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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CNN2-WAC (FusionGDB2 ID:HG1265TG51322) |
Fusion Gene Summary for CNN2-WAC |
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Fusion gene information | Fusion gene name: CNN2-WAC | Fusion gene ID: hg1265tg51322 | Hgene | Tgene | Gene symbol | CNN2 | WAC | Gene ID | 1265 | 51322 |
Gene name | calponin 2 | WW domain containing adaptor with coiled-coil | |
Synonyms | - | BM-016|DESSH|PRO1741|Wwp4 | |
Cytomap | ('CNN2')('WAC') 19p13.3 | 10p12.1|10p12.1-p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | calponin-2calponin H2, smooth muscleneutral calponin | WW domain-containing adapter protein with coiled-coil | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q99439 | . | |
Ensembl transtripts involved in fusion gene | ENST00000263097, ENST00000348419, ENST00000606983, ENST00000562958, ENST00000565096, | ||
Fusion gene scores | * DoF score | 9 X 8 X 6=432 | 13 X 16 X 7=1456 |
# samples | 9 | 16 | |
** MAII score | log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1456*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CNN2 [Title/Abstract] AND WAC [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CNN2(1038780)-WAC(28907926), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CNN2 | GO:0032970 | regulation of actin filament-based process | 16236705 |
Hgene | CNN2 | GO:0071260 | cellular response to mechanical stimulus | 16236705 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CNN2-WAC |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CNN2-WAC |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CNN2-WAC |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1038780/:28907926) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CNN2 | . |
FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CNN2-WAC |
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Fusion Gene PPI Analysis for CNN2-WAC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CNN2-WAC |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CNN2-WAC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CNN2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | CNN2 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
Hgene | CNN2 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Hgene | CNN2 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Hgene | CNN2 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Hgene | CNN2 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND | |
Tgene | C4225239 | DESANTO-SHINAWI SYNDROME | 1 | CTD_human;ORPHANET | |
Tgene | C4225431 | CHROMOSOME 10p12-p11 DELETION SYNDROME | 1 | ORPHANET |