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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP42-KMO (FusionGDB2 ID:HG143872TG8564)

Fusion Gene Summary for ARHGAP42-KMO

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP42-KMO
	Fusion gene ID: hg143872tg8564
		Hgene	Tgene
	Gene symbol	ARHGAP42	KMO
	Gene ID	143872	8564
	Gene name	Rho GTPase activating protein 42	kynurenine 3-monooxygenase
	Synonyms	AD031\|GRAF3\|TMEM133	dJ317G22.1
	Cytomap	('ARHGAP42')('KMO') 11q22.1	1q43
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133	kynurenine 3-monooxygenasekynurenine 3-hydroxylase
	Modification date	20200313	20200313
	UniProtAcc	.	O15229
	Ensembl transtripts involved in fusion gene	ENST00000534060, ENST00000298815, ENST00000524892,
Fusion gene scores	* DoF score	11 X 7 X 7=539	3 X 3 X 3=27
	# samples	12	4
	** MAII score	log2(12/539*10)=-2.16725086714399 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARHGAP42 [Title/Abstract] AND KMO [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP42(100730356)-KMO(241749981), # samples:3
Anticipated loss of major functional domain due to fusion event.	ARHGAP42-KMO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP42-KMO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGAP42	GO:0090630	activation of GTPase activity	24335996
Tgene	KMO	GO:0009651	response to salt stress	10672018
Tgene	KMO	GO:0019674	NAD metabolic process	23575632\|29429898
Tgene	KMO	GO:0070189	kynurenine metabolic process	10672018\|26752518\|29208702\|29429898

Fusion gene breakpoints across ARHGAP42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KMO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-A8YO-01A	ARHGAP42	chr11	100730356	-	KMO	chr1	241749981	+
ChimerDB4	LIHC	TCGA-BC-A8YO-01A	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
ChimerDB4	LIHC	TCGA-BC-A8YO	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+

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Fusion Gene ORF analysis for ARHGAP42-KMO

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000534060	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
3UTR-3CDS	ENST00000534060	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
3UTR-3CDS	ENST00000534060	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
3UTR-3CDS	ENST00000534060	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
3UTR-intron	ENST00000534060	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
3UTR-intron	ENST00000534060	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
3UTR-intron	ENST00000534060	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
3UTR-intron	ENST00000534060	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
5CDS-intron	ENST00000298815	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
5CDS-intron	ENST00000298815	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
5CDS-intron	ENST00000298815	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
5CDS-intron	ENST00000298815	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
5CDS-intron	ENST00000524892	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
5CDS-intron	ENST00000524892	ENST00000366557	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
5CDS-intron	ENST00000524892	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
5CDS-intron	ENST00000524892	ENST00000484628	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
In-frame	ENST00000298815	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
In-frame	ENST00000298815	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
In-frame	ENST00000298815	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
In-frame	ENST00000298815	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
In-frame	ENST00000524892	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
In-frame	ENST00000524892	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+
In-frame	ENST00000524892	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+
In-frame	ENST00000524892	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000524892	ARHGAP42	chr11	100730356	+	ENST00000366558	KMO	chr1	241749981	+	1010	410	26	874	282
ENST00000524892	ARHGAP42	chr11	100730356	+	ENST00000366559	KMO	chr1	241749981	+	4403	410	26	913	295
ENST00000298815	ARHGAP42	chr11	100730356	+	ENST00000366558	KMO	chr1	241749981	+	987	387	3	851	282
ENST00000298815	ARHGAP42	chr11	100730356	+	ENST00000366559	KMO	chr1	241749981	+	4380	387	3	890	295
ENST00000524892	ARHGAP42	chr11	100730356	+	ENST00000366558	KMO	chr1	241749980	+	1010	410	26	874	282
ENST00000524892	ARHGAP42	chr11	100730356	+	ENST00000366559	KMO	chr1	241749980	+	4403	410	26	913	295
ENST00000298815	ARHGAP42	chr11	100730356	+	ENST00000366558	KMO	chr1	241749980	+	987	387	3	851	282
ENST00000298815	ARHGAP42	chr11	100730356	+	ENST00000366559	KMO	chr1	241749980	+	4380	387	3	890	295

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000524892	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+	0.003333442	0.9966666
ENST00000524892	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+	0.001766106	0.9982339
ENST00000298815	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+	0.003118659	0.99688137
ENST00000298815	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749981	+	0.001760849	0.99823916
ENST00000524892	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	0.003333442	0.9966666
ENST00000524892	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	0.001766106	0.9982339
ENST00000298815	ENST00000366558	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	0.003118659	0.99688137
ENST00000298815	ENST00000366559	ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	0.001760849	0.99823916

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Fusion Genomic Features for ARHGAP42-KMO

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	4.21E-06	0.9999958
ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	4.21E-06	0.9999958
ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	4.21E-06	0.9999958
ARHGAP42	chr11	100730356	+	KMO	chr1	241749980	+	4.21E-06	0.9999958

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP42-KMO

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:100730356/chr1:241749981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KMO O15229
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). {ECO:0000269\|PubMed:23575632, ECO:0000269\|PubMed:26752518, ECO:0000269\|PubMed:28604669, ECO:0000269\|PubMed:29208702, ECO:0000269\|PubMed:29429898, ECO:0000305\|PubMed:12402501}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366557

317_318

319

453.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366558

317_318

319

474.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366559

317_318

319

487.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366557

317_318

319

453.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366558

317_318

319

474.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366559

317_318

319

487.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366557

385_404

319

453.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366557

425_445

319

453.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366558

385_404

319

474.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366558

425_445

319

474.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366559

385_404

319

487.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366559

425_445

319

487.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366557

385_404

319

453.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366557

425_445

319

453.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366558

385_404

319

474.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366558

425_445

319

474.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366559

385_404

319

487.0

Transmembrane

Helical

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366559

425_445

319

487.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

225_261

128

875.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

225_261

128

875.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

619_762

128

875.0

Compositional bias

Note=Ser-rich

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

619_762

128

875.0

Compositional bias

Note=Ser-rich

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

265_374

128

875.0

Domain

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

376_572

128

875.0

Domain

Rho-GAP

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

7_262

128

875.0

Domain

Note=BAR

Hgene

ARHGAP42

chr11:100730356

chr1:241749980

ENST00000298815

816_874

128

875.0

Domain

SH3

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

265_374

128

875.0

Domain

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

376_572

128

875.0

Domain

Rho-GAP

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

7_262

128

875.0

Domain

Note=BAR

Hgene

ARHGAP42

chr11:100730356

chr1:241749981

ENST00000298815

816_874

128

875.0

Domain

SH3

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366557

37_40

319

453.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366558

37_40

319

474.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749980

ENST00000366559

37_40

319

487.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366557

37_40

319

453.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366558

37_40

319

474.0

Nucleotide binding

FAD

Tgene

KMO

chr11:100730356

chr1:241749981

ENST00000366559

37_40

319

487.0

Nucleotide binding

FAD

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Fusion Gene Sequence for ARHGAP42-KMO

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6112_6112_1_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366558_length(transcript)=987nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAG
AGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAG
CGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACAC
TACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCC
GTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAAT
TAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTA

>6112_6112_1_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV
DSLEQISNLISR

--------------------------------------------------------------
>6112_6112_2_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366559_length(transcript)=4380nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACAT
GTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATG
GTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGA
TCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATA
GCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGT
TTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGA
TAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAA
CATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTA
AGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGG
ACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGAT
AAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTAT
TATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTA
TCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAAC
CTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTG
CCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCA
CCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAA
ATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGA
CCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAA
ATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGA
GTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAAT
CCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGAT
TGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCT
GGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGT
CTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCA
AAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATT
ATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCAC
ACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATAT
ATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCAC
CCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGG
TTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGT
TGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTC
ATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGG
TCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGA
TCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAG
CTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTT
ATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACAC
TTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCAC
TGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATG
TCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCA
TCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTC
TCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGAT
CCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTT
GCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAAT
GTTGAATATATGGACTTTCTCAGATTAGGAAATACCAATTAAAAATATAATAAATAGCTA

>6112_6112_2_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA
HFRNTTCFPAKAVDSLEQISNLISR

--------------------------------------------------------------
>6112_6112_3_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366558_length(transcript)=987nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAG
AGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAG
CGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACAC
TACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCC
GTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAAT
TAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTA

>6112_6112_3_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV
DSLEQISNLISR

--------------------------------------------------------------
>6112_6112_4_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366559_length(transcript)=4380nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACAT
GTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATG
GTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGA
TCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATA
GCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGT
TTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGA
TAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAA
CATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTA
AGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGG
ACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGAT
AAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTAT
TATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTA
TCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAAC
CTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTG
CCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCA
CCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAA
ATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGA
CCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAA
ATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGA
GTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAAT
CCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGAT
TGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCT
GGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGT
CTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCA
AAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATT
ATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCAC
ACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATAT
ATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCAC
CCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGG
TTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGT
TGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTC
ATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGG
TCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGA
TCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAG
CTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTT
ATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACAC
TTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCAC
TGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATG
TCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCA
TCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTC
TCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGAT
CCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTT
GCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAAT
GTTGAATATATGGACTTTCTCAGATTAGGAAATACCAATTAAAAATATAATAAATAGCTA

>6112_6112_4_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA
HFRNTTCFPAKAVDSLEQISNLISR

--------------------------------------------------------------
>6112_6112_5_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366558_length(transcript)=1010nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAA
TAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCA
GCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATA
CAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATG
CATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATA
ATTAAACTGAATGTAGAGTA

>6112_6112_5_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV
DSLEQISNLISR

--------------------------------------------------------------
>6112_6112_6_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366559_length(transcript)=4403nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGA
CCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAA
ACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCT
TGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATC
TCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCC
ATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGG
GGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAA
GATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCA
ACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAAC
CACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATT
TTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTAT
CTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTG
GTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTAT
TTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGT
ACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGG
ACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAG
CCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGA
TTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATT
AATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAA
TGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGG
GGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGG
GAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAA
AACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTG
GTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGG
ATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAAT
TCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGA
AAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGT
GGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTC
GGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATC
CAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCG
CTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCA
TCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGG
AGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATT
AACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATC
TACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCC
TCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTG
GGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTT
ACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATAC
TATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCC
GCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTC
CTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTAT
TAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATC
CCATTATTTAGAGCGAAATAAATGTTGAATATATGGACTTTCTCAGATTAGGAAATACCAATTAAAAATATAATAAATAGCTA

>6112_6112_6_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA
HFRNTTCFPAKAVDSLEQISNLISR

--------------------------------------------------------------
>6112_6112_7_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366558_length(transcript)=1010nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAA
TAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCA
GCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATA
CAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATG
CATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATA
ATTAAACTGAATGTAGAGTA

>6112_6112_7_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV
DSLEQISNLISR

--------------------------------------------------------------
>6112_6112_8_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366559_length(transcript)=4403nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGA
CCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAA
ACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCT
TGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATC
TCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCC
ATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGG
GGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAA
GATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCA
ACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAAC
CACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATT
TTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTAT
CTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTG
GTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTAT
TTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGT
ACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGG
ACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAG
CCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGA
TTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATT
AATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAA
TGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGG
GGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGG
GAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAA
AACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTG
GTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGG
ATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAAT
TCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGA
AAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGT
GGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTC
GGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATC
CAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCG
CTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCA
TCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGG
AGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATT
AACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATC
TACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCC
TCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTG
GGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTT
ACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATAC
TATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCC
GCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTC
CTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTAT
TAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATC
CCATTATTTAGAGCGAAATAAATGTTGAATATATGGACTTTCTCAGATTAGGAAATACCAATTAAAAATATAATAAATAGCTA

>6112_6112_8_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA
HFRNTTCFPAKAVDSLEQISNLISR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP42-KMO

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGAP42-KMO

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGAP42-KMO

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0036341	Schizophrenia	5	PSYGENET
Tgene		C0041696	Unipolar Depression	2	PSYGENET
Tgene		C1269683	Major Depressive Disorder	2	PSYGENET
Tgene		C0005587	Depression, Bipolar	1	PSYGENET
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C0162820	Dermatitis, Allergic Contact	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ARHGAP42-KMO (FusionGDB2 ID:HG143872TG8564)

Fusion Gene Summary for ARHGAP42-KMO

Fusion Gene ORF analysis for ARHGAP42-KMO

Fusion Genomic Features for ARHGAP42-KMO

Fusion Protein Features for ARHGAP42-KMO

Fusion Gene Sequence for ARHGAP42-KMO

Fusion Gene PPI Analysis for ARHGAP42-KMO

Related Drugs for ARHGAP42-KMO

Related Diseases for ARHGAP42-KMO

Fusion Gene Studies
in Kim Lab