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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADORA1-KRBA1 (FusionGDB2 ID:HG134TG84626)

Fusion Gene Summary for ADORA1-KRBA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADORA1-KRBA1
Fusion gene ID: hg134tg84626
HgeneTgene
Gene symbol

ADORA1

KRBA1

Gene ID

134

84626

Gene nameadenosine A1 receptorKRAB-A domain containing 1
SynonymsRDC7-
Cytomap('ADORA1')('KRBA1')

1q32.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionadenosine receptor A1adenosine A1 receptor variant 1adenosine A1 receptor variant 2protein KRBA1
Modification date2020031320200313
UniProtAcc

P30542

.
Ensembl transtripts involved in fusion geneENST00000309502, ENST00000337894, 
ENST00000367235, ENST00000367236, 
ENST00000472535, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ADORA1 [Title/Abstract] AND KRBA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADORA1(203112619)-KRBA1(149417442), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ADORA1-KRBA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADORA1-KRBA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ADORA1-KRBA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:203112619/:149417442)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADORA1

P30542

.
FUNCTION: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADORA1-KRBA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADORA1-KRBA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADORA1-KRBA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADORA1P30542DB00201CaffeineAntagonist|MultitargetSmall moleculeApproved
HgeneADORA1P30542DB00277TheophyllineAntagonistSmall moleculeApproved
HgeneADORA1P30542DB00651DyphyllineAntagonistSmall moleculeApproved
HgeneADORA1P30542DB01223AminophyllineAntagonistSmall moleculeApproved
HgeneADORA1P30542DB01303OxtriphyllineAntagonistSmall moleculeApproved
HgeneADORA1P30542DB00824EnprofyllineInhibitorSmall moleculeApproved|Experimental
HgeneADORA1P30542DB00193TramadolStimulatorSmall moleculeApproved|Investigational
HgeneADORA1P30542DB00555LamotrigineInhibitorSmall moleculeApproved|Investigational
HgeneADORA1P30542DB00640AdenosineAgonistSmall moleculeApproved|Investigational
HgeneADORA1P30542DB00806PentoxifyllineAntagonistSmall moleculeApproved|Investigational
HgeneADORA1P30542DB00996GabapentinAgonistSmall moleculeApproved|Investigational
HgeneADORA1P30542DB04932DefibrotideBiotechApproved|Investigational
HgeneADORA1P30542DB09061CannabidiolActivatorSmall moleculeApproved|Investigational
HgeneADORA1P30542DB11757IstradefyllineAntagonistSmall moleculeApproved|Investigational

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Related Diseases for ADORA1-KRBA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADORA1C0020649Hypotension2CTD_human
HgeneADORA1C0007370Catalepsy1CTD_human
HgeneADORA1C0007787Transient Ischemic Attack1CTD_human
HgeneADORA1C0013182Drug Allergy1CTD_human
HgeneADORA1C0013221Drug toxicity1CTD_human
HgeneADORA1C0022116Ischemia1CTD_human
HgeneADORA1C0027051Myocardial Infarction1CTD_human
HgeneADORA1C0027746Nerve Degeneration1CTD_human
HgeneADORA1C0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneADORA1C0036341Schizophrenia1PSYGENET
HgeneADORA1C0038525Subarachnoid Hemorrhage1CTD_human
HgeneADORA1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneADORA1C0041755Adverse reaction to drug1CTD_human
HgeneADORA1C0086189Drug Withdrawal Symptoms1CTD_human
HgeneADORA1C0087169Withdrawal Symptoms1CTD_human
HgeneADORA1C0233612Waxy flexibility1CTD_human
HgeneADORA1C0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneADORA1C0242973Ventricular Dysfunction1CTD_human
HgeneADORA1C0270192Perinatal Subarachnoid Hemorrhage1CTD_human
HgeneADORA1C0428977Bradycardia1CTD_human
HgeneADORA1C0472381Posterior Circulation Transient Ischemic Attack1CTD_human
HgeneADORA1C0472383Subarachnoid Hemorrhage, Spontaneous1CTD_human
HgeneADORA1C0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneADORA1C0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneADORA1C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneADORA1C0751019Carotid Circulation Transient Ischemic Attack1CTD_human
HgeneADORA1C0751020Transient Ischemic Attack, Vertebrobasilar Circulation1CTD_human
HgeneADORA1C0751021Crescendo Transient Ischemic Attacks1CTD_human
HgeneADORA1C0751022Brain Stem Ischemia, Transient1CTD_human
HgeneADORA1C0751530Subarachnoid Hemorrhage, Aneurysmal1CTD_human
HgeneADORA1C0751845Middle Cerebral Artery Embolus1CTD_human
HgeneADORA1C0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneADORA1C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneADORA1C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneADORA1C0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneADORA1C0795688Subarachnoid Hemorrhage, Intracranial1CTD_human
HgeneADORA1C0917805Transient Cerebral Ischemia1CTD_human
HgeneADORA1C1527335Transient Ischemic Attack, Anterior Circulation1CTD_human