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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAH14-ARF1 (FusionGDB2 ID:HG127602TG375)

Fusion Gene Summary for DNAH14-ARF1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH14-ARF1
Fusion gene ID: hg127602tg375
HgeneTgene
Gene symbol

DNAH14

ARF1

Gene ID

127602

375

Gene namedynein axonemal heavy chain 14ADP ribosylation factor 1
SynonymsC1orf67|Dnahc14|HL-18|HL18PVNH8
Cytomap('DNAH14')('ARF1')

1q42.12

1q42.13

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 14, axonemalaxonemal beta dynein heavy chain 14ciliary dynein heavy chain 14dynein, axonemal, heavy polypeptide 14ADP-ribosylation factor 1
Modification date2020031320200322
UniProtAcc.

P84077

Ensembl transtripts involved in fusion geneENST00000498360, ENST00000445597, 
ENST00000366849, ENST00000366850, 
ENST00000400952, ENST00000430092, 
ENST00000366848, ENST00000439375, 
Fusion gene scores* DoF score8 X 6 X 4=1929 X 10 X 6=540
# samples 711
** MAII scorelog2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH14 [Title/Abstract] AND ARF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAH14(225117537)-ARF1(228284779), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-YD-A89C-06ADNAH14chr1

225117537

-ARF1chr1

228284779

+
ChimerDB4SKCMTCGA-YD-A89C-06ADNAH14chr1

225117537

+ARF1chr1

228284779

+


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Fusion Gene ORF analysis for DNAH14-ARF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000498360ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
3UTR-5UTRENST00000498360ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
3UTR-5UTRENST00000498360ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
3UTR-5UTRENST00000498360ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
5CDS-3UTRENST00000445597ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
5CDS-5UTRENST00000445597ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
5CDS-5UTRENST00000445597ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
5CDS-5UTRENST00000445597ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-3UTRENST00000366849ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-3UTRENST00000366850ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-3UTRENST00000400952ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-3UTRENST00000430092ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366849ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366849ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366849ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366850ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366850ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000366850ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000400952ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000400952ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000400952ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000430092ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000430092ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
5UTR-5UTRENST00000430092ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-3UTRENST00000366848ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-3UTRENST00000439375ENST00000478424DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000366848ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000366848ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000366848ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000439375ENST00000272102DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000439375ENST00000540651DNAH14chr1

225117537

+ARF1chr1

228284779

+
intron-5UTRENST00000439375ENST00000541182DNAH14chr1

225117537

+ARF1chr1

228284779

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNAH14-ARF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNAH14chr1225117537+ARF1chr1228284778+1.11E-070.9999999
DNAH14chr1225117537+ARF1chr1228284778+1.11E-070.9999999


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNAH14-ARF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:225117537/:228284779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARF1

P84077

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNAH14-ARF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNAH14-ARF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAH14-ARF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneARF1P84077DB09462GlycerinSmall moleculeApproved|Investigational

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Related Diseases for DNAH14-ARF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1868720Periventricular Nodular Heterotopia1ORPHANET
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4748602PERIVENTRICULAR NODULAR HETEROTOPIA 81UNIPROT