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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CSK-TMEM266 (FusionGDB2 ID:HG1445TG123591) |
Fusion Gene Summary for CSK-TMEM266 |
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Fusion gene information | Fusion gene name: CSK-TMEM266 | Fusion gene ID: hg1445tg123591 | Hgene | Tgene | Gene symbol | CSK | TMEM266 | Gene ID | 1445 | 123591 |
Gene name | C-terminal Src kinase | transmembrane protein 266 | |
Synonyms | - | C15orf27|HVRP1|HsHVRP1|hTMEM266 | |
Cytomap | ('CSK','CSK')('C15orf27','TMEM266') 15q24.1 | 15q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein kinase CSKC-Src kinaseCSK, non-receptor tyrosine kinasec-src tyrosine kinaseprotein-tyrosine kinase CYL | transmembrane protein 266Hv1 related protein 1transmembrane protein C15orf27 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | P41240 | . | |
Ensembl transtripts involved in fusion gene | ENST00000220003, ENST00000439220, ENST00000309470, ENST00000567571, | ||
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 3 | 3 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(3/8*10)=1.90689059560852 | |
Context | PubMed: CSK [Title/Abstract] AND TMEM266 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CSK(75075061)-C15orf27(76426509), # samples:2 CSK(75075061)-TMEM266(76426509), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CSK | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport | 20605918 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-EE-A2MR-06A | CSK | chr15 | 75075061 | - | C15orf27 | chr15 | 76426509 | + |
ChimerDB4 | SKCM | TCGA-EE-A2MR-06A | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
ChimerDB4 | SKCM | TCGA-EE-A2MR-06A | CSK | chr15 | 75075061 | + | TMEM266 | chr15 | 76426509 | + |
ChimerDB4 | SKCM | TCGA-EE-A2MR | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
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Fusion Gene ORF analysis for CSK-TMEM266 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000220003 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
5UTR-5UTR | ENST00000220003 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
5UTR-5UTR | ENST00000439220 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
5UTR-5UTR | ENST00000439220 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
5UTR-intron | ENST00000220003 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
5UTR-intron | ENST00000220003 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
5UTR-intron | ENST00000439220 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
5UTR-intron | ENST00000439220 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
intron-5UTR | ENST00000309470 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
intron-5UTR | ENST00000309470 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
intron-5UTR | ENST00000567571 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
intron-5UTR | ENST00000567571 | ENST00000388942 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
intron-intron | ENST00000309470 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
intron-intron | ENST00000309470 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
intron-intron | ENST00000567571 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426509 | + |
intron-intron | ENST00000567571 | ENST00000559079 | CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CSK-TMEM266 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + | 0.001045065 | 0.9989549 |
CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + | 0.001045065 | 0.9989549 |
CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + | 0.001045065 | 0.9989549 |
CSK | chr15 | 75075061 | + | C15orf27 | chr15 | 76426508 | + | 0.001045065 | 0.9989549 |
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Fusion Protein Features for CSK-TMEM266 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75075061/:76426509) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CSK | . |
FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CSK-TMEM266 |
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Fusion Gene PPI Analysis for CSK-TMEM266 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CSK-TMEM266 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CSK | P41240 | DB01254 | Dasatinib | Small molecule | Approved|Investigational | |
Hgene | CSK | P41240 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CSK-TMEM266 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CSK | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | CSK | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Hgene | CSK | C0242380 | Libman-Sacks Disease | 1 | CTD_human |
Hgene | CSK | C0458247 | Allodynia | 1 | CTD_human |
Hgene | CSK | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
Hgene | CSK | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
Hgene | CSK | C0751213 | Tactile Allodynia | 1 | CTD_human |
Hgene | CSK | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
Hgene | CSK | C2936719 | Mechanical Allodynia | 1 | CTD_human |