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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:NCOA7-SCYL2 (FusionGDB2 ID:HG135112TG55681) |
Fusion Gene Summary for NCOA7-SCYL2 |
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Fusion gene information | Fusion gene name: NCOA7-SCYL2 | Fusion gene ID: hg135112tg55681 | Hgene | Tgene | Gene symbol | NCOA7 | SCYL2 | Gene ID | 135112 | 55681 |
Gene name | nuclear receptor coactivator 7 | SCY1 like pseudokinase 2 | |
Synonyms | ERAP140|ESNA1|NCOA7-AS|Nbla00052|Nbla10993|TLDC4|dJ187J11.3 | AMCNACC|CVAK104 | |
Cytomap | ('NCOA7')('SCYL2') 6q22.31-q22.32 | 12q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor coactivator 7140 kDa estrogen receptor-associated proteinTBC/LysM-associated domain containing 4estrogen nuclear receptor coactivator 1estrogen receptor associated protein 140 kDaputative protein product of Nbla00052putative protein | SCY1-like protein 2SCY1-like 2SCY1-like, kinase-like 2coated vesicle-associated kinase of 104 kDa | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000487635, ENST00000368357, ENST00000392477, ENST00000229634, | ||
Fusion gene scores | * DoF score | 14 X 9 X 7=882 | 8 X 8 X 7=448 |
# samples | 15 | 9 | |
** MAII score | log2(15/882*10)=-2.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCOA7 [Title/Abstract] AND SCYL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NCOA7(126136550)-SCYL2(100676721), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOA7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11971969 |
Tgene | SCYL2 | GO:0002092 | positive regulation of receptor internalization | 19643732 |
Tgene | SCYL2 | GO:0008333 | endosome to lysosome transport | 19643732 |
Tgene | SCYL2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 19643732 |
Tgene | SCYL2 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway | 19643732 |
Tgene | SCYL2 | GO:2000370 | positive regulation of clathrin-dependent endocytosis | 19643732 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-IN-7808-01A | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
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Fusion Gene ORF analysis for NCOA7-SCYL2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000487635 | ENST00000550067 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
3UTR-5UTR | ENST00000487635 | ENST00000360820 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5CDS-3UTR | ENST00000368357 | ENST00000550067 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5CDS-3UTR | ENST00000392477 | ENST00000550067 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5CDS-5UTR | ENST00000368357 | ENST00000360820 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5CDS-5UTR | ENST00000392477 | ENST00000360820 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5UTR-3UTR | ENST00000229634 | ENST00000550067 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
5UTR-5UTR | ENST00000229634 | ENST00000360820 | NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676721 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for NCOA7-SCYL2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676720 | + | 3.40E-06 | 0.99999666 |
NCOA7 | chr6 | 126136550 | + | SCYL2 | chr12 | 100676720 | + | 3.40E-06 | 0.99999666 |
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Fusion Protein Features for NCOA7-SCYL2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:126136550/:100676721) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for NCOA7-SCYL2 |
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Fusion Gene PPI Analysis for NCOA7-SCYL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NCOA7-SCYL2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NCOA7-SCYL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOA7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | NCOA7 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |