Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C4orf32-EIF4E (FusionGDB2 ID:HG132720TG1977)

Fusion Gene Summary for C4orf32-EIF4E

check button Fusion gene summary
Fusion gene informationFusion gene name: C4orf32-EIF4E
Fusion gene ID: hg132720tg1977
HgeneTgene
Gene symbol

C4orf32

EIF4E

Gene ID

132720

1977

Gene namefamily with sequence similarity 241 member Aeukaryotic translation initiation factor 4E
SynonymsC4orf32AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E
Cytomap('C4orf32')('EIF4E')

4q25

4q23

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein FAM241Auncharacterized protein C4orf32eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309733, 
Fusion gene scores* DoF score2 X 1 X 2=44 X 3 X 3=36
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C4orf32 [Title/Abstract] AND EIF4E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC4orf32(113066889)-EIF4E(99823133), # samples:1
Anticipated loss of major functional domain due to fusion event.C4orf32-EIF4E seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C4orf32-EIF4E seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF4E

GO:0006417

regulation of translation

22578813


check buttonFusion gene breakpoints across C4orf32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EIF4E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3858C4orf32chr4

113066889

+EIF4Echr4

99823133

-


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Fusion Gene ORF analysis for C4orf32-EIF4E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309733ENST00000504472C4orf32chr4

113066889

+EIF4Echr4

99823133

-
In-frameENST00000309733ENST00000280892C4orf32chr4

113066889

+EIF4Echr4

99823133

-
In-frameENST00000309733ENST00000450253C4orf32chr4

113066889

+EIF4Echr4

99823133

-
In-frameENST00000309733ENST00000504432C4orf32chr4

113066889

+EIF4Echr4

99823133

-
In-frameENST00000309733ENST00000505992C4orf32chr4

113066889

+EIF4Echr4

99823133

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000309733C4orf32chr4113066889+ENST00000450253EIF4Echr499823133-1031733770972300
ENST00000309733C4orf32chr4113066889+ENST00000280892EIF4Echr499823133-123633770972300
ENST00000309733C4orf32chr4113066889+ENST00000504432EIF4Echr499823133-115633770972300
ENST00000309733C4orf32chr4113066889+ENST00000505992EIF4Echr499823133-1196337701065331

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309733ENST00000450253C4orf32chr4113066889+EIF4Echr499823133-0.000451280.99954873
ENST00000309733ENST00000280892C4orf32chr4113066889+EIF4Echr499823133-0.0018251290.9981749
ENST00000309733ENST00000504432C4orf32chr4113066889+EIF4Echr499823133-0.0020498750.99795014
ENST00000309733ENST00000505992C4orf32chr4113066889+EIF4Echr499823133-0.0012433840.99875665

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Fusion Genomic Features for C4orf32-EIF4E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C4orf32-EIF4E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:113066889/chr4:99823133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF4Echr4:113066889chr4:99823133ENST0000028089207102_10326238.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000028089207132_13926238.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000028089207157_16226238.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000002808920737_4026238.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000002808920756_5726238.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000002808920773_7726238.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000045025307102_1036218.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000045025307132_1396218.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000045025307157_1626218.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000004502530737_406218.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000004502530756_576218.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000004502530773_776218.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000050599208102_1036249.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000050599208132_1396249.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST0000050599208157_1626249.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000005059920837_406249.0RegionEIF4EBP1/2/3 binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000005059920856_576249.0Region7-methylguanosine-containing mRNA cap binding
TgeneEIF4Echr4:113066889chr4:99823133ENST000005059920873_776249.0RegionEIF4EBP1/2/3 binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC4orf32chr4:113066889chr4:99823133ENST00000309733+12100_12051133.0TransmembraneHelical


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Fusion Gene Sequence for C4orf32-EIF4E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11795_11795_1_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000280892_length(transcript)=1236nt_BP=337nt
GAGCCAGTGACAGGAGGGGCCGGGCTGGTACTTCAGGCGCCCAGGCCGGCGGGGCGCGCTCCGGCGGCTCCTGTCAGCGGCGGGTGCGGC
GGATCCCAGGGCAGCCTTCGGGCGGCGGCGCTGCCTGGTGCGTCGCGGCGTGGTCCTCCGGCGGCTGTCCGGGGCGGTAGGAGTTGGCTG
CGGGATGTGCTCAGCCGGGGAGCTGCTGCGGGGCGGCGACGGCGGGGAACGCGACGAGGACGGGGACGCGCTGGCGGAGCGGGAGGCGGC
AGGGACCGGGTGGGATCCCGGGGCGAGCCCGCGGCGGCGCGGACAGCGGCCGAAGGAGAGCGAGCAGGAAACCACCCCTACTCCTAATCC
CCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGATGGGC
ACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGC
TCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGA
TGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACACT
TCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGC
AATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGT
GATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTGAGT
ATTCTCATAGGAGACTGCGTCAAGCAATCGAGATTTGGGAGCTGAACCAAAGCCTCTTCAAAAAGCAGAGTGGACTGCATTTAAATTTGA
TTTCCATCTTAATGTTACTCAGATATAAGAGAAGTCTCATTCGCCTTTGTCTTGTACTTCTGTGTTCATTTTTTTTTTTTTTTTTGGCTA

>11795_11795_1_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000280892_length(amino acids)=300AA_BP=89
MSAAGAADPRAAFGRRRCLVRRGVVLRRLSGAVGVGCGMCSAGELLRGGDGGERDEDGDALAEREAAGTGWDPGASPRRRGQRPKESEQE
TTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDG
IEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERL

--------------------------------------------------------------
>11795_11795_2_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000450253_length(transcript)=10317nt_BP=337nt
GAGCCAGTGACAGGAGGGGCCGGGCTGGTACTTCAGGCGCCCAGGCCGGCGGGGCGCGCTCCGGCGGCTCCTGTCAGCGGCGGGTGCGGC
GGATCCCAGGGCAGCCTTCGGGCGGCGGCGCTGCCTGGTGCGTCGCGGCGTGGTCCTCCGGCGGCTGTCCGGGGCGGTAGGAGTTGGCTG
CGGGATGTGCTCAGCCGGGGAGCTGCTGCGGGGCGGCGACGGCGGGGAACGCGACGAGGACGGGGACGCGCTGGCGGAGCGGGAGGCGGC
AGGGACCGGGTGGGATCCCGGGGCGAGCCCGCGGCGGCGCGGACAGCGGCCGAAGGAGAGCGAGCAGGAAACCACCCCTACTCCTAATCC
CCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGATGGGC
ACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGC
TCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGA
TGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACACT
TCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGC
AATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGT
GATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTGAGT
ATTCTCATAGGAGACTGCGTCAAGCAATCGAGATTTGGGAGCTGAACCAAAGCCTCTTCAAAAAGCAGAGTGGACTGCATTTAAATTTGA
TTTCCATCTTAATGTTACTCAGATATAAGAGAAGTCTCATTCGCCTTTGTCTTGTACTTCTGTGTTCATTTTTTTTTTTTTTTTTGGCTA
GAGTTTCCACTATCCCAATCAAAGAATTACAGTACACATCCCCAGAATCCATAAATGTGTTCCTGGCCCACTCTGTAATAGTTCAGTAGA
ATTACCATTAATTACATACAGATTTTACCTATCCACAATAGTCAGAAAACAACTTGGCATTTCTATACTTTACAGGAAAAAAAATTCTGT
TGTTCCATTTTATGCAGAAGCATATTTTGCTGGTTTGAAAGATTATGATGCATACAGTTTTCTAGCAATTTTCTTTGTTTCTTTTTACAG
CATTGTCTTTGCTGTACTCTTGCTGATGGCTGCTAGATTTTAATTTATTTGTTTCCCTACTTGATAATATTAGTGATTCTGATTTCAGTT
TTTCATTTGTTTTGCTTTTGTTTTTTTCCTCATGTAACATTGGTGAAGGATCCAGGAATATGACACAAAGGTGGAATAAACATTAATTTT
GTGCATTCTTTGGTAATTTTTTTTGTTTTTTGTAACTACAAAGCTTTGCTACAAATTTATGCATTTCATTCAAATCAGTGATCTATGTTT
GTGTGATTTCCTAAACATAATTGTGGATTATAAAAAATGTAACATCATAATTACATTCCTAACTAGAATTAGTATGTCTGTTTTTGTATC
TTTATGCTGTATTTTAACACTTTGTATTACTTAGGTTATTTTGCTTTGGTTAAAAATGGCTCAAGTAGAAAAGCAGTCCCATTCATATTA
AGACAGTGTACAAAACTGTAAATAAAATGTGTACAGTGAATTGTCTTTTAGACAACTAGATTTGTCCTTTTATTTCTCCATCTTTATAGA
AGGAATTTGTACTTCTTATTGCAAGGCAGTCTCTATATTATGTCTTCTTTTGTGGTGTCTTCCATGTGAACAGCATAAGTTTGGAGCACT
AGTTTGATTATTATGTTTATTACAATTTTTAATAAATTGAATAGGTAGTATCATATATATGGAATTAAATTGATGTGGCTATCTTTGTTT
TTTTATAAAGTAAGGCACAGTCATTCAGTCTTAGGTAAATAATGTACTCTCTTAATATGTTAATACTCATGAGAATTGGGATCTGATGCA
TCACCATTTGATTGGTAGCAACAGTGGTTGTAAAACTTGGTTGCTGAATTGAGTTGTTTCTATGTTAAGTGTCAAAATGATAGTGTAGGG
AAAGTACAGGTGGTGGGGACATATGCATTAAGAATCTTGTTAGTGTTGCAATCTAAATAGAATGGAATAAACAGGTGTTAAGACATATTT
ATAGTGGTAAATTGTTGTAGTATGGTATTCTGTAAACTTGAAAACTTGATCTACTCTTTGTAGGTATCATTTGAAAGCAAACTTGAAAAT
GTTTTGTACATAGTACATACTTGTATAGTCCTGTGAGATGAAGTATGGCTATCAGACCAAAGGATAAGCCAAACTGTAGGTAGCAGAATG
GAAATTATTATTTTGAGAGGAAAATTTGTCTTTGAATGGTGATTATGACTTAATCATTTTAAAACTGATAAACTTGACAAAAACCCTGTA
TGAAATAAACATGAAATTAATAGCACTGATTTCATTGTAAAATTTTAAAGCAGTTTAAAGGGTACCACAGGTTATCACAGTACTCTCAAT
GCCACAAACACCTCTTGTTCAGTATTCTAGAAATACTGAATCAGAATTCTGTGTTTATTATAATCTCAGCATACTGTACATAATATCTGC
TAGTTAAACTTGGGTAATTGGTTAAGGTGACTTACTGTCTATGTCAATATGTATAGTTTTGAGTACTTCAAGAGTTTACTTAAAAGTGAT
GATGTTACTGGTATGTTGGCAGTGGGTGGGACTGAAGTAGTGTATCTATTATAAATTGATCTATTTTCTTAATTCTAAGATGAAGTCCAA
TTTTAAGCATCAGCTTTTAGGTGCAAAGGAGGAATTAACACATTAAATGTATACAGTTCTAAATTTTTGAAATAACTGATGTGTAGCATT
TGATTATTGGTATTACCATTTTAGAATCATGATGTTATTTTAAACCTTTTTCCTGGGGACAAGAAAGGATAATAAATTACGCTGAATCAC
TTTTGGCAGTTGCCACTTAAATAGTACAGTGACTTGCAACTTTTATAACTTTATCAGCATCTTCTCTAAATACAAAATTAGGCTATATGT
TATTTTCCAACTTACTGTTTTCTCTCTGTTTAGCAGGATATTATAAATAGATTAAATAGATATATTTTCTTTTTTTTTTTTTTTTTTTGA
GACGGAGTCTCGCTTTGTCTCCCAGGCTGGAGTGCAGTGGCGTGATCTCCCAGTAGCTGGGACTACAAGCACCTGCCACCATGCCCGGCT
AATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAAGATGGTCTCAATCTCCTGACTTTGTGATCTGCCTGCTTCTG
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTACCCAGCCCAAATAGATGTATTTTCATAATAGAGAATTGAAATAGGCTTTAA
TGGGTGAATAGCAGTTTATTGTAGGCATGTGACATTTCATTTAATGAATTTAAAGTTTATTATCCCAATTCTACAGAAGGATTTAATGCA
TACTATGCAATTAAATAATTATAACACTACATAGTAATAATTTATGTGCCAGGCAGTAGTTCAGTCACTTTACATGCTTATTAACCTGCA
GAATAATCTTTTGAGATGTAGGTGCTGTTACTGAGAATTTAACTTTTGCTTGTAAATTGCAAAGGGTGGATTTGAATTCTGGAAATTTGG
TTCCAGAGACAATAATTACATAACACTTTCTCCATAGGGTACAGCCTGTCTAATAGGCTATAGTAAATCACCTCAGCTTGTTATAGGTCG
GGCATGCAAACATTTCTCCATTTTACTCCCTTTGGTAATGAATCTAGTAATAGATGGAAATTTTCCCTAGATTCACTGTGTTAGTCAGTT
GGGGAAGTTTGGAGGCAAAGATACAGGAGTTTATGGGGAGGTAGTGTACATAAATATAATCATATGCTATATAAGGAAGTTTTGGTCAGC
AGCAGACCATATATAGGATGGTGGGCCAGTAACATTGTAACACTGTATTTTTACTGTATCTTTTCCATGTTTTGTTATGTTTAGATACAC
AAATAACATTATGGAGTATTCAGTATGGTAACATGCCATACAGGTTTGTAGCCTAGGAGCAGTAATAGACTGTTCCCTGAAACCTATATT
TGTGGTAGGTTTATACCATTCAGGTTTGTGTAAGTACACAACGAAATCATCTAATGGCCCATTTCTCAAAACATATTCCCATCATTAATC
AATGCATGGTCATGTTTTCGTATACATTTTAAGCTTCTGTATTCTAATCTAATATAAATGGCAAAATATTCAAACTGATAGGCATTGAGA
TTCTTAAATGCTAAAGTTGCATTCAAAAGGATAATTTTAGGCGTTGTGACAAAGCAGTGTTATATTTTAAAGTTAGTGACAAGGCTATGC
ACCTTTTATCTCTAATTGTTTCTTACAGAATGTTTTTATTATTGAGTAGTAAAACAATAAATGTCAGATCCTTTATACAAATTCAAGATT
GACATTGATAAACAAAACTTCAGCATATCACTCAAGGTCAGCGTAGAAATTGTGTGTCTGGAAACTTCTATAGTAATTTTATATTACTGT
GACATTAGTATGTGATCACTTTTCTAGTAATGTTTTAAAAAAATATATCTTACAGGCCAGGCATAGTGCTTTATGCCTGTAATCCCAGCA
CTTTGGGAGGCCAAGGTGGCAGGATTGCATGAGTCCAGGAGTTCAACACCAGTCTGGGCAATAAAGTGAGACCCCATCGCTACAAACAAA
TTAAAAAATATTTATGTATGTGTGTAATATATATAATATATAACAAAACACATATGTATGTGTATATATAGTATGTCTGGCAGAGTACAA
TTTAGGGGTTAAGACTGGTCCCTCACATATGGTGTGAGAAACACTGTTCACAGGTTGCTTTCCCCATTAGCCCAGGGCAACTCATTTGCC
CATCATTTCCTAGAACAACCGGGTCTGTTACGTCTACAGTTTTCATCTTCATGCAGTTATGGATTTGGTGTCAAAAACTTTGGTCCTGTT
CTCTACCATCTTAAAATAAACTCTTGTGTCCTGCTTTACTATGAATTGCAAAGTAGGCATTAGGTAGCCTTCCTACTACCATAGTTTAGA
GTTCAATATTCTTATGACCATTCTACTGGTAGAAGCAAAAAATGAACTTGTAGGCATGTGATCACATGTGCCTATGGTGCTGTCTTTTCC
AGTACAGGGGAACTAATTTTCATATTTTAATCTTGCAGCTTTTTGTTTACTTCATGCATTGTGATTTCTCATAGTTTTGCACAGAACTCA
CTTCCCTACCTTTTCTGAAACAAAAGTATGTATACACACATACATATGTATTGAGCACCTCTATTTACTGTGTTCCACGTGCTGGGCATA
TAGCAAGAACAGAATGGTCTGGGGCCCTGCTCTAAAGAAGATTTAAAAGCAAACATATATTAAAAATGCGTGAGTCTGGCCAGGAGCAGT
GGCTCATGCCTGCAACCCCAGCACTTTGGGAGGCTGAAGCGGGTGAATCACCTGAGATCAGGAGTTGAGACCAGCCTGGCCAACATGGTG
AAACCCCGTCTCTACTAAAAATACAAAAATTAGCCTGGCATGGTGGCATGCGCCTGTAATTCCAGCTACTTTGGAGACTGAGACAGGAGA
ATCACTTGAGCCCAGGAAGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAA
AAAAAAAAAAAAAACGTGTCTGTTCATAAGGTTCTACAAATAGCTGTTGTTACAGAAAATAGGACTAGGGTTTTATTACTGGGGATTATG
CAGTCGAGGTAAATATAAAATGAGGTTGTTTCTTCTTTTTTTTATTTGAGACAGAGTCTTGTTTGCCAGGCTGGAGTGCAGTGGCGTGCT
CTTAGCTCCGCCTCCCGGGATCAAACGATTCTCTTGCCTCAGCCTCTCGAGTAGCTGGGACTACAGGCGCGTGCCACCACACCCAGCTGA
TTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGATGGCCAGGATGGTCTCGATCTTTTGACCTCATGATCCACCCACCTCGGCCTCC
CAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCCTGGTTCTAAATACTCTTCCAGCTCTAAAACATTGATTCTAAACAGATC
ACATTCCAGGAGGACTCTAGCAAACCAGCATATGCAAATTATAGCTTTTGCAAGACCGTTTCTACTTTTATATTACTGAACTCTATATGA
TTGTCCAAGTAAAGTTTTGTGTCTCTTTGATTATTTGATTGTACTTTAAAATTTTTTCACCATTCATTTAACATTTTTTACCATACTGTA
GTATTTTTAATGCAATTGTGTTTGCATTGGTGTGGCTTTAGAGGCTTCTCCAACCACCTTCCCAAAATACTGATCTGTGATTTTTTTCTT
TAATGTTTGGCCAAACATAATACATGCTTATTTTATTTTTCATCCCTACAGAAAGGTAGAAGATGAGAATTCTGTCTCCTACTGTTGTTT
TTCAAGGTGCCACTCAAATTTCTTGTACGTGTCTAGAAACTTGTGCATACAATAGAAGTACACTGTGGCTGGGCATGGTGGCTCATGCCT
GTAATCCCAGCACTTTGTGAAGCTGAGGTGGGTGGATCACCTGAGGTCAGGGAGTTTGAGACCAGCCTGGCCAACATGATGAAACCCCGT
CTTTACTAAAATTAGAAAAAATTAGCCAGGCGTGGTGGTGTGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCATGAGAATCACTTG
AACTCGGGTGGCAGAGGCTGCAGTGAGCTGAGATCATGCCACTGCATTCCAGCCTGCGCAGCTGAGCCAGACTCCATCTCCAAAAAAAAA
AAAAAAAAAAAAAAAAGATGTCCAATATATGTAACTTTTTTCTTTGGACACAAAAATTCCATTAGCTTTGTTTTCTCATTTTTACTTGTC
ATGATGTATGTCGAACACATTATTTTTAGTGTCTGGTGTTCCATTATACAGATGTCTCTCTTGTTGGTTGAATTTTTGCATTCACAGACC
CTCAAGTTGGATTCATATCTTTTTACACTAAGCATAAAGAAGACGGATTGGGGTCGGGTATGGTGGCTCACGCCTGTAATCCCAGCACTT
CGGGAGGCTGAGGTGGGCGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATACTGAAACCCCGTCTCTAAAAATATGAAAAA
AAAATTAGCCAGGCGTGGTGGTGCGCAGCTGTAGCCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGG
TTGCAGTGAGCATATTGCACCATTGCATTCCAGCCTGCACGACAGAGGAAGACGCCATTTCAAAAAAAAAAAAAAAAAGACGGATTGATT
TTCTTCAGCAGTATCAAGTGGCACTTACCATCCACCCCTTTAACACCCAAACCATTCTAATCCATGTATACAGACCATCATCTGTTTCGT
TATTGTGTTCTATAATGCAGCTTTGCGAGTTATGCAGTTTTGGTCCTCATGATATTTTTCTGATTGGTTTTTAATGTATTTTGTTCTAAC
GAGCCAACATTGTTATACATGTAATTTGTTTATTTGCTAGATTGTACTCTTTCCCAAAGATGGGCTATGAACTAGCATCTACTTTCATTT
TACCTATTTACCTGTAAACATTGAAAAAACTGAATCAAATGCAGTGATATCGGACCTAGTTTTATTGTTATGCCTTATAATGAATTTAAC
TTCACAGTTTTCTAAATGAGAGCATTTCCCAAAGACATCTTTATGGTCATAACCAGTTTCCCTTGGCATTTGATTTATTTTTATTTTTAT
TTATTTATCTTTTTGAGAAGGAGTTTCGCTCTTGTTGCCCAGGCTAGAGTGCAATGGCGTGATCTCGGGTCACTGCAACCTCTGCCTCCC
GGGTTCAAGCGATTCTCCTGCCTCAGCCTCCAAGTAGCTGGGATTACAGGCATGCACCACCACGCCCGACTAATTTGTATTTTTAGAGAC
GGGGTTTCTCCGTGTTGGTCAGGCTGGTCTCAAACTTCCAACCTCAGGTGATCCGCCCGCCGTGGCCTCCCAAAGTGTTGGGATTACAGG
CGTGAGCCACAGTGTCTGGCCTGATTTGTTTTTAAGAGCATTATTTTTCTGCTTTATTTTGTGACTTCAACATTTGACACAATTTTGGGT
GAATGGTTTGTGCATGGTGCCTGACATCGTGTTTTGATGTGTAGTATATGCCATAGGACATGTGAGACAAGATATGTCCCAACTTGACCT
TGTTTTGTATTGTTTATGTCAAGGTGTTGAGTGTATTAGATATACTGTTGGGGCTCTGTGTTCTAGCTCTGCCTTTTAGATAATAACCAT
GGTTAAATATTGCAATGTCCTGCATGTCTCCACACATGGGTTTTGTAACTGAGTCAGAATGATAAGTGATTAGTAAGCACATTTTTTCTC
CTTTCAGGAAACCACTATTTTCCTTTTCTACATGCTGTTTTGTAAGTAGTACTTTTATGAAGGTTGTCTTCAAATGTTCGCATCTTCCAT
TTCTACTGCCCTTGGGTTATCCATCCTGTCATTTTGTGCCAATCACTTTTTTTTTTAACTTTTAAGTTCAGGGATGAAAGTGTAGATTTG
TTACATAGGTAAACTTGTGTCATGGGGTTGTTGTACAGATTATTTCATCACCCAGGTGTTAAGCCTAGTATGCACTAGTTGTTTTTCCTG
ATCCTCTCCCTGCTCCCACCCTCCACCCTCTGATAGGCCCCAGTGTGTGTTGTTCCCCTCTGTGTGTCCATGTGTTCTCATCATTTAGCT
CCCACTTACAAGTGAGAATGTGGTGTTTGGTTTTCTGTTCCTGCATTAGTTTGCTAAGGATAATGGCCTCGAGCTCCATCCAAGTCCCTG
TAAAGGACATGATCTTGTACTTTTTTATGGCTGCATAGTATTCTGTGGTGTATATGTACCACATTTTCTTTATCCAGTCTATCATTAGGC
ATTTAGGTTGATTCCATGTTTTTGCTATTGTGAATAGTGCTGCAATGAACATACATGTGCATGTCTTTTTATAATAGAATGATTTATATT
CTGTTGTGTATATACCCAGTAATGGGATTGCTGAGTTGAATGCTATTTCTGCCTTTAGGTCTTTGATGAATTGCCACACTGTCTTCCACA
ATGGTTGAACTAATTTACACTCCCACCAACGGTGAATAAGTGTTCACTTTTCTCCACAACCTTGTCAGCATCTATTATTTTTTGACTTTT
TAGTAATAGCCATTCTGACTGCTCACATCTATTTTGTAAATAAAGTTTTATTGAAACATGGCCTTACCCATTTGTTTACATATATTCATG
GCTGTTTTTGTGCCACAATGTCAGAGTTGTCTTAAAGTAGACAGAGACTATCTGGCTGTAAAGCCTGAGATATATACTAACTGGTTCTTT
ATGTAAAAAGTTTGCTGACCACCTACTCTAAACGTTTTGCAGTGATGGTAGTGTTGGCAAAAAACCAAATAGCTTACCCTCTTTAAATTT
CCCTTTTACTTCTTACAAACTCCTAACACCATTTACGACTTTGTCATCAATATGGTCAACTAAGCTTGGTTTGCATGGCTCTACTTCCTT
TCACCTTCCACTTAGGCAGTGTCTCCAAGTCCACTGCAGTTTCTATTTGTCTCCTGACTGTTACTGTATCAGTTCTTACCTAAATAACAT
AACAACTGATCTCCCTACTTTTTGCCTATGCCCTCAAATGTGCTCATTGTTGATCTATCTCCCTGTTAGGTGTTCTTTTTCTCCTCTTTA
GAAAGCAGCCAAGGAAACCAGGGTTCTCTCAAAGTGGAAAATACTGGAACTTATGTACTGTTATCATAATGATAGTTGGTGTTTTGAATT

>11795_11795_2_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000450253_length(amino acids)=300AA_BP=89
MSAAGAADPRAAFGRRRCLVRRGVVLRRLSGAVGVGCGMCSAGELLRGGDGGERDEDGDALAEREAAGTGWDPGASPRRRGQRPKESEQE
TTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDG
IEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERL

--------------------------------------------------------------
>11795_11795_3_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000504432_length(transcript)=1156nt_BP=337nt
GAGCCAGTGACAGGAGGGGCCGGGCTGGTACTTCAGGCGCCCAGGCCGGCGGGGCGCGCTCCGGCGGCTCCTGTCAGCGGCGGGTGCGGC
GGATCCCAGGGCAGCCTTCGGGCGGCGGCGCTGCCTGGTGCGTCGCGGCGTGGTCCTCCGGCGGCTGTCCGGGGCGGTAGGAGTTGGCTG
CGGGATGTGCTCAGCCGGGGAGCTGCTGCGGGGCGGCGACGGCGGGGAACGCGACGAGGACGGGGACGCGCTGGCGGAGCGGGAGGCGGC
AGGGACCGGGTGGGATCCCGGGGCGAGCCCGCGGCGGCGCGGACAGCGGCCGAAGGAGAGCGAGCAGGAAACCACCCCTACTCCTAATCC
CCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGATGGGC
ACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGC
TCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGA
TGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACACT
TCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGC
AATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGT
GATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTGAGT
ATTCTCATAGGAGACTGCGTCAAGCAATCGAGATTTGGGAGCTGAACCAAAGCCTCTTCAAAAAGCAGAGTGGACTGCATTTAAATTTGA

>11795_11795_3_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000504432_length(amino acids)=300AA_BP=89
MSAAGAADPRAAFGRRRCLVRRGVVLRRLSGAVGVGCGMCSAGELLRGGDGGERDEDGDALAEREAAGTGWDPGASPRRRGQRPKESEQE
TTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDG
IEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERL

--------------------------------------------------------------
>11795_11795_4_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000505992_length(transcript)=1196nt_BP=337nt
GAGCCAGTGACAGGAGGGGCCGGGCTGGTACTTCAGGCGCCCAGGCCGGCGGGGCGCGCTCCGGCGGCTCCTGTCAGCGGCGGGTGCGGC
GGATCCCAGGGCAGCCTTCGGGCGGCGGCGCTGCCTGGTGCGTCGCGGCGTGGTCCTCCGGCGGCTGTCCGGGGCGGTAGGAGTTGGCTG
CGGGATGTGCTCAGCCGGGGAGCTGCTGCGGGGCGGCGACGGCGGGGAACGCGACGAGGACGGGGACGCGCTGGCGGAGCGGGAGGCGGC
AGGGACCGGGTGGGATCCCGGGGCGAGCCCGCGGCGGCGCGGACAGCGGCCGAAGGAGAGCGAGCAGGAAACCACCCCTACTCCTAATCC
CCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGATGGGC
ACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGC
TCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGA
TGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACAAG
ATGGGATCTTGCTATGTTGCCCAGGTTGGTCTCAAACTTCTGGCCTCAAGTGATCCTCCCACTTCAGCCTCCCAAAGTGCTGGAATTACA
GCTTCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGAT
AGCAATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGAT
AGTGATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTG
AGTATTCTCATAGGAGACTGCGTCAAGCAATCGAGATTTGGGAGCTGAACCAAAGCCTCTTCAAAAAGCAGAGTGGACTGCATTTAAATT

>11795_11795_4_C4orf32-EIF4E_C4orf32_chr4_113066889_ENST00000309733_EIF4E_chr4_99823133_ENST00000505992_length(amino acids)=331AA_BP=89
MSAAGAADPRAAFGRRRCLVRRGVVLRRLSGAVGVGCGMCSAGELLRGGDGGERDEDGDALAEREAAGTGWDPGASPRRRGQRPKESEQE
TTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDG
IEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C4orf32-EIF4E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C4orf32-EIF4E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C4orf32-EIF4E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneC0751958Lymphoma, Lymphocytic, Intermediate1CTD_human