCCTGCTAAGCCAAACAGAGAAGGAAACTGGCTCCACCTCCAT
CCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCACACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGG
AATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGACTGTCTGGAACCGCACTGCAGAGAAATGTGATTTGTTCATCCAGGAGGGGGC
CCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGT
GCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTACGTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCT
GGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGAT
CTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGG
CAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGAC
AGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATCAGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCA
AGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTCAGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGAC
TCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTA
CATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTT
CATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTATACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTG
AGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGCGTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTG
TGTTCACACACACACACACACACACACACACACACACACACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTT
TTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAGTCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCC
CAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCACTGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCC
AGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGATGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCC
ATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGTCCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCT
GCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAAGCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTG
TTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGGAGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCT
CCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGGCTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCC
ACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCTCCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGT
CTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGAGCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCC
AGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCTGTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCG
AGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTCCTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACC
CAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGGATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATA
TGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTCCTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAG
GATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATGCCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTG
TCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACACTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTT
GTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTTATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTT
TAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAGAAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTA
AGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAACATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAA
AACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAAAAATAAAACACTTCTTGGTAAC

>4819_4819_6_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000381983_length(amino acids)=477AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKETGSTSIQAADS
TAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSG
VLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKM
MLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAA
ANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_7_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000436648_length(transcript)=3741nt_BP=444nt
ACTTGCCGGCACCTGCAGCCCGCCTAGACCCGGCGCTCGGGCGTCCCGCGCTGCACTTGCTCGCCGCGTGACTGGAGGACCGAGCCCCCA
CATTTTCTTTATGTGGTTGTGGTGGGGGCACAGTAATGCCCTGTGCGCCGTAGCGTTCCTGTGGGGATGTGGCCGGGGGGCGTCGGGAAG
CGTCACTGCTTGATGTCCGAGCTCAGCGATGAAGCCAGCGAGCCGGAACTCCTGAACCGCAGCTTGTCCATGTGGCACGGGCTCGGGACA
CAGGTCAGCGGGGAGGAGCTGGATGTCCCCCTGGATCTTCACACAGCTGCTTCCATTGGCCAGTATGAAGTGGTGAAGGAGTGTGTGCAG
CGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAGCAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTG
GATCAAAGTGGAACAGCTGAAGCCATATCATGCTCATAAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGA
TGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAAGACCAGGATCTCACCATCCCGGAGTCTAGTACCGTGAAGGGGATGATGGCCGG
ACCGATGGCCGCGTTTAAATGGCAGCCAACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCATTTCCATCATTTCCTGCTAAGCCAAAC
AGAGAAGCCAGCTGTCTGTTACCAGGCAATCACGAAGAAGTTGAAAATATGTGAAGAGGAAACTGGCTCCACCTCCATCCAGGCAGCTGA
CAGCACAGCCGTGAATGGCAGCATCACACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGGAATCGTCTCCAA
CTTGCTAAAAATGGGTCACACAGTGACTGTCTGGAACCGCACTGCAGAGAAATGTGATTTGTTCATCCAGGAGGGGGCCCGTCTGGGAAG
AACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACTTTCGCCTGCGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTGGGCCCCAG
TGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTACGTGGACATGTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCCCAGGTGAT
TGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGG
AGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAA
GATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCA
GCAGACACTCTTGGACATCCTCAATCAGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAA
GCCTGATTTCTACCTGAAATACATTCAGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGC
TGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGC
TGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCA
GCCCACCTATCTCCATTTCCTTTTATACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGG
AGGGGACAAGTGTCAGCAGGATTGGCGTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACA
CACACACACACACACACACACACACACACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAG
CTTGTCTTATCTCAAACCCCTTCCAGTCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAG
GCTGTAGTCATGTCCCCATCCCCCACTGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGC
CCTTGGGGCCCTCCAACCTCAGGTGATGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTT
GTGAACTGAAAAGAGACTGGCAGAGTCCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCAT
GGAGGCCCGGCCCTCACCGCCTCGAAGCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTG
GATTTGCATTCCATCCCTTGGGAGGGAGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTC
CGTTAGGCCACAGACTCTTCACCTGGCTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGC
CAAGTCCCCTGCATGCCCACCGCTCTCCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGG
CCCAGACCCAGCCTGACCAACGATGAGCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTC
TTCGGTGCTTCCCGGGCCCGGGGTCTGTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGG
GACATCCTAGAGGCCCTACATTTGTCCTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCA
GTTTTTTATCCCTCTGCATGGGTTGGATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATA
TAGGGTGGCCACACTAGGGCGGGGTCCTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGA
CGAGTGGGGGGAGGGCAGGGAAGATGCCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAA
GCCTGTTCTAGTCCTGGCGGAACACACTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTG
TTGACAATTCTGTAAAGTTCCTTTTTATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAAT
GTGACACTTGTGAAAAAGCTTGTAAGAAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATT
TTTATTTTTGCTTTGTTTTTAATGAACATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTG
TGCAATTAACAAAGCTACTGCAAGAAAAATAAAACACTTCTTGGTAACACA

>4819_4819_7_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000436648_length(amino acids)=413AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAV
CYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEV
VSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLY
EDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYL
KYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------
>4819_4819_8_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000591451_length(transcript)=2120nt_BP=444nt
ACTTGCCGGCACCTGCAGCCCGCCTAGACCCGGCGCTCGGGCGTCCCGCGCTGCACTTGCTCGCCGCGTGACTGGAGGACCGAGCCCCCA
CATTTTCTTTATGTGGTTGTGGTGGGGGCACAGTAATGCCCTGTGCGCCGTAGCGTTCCTGTGGGGATGTGGCCGGGGGGCGTCGGGAAG
CGTCACTGCTTGATGTCCGAGCTCAGCGATGAAGCCAGCGAGCCGGAACTCCTGAACCGCAGCTTGTCCATGTGGCACGGGCTCGGGACA
CAGGTCAGCGGGGAGGAGCTGGATGTCCCCCTGGATCTTCACACAGCTGCTTCCATTGGCCAGTATGAAGTGGTGAAGGAGTGTGTGCAG
CGGGAGCCGATATGTGGATTTACTCCCTTGATGGAAGCAGCTGCTGCTGGCCATGAGATAATCGTGCAGTATTTTCTGAATCACTGCCTG
GATCAAAGTGGAACAGCTGAAGCCATATCATGCTCATAAAGAGGAAATGATAAAAATTAACAAGGGTAAACGATTCCAGCAAGCGGTAGA
TGCTGTCGAAGAGTTCCTCAGGAGAGCCAAAGGGAAAGACCAGACGTCATCCCACAATTCTTCTGATGACAAGAATCGACGTAATTCCAG
TGAGGAGAGAAGTAGGCCAAACTCAGGTGATGAGAAGCGCAAACTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATGGGAGAAGGAAA
GAAGAGGGTGTCTTCAGGCTCTTCAGAGAGAGGCTCCAAATCCCCTCTGAAAAGAGCCCAAGAGCAAAGTCCCCGGAAGCGGGGTCGGCC
CCCAAAGGATGAGAAGGATCTCACCATCCCGGAGTCTAGTACCGTGAAGGGGATGATGGCCGGACCGATGGCCGCGTTTAAATGGCAGCC
AACCGCAAGCGAGCCTGTTAAAGATGCAGATCCTCATTTCCATCATTTCCTGCTAAGCCAAACAGAGAAGCCAGCTGTCTGTTACCAGGC
AATCACGAAGAAGTTGAAAATATGTGAAGAGGAAACTGGCTCCACCTCCATCCAGGCAGCTGACAGCACAGCCGTGAATGGCAGCATCAC
ACCCACAGACAAAAAGATAGGATTTTTGGGCCTTGGTCTCATGGGAAGTGGAATCGTCTCCAACTTGCTAAAAATGGGTCACACAGTGAC
TGTCTGGAACCGCACTGCAGAGAAAGAGGGGGCCCGTCTGGGAAGAACCCCCGCTGAAGTCGTCTCAACCTGCGACATCACTTTCGCCTG
CGTGTCGGATCCCAAGGCGGCCAAGGACCTGGTGCTGGGCCCCAGTGGTGTGCTGCAAGGGATCCGCCCTGGGAAGTGCTACGTGGACAT
GTCAACAGTGGACGCTGACACCGTCACTGAGCTGGCCCAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGGAAGCCCCCGTCTCAGGGAA
TCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCAGCAGCTGCTTCCAGGCGAT
GGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCCAAGGGAGCTTCATGGCCAC
TATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATCAGGGACAGTTGGCCAGCAT
CTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTCAGAAGGATCTCCGCTTAGC
CATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAGCCAAGGCGCTGGACCAGTC
TGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCCAATCCCCCCTCTGACCCCC
TCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTATACAGACTTTGAGACTTGCC
ATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGG

>4819_4819_8_ANKS3-GLYR1_ANKS3_chr16_4774751_ENST00000592711_GLYR1_chr16_4882913_ENST00000591451_length(amino acids)=488AA_BP=
MKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSS
GSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKL
KICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKEGARLGRTPAEVVSTCDITFACVSDPK
AAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSF
FLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGD
AVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKS3-GLYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneGLYR1chr16:4774751chr16:4882913ENST00000321919216214_21751.666666666666664554.0histone H3
TgeneGLYR1chr16:4774751chr16:4882913ENST00000381983215214_21751.666666666666664537.0histone H3
TgeneGLYR1chr16:4774751chr16:4882913ENST00000436648215214_21751.666666666666664473.0histone H3
TgeneGLYR1chr16:4774751chr16:4882913ENST00000591451216214_21751.666666666666664548.0histone H3
TgeneGLYR1chr16:4774751chr16:4882913ENST00000321919216216_22551.666666666666664554.0KDM1B
TgeneGLYR1chr16:4774751chr16:4882913ENST00000381983215216_22551.666666666666664537.0KDM1B
TgeneGLYR1chr16:4774751chr16:4882913ENST00000436648215216_22551.666666666666664473.0KDM1B
TgeneGLYR1chr16:4774751chr16:4882913ENST00000591451216216_22551.666666666666664548.0KDM1B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANKS3chr16:4774751chr16:4882913ENST00000304283-6181_422191.0717.0NEK7
HgeneANKS3chr16:4774751chr16:4882913ENST00000585773-4161_422118.0529.0NEK7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKS3-GLYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKS3-GLYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKS3C0037221Situs Inversus1ORPHANET