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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC148-WDSUB1 (FusionGDB2 ID:HG130940TG151525)

Fusion Gene Summary for CCDC148-WDSUB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC148-WDSUB1
Fusion gene ID: hg130940tg151525
HgeneTgene
Gene symbol

CCDC148

WDSUB1

Gene ID

130940

151525

Gene namecoiled-coil domain containing 148WD repeat, sterile alpha motif and U-box domain containing 1
Synonyms-UBOX6|WDSAM1
Cytomap('CCDC148')('WDSUB1')

2q24.1

2q24.2

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 148WD repeat, SAM and U-box domain-containing protein 1
Modification date2020031320200313
UniProtAcc

Q8NFR7

.
Ensembl transtripts involved in fusion geneENST00000283233, ENST00000409187, 
ENST00000536771, ENST00000409889, 
ENST00000491563, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 3=27
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC148 [Title/Abstract] AND WDSUB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC148(159165945)-WDSUB1(160092701), # samples:2
Anticipated loss of major functional domain due to fusion event.CCDC148-WDSUB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC148-WDSUB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC148-WDSUB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC148-WDSUB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCDC148 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WDSUB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HO-01ACCDC148chr2

159165945

-WDSUB1chr2

160092701

-


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Fusion Gene ORF analysis for CCDC148-WDSUB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000283233ENST00000358147CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000283233ENST00000359774CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000283233ENST00000409990CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000409187ENST00000358147CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000409187ENST00000359774CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000409187ENST00000392796CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000409187ENST00000409124CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000409187ENST00000409990CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000536771ENST00000358147CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000536771ENST00000359774CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
Frame-shiftENST00000536771ENST00000409990CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
In-frameENST00000283233ENST00000392796CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
In-frameENST00000283233ENST00000409124CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
In-frameENST00000536771ENST00000392796CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
In-frameENST00000536771ENST00000409124CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000409889ENST00000358147CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000409889ENST00000359774CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000409889ENST00000392796CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000409889ENST00000409124CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000409889ENST00000409990CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000491563ENST00000358147CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000491563ENST00000359774CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000491563ENST00000392796CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000491563ENST00000409124CCDC148chr2

159165945

-WDSUB1chr2

160092701

-
intron-3CDSENST00000491563ENST00000409990CCDC148chr2

159165945

-WDSUB1chr2

160092701

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283233CCDC148chr2159165945-ENST00000392796WDSUB1chr2160092701-181414242871492401
ENST00000283233CCDC148chr2159165945-ENST00000409124WDSUB1chr2160092701-178114242871492401
ENST00000536771CCDC148chr2159165945-ENST00000392796WDSUB1chr2160092701-158811983461266306
ENST00000536771CCDC148chr2159165945-ENST00000409124WDSUB1chr2160092701-155511983461266306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283233ENST00000392796CCDC148chr2159165945-WDSUB1chr2160092701-0.0008848530.99911517
ENST00000283233ENST00000409124CCDC148chr2159165945-WDSUB1chr2160092701-0.0008879890.99911195
ENST00000536771ENST00000392796CCDC148chr2159165945-WDSUB1chr2160092701-0.0008904150.99910957
ENST00000536771ENST00000409124CCDC148chr2159165945-WDSUB1chr2160092701-0.0008918090.99910814

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Fusion Genomic Features for CCDC148-WDSUB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CCDC148-WDSUB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:159165945/chr2:160092701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC148

Q8NFR7

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC148chr2:159165945chr2:160092701ENST00000283233-914166_195370592.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000536771-78166_195284300.0Coiled coilOntology_term=ECO:0000255
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757332_396332385.0DomainSAM
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757403_476332385.0DomainNote=U-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC148chr2:159165945chr2:160092701ENST00000283233-914352_417370592.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000283233-914466_498370592.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000409889-17166_1950256.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000409889-17352_4170256.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000409889-17466_4980256.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000536771-78352_417284300.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000536771-78466_498284300.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC148chr2:159165945chr2:160092701ENST00000283233-914395_428370592.0Compositional biasNote=Glu/Lys-rich
HgeneCCDC148chr2:159165945chr2:160092701ENST00000409889-17395_4280256.0Compositional biasNote=Glu/Lys-rich
HgeneCCDC148chr2:159165945chr2:160092701ENST00000536771-78395_428284300.0Compositional biasNote=Glu/Lys-rich
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911332_396424477.0DomainSAM
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911403_476424477.0DomainNote=U-box
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911332_396424477.0DomainSAM
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911403_476424477.0DomainNote=U-box
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911332_396424477.0DomainSAM
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911403_476424477.0DomainNote=U-box
TgeneWDSUB1chr2:159165945chr2:160092701ENST000003581475710_47332385.0RepeatNote=WD 1
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757137_176332385.0RepeatNote=WD 4
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757178_228332385.0RepeatNote=WD 5
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757237_276332385.0RepeatNote=WD 6
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035814757279_318332385.0RepeatNote=WD 7
TgeneWDSUB1chr2:159165945chr2:160092701ENST000003581475752_91332385.0RepeatNote=WD 2
TgeneWDSUB1chr2:159165945chr2:160092701ENST000003581475795_134332385.0RepeatNote=WD 3
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035977491110_47424477.0RepeatNote=WD 1
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911137_176424477.0RepeatNote=WD 4
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911178_228424477.0RepeatNote=WD 5
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911237_276424477.0RepeatNote=WD 6
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000359774911279_318424477.0RepeatNote=WD 7
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035977491152_91424477.0RepeatNote=WD 2
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000035977491195_134424477.0RepeatNote=WD 3
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000039279691110_47424477.0RepeatNote=WD 1
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911137_176424477.0RepeatNote=WD 4
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911178_228424477.0RepeatNote=WD 5
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911237_276424477.0RepeatNote=WD 6
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000392796911279_318424477.0RepeatNote=WD 7
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000039279691152_91424477.0RepeatNote=WD 2
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000039279691195_134424477.0RepeatNote=WD 3
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000040999091110_47424477.0RepeatNote=WD 1
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911137_176424477.0RepeatNote=WD 4
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911178_228424477.0RepeatNote=WD 5
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911237_276424477.0RepeatNote=WD 6
TgeneWDSUB1chr2:159165945chr2:160092701ENST00000409990911279_318424477.0RepeatNote=WD 7
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000040999091152_91424477.0RepeatNote=WD 2
TgeneWDSUB1chr2:159165945chr2:160092701ENST0000040999091195_134424477.0RepeatNote=WD 3


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Fusion Gene Sequence for CCDC148-WDSUB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13666_13666_1_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000283233_WDSUB1_chr2_160092701_ENST00000392796_length(transcript)=1814nt_BP=1424nt
ATAGAGACCGATGCTGTTCAGCGCGAGAGGGCCTGGAGAGGGTGGGTGTGAGAGAGAAGGTGTCTCAGGTCTCGGGCGCGGGAGGGGGTG
GCGGAGAGGACAGGGAGATTCCCCAGCGCTGGCTCTGAAATCTGGGGCAGGCTTTCCTTGCCTTACTGCCAATCCCAACTGTGCCTGGTA
GGGTTTGTCCCTGGCGTCAAAGGTAGGAACAGCTGAGCCCTTAGATGTACCCCTGACGGCGAGAGCCCAGGAGTGGGCGTTTCACTTTTC
CTGCGTTTGGGGAGTCCCTGAGGCTATGCCCTTTGACCTTTGACATGTGTGCAGCTTCTGCTTCTCCAGATAATCTGGTATTCCATATGA
AAAATGAGATGAGAAACATCAAGTACAAACCAGTAGACTATCAACAATTGCGTGCATTAACTGAAGCAAAGAAATTGGCTTCTGCCTCTG
CAAAGCTAAAGATCAGAAAAGCAATGTTGACTTCAAAGTTATCCAAAGAACAAACACTAATAAAACAACACAAGCAAGTGTGGTGGCAGG
AATACCAGAGGCTGAATGAAGTCAGATGTAAAATGGAATCTGAAATAAAATCCCTTCTCAATGAAGAGAACATTGGAAATGAATGTCTTT
GTGACCTTACAAATTTTGAGCAAGAGCTATCAGAACAACAGTGCACATATCTTAAAAATGTAATAAATCCTATTCAGCAGCTGAGAGCAG
ATCTAAAATACAGACAGCATCACACTTTGCAGCATTCACACCCACATATTGAGTTTAACTCCATGAAAGTATTGGAAGAGGTTGACTTTG
TGAAGAAACAATTGAAAACTGTCTTTGAAAGACTTAGGCTGGAGCAACAGAGAATAGAAAATGATCTTTCAGACTGGAGTATAAAGATTC
TAGATCATTCTTTGGAAGAAAAGACTAACCCGCTTAGTGAACTGCCCATTGAATTAGAAAGTTTGGAATGCCCATACCCTGATTTGAAAT
CTTCAATTCTCAGTGAGTTCTATAAGTTTACACAGAAATATCAGAAGAAGCTTCAAGACTTTAATCTGCAGTTGGAAGACATATACAGAA
ACTGTCAACTAAGTGAAGAAGACCACTGGATTTACCAGGCTATTTTGGATCAGTACCCTGGAGATCTCTTTGGAAGAAGGACTCTGTATC
TGGACATGTTACAAAGATATTTTCCTCACAAATCTAGGCATGATTTGGTTGAACACGAGAAATATTGTGACCAATATCGCTTTGCTATAG
AGCAGCAAAATATCCTGATATCAAATTGGAATAAAAATAAGAAAGACTTTATACAGAAGGCTGTGCTGACACTCACTGAGGCTTGTGCAA
CACATGAAATGGAGAGCATGTTGGCTAAGGACAAGAAAAAGCAACAGGAATTGTGTGCTGATCTGAAAGCCAAGATGGCTATTCATATGA
AAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGTCCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAA
TAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAAAAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCT
CATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAGCAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAA
AAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAAAAGCCTTTTTGTACTAGTGAAAAGAATCTTCAGCTATATAGAAA
TAAAGTTATACTTT

>13666_13666_1_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000283233_WDSUB1_chr2_160092701_ENST00000392796_length(amino acids)=401AA_BP=379
MRLCPLTFDMCAASASPDNLVFHMKNEMRNIKYKPVDYQQLRALTEAKKLASASAKLKIRKAMLTSKLSKEQTLIKQHKQVWWQEYQRLN
EVRCKMESEIKSLLNEENIGNECLCDLTNFEQELSEQQCTYLKNVINPIQQLRADLKYRQHHTLQHSHPHIEFNSMKVLEEVDFVKKQLK
TVFERLRLEQQRIENDLSDWSIKILDHSLEEKTNPLSELPIELESLECPYPDLKSSILSEFYKFTQKYQKKLQDFNLQLEDIYRNCQLSE
EDHWIYQAILDQYPGDLFGRRTLYLDMLQRYFPHKSRHDLVEHEKYCDQYRFAIEQQNILISNWNKNKKDFIQKAVLTLTEACATHEMES
MLAKDKKKQQELCADLKAKMAIHMKRKQWKIGSAKRNVQVP

--------------------------------------------------------------
>13666_13666_2_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000283233_WDSUB1_chr2_160092701_ENST00000409124_length(transcript)=1781nt_BP=1424nt
ATAGAGACCGATGCTGTTCAGCGCGAGAGGGCCTGGAGAGGGTGGGTGTGAGAGAGAAGGTGTCTCAGGTCTCGGGCGCGGGAGGGGGTG
GCGGAGAGGACAGGGAGATTCCCCAGCGCTGGCTCTGAAATCTGGGGCAGGCTTTCCTTGCCTTACTGCCAATCCCAACTGTGCCTGGTA
GGGTTTGTCCCTGGCGTCAAAGGTAGGAACAGCTGAGCCCTTAGATGTACCCCTGACGGCGAGAGCCCAGGAGTGGGCGTTTCACTTTTC
CTGCGTTTGGGGAGTCCCTGAGGCTATGCCCTTTGACCTTTGACATGTGTGCAGCTTCTGCTTCTCCAGATAATCTGGTATTCCATATGA
AAAATGAGATGAGAAACATCAAGTACAAACCAGTAGACTATCAACAATTGCGTGCATTAACTGAAGCAAAGAAATTGGCTTCTGCCTCTG
CAAAGCTAAAGATCAGAAAAGCAATGTTGACTTCAAAGTTATCCAAAGAACAAACACTAATAAAACAACACAAGCAAGTGTGGTGGCAGG
AATACCAGAGGCTGAATGAAGTCAGATGTAAAATGGAATCTGAAATAAAATCCCTTCTCAATGAAGAGAACATTGGAAATGAATGTCTTT
GTGACCTTACAAATTTTGAGCAAGAGCTATCAGAACAACAGTGCACATATCTTAAAAATGTAATAAATCCTATTCAGCAGCTGAGAGCAG
ATCTAAAATACAGACAGCATCACACTTTGCAGCATTCACACCCACATATTGAGTTTAACTCCATGAAAGTATTGGAAGAGGTTGACTTTG
TGAAGAAACAATTGAAAACTGTCTTTGAAAGACTTAGGCTGGAGCAACAGAGAATAGAAAATGATCTTTCAGACTGGAGTATAAAGATTC
TAGATCATTCTTTGGAAGAAAAGACTAACCCGCTTAGTGAACTGCCCATTGAATTAGAAAGTTTGGAATGCCCATACCCTGATTTGAAAT
CTTCAATTCTCAGTGAGTTCTATAAGTTTACACAGAAATATCAGAAGAAGCTTCAAGACTTTAATCTGCAGTTGGAAGACATATACAGAA
ACTGTCAACTAAGTGAAGAAGACCACTGGATTTACCAGGCTATTTTGGATCAGTACCCTGGAGATCTCTTTGGAAGAAGGACTCTGTATC
TGGACATGTTACAAAGATATTTTCCTCACAAATCTAGGCATGATTTGGTTGAACACGAGAAATATTGTGACCAATATCGCTTTGCTATAG
AGCAGCAAAATATCCTGATATCAAATTGGAATAAAAATAAGAAAGACTTTATACAGAAGGCTGTGCTGACACTCACTGAGGCTTGTGCAA
CACATGAAATGGAGAGCATGTTGGCTAAGGACAAGAAAAAGCAACAGGAATTGTGTGCTGATCTGAAAGCCAAGATGGCTATTCATATGA
AAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGTCCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAA
TAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAAAAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCT
CATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAGCAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAA
AAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAAAAGCCTTTTTGTACTAGTGAAAAGA

>13666_13666_2_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000283233_WDSUB1_chr2_160092701_ENST00000409124_length(amino acids)=401AA_BP=379
MRLCPLTFDMCAASASPDNLVFHMKNEMRNIKYKPVDYQQLRALTEAKKLASASAKLKIRKAMLTSKLSKEQTLIKQHKQVWWQEYQRLN
EVRCKMESEIKSLLNEENIGNECLCDLTNFEQELSEQQCTYLKNVINPIQQLRADLKYRQHHTLQHSHPHIEFNSMKVLEEVDFVKKQLK
TVFERLRLEQQRIENDLSDWSIKILDHSLEEKTNPLSELPIELESLECPYPDLKSSILSEFYKFTQKYQKKLQDFNLQLEDIYRNCQLSE
EDHWIYQAILDQYPGDLFGRRTLYLDMLQRYFPHKSRHDLVEHEKYCDQYRFAIEQQNILISNWNKNKKDFIQKAVLTLTEACATHEMES
MLAKDKKKQQELCADLKAKMAIHMKRKQWKIGSAKRNVQVP

--------------------------------------------------------------
>13666_13666_3_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000536771_WDSUB1_chr2_160092701_ENST00000392796_length(transcript)=1588nt_BP=1198nt
ATAGAGACCGATGCTGTTCAGCGCGAGAGGGCCTGGAGAGGGTGGGTGTGAGAGAGAAGGTGTCTCAGGTCTCGGGCGCGGGAGGGGGTG
GCGGAGAGGACAGGGAGATTCCCCAGCGCTGGCTCTGAAATCTGGGGCAGGCTTTCCTTGCCTTACTGCCAATCCCAACTGTGCCTGGTA
GGGTTTGTCCCTGGCGTCAAAGGTAGGAACAGCTGAGCCCTTAGATGTACCCCTGACGGCGAGAGCCCAGGAGTGGGCGTTTCACTTTTC
CTGCGTTTGGGGAGTCCCTGAGGCTATGCCCTTTGACCTTTGACATGTGTGCAGCTTCTGCTTCTCCAGATGTAAAATGGAATCTGAAAT
AAAATCCCTTCTCAATGAAGAGAACATTGGAAATGAATGTCTTTGTGACCTTACAAATTTTGAGCAAGAGCTATCAGAACAACAGTGCAC
ATATCTTAAAAATGTAATAAATCCTATTCAGCAGCTGAGAGCAGATCTAAAATACAGACAGCATCACACTTTGCAGCATTCACACCCACA
TATTGAGTTTAACTCCATGAAAGTATTGGAAGAGGTTGACTTTGTGAAGAAACAATTGAAAACTGTCTTTGAAAGACTTAGGCTGGAGCA
ACAGAGAATAGAAAATGATCTTTCAGACTGGAGTATAAAGATTCTAGATCATTCTTTGGAAGAAAAGACTAACCCGCTTAGTGAACTGCC
CATTGAATTAGAAAGTTTGGAATGCCCATACCCTGATTTGAAATCTTCAATTCTCAGTGAGTTCTATAAGTTTACACAGAAATATCAGAA
GAAGCTTCAAGACTTTAATCTGCAGTTGGAAGACATATACAGAAACTGTCAACTAAGTGAAGAAGACCACTGGATTTACCAGGCTATTTT
GGATCAGTACCCTGGAGATCTCTTTGGAAGAAGGACTCTGTATCTGGACATGTTACAAAGATATTTTCCTCACAAATCTAGGCATGATTT
GGTTGAACACGAGAAATATTGTGACCAATATCGCTTTGCTATAGAGCAGCAAAATATCCTGATATCAAATTGGAATAAAAATAAGAAAGA
CTTTATACAGAAGGCTGTGCTGACACTCACTGAGGCTTGTGCAACACATGAAATGGAGAGCATGTTGGCTAAGGACAAGAAAAAGCAACA
GGAATTGTGTGCTGATCTGAAAGCCAAGATGGCTATTCATATGAAAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGT
CCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAATAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAA
AAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCTCATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAG
CAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAAAAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAA
AAGCCTTTTTGTACTAGTGAAAAGAATCTTCAGCTATATAGAAATAAAGTTATACTTT

>13666_13666_3_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000536771_WDSUB1_chr2_160092701_ENST00000392796_length(amino acids)=306AA_BP=284
MESEIKSLLNEENIGNECLCDLTNFEQELSEQQCTYLKNVINPIQQLRADLKYRQHHTLQHSHPHIEFNSMKVLEEVDFVKKQLKTVFER
LRLEQQRIENDLSDWSIKILDHSLEEKTNPLSELPIELESLECPYPDLKSSILSEFYKFTQKYQKKLQDFNLQLEDIYRNCQLSEEDHWI
YQAILDQYPGDLFGRRTLYLDMLQRYFPHKSRHDLVEHEKYCDQYRFAIEQQNILISNWNKNKKDFIQKAVLTLTEACATHEMESMLAKD
KKKQQELCADLKAKMAIHMKRKQWKIGSAKRNVQVP

--------------------------------------------------------------
>13666_13666_4_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000536771_WDSUB1_chr2_160092701_ENST00000409124_length(transcript)=1555nt_BP=1198nt
ATAGAGACCGATGCTGTTCAGCGCGAGAGGGCCTGGAGAGGGTGGGTGTGAGAGAGAAGGTGTCTCAGGTCTCGGGCGCGGGAGGGGGTG
GCGGAGAGGACAGGGAGATTCCCCAGCGCTGGCTCTGAAATCTGGGGCAGGCTTTCCTTGCCTTACTGCCAATCCCAACTGTGCCTGGTA
GGGTTTGTCCCTGGCGTCAAAGGTAGGAACAGCTGAGCCCTTAGATGTACCCCTGACGGCGAGAGCCCAGGAGTGGGCGTTTCACTTTTC
CTGCGTTTGGGGAGTCCCTGAGGCTATGCCCTTTGACCTTTGACATGTGTGCAGCTTCTGCTTCTCCAGATGTAAAATGGAATCTGAAAT
AAAATCCCTTCTCAATGAAGAGAACATTGGAAATGAATGTCTTTGTGACCTTACAAATTTTGAGCAAGAGCTATCAGAACAACAGTGCAC
ATATCTTAAAAATGTAATAAATCCTATTCAGCAGCTGAGAGCAGATCTAAAATACAGACAGCATCACACTTTGCAGCATTCACACCCACA
TATTGAGTTTAACTCCATGAAAGTATTGGAAGAGGTTGACTTTGTGAAGAAACAATTGAAAACTGTCTTTGAAAGACTTAGGCTGGAGCA
ACAGAGAATAGAAAATGATCTTTCAGACTGGAGTATAAAGATTCTAGATCATTCTTTGGAAGAAAAGACTAACCCGCTTAGTGAACTGCC
CATTGAATTAGAAAGTTTGGAATGCCCATACCCTGATTTGAAATCTTCAATTCTCAGTGAGTTCTATAAGTTTACACAGAAATATCAGAA
GAAGCTTCAAGACTTTAATCTGCAGTTGGAAGACATATACAGAAACTGTCAACTAAGTGAAGAAGACCACTGGATTTACCAGGCTATTTT
GGATCAGTACCCTGGAGATCTCTTTGGAAGAAGGACTCTGTATCTGGACATGTTACAAAGATATTTTCCTCACAAATCTAGGCATGATTT
GGTTGAACACGAGAAATATTGTGACCAATATCGCTTTGCTATAGAGCAGCAAAATATCCTGATATCAAATTGGAATAAAAATAAGAAAGA
CTTTATACAGAAGGCTGTGCTGACACTCACTGAGGCTTGTGCAACACATGAAATGGAGAGCATGTTGGCTAAGGACAAGAAAAAGCAACA
GGAATTGTGTGCTGATCTGAAAGCCAAGATGGCTATTCATATGAAAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGT
CCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAATAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAA
AAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCTCATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAG
CAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAAAAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAA
AAGCCTTTTTGTACTAGTGAAAAGA

>13666_13666_4_CCDC148-WDSUB1_CCDC148_chr2_159165945_ENST00000536771_WDSUB1_chr2_160092701_ENST00000409124_length(amino acids)=306AA_BP=284
MESEIKSLLNEENIGNECLCDLTNFEQELSEQQCTYLKNVINPIQQLRADLKYRQHHTLQHSHPHIEFNSMKVLEEVDFVKKQLKTVFER
LRLEQQRIENDLSDWSIKILDHSLEEKTNPLSELPIELESLECPYPDLKSSILSEFYKFTQKYQKKLQDFNLQLEDIYRNCQLSEEDHWI
YQAILDQYPGDLFGRRTLYLDMLQRYFPHKSRHDLVEHEKYCDQYRFAIEQQNILISNWNKNKKDFIQKAVLTLTEACATHEMESMLAKD
KKKQQELCADLKAKMAIHMKRKQWKIGSAKRNVQVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC148-WDSUB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC148-WDSUB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC148-WDSUB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource