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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CREBL2-DDX47 (FusionGDB2 ID:HG1389TG51202) |
Fusion Gene Summary for CREBL2-DDX47 |
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Fusion gene information | Fusion gene name: CREBL2-DDX47 | Fusion gene ID: hg1389tg51202 | Hgene | Tgene | Gene symbol | CREBL2 | DDX47 | Gene ID | 1389 | 51202 |
Gene name | cAMP responsive element binding protein like 2 | DEAD-box helicase 47 | |
Synonyms | - | E4-DBP|HQ0256|MSTP162|RRP3 | |
Cytomap | ('CREBL2')('DDX47') 12p13.1 | 12p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-responsive element-binding protein-like 2MHBs-binding protein 1 | probable ATP-dependent RNA helicase DDX47DEAD (Asp-Glu-Ala-Asp) box polypeptide 47DEAD box polypeptide 47DEAD box protein 47E4-DEAD box protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | O60519 | Q9H0S4 | |
Ensembl transtripts involved in fusion gene | ENST00000540224, ENST00000228865, | ENST00000228865, ENST00000540224, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 4 X 4 X 4=64 |
# samples | 4 | 4 | |
** MAII score | log2(4/40*10)=0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CREBL2 [Title/Abstract] AND DDX47 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CREBL2(12765121)-DDX47(12974142), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | CREBL2-DDX47 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. CREBL2-DDX47 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DDX47 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 15977068 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-EY-A1GR-01A | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
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Fusion Gene ORF analysis for CREBL2-DDX47 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000540224 | ENST00000352940 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
3UTR-3CDS | ENST00000540224 | ENST00000358007 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
3UTR-3UTR | ENST00000540224 | ENST00000392155 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
5CDS-3UTR | ENST00000228865 | ENST00000392155 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
Frame-shift | ENST00000228865 | ENST00000352940 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
Frame-shift | ENST00000228865 | ENST00000358007 | CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974142 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CREBL2-DDX47 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974141 | + | 2.81E-06 | 0.99999714 |
CREBL2 | chr12 | 12765121 | + | DDX47 | chr12 | 12974141 | + | 2.81E-06 | 0.99999714 |
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Fusion Protein Features for CREBL2-DDX47 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:12765121/:12974142) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CREBL2 | DDX47 |
FUNCTION: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. {ECO:0000269|PubMed:9693048}. | FUNCTION: Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. {ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CREBL2-DDX47 |
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Fusion Gene PPI Analysis for CREBL2-DDX47 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CREBL2-DDX47 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CREBL2-DDX47 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |