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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COL4A2-NUBPL (FusionGDB2 ID:HG1284TG80224)

Fusion Gene Summary for COL4A2-NUBPL

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A2-NUBPL
Fusion gene ID: hg1284tg80224
HgeneTgene
Gene symbol

COL4A2

NUBPL

Gene ID

1284

80224

Gene namecollagen type IV alpha 2 chainnucleotide binding protein like
SynonymsBSVD2|ICH|POREN2C14orf127|IND1|MC1DN21|huInd1
Cytomap('COL4A2')('NUBPL')

13q34

14q12

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-2(IV) chaincanstatiniron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase
Modification date2020031320200313
UniProtAcc

P08572

.
Ensembl transtripts involved in fusion geneENST00000360467, ENST00000462309, 
Fusion gene scores* DoF score15 X 13 X 10=195017 X 14 X 7=1666
# samples 1717
** MAII scorelog2(17/1950*10)=-3.51986747249927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1666*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL4A2 [Title/Abstract] AND NUBPL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOL4A2(110960470)-NUBPL(32068495), # samples:1
Anticipated loss of major functional domain due to fusion event.COL4A2-NUBPL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A2-NUBPL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOL4A2

GO:0016525

negative regulation of angiogenesis

10625665


check buttonFusion gene breakpoints across COL4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NUBPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A48G-01ACOL4A2chr13

110960470

-NUBPLchr14

32068495

+


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Fusion Gene ORF analysis for COL4A2-NUBPL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360467ENST00000418681COL4A2chr13

110960470

-NUBPLchr14

32068495

+
In-frameENST00000360467ENST00000281081COL4A2chr13

110960470

-NUBPLchr14

32068495

+
In-frameENST00000360467ENST00000536705COL4A2chr13

110960470

-NUBPLchr14

32068495

+
intron-3CDSENST00000462309ENST00000281081COL4A2chr13

110960470

-NUBPLchr14

32068495

+
intron-3CDSENST00000462309ENST00000536705COL4A2chr13

110960470

-NUBPLchr14

32068495

+
intron-intronENST00000462309ENST00000418681COL4A2chr13

110960470

-NUBPLchr14

32068495

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360467COL4A2chr13110960470-ENST00000281081NUBPLchr1432068495+31184052731073266
ENST00000360467COL4A2chr13110960470-ENST00000536705NUBPLchr1432068495+30874052731073266

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360467ENST00000281081COL4A2chr13110960470-NUBPLchr1432068495+0.0004929370.99950707
ENST00000360467ENST00000536705COL4A2chr13110960470-NUBPLchr1432068495+0.0004727550.9995272

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Fusion Genomic Features for COL4A2-NUBPL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for COL4A2-NUBPL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:110960470/chr14:32068495)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A2

P08572

.
FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A2chr13:110960470chr14:32068495ENST00000360467-3481489_1712331713.0DomainCollagen IV NC1
HgeneCOL4A2chr13:110960470chr14:32068495ENST00000360467-348184_1484331713.0RegionNote=Triple-helical region
TgeneNUBPLchr13:110960470chr14:32068495ENST0000028108121175_8297320.0Nucleotide bindingATP


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Fusion Gene Sequence for COL4A2-NUBPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18359_18359_1_COL4A2-NUBPL_COL4A2_chr13_110960470_ENST00000360467_NUBPL_chr14_32068495_ENST00000281081_length(transcript)=3118nt_BP=405nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCA
GTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATG
TCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTA
GATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACA
GGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTC
CTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTA
GCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTT
TCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCC
AAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAAT
CATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTG
CTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAG
TTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGT
GTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATA
TGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTT
AGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCT
TCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGC
TGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCT
TTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCAT
GAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATG
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTG
CACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTC
CTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAA
AACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACT
GATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTG
TCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATG
TGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAA
TAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTA
CCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTG
AGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGT
ATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTC
AACTGCATGTAAATCTACAATTATCTCAAAATAAAAATAAAAGTTAAAAAAACACAAA

>18359_18359_1_COL4A2-NUBPL_COL4A2_chr13_110960470_ENST00000360467_NUBPL_chr14_32068495_ENST00000281081_length(amino acids)=266AA_BP=42
MTGAQSGRTASMGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLASKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMS
MGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVL
GLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSPSE

--------------------------------------------------------------
>18359_18359_2_COL4A2-NUBPL_COL4A2_chr13_110960470_ENST00000360467_NUBPL_chr14_32068495_ENST00000536705_length(transcript)=3087nt_BP=405nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCA
GTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATG
TCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTA
GATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACA
GGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTC
CTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTA
GCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTT
TCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCC
AAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAAT
CATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTG
CTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAG
TTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGT
GTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATA
TGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTT
AGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCT
TCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGC
TGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCT
TTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCAT
GAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATG
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTG
CACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTC
CTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAA
AACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACT
GATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTG
TCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATG
TGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAA
TAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTA
CCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTG
AGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGT
ATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTC
AACTGCATGTAAATCTACAATTATCTC

>18359_18359_2_COL4A2-NUBPL_COL4A2_chr13_110960470_ENST00000360467_NUBPL_chr14_32068495_ENST00000536705_length(amino acids)=266AA_BP=42
MTGAQSGRTASMGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLASKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMS
MGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVL
GLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSPSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COL4A2-NUBPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COL4A2-NUBPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COL4A2-NUBPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A2C3280970PORENCEPHALY 24GENOMICS_ENGLAND;UNIPROT
HgeneCOL4A2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCOL4A2C0027726Nephrotic Syndrome1CTD_human
HgeneCOL4A2C0149925Small cell carcinoma of lung1CTD_human
HgeneCOL4A2C3281105HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO1GENOMICS_ENGLAND
HgeneCOL4A2C4082173Porencephaly1CTD_human;GENOMICS_ENGLAND
TgeneC1838979MITOCHONDRIAL COMPLEX I DEFICIENCY4GENOMICS_ENGLAND;ORPHANET
TgeneC0751651Mitochondrial Diseases2CTD_human;GENOMICS_ENGLAND
TgeneC4748792MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 212GENOMICS_ENGLAND;UNIPROT
TgeneC0949855Electron Transport Chain Deficiencies, Mitochondrial1CTD_human
TgeneC0949856Oxidative Phosphorylation Deficiencies1CTD_human
TgeneC0949857Mitochondrial Respiratory Chain Deficiencies1CTD_human