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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CANT1-PLEKHA7 (FusionGDB2 ID:HG124583TG144100)

Fusion Gene Summary for CANT1-PLEKHA7

check button Fusion gene summary
Fusion gene informationFusion gene name: CANT1-PLEKHA7
Fusion gene ID: hg124583tg144100
HgeneTgene
Gene symbol

CANT1

PLEKHA7

Gene ID

124583

144100

Gene namecalcium activated nucleotidase 1pleckstrin homology domain containing A7
SynonymsDBQD|DBQD1|EDM7|SCAN-1|SCAN1|SHAPY-
Cytomap('CANT1')('PLEKHA7')

17q25.3

11p15.2-p15.1

Type of geneprotein-codingprotein-coding
Descriptionsoluble calcium-activated nucleotidase 1Ca2+-dependent endoplasmic reticulum nucleoside diphosphataseapyrase homologmicromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossificationputative MAPK-activating protein pleckstrin homology domain-containing family A member 7PH domain-containing family A member 7pleckstrin homology domain containing, family A member 2pleckstrin homology domain containing, family A member 7pleckstrin homology domain-containing family A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000302345, ENST00000392446, 
ENST00000591773, ENST00000591732, 
Fusion gene scores* DoF score9 X 9 X 6=48611 X 9 X 4=396
# samples 1011
** MAII scorelog2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CANT1 [Title/Abstract] AND PLEKHA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCANT1(76993074)-PLEKHA7(16892729), # samples:1
Anticipated loss of major functional domain due to fusion event.CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CANT1-PLEKHA7 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CANT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PLEKHA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12U-01ACANT1chr17

76993074

-PLEKHA7chr11

16892729

-


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Fusion Gene ORF analysis for CANT1-PLEKHA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302345ENST00000332954CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
5CDS-intronENST00000302345ENST00000532079CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
5CDS-intronENST00000392446ENST00000332954CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
5CDS-intronENST00000392446ENST00000532079CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
5CDS-intronENST00000591773ENST00000332954CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
5CDS-intronENST00000591773ENST00000532079CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000302345ENST00000355661CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000302345ENST00000448080CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000302345ENST00000531066CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000392446ENST00000355661CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000392446ENST00000448080CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
Frame-shiftENST00000392446ENST00000531066CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
In-frameENST00000591773ENST00000355661CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
In-frameENST00000591773ENST00000448080CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
In-frameENST00000591773ENST00000531066CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
intron-3CDSENST00000591732ENST00000355661CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
intron-3CDSENST00000591732ENST00000448080CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
intron-3CDSENST00000591732ENST00000531066CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
intron-intronENST00000591732ENST00000332954CANT1chr17

76993074

-PLEKHA7chr11

16892729

-
intron-intronENST00000591732ENST00000532079CANT1chr17

76993074

-PLEKHA7chr11

16892729

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591773CANT1chr1776993074-ENST00000531066PLEKHA7chr1116892729-5329103199046251211
ENST00000591773CANT1chr1776993074-ENST00000355661PLEKHA7chr1116892729-5779103199041751061
ENST00000591773CANT1chr1776993074-ENST00000448080PLEKHA7chr1116892729-5598103199041781062

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591773ENST00000531066CANT1chr1776993074-PLEKHA7chr1116892729-0.0028599890.99714005
ENST00000591773ENST00000355661CANT1chr1776993074-PLEKHA7chr1116892729-0.0027439010.9972561
ENST00000591773ENST00000448080CANT1chr1776993074-PLEKHA7chr1116892729-0.0022466730.9977533

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Fusion Genomic Features for CANT1-PLEKHA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CANT1-PLEKHA7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:76993074/chr11:16892729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANT1chr17:76993074chr11:16892729ENST00000302345-241_44210402.0Topological domainCytoplasmic
HgeneCANT1chr17:76993074chr11:16892729ENST00000392446-351_44210402.0Topological domainCytoplasmic
HgeneCANT1chr17:76993074chr11:16892729ENST00000591773-461_44210402.0Topological domainCytoplasmic
HgeneCANT1chr17:76993074chr11:16892729ENST00000302345-2445_62210402.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCANT1chr17:76993074chr11:16892729ENST00000392446-3545_62210402.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCANT1chr17:76993074chr11:16892729ENST00000591773-4645_62210402.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePLEKHA7chr17:76993074chr11:16892729ENST000003556612231067_1094731122.0Coiled coilOntology_term=ECO:0000255
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000355661223700_801731122.0Coiled coilOntology_term=ECO:0000255
TgenePLEKHA7chr17:76993074chr11:16892729ENST000004480802231067_1094731123.0Coiled coilOntology_term=ECO:0000255
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000448080223700_801731123.0Coiled coilOntology_term=ECO:0000255
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000355661223567_599731122.0Compositional biasNote=Pro-rich
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000355661223845_942731122.0Compositional biasNote=Pro-rich
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000448080223567_599731123.0Compositional biasNote=Pro-rich
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000448080223845_942731123.0Compositional biasNote=Pro-rich
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000355661223164_282731122.0DomainPH
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000448080223164_282731123.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANT1chr17:76993074chr11:16892729ENST00000302345-2463_401210402.0Topological domainLumenal
HgeneCANT1chr17:76993074chr11:16892729ENST00000392446-3563_401210402.0Topological domainLumenal
HgeneCANT1chr17:76993074chr11:16892729ENST00000591773-4663_401210402.0Topological domainLumenal
TgenePLEKHA7chr17:76993074chr11:16892729ENST0000035566122354_87731122.0DomainWW 2
TgenePLEKHA7chr17:76993074chr11:16892729ENST000003556612239_42731122.0DomainWW 1
TgenePLEKHA7chr17:76993074chr11:16892729ENST0000044808022354_87731123.0DomainWW 2
TgenePLEKHA7chr17:76993074chr11:16892729ENST000004480802239_42731123.0DomainWW 1


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Fusion Gene Sequence for CANT1-PLEKHA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12784_12784_1_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000355661_length(transcript)=5779nt_BP=1031nt
GCGCGCGGGGCGGAAGTCGGCCACCTTCCTCCGTCCCGGCCGTTAGCCCAGCCAAGCCCAGCCAAGCCCAGCCAAGCCCCGCCGATCGCG
GGCACCGGAGCCAGCCCCGCAGCGGGAGCCTAACCCAGAGGAAGTGGAGACTCCTTTACTGCACATCTGTCTGCTCCAGGCCAGGCACTG
TTCTAGGAGCCAGGATACAGAGGTGGAGACAGAAACAAACAAACCGATAACTGTATACAATACTCTAACGTCAGAGGGACCACAGAGCAC
CAGCCTGCATGGAACTTCCTTCCTCACTCAGCTTCCCACGTTGCCAGCTGGGACAGGGGAGATGGAGTAATTTTGCTGTGGAAAGACTTC
ACGTCTTGCCGAATGAAAGTCCCGCCTGTCTGTCACGCTGATGCCCGTGCAGCTGTCTGAGCACCCGGAATGGAATGAGTCTATGCACTC
CCTCCGGATCAGTGTGGGGGGCCTTCCTGTGCTGGCGTCCATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCT
GACGTTCTTTGTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCCACCCACAATGCACACAACTG
GAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACCTACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAAT
CGCAGTTATCGCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAAAAGGGCTACCTGACCCTGTC
AGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGACCATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCT
ATCCGACCTGATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATCGAAGGCAGCAAAGCCGTGCC
CTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAAGCCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT
TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC
AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT
GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG
CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC
TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGCTGTGCACACGGGGATGCGAGCG
CTCATCTATAACAGCTCCACAGCGGGCTCTCAGGCCGAGCAGTCAGGCATGAGGACCTACTACTTCAGTGCCGACACCCAGGAGGACATG
AACGCTTGGGTCAGGGCCATGAACCAGGCTGCACAGGTGCTGTCTCGATCGTCACTGAAGAGGGATATGGAGAAGGTGGAGCGGCAGGCT
GTCCCCCAGGCCAACCACACAGAGTCCTGTCACGAATGTGGCCGGGTGGGACCCGGACATACGAGAGATTGTCCTCATCGTGGCCATGAT
GACATTGTCAACTTCGAGAGGCAGGAGCAGGAGGGAGAGCAGTACCGTTCCCAGAGGGACCCACTGGAGGGCAAGCGGGACCGGAGCAAG
GCCAGGTCTCCGTACTCGCCAGCCGAGGAGGATGCCTTGTTTATGGATTTACCCACTGGCCCAAGAGGCCAGCAGGCACAGCCCCAACGG
GCAGAGAAGAATGGAATGCTGCCTGCCTCATATGGCCCAGGAGAACAGAATGGGACTGGTGGGTACCAGCGGGCCTTTCCTCCCAGGACC
AACCCTGAAAAACACAGCCAAAGGAAGAGCAATCTGGCCCAGGTGGAGCACTGGGCAAGGGCCCAGAAAGGGGATAGCAGGAGTCTTCCC
TTGGACCAGACGCTTCCTCGCCAGGGTCCTGGCCAATCCCTGTCCTTCCCAGAAAACTACCAGACTCTTCCCAAGAGCACCCGACACCCC
TCGGGGGGCTCCTCGCCACCTCCCCGAAACCTGCCAAGTGACTACAAGTATGCGCAGGACCGAGCCAGCCACCTGAAGATGTCGAGTGAA
GAGCGCCGGGCGCACCGGGATGGCACCGTGTGGCAGCTCTACGAGTGGCAGCAGCGCCAGCAGTTCCGGCACGGCAGCCCCACAGCGCCC
ATCTGCCTTGGCTCCCCAGAGTTCACCGACCAGGGCCGGAGCAGGAGCATGCTAGAGGTGCCCCGCTCCATCTCTGTGCCTCCATCTCCC
TCGGACATCCCTCCCCCAGGACCCCCAAGGGTCTTCCCACCCCGGCGGCCACACACACCAGCAGAGCGAGTCACAGTGAAGCCACCGGAC
CAGAGGAGGAGTGTGGACATCTCGCTGGGGGATTCTCCAAGGAGGGCACGGGGCCACGCTGTCAAGAACTCATCTCATGTGGACCGACGC
TCCATGCCCTCCATGGGTTACATGACCCACACCGTCAGCGCTCCCAGTTTACATGGAAAATCGGCTGATGATACCTACCTCCAGCTGAAG
AAAGACCTGGAGTACCTGGATCTAAAGATGACAGGCCGGGACCTTCTCAAGGATCGAAGTCTGAAGCCTGTGAAGATCGCTGAGAGCGAC
ACTGACGTCAAACTGAGCATCTTCTGTGAACAAGACAGGGTCCTCCAGGACTTGGAAGACAAGATACGAGCCCTTAAAGAGAACAAAGAC
CAGCTAGAATCTGTGCTGGAGGTGTTGCACAGACAGATGGAGCAGTACCGAGACCAGCCCCAGCACTTGGAGAAGATTGCCTACCAGCAG
AAGTTGCTGCAGGAGGACCTTGTCCATATCCGAGCTGAGCTCTCCAGAGAGTCCACTGAGATGGAAAATGCTTGGAACGAATACCTGAAG
TTGGAGAATGATGTGGAACAGCTGAAGCAGACCCTGCAGGAGCAACACAGAAGAGCCTTTTTTTTCCAGGAGAAATCGCAGATACAGAAA
GATCTATGGAGAATTGAAGATGTCACTGCAGGCCTGAGTGCAAATAAAGAGAACTTCAGAATTCTAGTGGAGTCAGTAAAAAATCCGGAG
AGAAAAACGGTGCCTTTGTTTCCTCACCCGCCTGTGCCTTCACTCTCAACTTCTGAGAGCAAGCCGCCCCCACAGCCCAGTCCTCCCACC
AGCCCTGTGCGGACCCCTCTGGAGGTTCGACTCTTCCCCCAGCTGCAAACCTACGTGCCGTACCGACCTCACCCACCCCAGCTGAGGAAA
GTGACATCCCCCCTTCAGTCACCAACTAAGGCGAAGCCCAAAGTTGAAGATGAAGCACCTCCCAGGCCCCCACTCCCCGAACTCTACAGC
CCAGAGGACCAGCCCCCGGCTGTGCCGCCTCTGCCAAGAGAGGCCACCATCATCCGGCACACATCTGTGCGGGGCCTCAAGCGGCAGTCA
GACGAGAGGAAGCGAGACCGGGAGCTGGGGCAGTGTGTGAATGGGGATTCCAGGGTGGAGCTGCGGTCGTATGTCAGTGAGCCTGAGCTG
GCGACCCTCAGCGGGGACATGGCCCAGCCCTCCCTAGGACTTGTGGGCCCTGAGAGCAGGTACCAGACGCTGCCAGGCAGAGGGCTCTCA
GGGTCCACGTCAAGGCTCCAGCAGTCGTCCACCATTGCTCCCTACGTCACACTCCGGAGGGGTCTCAATGCCGAAAGCAGCAAGGCGACC
TTCCCTAGACCTAAGAGTGCCTTGGAGCGCCTGTACTCAGGGGATCACCAGCGAGGCAAGATGAGTGCAGAGGAGCAGCTGGAGCGCATG
AAGCGACACCAGAAGGCCCTGGTCCGAGAGCGCAAGAGGACACTGGGCCAAGGGGAGAGGACGGGCCTGCCCTCATCTCGCTACCTCAGC
CGGCCGCTCCCTGGAGATCTTGGCTCAGTATGTTAGGAGGGGCCAGGCAGCGGGGCAGGGACAGGGAGCCGAGTGCCCCTCAGAGTCCCC
CAAACACAAGCACATCACACCTCCCAGTGAGAGAGCTGTCCATTGACCTACATGGTTCAGAGAACACCCCACGGGGCTGTTTGTCCACGA
CCCAGGCTGGACGAATGCCTGGTCAGAGGGTGACCTGAACCAGAGCTGGAGTGAGGATCAAACAGGCCCAGGAGCCTGAGGAAATACCCA
GTCAGTCCTCCCAGCCGCGATGGAGAGGGGCCTTTGCAGGCGTTCGGAATCTCGGCTGAATTCAGGACCTGGGAATACAGGGTTCAGAGA
GGAGAGGAGGAAGATGGTGACATGATTTGGTTAGAAGCACAAGCAAACTGATCAGCCTCCCAGACCTGCCAGCAGATGCTGTGTGAGGGT
GATGGAGCACGGGGTCACACCCCTGCCCCAAGGGCCACTGGTCTCCCTGGGCTTGCAGTGCAGAGGCCTCAGGGTGTCTGGGATTGCTGG
GGAGGCCTGTGCTGCCCCCTGGTGGCGCTTCCTGGCGCTGCGCCCTGTCCACAGTCACCTTAGGTCCCTTTGGAAACATTCCATTTGACT
TTTCCCTGTTGTTTGAAATCCCATGTTTCCCTAAACCTCTAGCCTGATTGTTCTTTCCCTAATTCATTGCACAAGCTCCTTTGCTTTTAG
TGTTACCGCTCATTGCCTCTCTAATCCTGCCTGATTGTGTTTACAGAAGCTTCTGATTTGCATTGAACATGCTCTAACTGGCCTGTGCTA
CTTATTACCGGGCTTGTAATAGCGGTTCTTGTCTCCATAGCCTGTTGAGTGTTCCCAGATGTGACTCACCTTTCTGCTGCCCTCTTCATG
CAGGCCTACTGACTCATAATTCACTTGTCCCAAAAGCCACCCCACAAGCCTGAGCCAACCTGCTGCCTGACGCCACAGTCATTGGCAGAG
GTCTGGGCATTATTAATTTATAAAAATCCATGCTTTACACCTGGACAGTAGACAGGGACTTCAGAGATTGCACGTTTGAATACATTCTCC
CAAGACTGAGGTTGTTCGGTTTTAATTCCTGTAGTCCAATCACACAATTTCTTATGGAAAACCTTTTGTGTTTCTGGTATTTAATAACTT
GAAGGGATAGCAAAATATACTGTGTATTCAGAGGGCCTCTCTGCAGCTGCTAGCTCAGACACCAAAGGGGTAAGGCCCAGGACATTCATA
TCTTTAAAAGCTGCAAACCTGGTAACCTTTAAACTTTTAAAACAAATGTCATATGGGGTAACACTGACCTTTTATAATTTGATGTCTCAA
ATGTAGAGATTATCTAAAAATCGTAACTTGAATACCTTGTAATTTTTCTCTTAAAAAAGAAGACTTGTGTAAGTCTCTGCATCAACGCCA
ATAAACATGTTGCTTAATAATAATGGATTGGCGTGGTTCTTCCCCAGGATACCTTATAGAGTCTAGTGAACTTTTCCTGTTTGTGGAAAC
AATCAGGCTGGGTTTAAATGAGGACTTGTCTCTATTTGGAGCATTTGTGAGCGTGTAAGGAAATGAGTGTTTTCTTTGTGAATCATTAAA
TTGATTTTTTCATCTTTGG

>12784_12784_1_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000355661_length(amino acids)=1061AA_BP=13
MGDSVRRRRHRGESHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSF
GKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA
LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHD
DIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT
NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSE
ERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD
QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESD
TDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK
LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPT
SPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS
DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKAT
FPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC

--------------------------------------------------------------
>12784_12784_2_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000448080_length(transcript)=5598nt_BP=1031nt
GCGCGCGGGGCGGAAGTCGGCCACCTTCCTCCGTCCCGGCCGTTAGCCCAGCCAAGCCCAGCCAAGCCCAGCCAAGCCCCGCCGATCGCG
GGCACCGGAGCCAGCCCCGCAGCGGGAGCCTAACCCAGAGGAAGTGGAGACTCCTTTACTGCACATCTGTCTGCTCCAGGCCAGGCACTG
TTCTAGGAGCCAGGATACAGAGGTGGAGACAGAAACAAACAAACCGATAACTGTATACAATACTCTAACGTCAGAGGGACCACAGAGCAC
CAGCCTGCATGGAACTTCCTTCCTCACTCAGCTTCCCACGTTGCCAGCTGGGACAGGGGAGATGGAGTAATTTTGCTGTGGAAAGACTTC
ACGTCTTGCCGAATGAAAGTCCCGCCTGTCTGTCACGCTGATGCCCGTGCAGCTGTCTGAGCACCCGGAATGGAATGAGTCTATGCACTC
CCTCCGGATCAGTGTGGGGGGCCTTCCTGTGCTGGCGTCCATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCT
GACGTTCTTTGTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCCACCCACAATGCACACAACTG
GAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACCTACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAAT
CGCAGTTATCGCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAAAAGGGCTACCTGACCCTGTC
AGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGACCATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCT
ATCCGACCTGATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATCGAAGGCAGCAAAGCCGTGCC
CTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAAGCCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT
TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC
AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT
GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG
CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC
TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGCTGTGCACACGGGGATGCGAGCG
CTCATCTATAACAGCTCCACAGCGGGCTCTCAGGCCGAGCAGTCAGGCATGAGGACCTACTACTTCAGTGCCGACACCCAGGAGGACATG
AACGCTTGGGTCAGGGCCATGAACCAGGCTGCACAGGTGCTGTCTCGATCGTCACTGAAGAGGGATATGGAGAAGGTGGAGCGGCAGGCT
GTCCCCCAGGCCAACCACACAGAGTCCTGTCACGAATGTGGCCGGGTGGGACCCGGACATACGAGAGATTGTCCTCATCGTGGCCATGAT
GACATTGTCAACTTCGAGAGGCAGGAGCAGGAGGGAGAGCAGTACCGTTCCCAGAGGGACCCACTGGAGGGCAAGCGGGACCGGAGCAAG
GCCAGGTCTCCGTACTCGCCAGCCGAGGAGGATGCCTTGTTTATGGATTTACCCACTGGCCCAAGAGGCCAGCAGGCACAGCCCCAACGG
GCAGAGAAGAATGGAATGCTGCCTGCCTCATATGGCCCAGGAGAACAGAATGGGACTGGTGGGTACCAGCGGGCCTTTCCTCCCAGGACC
AACCCTGAAAAACACAGCCAAAGGAAGAGCAATCTGGCCCAGGTGGAGCACTGGGCAAGGGCCCAGAAAGGGGATAGCAGGAGTCTTCCC
TTGGACCAGACGCTTCCTCGCCAGGGTCCTGGCCAATCCCTGTCCTTCCCAGAAAACTACCAGACTCTTCCCAAGAGCACCCGACACCCC
TCGGGGGGCTCCTCGCCACCTCCCCGAAACCTGCCAAGTGACTACAAGTATGCGCAGGACCGAGCCAGCCACCTGAAGATGTCGAGTGAA
GAGCGCCGGGCGCACCGGGATGGCACCGTGTGGCAGCTCTACGAGTGGCAGCAGCGCCAGCAGTTCCGGCACGGCAGCCCCACAGCGCCC
ATCTGCCTTGGCTCCCCAGAGTTCACCGACCAGGGCCGGAGCAGGAGCATGCTAGAGGTGCCCCGCTCCATCTCTGTGCCTCCATCTCCC
TCGGACATCCCTCCCCCAGGACCCCCAAGGGTCTTCCCACCCCGGCGGCCACACACACCAGCAGAGCGAGTCACAGTGAAGCCACCGGAC
CAGAGGAGGAGTGTGGACATCTCGCTGGGGGATTCTCCAAGGAGGGCACGGGGCCACGCTGTCAAGAACTCATCTCATGTGGACCGACGC
TCCATGCCCTCCATGGGTTACATGACCCACACCGTCAGCGCTCCCAGTTTACATGGAAAATCGGCTGATGATACCTACCTCCAGCTGAAG
AAAGACCTGGAGTACCTGGATCTAAAGATGACAGGCCGGGACCTTCTCAAGGATCGAAGTCTGAAGCCTGTGAAGATCGCTGAGAGCGAC
ACTGACGTCAAACTGAGCATCTTCTGTGAACAAGACAGGGTCCTCCAGGACTTGGAAGACAAGATACGAGCCCTTAAAGAGAACAAAGAC
CAGCTAGAATCTGTGCTGGAGGTGTTGCACAGACAGATGGAGCAGTACCGAGACCAGCCCCAGCACTTGGAGAAGATTGCCTACCAGCAG
AAGTTGCTGCAGGAGGACCTTGTCCATATCCGAGCTGAGCTCTCCAGAGAGTCCACTGAGATGGAAAATGCTTGGAACGAATACCTGAAG
TTGGAGAATGATGTGGAACAGCTGAAGCAGACCCTGCAGGAGCAACACAGAAGAGCCTTTTTTTTCCAGGAGAAATCGCAGATACAGAAA
GATCTATGGAGAATTGAAGATGTCACTGCAGGCCTGAGTGCAAATAAAGAGAACTTCAGAATTCTAGTGGAGTCAGTAAAAAATCCGGAG
AGAAAAACGGTGCCTTTGTTTCCTCACCCGCCTGTGCCTTCACTCTCAACTTCTGAGAGCAAGCCGCCCCCACAGCCCAGTCCTCCCACC
AGCCCTGTGCGGACCCCTCTGGAGGTTCGACTCTTCCCCCAGCTGCAAACCTACGTGCCGTACCGACCTCACCCACCCCAGCTGAGGAAA
GTGACATCCCCCCTTCAGTCACCAACTAAGGCGAAGCCCAAAGTTCAGGAAGATGAAGCACCTCCCAGGCCCCCACTCCCCGAACTCTAC
AGCCCAGAGGACCAGCCCCCGGCTGTGCCGCCTCTGCCAAGAGAGGCCACCATCATCCGGCACACATCTGTGCGGGGCCTCAAGCGGCAG
TCAGACGAGAGGAAGCGAGACCGGGAGCTGGGGCAGTGTGTGAATGGGGATTCCAGGGTGGAGCTGCGGTCGTATGTCAGTGAGCCTGAG
CTGGCGACCCTCAGCGGGGACATGGCCCAGCCCTCCCTAGGACTTGTGGGCCCTGAGAGCAGGTACCAGACGCTGCCAGGCAGAGGGCTC
TCAGGGTCCACGTCAAGGCTCCAGCAGTCGTCCACCATTGCTCCCTACGTCACACTCCGGAGGGGTCTCAATGCCGAAAGCAGCAAGGCG
ACCTTCCCTAGACCTAAGAGTGCCTTGGAGCGCCTGTACTCAGGGGATCACCAGCGAGGCAAGATGAGTGCAGAGGAGCAGCTGGAGCGC
ATGAAGCGACACCAGAAGGCCCTGGTCCGAGAGCGCAAGAGGACACTGGGCCAAGGGGAGAGGACGGGCCTGCCCTCATCTCGCTACCTC
AGCCGGCCGCTCCCTGGAGATCTTGGCTCAGTATGTTAGGAGGGGCCAGGCAGCGGGGCAGGGACAGGGAGCCGAGTGCCCCTCAGAGTC
CCCCAAACACAAGCACATCACACCTCCCAGTGAGAGAGCTGTCCATTGACCTACATGGTTCAGAGAACACCCCACGGGGCTGTTTGTCCA
CGACCCAGGCTGGACGAATGCCTGGTCAGAGGGTGACCTGAACCAGAGCTGGAGTGAGGATCAAACAGGCCCAGGAGCCTGAGGAAATAC
CCAGTCAGTCCTCCCAGCCGCGATGGAGAGGGGCCTTTGCAGGCGTTCGGAATCTCGGCTGAATTCAGGACCTGGGAATACAGGGTTCAG
AGAGGAGAGGAGGAAGATGGTGACATGATTTGGTTAGAAGCACAAGCAAACTGATCAGCCTCCCAGACCTGCCAGCAGATGCTGTGTGAG
GGTGATGGAGCACGGGGTCACACCCCTGCCCCAAGGGCCACTGGTCTCCCTGGGCTTGCAGTGCAGAGGCCTCAGGGTGTCTGGGATTGC
TGGGGAGGCCTGTGCTGCCCCCTGGTGGCGCTTCCTGGCGCTGCGCCCTGTCCACAGTCACCTTAGGTCCCTTTGGAAACATTCCATTTG
ACTTTTCCCTGTTGTTTGAAATCCCATGTTTCCCTAAACCTCTAGCCTGATTGTTCTTTCCCTAATTCATTGCACAAGCTCCTTTGCTTT
TAGTGTTACCGCTCATTGCCTCTCTAATCCTGCCTGATTGTGTTTACAGAAGCTTCTGATTTGCATTGAACATGCTCTAACTGGCCTGTG
CTACTTATTACCGGGCTTGTAATAGCGGTTCTTGTCTCCATAGCCTGTTGAGTGTTCCCAGATGTGACTCACCTTTCTGCTGCCCTCTTC
ATGCAGGCCTACTGACTCATAATTCACTTGTCCCAAAAGCCACCCCACAAGCCTGAGCCAACCTGCTGCCTGACGCCACAGTCATTGGCA
GAGGTCTGGGCATTATTAATTTATAAAAATCCATGCTTTACACCTGGACAGTAGACAGGGACTTCAGAGATTGCACGTTTGAATACATTC
TCCCAAGACTGAGGTTGTTCGGTTTTAATTCCTGTAGTCCAATCACACAATTTCTTATGGAAAACCTTTTGTGTTTCTGGTATTTAATAA
CTTGAAGGGATAGCAAAATATACTGTGTATTCAGAGGGCCTCTCTGCAGCTGCTAGCTCAGACACCAAAGGGGTAAGGCCCAGGACATTC
ATATCTTTAAAAGCTGCAAACCTGGTAACCTTTAAACTTTTAAAACAAATGTCATATGGGGTAACACTGACCTTTTATAATTTGATGTCT
CAAATGTAGAGATTATCTAAAAATCGTAACTTGAATACCTTGTAATTTTTCTCTTAAAAAAGAAGACTTGTGTAAGTCTCTGCATCAACG
CCAATAAACATGTTGCTT

>12784_12784_2_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000448080_length(amino acids)=1062AA_BP=13
MGDSVRRRRHRGESHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSF
GKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA
LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHD
DIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT
NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSE
ERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD
QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESD
TDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK
LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPT
SPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQ
SDERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKA
TFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC

--------------------------------------------------------------
>12784_12784_3_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000531066_length(transcript)=5329nt_BP=1031nt
GCGCGCGGGGCGGAAGTCGGCCACCTTCCTCCGTCCCGGCCGTTAGCCCAGCCAAGCCCAGCCAAGCCCAGCCAAGCCCCGCCGATCGCG
GGCACCGGAGCCAGCCCCGCAGCGGGAGCCTAACCCAGAGGAAGTGGAGACTCCTTTACTGCACATCTGTCTGCTCCAGGCCAGGCACTG
TTCTAGGAGCCAGGATACAGAGGTGGAGACAGAAACAAACAAACCGATAACTGTATACAATACTCTAACGTCAGAGGGACCACAGAGCAC
CAGCCTGCATGGAACTTCCTTCCTCACTCAGCTTCCCACGTTGCCAGCTGGGACAGGGGAGATGGAGTAATTTTGCTGTGGAAAGACTTC
ACGTCTTGCCGAATGAAAGTCCCGCCTGTCTGTCACGCTGATGCCCGTGCAGCTGTCTGAGCACCCGGAATGGAATGAGTCTATGCACTC
CCTCCGGATCAGTGTGGGGGGCCTTCCTGTGCTGGCGTCCATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCT
GACGTTCTTTGTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCCACCCACAATGCACACAACTG
GAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACCTACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAAT
CGCAGTTATCGCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAAAAGGGCTACCTGACCCTGTC
AGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGACCATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCT
ATCCGACCTGATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATCGAAGGCAGCAAAGCCGTGCC
CTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAAGCCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT
TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC
AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT
GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG
CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC
TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGCTGTGCACACGGGGATGCGAGCG
CTCATCTATAACAGCTCCACAGCGGGCTCTCAGGCCGAGCAGTCAGGCATGAGGACCTACTACTTCAGTGCCGACACCCAGGAGGACATG
AACGCTTGGGTCAGGGCCATGAACCAGGCTGCACAGGTGCTGTCTCGATCGTCACTGAAGAGGGATATGGAGAAGGTGGAGCGGCAGGCT
GTCCCCCAGGCCAACCACACAGAGTCCTGTCACGAATGTGGCCGGGTGGGACCCGGACATACGAGAGATTGTCCTCATCGTGGCCATGAT
GACATTGTCAACTTCGAGAGGCAGGAGCAGGAGGGAGAGCAGTACCGTTCCCAGAGGGACCCACTGGAGGGCAAGCGGGACCGGAGCAAG
GCCAGGTCTCCGTACTCGCCAGCCGAGGAGGATGCCTTGTTTATGGATTTACCCACTGGCCCAAGAGGCCAGCAGGCACAGCCCCAACGG
GCAGAGAAGAATGGAATGCTGCCTGCCTCATATGGCCCAGGAGAACAGAATGGGACTGGTGGGTACCAGCGGGCCTTTCCTCCCAGGACC
AACCCTGAAAAACACAGCCAAAGGAAGAGCAATCTGGCCCAGGTGGAGCACTGGGCAAGGGCCCAGAAAGGGGATAGCAGGAGTCTTCCC
TTGGACCAGACGCTTCCTCGCCAGGGTCCTGGCCAATCCCTGTCCTTCCCAGAAAACTACCAGACTCTTCCCAAGAGCACCCGACACCCC
TCGGGGGGCTCCTCGCCACCTCCCCGAAACCTGCCAAGTGACTACAAGTATGCGCAGGACCGAGCCAGCCACCTGAAGATGTCGAGTGAA
GAGCGCCGGGCGCACCGGGATGGCACCGTGTGGCAGCTCTACGAGTGGCAGCAGCGCCAGCAGTTCCGGCACGGCAGCCCCACAGCGCCC
ATCTGCCTTGGCTCCCCAGAGTTCACCGACCAGGGCCGGAGCAGGAGCATGCTAGAGGTGCCCCGCTCCATCTCTGTGCCTCCATCTCCC
TCGGACATCCCTCCCCCAGGACCCCCAAGGGTCTTCCCACCCCGGCGGCCACACACACCAGCAGAGCGAGTCACAGTGAAGCCACCGGAC
CAGAGGAGGAGTGTGGACATCTCGCTGGGGGATTCTCCAAGGAGGGCACGGGGCCACGCTGTCAAGAACTCATCTCATGTGGACCGACGC
TCCATGCCCTCCATGGGTTACATGACCCACACCGTCAGCGCTCCCAGTTTACATGGAAAATCGGCTGATGATACCTACCTCCAGCTGAAG
AAAGACCTGGAGTACCTGGATCTAAAGATGACAGGCCGGGACCTTCTCAAGGATCGAAGTCTGAAGCCTGTGAAGATCGCTGAGAGCGAC
ACTGACGTCAAACTGAGCATCTTCTGTGAACAAGACAGGGTCCTCCAGGACTTGGAAGACAAGATACGAGCCCTTAAAGAGAACAAAGAC
CAGCTAGAATCTGTGCTGGAGGTGTTGCACAGACAGATGGAGCAGTACCGAGACCAGCCCCAGCACTTGGAGAAGATTGCCTACCAGCAG
AAGTTGCTGCAGGAGGACCTTGTCCATATCCGAGCTGAGCTCTCCAGAGAGTCCACTGAGATGGAAAATGCTTGGAACGAATACCTGAAG
TTGGAGAATGATGTGGAACAGCTGAAGCAGACCCTGCAGGAGCAACACAGAAGAGCCTTTTTTTTCCAGGAGAAATCGCAGATACAGAAA
GATCTATGGAGAATTGAAGATGTCACTGCAGGCCTGAGTGCAAATAAAGAGAACTTCAGAATTCTAGTGGAGTCAGTAAAAAATCCGGAG
AGAAAAACGGTGCCTTTGTTTCCTCACCCGCCTGTGCCTTCACTCTCAACTTCTGAGAGCAAGCCGCCCCCACAGCCCAGTCCTCCCACC
AGCCCTGTGCGGACCCCTCTGGAGGTTCGACTCTTCCCCCAGCTGCAAACCTACGTGCCGTACCGACCTCACCCACCCCAGCTGAGGAAA
GTGACATCCCCCCTTCAGTCACCAACTAAGGCGAAGCCCAAAGTTGAAGATGAAGCACCTCCCAGGCCCCCACTCCCCGAACTCTACAGC
CCAGAGGACCAGCCCCCGGCTGTGCCGCCTCTGCCAAGAGAGGCCACCATCATCCGGCACACATCTGTGCGGGGCCTCAAGCGGCAGTCA
GACGAGAGGAAGCGAGACCGGGAGCTGGGGCAGTGTGTGAATGGGGATTCCAGGGTGGAGCTGCGGTCGTATGTCAGTGAGCCTGAGCTG
GCGACCCTCAGCGGGGACATGGCCCAGCCCTCCCTAGGACTTGTGGGCCCTGAGAGCAGGTACCAGACGCTGCCAGGCAGAGGGCTCTCA
GGGTCCACGTCAAGGCTCCAGCAGTCGTCCACCATTGCTCCCTACGTCACACTCCGGAGGGGTCTCAATGCCGAAAGCAGCAAGGCGACC
TTCCCTAGACCTAAGAGTGCCTTGGAGCGCCTGTACTCAGGGGATCACCAGCGAGGCAAGATGAGTGCAGAGGAGCAGCTGGAGCGCATG
AAGCGACACCAGAAGGCCCTGGTCCGAGAGCGCAAGAGGACACTGGGCCAAGGGGAGAGGACGGGCCTGCCCTCATCTCGCTACCTCAGC
CGGCCGCTCCCTGGAGATCTTGGCTCATGGAAGCGTGAGCAGGACTTTGACCTGCAGTTGCTGGAACGGGTCGTGCAAGGGGAAAAAAAG
GACAAGGAGGAGAATGGCTGGTTGAAAGTGCAGGCCATGCCTGTCACTGAGTTGGACCTGGAGCCTCAAGACTATGACTTGGACATCAGC
AGAGAGCTGTCCAAACCAGAGAAGGTGTCAATCCCTGAGCGCTACGTGGAGCTAGATCCCGAAGAGCCACCCAGCCTTGAGGAGCTGCAG
GCGCGGTACCGCAAAGCCGAGAAGATCCGCAACATCCTCGCCCGGTCAAGCATGTGCAACCTACAGCCGACCTCAGGCCAGGACCAGAAC
AGTGTGGCTGACCTGGACTTGCAGCTGCAGGAGCAGGAGCGCATCATCAACATCTCCTACGCCCTGGCCTCCGAGGCCTCCCAGCGTAGC
AAGCAGGTGGCAGCCCAGGCAGTGACTGACCCGTGACCCAGCATGCAAAGAAGCCTGGAGCCAGGGGCCCAGTGGAACCAGCTTCCTCCA
AGGAGATGACCTTTCTGCCCCCAAGGAAACCCCTTCCAGCTGAGCAGGGAATCCGGCCGGAGGAAGGAGCAGCTTACCGACTGCGGGTGT
TCACCACAGGCCAGGCCCTAATATGCACCCACTAGTTTAGCTCAGACTCCTCTCTACATATGAATGGCAAAGGCACTTTTGATATACACT
GTAAAATACACTGTATTTTAGAATCGGAATCTATTTTCTAATGTTCCCCTCAAGGGCTGAGTGGCAGGAAGGTTGAGGATGCAGGACTTT
GCAGCTGCACGTACAGATTCAGGTACTTCTGGGTGACAGGTGTTGTGGGGGCAGGAAGGGCGGGGCAAGCCGAGGCTAGTCCAACTTCCA
ATGACCTCAGGAGAAAGTGAGATTTAAAGAGGTGTTCCCAGTAGACTCCAGCAAGAGGCTGGTTGGCGTGCTGTCTGGGAGAAGAGGGGC
CCTTGGCTGCAGAGATCAGCTGTCCCTGACCTGATGACCAGCTCTGTGTGAAACTCCACGAGGATCACACGTGGAGCCCAAGTCTGTGCC
TTGCCCCTTGGGTTTGGCTTAGGGGCAACAGTGTGTTCAAGAGGACTGGGGCCCACAACCTGCCCCCAGGCTTCCTCCAGCAAAAGGCTC
TTGTCAGAAAGAAAAAAGC

>12784_12784_3_CANT1-PLEKHA7_CANT1_chr17_76993074_ENST00000591773_PLEKHA7_chr11_16892729_ENST00000531066_length(amino acids)=1211AA_BP=13
MGDSVRRRRHRGESHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSF
GKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA
LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHD
DIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT
NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSE
ERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD
QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESD
TDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK
LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPT
SPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS
DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKAT
FPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSWKREQDFDLQLLERVVQGEKK
DKEENGWLKVQAMPVTELDLEPQDYDLDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSGQDQN
SVADLDLQLQEQERIINISYALASEASQRSKQVAAQAVTDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CANT1-PLEKHA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000355661223538_69673.666666666666671122.0CTNND1
TgenePLEKHA7chr17:76993074chr11:16892729ENST00000448080223538_69673.666666666666671123.0CTNND1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CANT1-PLEKHA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CANT1-PLEKHA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANT1C4012146DESBUQUOIS DYSPLASIA 17GENOMICS_ENGLAND;UNIPROT
HgeneCANT1C0432242Desbuquois syndrome1CTD_human;ORPHANET
HgeneCANT1C4540251EPIPHYSEAL DYSPLASIA, MULTIPLE, 71GENOMICS_ENGLAND;UNIPROT
TgeneC0017605Angle Closure Glaucoma2CTD_human
TgeneC0008924Cleft upper lip1GENOMICS_ENGLAND