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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK1E-GMPPA (FusionGDB2 ID:HG1454TG29926)

Fusion Gene Summary for CSNK1E-GMPPA

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1E-GMPPA
Fusion gene ID: hg1454tg29926
HgeneTgene
Gene symbol

CSNK1E

GMPPA

Gene ID

1454

29926

Gene namecasein kinase 1 epsilonGDP-mannose pyrophosphorylase A
SynonymsCKIe|CKIepsilon|HCKIEAAMR
Cytomap('CSNK1E')('GMPPA')

22q13.1

2q35

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform epsilonmannose-1-phosphate guanyltransferase alphaGMPP-alphaGTP-mannose-1-phosphate guanylyltransferase alphaepididymis secretory sperm binding proteinmannose-1-phosphate guanylyltransferase (GDP)
Modification date2020032920200313
UniProtAcc

P49674

Q96IJ6

Ensembl transtripts involved in fusion geneENST00000359867, ENST00000396832, 
ENST00000400206, ENST00000403904, 
ENST00000405675, ENST00000413574, 
ENST00000498529, 
Fusion gene scores* DoF score13 X 9 X 10=11701 X 1 X 1=1
# samples 171
** MAII scorelog2(17/1170*10)=-2.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CSNK1E [Title/Abstract] AND GMPPA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1E(38689260)-GMPPA(220364677), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1E

GO:0006468

protein phosphorylation

15917222|17244647

HgeneCSNK1E

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1E

GO:0032091

negative regulation of protein binding

23109420

HgeneCSNK1E

GO:0060070

canonical Wnt signaling pathway

14722104

HgeneCSNK1E

GO:1903827

regulation of cellular protein localization

17244647



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A6EVCSNK1Echr22

38689260

-GMPPAchr2

220364677

+


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Fusion Gene ORF analysis for CSNK1E-GMPPA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000359867ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000359867ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000359867ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000359867ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000359867ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000396832ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000396832ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000396832ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000396832ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000396832ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000400206ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000400206ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000400206ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000400206ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
3UTR-5UTRENST00000400206ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
5CDS-5UTRENST00000403904ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
5CDS-5UTRENST00000403904ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
5CDS-5UTRENST00000403904ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
5CDS-5UTRENST00000403904ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
5CDS-5UTRENST00000403904ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000405675ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000405675ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000405675ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000405675ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000405675ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000413574ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000413574ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000413574ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000413574ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000413574ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000498529ENST00000313597CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000498529ENST00000341142CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000498529ENST00000358215CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000498529ENST00000373908CSNK1Echr22

38689260

-GMPPAchr2

220364677

+
intron-5UTRENST00000498529ENST00000373917CSNK1Echr22

38689260

-GMPPAchr2

220364677

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CSNK1E-GMPPA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK1Echr2238689255-GMPPAchr2220364682+0.36319630.63680375
CSNK1Echr2238689255-GMPPAchr2220364682+0.36319630.63680375


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CSNK1E-GMPPA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38689260/:220364677)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1E

P49674

GMPPA

Q96IJ6

FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191}.FUNCTION: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. {ECO:0000269|PubMed:24035193}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CSNK1E-GMPPA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CSNK1E-GMPPA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK1E-GMPPA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSNK1E-GMPPA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1EC0005586Bipolar Disorder5PSYGENET
HgeneCSNK1EC0036341Schizophrenia2PSYGENET
TgeneC0271742Glucocorticoid deficiency with achalasia1ORPHANET
TgeneC3809738ALACRIMA, ACHALASIA, AND MENTAL RETARDATION SYNDROME1CTD_human;GENOMICS_ENGLAND;UNIPROT