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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP42-KMO (FusionGDB2 ID:HG143872TG8564)

Fusion Gene Summary for ARHGAP42-KMO

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP42-KMO
Fusion gene ID: hg143872tg8564
HgeneTgene
Gene symbol

ARHGAP42

KMO

Gene ID

143872

8564

Gene nameRho GTPase activating protein 42kynurenine 3-monooxygenase
SynonymsAD031|GRAF3|TMEM133dJ317G22.1
Cytomap('ARHGAP42')('KMO')

11q22.1

1q43

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133kynurenine 3-monooxygenasekynurenine 3-hydroxylase
Modification date2020031320200313
UniProtAcc.

O15229

Ensembl transtripts involved in fusion geneENST00000534060, ENST00000298815, 
ENST00000524892, 
Fusion gene scores* DoF score11 X 7 X 7=5393 X 3 X 3=27
# samples 124
** MAII scorelog2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP42 [Title/Abstract] AND KMO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP42(100730356)-KMO(241749981), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGAP42-KMO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP42-KMO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP42

GO:0090630

activation of GTPase activity

24335996

TgeneKMO

GO:0009651

response to salt stress

10672018

TgeneKMO

GO:0019674

NAD metabolic process

23575632|29429898

TgeneKMO

GO:0070189

kynurenine metabolic process

10672018|26752518|29208702|29429898


check buttonFusion gene breakpoints across ARHGAP42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KMO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A8YO-01AARHGAP42chr11

100730356

-KMOchr1

241749981

+
ChimerDB4LIHCTCGA-BC-A8YO-01AARHGAP42chr11

100730356

+KMOchr1

241749981

+
ChimerDB4LIHCTCGA-BC-A8YOARHGAP42chr11

100730356

+KMOchr1

241749980

+


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Fusion Gene ORF analysis for ARHGAP42-KMO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000534060ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749981

+
3UTR-3CDSENST00000534060ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749980

+
3UTR-3CDSENST00000534060ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749981

+
3UTR-3CDSENST00000534060ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749980

+
3UTR-intronENST00000534060ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749981

+
3UTR-intronENST00000534060ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749980

+
3UTR-intronENST00000534060ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749981

+
3UTR-intronENST00000534060ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749980

+
5CDS-intronENST00000298815ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749981

+
5CDS-intronENST00000298815ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749980

+
5CDS-intronENST00000298815ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749981

+
5CDS-intronENST00000298815ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749980

+
5CDS-intronENST00000524892ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749981

+
5CDS-intronENST00000524892ENST00000366557ARHGAP42chr11

100730356

+KMOchr1

241749980

+
5CDS-intronENST00000524892ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749981

+
5CDS-intronENST00000524892ENST00000484628ARHGAP42chr11

100730356

+KMOchr1

241749980

+
In-frameENST00000298815ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749981

+
In-frameENST00000298815ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749980

+
In-frameENST00000298815ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749981

+
In-frameENST00000298815ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749980

+
In-frameENST00000524892ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749981

+
In-frameENST00000524892ENST00000366558ARHGAP42chr11

100730356

+KMOchr1

241749980

+
In-frameENST00000524892ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749981

+
In-frameENST00000524892ENST00000366559ARHGAP42chr11

100730356

+KMOchr1

241749980

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524892ARHGAP42chr11100730356+ENST00000366558KMOchr1241749981+101041026874282
ENST00000524892ARHGAP42chr11100730356+ENST00000366559KMOchr1241749981+440341026913295
ENST00000298815ARHGAP42chr11100730356+ENST00000366558KMOchr1241749981+9873873851282
ENST00000298815ARHGAP42chr11100730356+ENST00000366559KMOchr1241749981+43803873890295
ENST00000524892ARHGAP42chr11100730356+ENST00000366558KMOchr1241749980+101041026874282
ENST00000524892ARHGAP42chr11100730356+ENST00000366559KMOchr1241749980+440341026913295
ENST00000298815ARHGAP42chr11100730356+ENST00000366558KMOchr1241749980+9873873851282
ENST00000298815ARHGAP42chr11100730356+ENST00000366559KMOchr1241749980+43803873890295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524892ENST00000366558ARHGAP42chr11100730356+KMOchr1241749981+0.0033334420.9966666
ENST00000524892ENST00000366559ARHGAP42chr11100730356+KMOchr1241749981+0.0017661060.9982339
ENST00000298815ENST00000366558ARHGAP42chr11100730356+KMOchr1241749981+0.0031186590.99688137
ENST00000298815ENST00000366559ARHGAP42chr11100730356+KMOchr1241749981+0.0017608490.99823916
ENST00000524892ENST00000366558ARHGAP42chr11100730356+KMOchr1241749980+0.0033334420.9966666
ENST00000524892ENST00000366559ARHGAP42chr11100730356+KMOchr1241749980+0.0017661060.9982339
ENST00000298815ENST00000366558ARHGAP42chr11100730356+KMOchr1241749980+0.0031186590.99688137
ENST00000298815ENST00000366559ARHGAP42chr11100730356+KMOchr1241749980+0.0017608490.99823916

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Fusion Genomic Features for ARHGAP42-KMO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP42chr11100730356+KMOchr1241749980+4.21E-060.9999958
ARHGAP42chr11100730356+KMOchr1241749980+4.21E-060.9999958
ARHGAP42chr11100730356+KMOchr1241749980+4.21E-060.9999958
ARHGAP42chr11100730356+KMOchr1241749980+4.21E-060.9999958

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP42-KMO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:100730356/chr1:241749981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KMO

O15229

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). {ECO:0000269|PubMed:23575632, ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669, ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898, ECO:0000305|PubMed:12402501}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMOchr11:100730356chr1:241749980ENST00000366557914317_318319453.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749980ENST00000366558915317_318319474.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749980ENST00000366559915317_318319487.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST00000366557914317_318319453.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST00000366558915317_318319474.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST00000366559915317_318319487.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749980ENST00000366557914385_404319453.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749980ENST00000366557914425_445319453.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749980ENST00000366558915385_404319474.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749980ENST00000366558915425_445319474.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749980ENST00000366559915385_404319487.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749980ENST00000366559915425_445319487.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366557914385_404319453.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366557914425_445319453.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366558915385_404319474.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366558915425_445319474.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366559915385_404319487.0TransmembraneHelical
TgeneKMOchr11:100730356chr1:241749981ENST00000366559915425_445319487.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+424225_261128875.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+424225_261128875.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+424619_762128875.0Compositional biasNote=Ser-rich
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+424619_762128875.0Compositional biasNote=Ser-rich
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+424265_374128875.0DomainPH
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+424376_572128875.0DomainRho-GAP
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+4247_262128875.0DomainNote=BAR
HgeneARHGAP42chr11:100730356chr1:241749980ENST00000298815+424816_874128875.0DomainSH3
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+424265_374128875.0DomainPH
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+424376_572128875.0DomainRho-GAP
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+4247_262128875.0DomainNote=BAR
HgeneARHGAP42chr11:100730356chr1:241749981ENST00000298815+424816_874128875.0DomainSH3
TgeneKMOchr11:100730356chr1:241749980ENST0000036655791437_40319453.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749980ENST0000036655891537_40319474.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749980ENST0000036655991537_40319487.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST0000036655791437_40319453.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST0000036655891537_40319474.0Nucleotide bindingFAD
TgeneKMOchr11:100730356chr1:241749981ENST0000036655991537_40319487.0Nucleotide bindingFAD


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Fusion Gene Sequence for ARHGAP42-KMO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6112_6112_1_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366558_length(transcript)=987nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAG
AGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAG
CGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACAC
TACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCC
GTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAAT

>6112_6112_1_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV

--------------------------------------------------------------
>6112_6112_2_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366559_length(transcript)=4380nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACAT
GTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATG
GTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGA
TCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATA
GCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGT
TTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGA
TAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAA
CATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTA
AGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGG
ACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGAT
AAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTAT
TATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTA
TCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAAC
CTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTG
CCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCA
CCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAA
ATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGA
CCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAA
ATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGA
GTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAAT
CCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGAT
TGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCT
GGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGT
CTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCA
AAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATT
ATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCAC
ACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATAT
ATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCAC
CCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGG
TTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGT
TGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTC
ATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGG
TCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGA
TCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAG
CTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTT
ATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACAC
TTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCAC
TGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATG
TCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCA
TCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTC
TCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGAT
CCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTT
GCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAAT

>6112_6112_2_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749980_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA

--------------------------------------------------------------
>6112_6112_3_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366558_length(transcript)=987nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAG
AGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAG
CGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACAC
TACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCC
GTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAAT

>6112_6112_3_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV

--------------------------------------------------------------
>6112_6112_4_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366559_length(transcript)=4380nt_BP=387nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT
CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG
TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACAT
GTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATG
GTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGA
TCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATA
GCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGT
TTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGA
TAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAA
CATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTA
AGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGG
ACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGAT
AAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTAT
TATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTA
TCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAAC
CTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTG
CCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCA
CCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAA
ATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGA
CCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAA
ATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGA
GTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAAT
CCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGAT
TGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCT
GGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGT
CTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCA
AAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATT
ATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCAC
ACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATAT
ATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCAC
CCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGG
TTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGT
TGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTC
ATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGG
TCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGA
TCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAG
CTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTT
ATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACAC
TTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCAC
TGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATG
TCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCA
TCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTC
TCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGAT
CCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTT
GCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAAT

>6112_6112_4_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000298815_KMO_chr1_241749981_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA

--------------------------------------------------------------
>6112_6112_5_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366558_length(transcript)=1010nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAA
TAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCA
GCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATA
CAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATG
CATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATA

>6112_6112_5_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV

--------------------------------------------------------------
>6112_6112_6_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366559_length(transcript)=4403nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGA
CCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAA
ACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCT
TGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATC
TCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCC
ATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGG
GGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAA
GATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCA
ACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAAC
CACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATT
TTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTAT
CTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTG
GTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTAT
TTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGT
ACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGG
ACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAG
CCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGA
TTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATT
AATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAA
TGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGG
GGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGG
GAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAA
AACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTG
GTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGG
ATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAAT
TCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGA
AAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGT
GGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTC
GGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATC
CAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCG
CTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCA
TCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGG
AGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATT
AACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATC
TACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCC
TCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTG
GGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTT
ACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATAC
TATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCC
GCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTC
CTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTAT
TAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATC

>6112_6112_6_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749980_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA

--------------------------------------------------------------
>6112_6112_7_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366558_length(transcript)=1010nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAA
TAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCA
GCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATA
CAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATG
CATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATA

>6112_6112_7_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366558_length(amino acids)=282AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER
FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV

--------------------------------------------------------------
>6112_6112_8_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366559_length(transcript)=4403nt_BP=410nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT
TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA
AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA
ATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGA
CCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAA
ACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCT
TGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATC
TCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCC
ATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGG
GGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAA
GATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCA
ACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAAC
CACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATT
TTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTAT
CTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTG
GTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTAT
TTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGT
ACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGG
ACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAG
CCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGA
TTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATT
AATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAA
TGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGG
GGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGG
GAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAA
AACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTG
GTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGG
ATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAAT
TCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGA
AAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGT
GGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTC
GGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATC
CAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCG
CTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCA
TCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGG
AGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATT
AACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATC
TACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCC
TCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTG
GGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTT
ACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATAC
TATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCC
GCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTC
CTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTAT
TAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATC

>6112_6112_8_ARHGAP42-KMO_ARHGAP42_chr11_100730356_ENST00000524892_KMO_chr1_241749981_ENST00000366559_length(amino acids)=295AA_BP=128
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV
NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA

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Fusion Gene PPI Analysis for ARHGAP42-KMO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP42-KMO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP42-KMO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia5PSYGENET
TgeneC0041696Unipolar Depression2PSYGENET
TgeneC1269683Major Depressive Disorder2PSYGENET
TgeneC0005587Depression, Bipolar1PSYGENET
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0162820Dermatitis, Allergic Contact1CTD_human