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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOA7-RNF146 (FusionGDB2 ID:HG135112TG81847)

Fusion Gene Summary for NCOA7-RNF146

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA7-RNF146
Fusion gene ID: hg135112tg81847
HgeneTgene
Gene symbol

NCOA7

RNF146

Gene ID

135112

81847

Gene namenuclear receptor coactivator 7ring finger protein 146
SynonymsERAP140|ESNA1|NCOA7-AS|Nbla00052|Nbla10993|TLDC4|dJ187J11.3-
Cytomap('NCOA7')('RNF146')

6q22.31-q22.32

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 7140 kDa estrogen receptor-associated proteinTBC/LysM-associated domain containing 4estrogen nuclear receptor coactivator 1estrogen receptor associated protein 140 kDaputative protein product of Nbla00052putative proteinE3 ubiquitin-protein ligase RNF146RING-type E3 ubiquitin transferase RNF146dactylidiniduna
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000487635, ENST00000368357, 
ENST00000392477, ENST00000229634, 
Fusion gene scores* DoF score14 X 9 X 7=8822 X 2 X 2=8
# samples 152
** MAII scorelog2(15/882*10)=-2.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NCOA7 [Title/Abstract] AND RNF146 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOA7(126136550)-RNF146(127601376), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA7

GO:0045944

positive regulation of transcription by RNA polymerase II

11971969

TgeneRNF146

GO:0051865

protein autoubiquitination

21478859



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01ANCOA7chr6

126136550

+RNF146chr6

127601376

+


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Fusion Gene ORF analysis for NCOA7-RNF146

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000487635ENST00000489534NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000309649NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000356799NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000368314NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000476956NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000477776NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000480444NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000608991NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000609447NCOA7chr6

126136550

+RNF146chr6

127601376

+
3UTR-5UTRENST00000487635ENST00000610153NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-3UTRENST00000368357ENST00000489534NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-3UTRENST00000392477ENST00000489534NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000309649NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000356799NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000368314NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000476956NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000477776NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000480444NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000608991NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000609447NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000368357ENST00000610153NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000309649NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000356799NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000368314NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000476956NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000477776NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000480444NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000608991NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000609447NCOA7chr6

126136550

+RNF146chr6

127601376

+
5CDS-5UTRENST00000392477ENST00000610153NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-3UTRENST00000229634ENST00000489534NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000309649NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000356799NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000368314NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000476956NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000477776NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000480444NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000608991NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000609447NCOA7chr6

126136550

+RNF146chr6

127601376

+
5UTR-5UTRENST00000229634ENST00000610153NCOA7chr6

126136550

+RNF146chr6

127601376

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NCOA7-RNF146


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOA7chr6126136550+RNF146chr6127601375+5.00E-081
NCOA7chr6126136550+RNF146chr6127601375+5.00E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOA7-RNF146


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:126136550/:127601376)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NCOA7-RNF146


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NCOA7-RNF146


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOA7-RNF146


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOA7-RNF146


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA7C0033578Prostatic Neoplasms1CTD_human
HgeneNCOA7C0376358Malignant neoplasm of prostate1CTD_human