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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COL4A1-ZNF675 (FusionGDB2 ID:HG1282TG171392)

Fusion Gene Summary for COL4A1-ZNF675

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A1-ZNF675
Fusion gene ID: hg1282tg171392
HgeneTgene
Gene symbol

COL4A1

ZNF675

Gene ID

1282

171392

Gene namecollagen type IV alpha 1 chainzinc finger protein 675
SynonymsBSVD|BSVD1|PADMAL|RATORTBZF|TIZ
Cytomap('COL4A1')('ZNF675')

13q34

19p12

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(IV) chainCOL4A1 NC1 domainarrestencollagen IV, alpha-1 polypeptidecollagen of basement membrane, alpha-1 chainzinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein
Modification date2020031320200313
UniProtAcc

P02462

.
Ensembl transtripts involved in fusion geneENST00000375820, ENST00000543140, 
ENST00000467182, 
Fusion gene scores* DoF score13 X 15 X 8=15605 X 5 X 4=100
# samples 155
** MAII scorelog2(15/1560*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL4A1 [Title/Abstract] AND ZNF675 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOL4A1(110959291)-ZNF675(23845960), # samples:2
Anticipated loss of major functional domain due to fusion event.COL4A1-ZNF675 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-ZNF675 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-ZNF675 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-ZNF675 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF675

GO:0000122

negative regulation of transcription by RNA polymerase II

11751921

TgeneZNF675

GO:0007249

I-kappaB kinase/NF-kappaB signaling

11751921

TgeneZNF675

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

11751921

TgeneZNF675

GO:0019221

cytokine-mediated signaling pathway

11751921

TgeneZNF675

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11751921

TgeneZNF675

GO:0043508

negative regulation of JUN kinase activity

11751921

TgeneZNF675

GO:0045671

negative regulation of osteoclast differentiation

11751921|11851921

TgeneZNF675

GO:0046329

negative regulation of JNK cascade

11751921

TgeneZNF675

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

11751921

TgeneZNF675

GO:2000678

negative regulation of transcription regulatory region DNA binding

11751921


check buttonFusion gene breakpoints across COL4A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF675 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-2J-AABP-01ACOL4A1chr13

110959291

-ZNF675chr19

23845960

-


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Fusion Gene ORF analysis for COL4A1-ZNF675

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375820ENST00000359788COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000375820ENST00000596211COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000375820ENST00000599168COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000375820ENST00000600313COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000375820ENST00000601010COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000375820ENST00000601935COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000359788COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000596211COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000599168COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000600313COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000601010COL4A1chr13

110959291

-ZNF675chr19

23845960

-
In-frameENST00000543140ENST00000601935COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000359788COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000596211COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000599168COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000600313COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000601010COL4A1chr13

110959291

-ZNF675chr19

23845960

-
intron-3CDSENST00000467182ENST00000601935COL4A1chr13

110959291

-ZNF675chr19

23845960

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375820COL4A1chr13110959291-ENST00000601935ZNF675chr1923845960-148320662556164
ENST00000375820COL4A1chr13110959291-ENST00000600313ZNF675chr1923845960-56720662559165
ENST00000375820COL4A1chr13110959291-ENST00000596211ZNF675chr1923845960-60520662442126
ENST00000375820COL4A1chr13110959291-ENST00000359788ZNF675chr1923845960-2335206621909615
ENST00000375820COL4A1chr13110959291-ENST00000601010ZNF675chr1923845960-71720662508148
ENST00000375820COL4A1chr13110959291-ENST00000599168ZNF675chr1923845960-60820662436124
ENST00000543140COL4A1chr13110959291-ENST00000601935ZNF675chr1923845960-146518844538164
ENST00000543140COL4A1chr13110959291-ENST00000600313ZNF675chr1923845960-54918844541165
ENST00000543140COL4A1chr13110959291-ENST00000596211ZNF675chr1923845960-58718844424126
ENST00000543140COL4A1chr13110959291-ENST00000359788ZNF675chr1923845960-2317188441891615
ENST00000543140COL4A1chr13110959291-ENST00000601010ZNF675chr1923845960-69918844490148
ENST00000543140COL4A1chr13110959291-ENST00000599168ZNF675chr1923845960-59018844418124

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375820ENST00000601935COL4A1chr13110959291-ZNF675chr1923845960-0.005727490.9942726
ENST00000375820ENST00000600313COL4A1chr13110959291-ZNF675chr1923845960-0.0153806860.9846193
ENST00000375820ENST00000596211COL4A1chr13110959291-ZNF675chr1923845960-0.017518240.9824818
ENST00000375820ENST00000359788COL4A1chr13110959291-ZNF675chr1923845960-0.0036357350.9963643
ENST00000375820ENST00000601010COL4A1chr13110959291-ZNF675chr1923845960-0.014882450.98511755
ENST00000375820ENST00000599168COL4A1chr13110959291-ZNF675chr1923845960-0.0349576030.9650424
ENST00000543140ENST00000601935COL4A1chr13110959291-ZNF675chr1923845960-0.0053740670.99462587
ENST00000543140ENST00000600313COL4A1chr13110959291-ZNF675chr1923845960-0.0132847720.98671526
ENST00000543140ENST00000596211COL4A1chr13110959291-ZNF675chr1923845960-0.0113738850.98862606
ENST00000543140ENST00000359788COL4A1chr13110959291-ZNF675chr1923845960-0.0038247040.9961753
ENST00000543140ENST00000601010COL4A1chr13110959291-ZNF675chr1923845960-0.0126268530.9873732
ENST00000543140ENST00000599168COL4A1chr13110959291-ZNF675chr1923845960-0.0232332350.97676677

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Fusion Genomic Features for COL4A1-ZNF675


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for COL4A1-ZNF675


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:110959291/chr19:23845960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A1

P02462

.
FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000250|UniProtKB:P02463}.; FUNCTION: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:18775695}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF675chr13:110959291chr19:23845960ENST00000359788044_751569.0DomainKRAB
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804144_1661569.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804172_1941569.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804200_2221569.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804228_2501569.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804256_2781569.0Zinc fingerC2H2-type 5
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804284_3061569.0Zinc fingerC2H2-type 6
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804312_3341569.0Zinc fingerC2H2-type 7
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804340_3621569.0Zinc fingerC2H2-type 8
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804368_3901569.0Zinc fingerC2H2-type 9
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804396_4181569.0Zinc fingerC2H2-type 10
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804424_4461569.0Zinc fingerC2H2-type 11
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804452_4741569.0Zinc fingerC2H2-type 12
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804480_5021569.0Zinc fingerC2H2-type 13
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804508_5301569.0Zinc fingerC2H2-type 14
TgeneZNF675chr13:110959291chr19:23845960ENST0000035978804536_5581569.0Zinc fingerC2H2-type 15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A1chr13:110959291chr19:23845960ENST00000375820-1521445_1669281670.0DomainCollagen IV NC1
HgeneCOL4A1chr13:110959291chr19:23845960ENST00000375820-152173_1440281670.0RegionNote=Triple-helical region


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Fusion Gene Sequence for COL4A1-ZNF675


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18347_18347_1_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000359788_length(transcript)=2335nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGTAATGTGTTCTCATTTTGCCC
AAGAGTTTTGGCCAGAGCAGAACATAAAAGATTCTTTTGAAAAAGTGACACTGAGAAGATATGAAAAATGTGGAAATGATAATTTTCAGT
TAAAAGGCTGTAAAAGTGTGGATGAATGTAAGTTGCACAAGGGAGGTTATAATGGACTTAACCAATGTTTACCAACTATGCAGAGCAAAA
TGTTTCAATGTGATAAATATGTGAAAGTCTTTAATAAATTTTCACATTCAGATAGACATAAGATAAAACATATGGAAAATAAACCTTTCA
AATGTAAAGAATGTGGCAGATCATTTTGCATGCTTTCACACCTAACTCGACATGAAAGAAATTATACCAAGGTGAATTTCTGCAAATGTG
AAGAATGTGAAAAAGCTGTTAACCAATCTTCAAAGCTTACTAAACATAAAAGAATTTATACTTGTGAGAAACTCTACAAATGTCAAGAAT
GTGACAGAACTTTTAACCAATTCTCAAACCTTACTGAATATAAAAAAGATTATGCTCGAGAGAAACCATACAAATGTGAAGAATGTGGCA
AAGCCTTTAACCAGTCCTCACACCTTACTACACATAAGATAATTCATACAGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCT
TTAACCAGTTCTCAAATCTTACTACACATAAAAAAATTCATACTGGAGAGCAACCCTACATATGTGAAGAATGTGGCAAGGCTTTTACCC
AATCCTCAACCCTTACTACACATAAGAGAATTCATACTGGAGAAAAACCCTACAAATGTGAAGAATGTGGAAAAGCTTTTAACCGATCCT
CAAAACTTACTGAACATAAAAACATTCATACTGGAGAGCAACCCTACAAATGTGAGGAATGCGGCAAAGCTTTTAACCGATCCTCAAATC
TTACGGAACATAGGAAAATTCATACCGAAGAGAAACCCTACAAATGTAAAGAATGTGGCAAAGCTTTTAAACACTCCTCAGCCCTTACTA
CACATAAGAGAATTCACACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCGATCCTCAAAACTTACTGAACATA
AGAAACTTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTATCCAATCCTCAAAACTTACTGAACATAAGAAAA
TTCATTCTGGAGAGATACCCTACAAGTGTGAAGAATGTGGCAAAGCTTTTAAACACTCCTCATCCCTTACTACACATAAAAGAATTCATA
CTGGGGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCGATCCTCAAAACTTACTGAACATAAGATAATTCATACTGGAG
AGAAACCCTATAAATGTGAGAGATGTGACAAAGCTTTTAACCAATCTGCAAACCTTACTAAACATAAAAAAATACATACTGGAGAGAAAC
TACAGAACTGGAATGTGTGATAATGATTTTGACAACACCTCAAATTTTTCTAAATATAAAGGAAATCATACTGGTGAAAAATTCTAGAAA
TGTAAAGAATGTGTCAAAGACTTTAAATGGTTTTCACACTTCATTGTATGTAAGATAATTCATACTGGAGAAAACTACAAGTGTGAAGAA
TTTGGCAATACTGTTAATTAAGGCTCAAACCTTATTGCACAGGAAAGCGTTTATACTTAAGAAAAATTGTACAAATATAAAGAGTGTAAA
ATAGCCATTAATATCTGTTGACATCTTAATATCAGAATGTTGGTACTTAATAAAAGCATTATAAATGCAATTACTGTCTAAAGACTTTAA
GAAAATATAAGCCTTTAAAGTGAAGAAGAGTATTCGTTTTGAAGACAAAGATTACAAACATAAAGAGGGTTGTAGTACATTTACT

>18347_18347_1_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000359788_length(amino acids)=615AA_BP=50
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGLN
QCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYT
CEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYI
CEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGK
AFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSS
SLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIHTGEKLQNWNV

--------------------------------------------------------------
>18347_18347_2_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000596211_length(transcript)=605nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGCCAAAAGCAATAGCCGATTT
GGATACCATCAAGACACCTGAAACCTTATCATGAGCCAGATGCCAAGGAAGAGACTCTGGGAGGATCCCAAGGACCCCCTGGTTGCAGCC
ATGTCAAGACTGACACTGAGAAGGACCCCAACTGTCATGAGCAACACCCATTGAACACAGCCACC

>18347_18347_2_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000596211_length(amino acids)=126AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGQKQ

--------------------------------------------------------------
>18347_18347_3_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000599168_length(transcript)=608nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGTAAGTGAGAATGAAAGTGAA
TACAACAGGTGACACTGATGAGAGGTCCAAAGGTCAAAGAGAAAGCCAGTCCTTAAAATGTGATTTGGGAAGCCGTGTTTTAAAGGAAAT
AATTTCTGGAAAGCCTGAGTATTTTATGCTCTCACATTTGAGCATTTTCTGTCTTATGCTTTTAAATT

>18347_18347_3_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000599168_length(amino acids)=124AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGK

--------------------------------------------------------------
>18347_18347_4_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000600313_length(transcript)=567nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGTCTCCCTCTGATGCCGAGCC
GAAGCTGGACTGTACTGCTGCCATCTCTGCTCACTGCAACCTCCCTGCCTGATTCTCCTGCCTCAGCCTGCCGAGTGCCTGCGATTGCAG
GTGCGCGCAGCCATGCCTGACTGGTTT

>18347_18347_4_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000600313_length(amino acids)=165AA_BP=50
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGLPLMPSRSWTVLLPSLLTATSLPDSPASACRVPAIAGARSHA

--------------------------------------------------------------
>18347_18347_5_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000601010_length(transcript)=717nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGAGTCTCGCCCTGTCGTCCAGC
CTGAAGTTCAGTGGTACAATCTCTGCTTACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGG
ACTATAGGCACATGCCACCATGCCTGACTAATTTTTGTACTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTTGAACTC
CTGACCTCGTGATCCATCTTCCTTGGCCTCCCAAAGTTCTGGTACAGGTGTGAGCCACAGAGCCTGGCCCAAAATTGTCTTTGTTTT

>18347_18347_5_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000601010_length(amino acids)=148AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPESRPVVQPEVQWYNLCLLQPPPPRFK

--------------------------------------------------------------
>18347_18347_6_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000601935_length(transcript)=1483nt_BP=206nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACA
CTGCACAGCGGAATTTATATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGA
TCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGATCTGTGGGACAGACCCAGC
AGGTGGTGCCCCATGTAAGAAGCAATGAAATGCATCATGATGGAACCCTCAAAAACGAAAGTGAAGTTACTGCACACCCCTTAGGTCCTC
TTTGGATTCCAGCATGATGCATCAAACCTTACCACGGCATGACTAGGGCCCAACCTGCTACCAGAAATAAAGGAAATGACGATGCAGAAC
CCACAACCCTGGATGATGTGGCTTCCTTGGATGACACAGGCCCCAGACATTACCTGGGGAATGCTGAAGAACACAACTCAGGAGGCTGAA
CAAATCTGCTTCAGACACAGATACCATTCAATCCATATAATTTGTTCTTTGCTATGCTTTTTATTCCACATTGCAACTCTTATAGAATAC
TGATTCTTCTTATTCTCTCTTTTTGCCTGCAACCCACACCTGCTATAAACTATTGGGCCCATCTTCTAGATCTGCCTTTCTTACGGCATT
TTACTTGGGAAGGTACCCCCTTCTCAGCCTCTGACAACGTGACCAATTGGCTGGGAGGTATTGACTTACCCCCGGTGGGGTCCCTCAGTA
ATGGCACACATTGGACTCAGGTGCCAAGTAACATTACATATCAATCCTTGATTGGAAAAGAATAATATTGATTATACTCATGTTTGTCTT
ATGTTATTTACTGGTTCTAGGGTGCAAAGCTGGAACACAAACTGTAACCATTGCACCAGTCAAACCTGTCGCTGCTCAGATCTGTATGCT
TCAATCAACAAAACCTGATGCAAAAAAACAGAAAAAGGGGAGATGTGGGAGATTGGTCAGAGTGGTGGAAAAAGGATAGGGAAAGAACGC
AAATTTTCTGAAATGTTGGAAGGTCCTGCAGAGCTCCAGGGGAGAATAGCTGAAGGCAGCTGTTCTATAACCCTGAGGCAGAGAGCAAGC
AGTAGGTACAAGGGAGTGTGGAAGAATTTATCTTAAACAGGCTTATTTACTTATGTTGATCAGGAACTGACCTTTGATCATTTGCGTGTG
TGACATTCCCTGAAAGGGGAACAATAAATGTTAATTACCTGCA

>18347_18347_6_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000375820_ZNF675_chr19_23845960_ENST00000601935_length(amino acids)=164AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGSVGQTQQVVPHVRSNEMHHDGTLKNESEVTAHPLGPLWIPA

--------------------------------------------------------------
>18347_18347_7_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000359788_length(transcript)=2317nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGTAATGTGTTCTCATTTTGCCCAAGAGTTTTGGCCAGAGC
AGAACATAAAAGATTCTTTTGAAAAAGTGACACTGAGAAGATATGAAAAATGTGGAAATGATAATTTTCAGTTAAAAGGCTGTAAAAGTG
TGGATGAATGTAAGTTGCACAAGGGAGGTTATAATGGACTTAACCAATGTTTACCAACTATGCAGAGCAAAATGTTTCAATGTGATAAAT
ATGTGAAAGTCTTTAATAAATTTTCACATTCAGATAGACATAAGATAAAACATATGGAAAATAAACCTTTCAAATGTAAAGAATGTGGCA
GATCATTTTGCATGCTTTCACACCTAACTCGACATGAAAGAAATTATACCAAGGTGAATTTCTGCAAATGTGAAGAATGTGAAAAAGCTG
TTAACCAATCTTCAAAGCTTACTAAACATAAAAGAATTTATACTTGTGAGAAACTCTACAAATGTCAAGAATGTGACAGAACTTTTAACC
AATTCTCAAACCTTACTGAATATAAAAAAGATTATGCTCGAGAGAAACCATACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTCCT
CACACCTTACTACACATAAGATAATTCATACAGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTTCTCAAATC
TTACTACACATAAAAAAATTCATACTGGAGAGCAACCCTACATATGTGAAGAATGTGGCAAGGCTTTTACCCAATCCTCAACCCTTACTA
CACATAAGAGAATTCATACTGGAGAAAAACCCTACAAATGTGAAGAATGTGGAAAAGCTTTTAACCGATCCTCAAAACTTACTGAACATA
AAAACATTCATACTGGAGAGCAACCCTACAAATGTGAGGAATGCGGCAAAGCTTTTAACCGATCCTCAAATCTTACGGAACATAGGAAAA
TTCATACCGAAGAGAAACCCTACAAATGTAAAGAATGTGGCAAAGCTTTTAAACACTCCTCAGCCCTTACTACACATAAGAGAATTCACA
CTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCGATCCTCAAAACTTACTGAACATAAGAAACTTCATACTGGAA
AGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTATCCAATCCTCAAAACTTACTGAACATAAGAAAATTCATTCTGGAGAGATAC
CCTACAAGTGTGAAGAATGTGGCAAAGCTTTTAAACACTCCTCATCCCTTACTACACATAAAAGAATTCATACTGGGGAGAAACCCTACA
AATGTGAAGAATGTGGCAAAGCTTTTAGCCGATCCTCAAAACTTACTGAACATAAGATAATTCATACTGGAGAGAAACCCTATAAATGTG
AGAGATGTGACAAAGCTTTTAACCAATCTGCAAACCTTACTAAACATAAAAAAATACATACTGGAGAGAAACTACAGAACTGGAATGTGT
GATAATGATTTTGACAACACCTCAAATTTTTCTAAATATAAAGGAAATCATACTGGTGAAAAATTCTAGAAATGTAAAGAATGTGTCAAA
GACTTTAAATGGTTTTCACACTTCATTGTATGTAAGATAATTCATACTGGAGAAAACTACAAGTGTGAAGAATTTGGCAATACTGTTAAT
TAAGGCTCAAACCTTATTGCACAGGAAAGCGTTTATACTTAAGAAAAATTGTACAAATATAAAGAGTGTAAAATAGCCATTAATATCTGT
TGACATCTTAATATCAGAATGTTGGTACTTAATAAAAGCATTATAAATGCAATTACTGTCTAAAGACTTTAAGAAAATATAAGCCTTTAA
AGTGAAGAAGAGTATTCGTTTTGAAGACAAAGATTACAAACATAAAGAGGGTTGTAGTACATTTACT

>18347_18347_7_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000359788_length(amino acids)=615AA_BP=50
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGLN
QCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYT
CEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYI
CEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGK
AFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSS
SLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIHTGEKLQNWNV

--------------------------------------------------------------
>18347_18347_8_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000596211_length(transcript)=587nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGCCAAAAGCAATAGCCGATTTGGATACCATCAAGACACC
TGAAACCTTATCATGAGCCAGATGCCAAGGAAGAGACTCTGGGAGGATCCCAAGGACCCCCTGGTTGCAGCCATGTCAAGACTGACACTG
AGAAGGACCCCAACTGTCATGAGCAACACCCATTGAACACAGCCACC

>18347_18347_8_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000596211_length(amino acids)=126AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGQKQ

--------------------------------------------------------------
>18347_18347_9_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000599168_length(transcript)=590nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGTAAGTGAGAATGAAAGTGAATACAACAGGTGACACTGA
TGAGAGGTCCAAAGGTCAAAGAGAAAGCCAGTCCTTAAAATGTGATTTGGGAAGCCGTGTTTTAAAGGAAATAATTTCTGGAAAGCCTGA
GTATTTTATGCTCTCACATTTGAGCATTTTCTGTCTTATGCTTTTAAATT

>18347_18347_9_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000599168_length(amino acids)=124AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGK

--------------------------------------------------------------
>18347_18347_10_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000600313_length(transcript)=549nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGTCTCCCTCTGATGCCGAGCCGAAGCTGGACTGTACTGC
TGCCATCTCTGCTCACTGCAACCTCCCTGCCTGATTCTCCTGCCTCAGCCTGCCGAGTGCCTGCGATTGCAGGTGCGCGCAGCCATGCCT
GACTGGTTT

>18347_18347_10_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000600313_length(amino acids)=165AA_BP=50
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGLPLMPSRSWTVLLPSLLTATSLPDSPASACRVPAIAGARSHA

--------------------------------------------------------------
>18347_18347_11_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000601010_length(transcript)=699nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGAGTCTCGCCCTGTCGTCCAGCCTGAAGTTCAGTGGTACA
ATCTCTGCTTACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACTATAGGCACATGCCAC
CATGCCTGACTAATTTTTGTACTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTTGAACTCCTGACCTCGTGATCCATC
TTCCTTGGCCTCCCAAAGTTCTGGTACAGGTGTGAGCCACAGAGCCTGGCCCAAAATTGTCTTTGTTTT

>18347_18347_11_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000601010_length(amino acids)=148AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPESRPVVQPEVQWYNLCLLQPPPPRFK

--------------------------------------------------------------
>18347_18347_12_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000601935_length(transcript)=1465nt_BP=188nt
CGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGGCAGCCGTCCCTCGCCGCC
TCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACGAGGAGCACAGCCGGGCCG
CTGCGAAGGGACTGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTAT
ATAAAAATGTGATTTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAG
AAAAAGAGCCTTTGACTGTGAAGAGACATGAGATGGTGAATGAACCCCCAGGATCTGTGGGACAGACCCAGCAGGTGGTGCCCCATGTAA
GAAGCAATGAAATGCATCATGATGGAACCCTCAAAAACGAAAGTGAAGTTACTGCACACCCCTTAGGTCCTCTTTGGATTCCAGCATGAT
GCATCAAACCTTACCACGGCATGACTAGGGCCCAACCTGCTACCAGAAATAAAGGAAATGACGATGCAGAACCCACAACCCTGGATGATG
TGGCTTCCTTGGATGACACAGGCCCCAGACATTACCTGGGGAATGCTGAAGAACACAACTCAGGAGGCTGAACAAATCTGCTTCAGACAC
AGATACCATTCAATCCATATAATTTGTTCTTTGCTATGCTTTTTATTCCACATTGCAACTCTTATAGAATACTGATTCTTCTTATTCTCT
CTTTTTGCCTGCAACCCACACCTGCTATAAACTATTGGGCCCATCTTCTAGATCTGCCTTTCTTACGGCATTTTACTTGGGAAGGTACCC
CCTTCTCAGCCTCTGACAACGTGACCAATTGGCTGGGAGGTATTGACTTACCCCCGGTGGGGTCCCTCAGTAATGGCACACATTGGACTC
AGGTGCCAAGTAACATTACATATCAATCCTTGATTGGAAAAGAATAATATTGATTATACTCATGTTTGTCTTATGTTATTTACTGGTTCT
AGGGTGCAAAGCTGGAACACAAACTGTAACCATTGCACCAGTCAAACCTGTCGCTGCTCAGATCTGTATGCTTCAATCAACAAAACCTGA
TGCAAAAAAACAGAAAAAGGGGAGATGTGGGAGATTGGTCAGAGTGGTGGAAAAAGGATAGGGAAAGAACGCAAATTTTCTGAAATGTTG
GAAGGTCCTGCAGAGCTCCAGGGGAGAATAGCTGAAGGCAGCTGTTCTATAACCCTGAGGCAGAGAGCAAGCAGTAGGTACAAGGGAGTG
TGGAAGAATTTATCTTAAACAGGCTTATTTACTTATGTTGATCAGGAACTGACCTTTGATCATTTGCGTGTGTGACATTCCCTGAAAGGG
GAACAATAAATGTTAATTACCTGCA

>18347_18347_12_COL4A1-ZNF675_COL4A1_chr13_110959291_ENST00000543140_ZNF675_chr19_23845960_ENST00000601935_length(amino acids)=164AA_BP=48
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL
GIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPGSVGQTQQVVPHVRSNEMHHDGTLKNESEVTAHPLGPLWIPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COL4A1-ZNF675


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COL4A1-ZNF675


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COL4A1-ZNF675


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A1C4551998Porencephaly, Type 1, Autosomal Dominant18CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCOL4A1C2673195Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCOL4A1C1843512BRAIN SMALL VESSEL DISEASE WITH HEMORRHAGE4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneCOL4A1C0018965Hematuria3GENOMICS_ENGLAND
HgeneCOL4A1C0266548Axenfeld anomaly (disorder)3CTD_human;GENOMICS_ENGLAND
HgeneCOL4A1C1860475Retinal vascular tortuosity3GENOMICS_ENGLAND
HgeneCOL4A1C0011881Diabetic Nephropathy2CTD_human
HgeneCOL4A1C0017667Nodular glomerulosclerosis2CTD_human
HgeneCOL4A1C0017668Focal glomerulosclerosis2CTD_human
HgeneCOL4A1C0086432Hyalinosis, Segmental Glomerular2CTD_human
HgeneCOL4A1C0265341Rieger syndrome2CTD_human
HgeneCOL4A1C0266484Schizencephaly2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCOL4A1C0302892Congenital porencephaly2CTD_human
HgeneCOL4A1C1280768Axenfeld syndrome2CTD_human
HgeneCOL4A1C1867983PORENCEPHALY, FAMILIAL2CTD_human;ORPHANET
HgeneCOL4A1C2675650Brain Small Vessel Disease With Axenfeld-Rieger Anomaly2CTD_human
HgeneCOL4A1C2678503AXENFELD-RIEGER SYNDROME, TYPE 32CTD_human
HgeneCOL4A1C3281105HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO2GENOMICS_ENGLAND;UNIPROT
HgeneCOL4A1C3495488Axenfeld-Rieger syndrome2CTD_human
HgeneCOL4A1C3698507Post-traumatic Porencephaly2CTD_human
HgeneCOL4A1C3714873Axenfeld-Rieger Syndrome, Type 12CTD_human
HgeneCOL4A1C4082173Porencephaly2CTD_human
HgeneCOL4A1C4082301Developmental Porencephaly2CTD_human
HgeneCOL4A1C0002878Anemia, Hemolytic1CTD_human
HgeneCOL4A1C0002879Anemia, Hemolytic, Acquired1CTD_human
HgeneCOL4A1C0002889Anemia, Microangiopathic1CTD_human
HgeneCOL4A1C0015393Eye Abnormalities1CTD_human
HgeneCOL4A1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCOL4A1C0026848Myopathy1GENOMICS_ENGLAND
HgeneCOL4A1C0027726Nephrotic Syndrome1CTD_human
HgeneCOL4A1C0036572Seizures1GENOMICS_ENGLAND
HgeneCOL4A1C0038454Cerebrovascular accident1GENOMICS_ENGLAND
HgeneCOL4A1C0149931Migraine Disorders1GENOMICS_ENGLAND
HgeneCOL4A1C0221021Microangiopathic hemolytic anemia1CTD_human
HgeneCOL4A1C0265221Walker-Warburg congenital muscular dystrophy1ORPHANET
HgeneCOL4A1C0270612Leukoencephalopathy1CTD_human
HgeneCOL4A1C0338656Impaired cognition1GENOMICS_ENGLAND
HgeneCOL4A1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
HgeneCOL4A1C0497327Dementia1GENOMICS_ENGLAND
HgeneCOL4A1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneCOL4A1C1135196Heart Failure, Diastolic1CTD_human
HgeneCOL4A1C1858991Childhood Ataxia with Central Nervous System Hypomyelinization1CTD_human
HgeneCOL4A1C1867327RETINAL ARTERIES, TORTUOSITY OF1CTD_human;ORPHANET;UNIPROT
HgeneCOL4A1C2733158Cerebral Small Vessel Diseases1GENOMICS_ENGLAND
HgeneCOL4A1C2930808Familial vascular leukoencephalopathy1ORPHANET
HgeneCOL4A1C2931870Familial schizencephaly1ORPHANET
HgeneCOL4A1C4013035BRAIN SMALL VESSEL DISEASE WITH OR WITHOUT OCULAR ANOMALIES1GENOMICS_ENGLAND