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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DNAH14-ARF1 (FusionGDB2 ID:HG127602TG375) |
Fusion Gene Summary for DNAH14-ARF1 |
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Fusion gene information | Fusion gene name: DNAH14-ARF1 | Fusion gene ID: hg127602tg375 | Hgene | Tgene | Gene symbol | DNAH14 | ARF1 | Gene ID | 127602 | 375 |
Gene name | dynein axonemal heavy chain 14 | ADP ribosylation factor 1 | |
Synonyms | C1orf67|Dnahc14|HL-18|HL18 | PVNH8 | |
Cytomap | ('DNAH14')('ARF1') 1q42.12 | 1q42.13 | |
Type of gene | protein-coding | protein-coding | |
Description | dynein heavy chain 14, axonemalaxonemal beta dynein heavy chain 14ciliary dynein heavy chain 14dynein, axonemal, heavy polypeptide 14 | ADP-ribosylation factor 1 | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | . | P84077 | |
Ensembl transtripts involved in fusion gene | ENST00000498360, ENST00000445597, ENST00000366849, ENST00000366850, ENST00000400952, ENST00000430092, ENST00000366848, ENST00000439375, | ||
Fusion gene scores | * DoF score | 8 X 6 X 4=192 | 9 X 10 X 6=540 |
# samples | 7 | 11 | |
** MAII score | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DNAH14 [Title/Abstract] AND ARF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DNAH14(225117537)-ARF1(228284779), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-YD-A89C-06A | DNAH14 | chr1 | 225117537 | - | ARF1 | chr1 | 228284779 | + |
ChimerDB4 | SKCM | TCGA-YD-A89C-06A | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
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Fusion Gene ORF analysis for DNAH14-ARF1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000498360 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
3UTR-5UTR | ENST00000498360 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
3UTR-5UTR | ENST00000498360 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
3UTR-5UTR | ENST00000498360 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5CDS-3UTR | ENST00000445597 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5CDS-5UTR | ENST00000445597 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5CDS-5UTR | ENST00000445597 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5CDS-5UTR | ENST00000445597 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-3UTR | ENST00000366849 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-3UTR | ENST00000366850 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-3UTR | ENST00000400952 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-3UTR | ENST00000430092 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366849 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366849 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366849 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366850 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366850 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000366850 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000400952 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000400952 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000400952 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000430092 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000430092 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
5UTR-5UTR | ENST00000430092 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-3UTR | ENST00000366848 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-3UTR | ENST00000439375 | ENST00000478424 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000366848 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000366848 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000366848 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000439375 | ENST00000272102 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000439375 | ENST00000540651 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
intron-5UTR | ENST00000439375 | ENST00000541182 | DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284779 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DNAH14-ARF1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284778 | + | 1.11E-07 | 0.9999999 |
DNAH14 | chr1 | 225117537 | + | ARF1 | chr1 | 228284778 | + | 1.11E-07 | 0.9999999 |
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Fusion Protein Features for DNAH14-ARF1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:225117537/:228284779) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | ARF1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DNAH14-ARF1 |
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Fusion Gene PPI Analysis for DNAH14-ARF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DNAH14-ARF1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ARF1 | P84077 | DB09462 | Glycerin | Small molecule | Approved|Investigational |
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Related Diseases for DNAH14-ARF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1868720 | Periventricular Nodular Heterotopia | 1 | ORPHANET | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human | |
Tgene | C4748602 | PERIVENTRICULAR NODULAR HETEROTOPIA 8 | 1 | UNIPROT |