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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ATF2-SOS2 (FusionGDB2 ID:HG1386TG6655)

Fusion Gene Summary for ATF2-SOS2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF2-SOS2
Fusion gene ID: hg1386tg6655
HgeneTgene
Gene symbol

ATF2

SOS2

Gene ID

1386

6655

Gene nameactivating transcription factor 2SOS Ras/Rho guanine nucleotide exchange factor 2
SynonymsCRE-BP1|CREB-2|CREB2|HB16|TREB7NS9|SOS-2
Cytomap('ATF2')('SOS2')

2q31.1

14q21.3

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-2activating transcription factor 2 splice variant ATF2-var2cAMP response element-binding protein CRE-BP1cAMP responsive element binding protein 2, formerlycAMP-dependent transcription factor ATF-2cyclic Ason of sevenless homolog 2guanine nucleotide releasing factor
Modification date2020032220200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264110, ENST00000345739, 
ENST00000392544, ENST00000409437, 
ENST00000409635, ENST00000426833, 
ENST00000487334, ENST00000538946, 
ENST00000392543, ENST00000409499, 
ENST00000409833, ENST00000413123, 
Fusion gene scores* DoF score12 X 11 X 9=118813 X 13 X 9=1521
# samples 1317
** MAII scorelog2(13/1188*10)=-3.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1521*10)=-3.16141350158679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF2 [Title/Abstract] AND SOS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF2(175976296)-SOS2(50641270), # samples:3
Anticipated loss of major functional domain due to fusion event.ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATF2-SOS2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ATF2-SOS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF2

GO:0006357

regulation of transcription by RNA polymerase II

19861239

HgeneATF2

GO:0006970

response to osmotic stress

21098032

HgeneATF2

GO:0006974

cellular response to DNA damage stimulus

22304920

HgeneATF2

GO:0045944

positive regulation of transcription by RNA polymerase II

16300731|18671972

HgeneATF2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

22982025


check buttonFusion gene breakpoints across ATF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SOS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GU-A42Q-01AATF2chr2

175976296

-SOS2chr14

50641270

-


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Fusion Gene ORF analysis for ATF2-SOS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264110ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000345739ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000392544ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000409437ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000409635ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000426833ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000487334ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-5UTRENST00000538946ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000264110ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000345739ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000392544ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000409437ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000409635ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000426833ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000487334ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
5CDS-intronENST00000538946ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
Frame-shiftENST00000392544ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
Frame-shiftENST00000409437ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
Frame-shiftENST00000426833ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
Frame-shiftENST00000487334ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
Frame-shiftENST00000538946ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
In-frameENST00000264110ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
In-frameENST00000345739ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
In-frameENST00000409635ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-3CDSENST00000392543ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-3CDSENST00000409499ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-3CDSENST00000409833ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-3CDSENST00000413123ENST00000216373ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-5UTRENST00000392543ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-5UTRENST00000409499ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-5UTRENST00000409833ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-5UTRENST00000413123ENST00000555794ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-intronENST00000392543ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-intronENST00000409499ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-intronENST00000409833ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-
intron-intronENST00000413123ENST00000543680ATF2chr2

175976296

-SOS2chr14

50641270

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345739ATF2chr2175976296-ENST00000216373SOS2chr1450641270-5275103037640591227
ENST00000264110ATF2chr2175976296-ENST00000216373SOS2chr1450641270-5372112729941561285
ENST00000409635ATF2chr2175976296-ENST00000216373SOS2chr1450641270-5335109043641191227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345739ENST00000216373ATF2chr2175976296-SOS2chr1450641270-0.0001604840.99983954
ENST00000264110ENST00000216373ATF2chr2175976296-SOS2chr1450641270-0.0001409280.9998591
ENST00000409635ENST00000216373ATF2chr2175976296-SOS2chr1450641270-0.0001772630.9998228

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Fusion Genomic Features for ATF2-SOS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATF2-SOS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:175976296/chr14:50641270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-10141_7276506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-9131_7218448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-11151_7276506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-10141_7218448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-11151_7258488.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-10161_7219373.3333333333333MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-101425_49276506.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-91325_49218448.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-111525_49276506.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-101425_49218448.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-111525_49258488.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-101625_49219373.3333333333333Zinc fingerC2H2-type
TgeneSOS2chr2:175976296chr14:50641270ENST000002163736231180_11833231333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr2:175976296chr14:50641270ENST000002163736231203_12083231333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr2:175976296chr14:50641270ENST00000216373623755_7583231333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr2:175976296chr14:50641270ENST00000216373623442_5463231333.0DomainPH
TgeneSOS2chr2:175976296chr14:50641270ENST00000216373623595_7393231333.0DomainN-terminal Ras-GEF
TgeneSOS2chr2:175976296chr14:50641270ENST00000216373623778_10173231333.0DomainRas-GEF

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-1014352_415276506.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-913352_415218448.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-16352_4150127.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-1115352_415276506.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-16352_4150145.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-1014352_415218448.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-18352_4150210.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-1115352_415258488.0DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-1016352_415219373.3333333333333DomainbZIP
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-1014405_414276506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-913405_414218448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-161_70127.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-16405_4140127.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-1115405_414276506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-161_70145.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-16405_4140145.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-1014405_414218448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-181_70210.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-18405_4140210.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-1115405_414258488.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-1016405_414219373.3333333333333MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-1014296_299276506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-1014354_374276506.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000264110-1014380_408276506.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-913296_299218448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-913354_374218448.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000345739-913380_408218448.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-16296_2990127.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-16354_3740127.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-16380_4080127.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-1115296_299276506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-1115354_374276506.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000392544-1115380_408276506.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-16296_2990145.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-16354_3740145.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-16380_4080145.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-1014296_299218448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-1014354_374218448.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000409635-1014380_408218448.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-18296_2990210.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-18354_3740210.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-18380_4080210.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-1115296_299258488.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-1115354_374258488.0RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000426833-1115380_408258488.0RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-1016296_299219373.3333333333333RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-1016354_374219373.3333333333333RegionBasic motif
HgeneATF2chr2:175976296chr14:50641270ENST00000487334-1016380_408219373.3333333333333RegionLeucine-zipper
HgeneATF2chr2:175976296chr14:50641270ENST00000392543-1625_490127.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000409499-1625_490145.0Zinc fingerC2H2-type
HgeneATF2chr2:175976296chr14:50641270ENST00000409833-1825_490210.0Zinc fingerC2H2-type
TgeneSOS2chr2:175976296chr14:50641270ENST00000216373623198_3883231333.0DomainDH


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Fusion Gene Sequence for ATF2-SOS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7414_7414_1_ATF2-SOS2_ATF2_chr2_175976296_ENST00000264110_SOS2_chr14_50641270_ENST00000216373_length(transcript)=5372nt_BP=1127nt
GTTGTCAGTCCGATCTCGCGAGAGAGGACGGAAGCCTGTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCT
TTGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACCGAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAA
AGGACTGCTTATTGATAACAGCTAAGGTATTCCTGGAAGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGTATTCTTGCCATGA
GAAAAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGGCAATACAAGGACCTGTGGAATATGAGTG
ATGACAAACCCTTTCTATGTACTGCGCCTGGATGTGGCCAGCGTTTTACCAACGAGGATCATTTGGCTGTCCATAAACATAAACATGAGA
TGACACTGAAATTTGGTCCAGCACGTAATGACAGTGTCATTGTGGCTGATCAGACCCCAACACCAACAAGATTCTTGAAAAACTGTGAAG
AAGTGGGTTTGTTTAATGAGTTGGCGAGTCCATTTGAGAATGAATTCAAGAAAGCTTCAGAAGATGACATTAAAAAAATGCCTCTAGATT
TATCCCCTCTTGCAACACCTATCATAAGAAGCAAAATTGAGGAGCCTTCTGTTGTAGAAACAACTCACCAGGATAGTCCTTTACCTCACC
CAGAGTCTACTACCAGTGATGAGAAGGAAGTACCATTGGCACAAACTGCACAGCCCACATCAGCTATTGTTCGTCCAGCATCATTACAGG
TTCCCAATGTGCTGCTTACAAGTTCTGACTCAAGTGTAATTATTCAGCAGGCAGTACCTTCACCAACCTCAAGTACTGTAATCACCCAGG
CACCATCCTCTAACAGGCCAATTGTCCCTGTACCAGGCCCATTTCCTCTTCTGTTACATCTTCCTAATGGACAAACCATGCCTGTTGCTA
TTCCTGCATCAATTACAAGTTCTAATGTGCATGTTCCAGCTGCAGTCCCACTCGTTCGACCAGTCACCATGGTGCCTAGTGTTCCAGGAA
TCCCAGGTCCTTCCTCTCCCCAACCAGTACAGTCAGAAGCAAAAATGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTC
CACGTCTTATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACA
GAGAATGTTTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGAC
CTGGAGATCCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCG
ATGGATGGGAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGC
ATATTTTTCTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGT
TAAAAGAAAAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAG
ATGAGAACAGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTC
TAGATCGAATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAA
AAGACTCTGAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAA
TTGAAAGGTTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAAT
TGCTGAGCTTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAA
TCAGTGCAGACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATC
ATTTTTATGACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGG
TAGAGTCAATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCAC
CAATTGAATGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACAC
TTTTGGAGTCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAA
ATTTATTAAAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGG
CAGTACTAAGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATT
CAGTGTCAGTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAG
ATCACTTTAAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGA
CCGAAGAAGGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAG
AAATTCAGCAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTG
CATCTGAAAAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGA
AATCAACTTTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACAC
CATTAGAAAGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATA
CACCATCTACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCT
TTGCTCCAGTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTC
CTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGA
GACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCAC
CAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTC
CACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTC
CAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATT
CAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATG
CAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGA
CATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACA
AAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTAT
ATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTG
AGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTT
CTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGG
TATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAA
GACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAA
TGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCT
ATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAA
CTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATT
TAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAA
GTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTAC

>7414_7414_1_ATF2-SOS2_ATF2_chr2_175976296_ENST00000264110_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=1285AA_BP=276
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYS
HQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKI
QICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFE
DNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRK
EYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPG
QFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEIL
QVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLK
KKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPG
IRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSK
SFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPP
PVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPP

--------------------------------------------------------------
>7414_7414_2_ATF2-SOS2_ATF2_chr2_175976296_ENST00000345739_SOS2_chr14_50641270_ENST00000216373_length(transcript)=5275nt_BP=1030nt
GTTGTCAGTCCGATCTCGCGAGAGAGGACGGAAGCCTGTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCT
TTGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACCGAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAA
AGGACTGCTTATTGATAACAGCTAAGGTATTCCTGGAAGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGTATTCTTGCCATGA
GAAAAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGGCAATACAAGGACCTGTGGAATATGAGTG
ATGACAAACCCTTTCTATGTACTGCGCCTGGATGTGGCCAGATCAGACCCCAACACCAACAAGATTCTTGAAAAACTGTGAAGAAGTGGG
TTTGTTTAATGAGTTGGCGAGTCCATTTGAGAATGAATTCAAGAAAGCTTCAGAAGATGACATTAAAAAAATGCCTCTAGATTTATCCCC
TCTTGCAACACCTATCATAAGAAGCAAAATTGAGGAGCCTTCTGTTGTAGAAACAACTCACCAGGATAGTCCTTTACCTCACCCAGAGTC
TACTACCAGTGATGAGAAGGAAGTACCATTGGCACAAACTGCACAGCCCACATCAGCTATTGTTCGTCCAGCATCATTACAGGTTCCCAA
TGTGCTGCTTACAAGTTCTGACTCAAGTGTAATTATTCAGCAGGCAGTACCTTCACCAACCTCAAGTACTGTAATCACCCAGGCACCATC
CTCTAACAGGCCAATTGTCCCTGTACCAGGCCCATTTCCTCTTCTGTTACATCTTCCTAATGGACAAACCATGCCTGTTGCTATTCCTGC
ATCAATTACAAGTTCTAATGTGCATGTTCCAGCTGCAGTCCCACTCGTTCGACCAGTCACCATGGTGCCTAGTGTTCCAGGAATCCCAGG
TCCTTCCTCTCCCCAACCAGTACAGTCAGAAGCAAAAATGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTCCACGTCT
TATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACAGAGAATG
TTTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGACCTGGAGA
TCCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCGATGGATG
GGAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGCATATTTT
TCTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGTTAAAAGA
AAAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAGATGAGAA
CAGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTCTAGATCG
AATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAAAAGACTC
TGAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAATTGAAAG
GTTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAATTGCTGAG
CTTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAATCAGTGC
AGACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATCATTTTTA
TGACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGGTAGAGTC
AATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCACCAATTGA
ATGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACACTTTTGGA
GTCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAAATTTATT
AAAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGGCAGTACT
AAGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATTCAGTGTC
AGTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAGATCACTT
TAAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGACCGAAGA
AGGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAGAAATTCA
GCAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTGCATCTGA
AAAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGAAATCAAC
TTTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACACCATTAGA
AAGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATACACCATC
TACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCTTTGCTCC
AGTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCC
TCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCC
TCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGA
TCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGG
GCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGT
ACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCC
TCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAAC
TCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTA
TTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCC
TTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCA
CTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATA
GATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTT
TTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGC
TGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACA
TAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTG
CCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAA
TTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTT
GCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCA
GCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAG
AGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTT

>7414_7414_2_ATF2-SOS2_ATF2_chr2_175976296_ENST00000345739_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=1227AA_BP=218
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAI
TALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGL
MISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSV
LLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIER
FEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKII
RRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRH
TTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLV
KLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTD
YLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVS
ASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKV
KPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCY

--------------------------------------------------------------
>7414_7414_3_ATF2-SOS2_ATF2_chr2_175976296_ENST00000409635_SOS2_chr14_50641270_ENST00000216373_length(transcript)=5335nt_BP=1090nt
GTCAGTCCGATCTCGCGAGAGAGGACGGAAGCCTGTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCTTTG
TAAACACGGCTGTGCTCAGGGCTCGCGGGTGACCGAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAAAGG
ACTGCTTATTGATAACAGCTAAGGTATTCCTGGAAGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGTATTCTTGCCATGAGAA
AAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGATACTGAATTCATTACTTAAAACCACCCAGAA
GAGAAACCTCCAGGCTCAGATAGCTTCACTGGCAATACAAGGACCTGTGGAATATGAGTGATGACAAACCCTTTCTATGTACTGCGCCTG
GATGTGGCCAGATCAGACCCCAACACCAACAAGATTCTTGAAAAACTGTGAAGAAGTGGGTTTGTTTAATGAGTTGGCGAGTCCATTTGA
GAATGAATTCAAGAAAGCTTCAGAAGATGACATTAAAAAAATGCCTCTAGATTTATCCCCTCTTGCAACACCTATCATAAGAAGCAAAAT
TGAGGAGCCTTCTGTTGTAGAAACAACTCACCAGGATAGTCCTTTACCTCACCCAGAGTCTACTACCAGTGATGAGAAGGAAGTACCATT
GGCACAAACTGCACAGCCCACATCAGCTATTGTTCGTCCAGCATCATTACAGGTTCCCAATGTGCTGCTTACAAGTTCTGACTCAAGTGT
AATTATTCAGCAGGCAGTACCTTCACCAACCTCAAGTACTGTAATCACCCAGGCACCATCCTCTAACAGGCCAATTGTCCCTGTACCAGG
CCCATTTCCTCTTCTGTTACATCTTCCTAATGGACAAACCATGCCTGTTGCTATTCCTGCATCAATTACAAGTTCTAATGTGCATGTTCC
AGCTGCAGTCCCACTCGTTCGACCAGTCACCATGGTGCCTAGTGTTCCAGGAATCCCAGGTCCTTCCTCTCCCCAACCAGTACAGTCAGA
AGCAAAAATGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTCCACGTCTTATGCTGGTGCCAGTGTATCACTGTTGGCA
CTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACAGAGAATGTTTGAACCAAGCTATTACTGCTCTCATGAA
TCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGACCTGGAGATCCTGTTTGCCCTTTTTATAGTCACCAATT
AAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCGATGGATGGGAAGGCAAAGATATTGGACAGTGTTGTAA
TGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGCATATTTTTCTGTTTGATGGCTTAATGATCAGTTGTAA
ACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGTTAAAAGAAAAATTTGTCATGAGGAAAATACAAATTTG
TGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAGATGAGAACAGCATAATATTTGCTGCTAAGTCTGCTGA
AGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTCTAGATCGAATGTTAGATTCAGTATTATTGAAAGAAGA
AAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAAAAGACTCTGAGGAAAACATTGTTTTTGAAGACAACTT
GCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAATTGAAAGGTTAACATATCATATGTATGCAGATCCCAA
TTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAATTGCTGAGCTTACTGATTGAACGGTTTGAAATTCCAGA
GCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAATCAGTGCAGACCTTAAAAGATTTCGCAAGGAATATGT
CCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATCATTTTTATGACTTTGAAAGAGACTTGGAATTGCTTGA
AAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGGTAGAGTCAATTGCTAAGATCATCAGGAGGAAGAAGCA
AGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCACCAATTGAATGGCATATCAGCAAACCAGGACAGTTTGA
AACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACACTTTTGGAGTCTGATCTTTACAGGAAAGTTCAACCGTC
TGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAAATTTATTAAAAATGATTCGCCATACCACAAATCTCAC
CCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGGCAGTACTAAGTAGAATTATAGAAATTCTGCAAGTTTT
TCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATTCAGTGTCAGTATACAGACTAGACCATACCTTTGAGGC
ACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAGATCACTTTAAAAAATACCTAGTAAAACTTAAGTCAAT
CAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGACCGAAGAAGGGAATAATGATTTTTTAAAAAAGAAAGG
GAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAGAAATTCAGCAGTATCAGAATCAGCCTTACTGTTTACG
GATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTGCATCTGAAAAAGAGTTTACAGATTATTTGTTCAACAA
GTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGAAATCAACTTTTTCCTTAAAATCTCCTGGAATAAGGCC
TAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACACCATTAGAAAGAGAACCATGTAAAATAAGCTTTAGTCG
GATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATACACCATCTACTCCACCAGTATCTGCTTCTTCAGACCT
TAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCTTTGCTCCAGTGCTTTTGCCACATTCAAAGTCTTTCTT
TAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTC
AAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCC
TGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCC
CCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAG
AGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAG
TCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTA
CAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCAT
TGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTA
CAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCA
TTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAG
TGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACA
AATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATT
GTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGA
AAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATG
TATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCC
ATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATC
TGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAA
ATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTT
AATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAG
TTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAACAAGATTAATAAA

>7414_7414_3_ATF2-SOS2_ATF2_chr2_175976296_ENST00000409635_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=1227AA_BP=218
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAI
TALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGL
MISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSV
LLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIER
FEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKII
RRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRH
TTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLV
KLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTD
YLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVS
ASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKV
KPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCY

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Fusion Gene PPI Analysis for ATF2-SOS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF2-SOS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF2-SOS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF2C0006826Malignant Neoplasms1CTD_human
HgeneATF2C0027651Neoplasms1CTD_human
HgeneATF2C0086692Benign Neoplasm1CTD_human
HgeneATF2C0235874Disease Exacerbation1CTD_human
TgeneC0028326Noonan Syndrome4CLINGEN;GENOMICS_ENGLAND;ORPHANET
TgeneC4225282NOONAN SYNDROME 92CTD_human;GENOMICS_ENGLAND;UNIPROT