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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CMTM4-TRIM40 (FusionGDB2 ID:HG146223TG135644)

Fusion Gene Summary for CMTM4-TRIM40

Fusion gene summary

Fusion gene information	Fusion gene name: CMTM4-TRIM40
	Fusion gene ID: hg146223tg135644
		Hgene	Tgene
	Gene symbol	CMTM4	TRIM40
	Gene ID	146223	135644
	Gene name	CKLF like MARVEL transmembrane domain containing 4	tripartite motif containing 40
	Synonyms	CKLFSF4	RNF35
	Cytomap	('CMTM4')('TRIM40') 16q21-q22.1	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	CKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4	tripartite motif-containing protein 40RING finger protein 35probable E3 NEDD8-protein ligasering finger RNF35
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000330687, ENST00000394106, ENST00000563952,
Fusion gene scores	* DoF score	9 X 7 X 5=315	3 X 4 X 3=36
	# samples	10	4
	** MAII score	log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CMTM4 [Title/Abstract] AND TRIM40 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CMTM4(66730243)-TRIM40(30113771), # samples:2
Anticipated loss of major functional domain due to fusion event.	CMTM4-TRIM40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CMTM4-TRIM40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CMTM4-TRIM40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CMTM4-TRIM40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRIM40	GO:0032088	negative regulation of NF-kappaB transcription factor activity	21474709
Tgene	TRIM40	GO:0042177	negative regulation of protein catabolic process	21474709
Tgene	TRIM40	GO:0045116	protein neddylation	21474709
Tgene	TRIM40	GO:1900181	negative regulation of protein localization to nucleus	21474709

Fusion gene breakpoints across CMTM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-R5-A805-01A	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
ChimerDB4	STAD	TCGA-R5-A805	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+

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Fusion Gene ORF analysis for CMTM4-TRIM40

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000330687	ENST00000307859	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000307859	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000376724	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000376724	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000383610	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000383610	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000400651	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000400651	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000418267	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000418267	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000421981	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000421981	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000425845	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000425845	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000429471	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000429471	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000430485	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000430485	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000431397	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000431397	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000433713	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000433713	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000434151	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000434151	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000436951	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000436951	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000437563	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000437563	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000445004	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000445004	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000456884	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000456884	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000462556	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000462556	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000470577	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000470577	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000475016	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000475016	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000476094	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000476094	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000486552	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000486552	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000488232	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000488232	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000489892	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000489892	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000497688	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000497688	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000547289	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000547289	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000548672	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000548672	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000549728	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000549728	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000330687	ENST00000552119	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000330687	ENST00000552119	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000307859	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000307859	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000376724	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000376724	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000383610	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000383610	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000400651	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000400651	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000418267	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000418267	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000421981	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000421981	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000425845	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000425845	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000429471	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000429471	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000430485	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000430485	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000431397	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000431397	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000433713	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000433713	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000434151	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000434151	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000436951	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000436951	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000437563	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000437563	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000445004	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000445004	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000456884	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000456884	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000462556	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000462556	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000470577	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000470577	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000475016	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000475016	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000476094	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000476094	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000486552	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000486552	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000488232	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000488232	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000489892	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000489892	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000497688	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000497688	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000547289	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000547289	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000548672	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000548672	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000549728	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000549728	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
5CDS-intron	ENST00000394106	ENST00000552119	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
5CDS-intron	ENST00000394106	ENST00000552119	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
In-frame	ENST00000330687	ENST00000396581	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
In-frame	ENST00000330687	ENST00000396581	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
In-frame	ENST00000394106	ENST00000396581	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
In-frame	ENST00000394106	ENST00000396581	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-3CDS	ENST00000563952	ENST00000396581	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-3CDS	ENST00000563952	ENST00000396581	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000307859	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000307859	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000376724	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000376724	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000383610	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000383610	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000400651	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000400651	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000418267	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000418267	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000421981	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000421981	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000425845	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000425845	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000429471	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000429471	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000430485	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000430485	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000431397	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000431397	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000433713	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000433713	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000434151	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000434151	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000436951	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000436951	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000437563	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000437563	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000445004	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000445004	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000456884	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000456884	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000462556	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000462556	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000470577	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000470577	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000475016	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000475016	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000476094	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000476094	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000486552	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000486552	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000488232	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000488232	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000489892	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000489892	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000497688	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000497688	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000547289	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000547289	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000548672	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000548672	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000549728	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000549728	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+
intron-intron	ENST00000563952	ENST00000552119	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+
intron-intron	ENST00000563952	ENST00000552119	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000330687	CMTM4	chr16	66730242	-	ENST00000396581	TRIM40	chr6	30113770	+	1723	368	134	799	221
ENST00000394106	CMTM4	chr16	66730242	-	ENST00000396581	TRIM40	chr6	30113770	+	1723	368	134	799	221
ENST00000330687	CMTM4	chr16	66730243	-	ENST00000396581	TRIM40	chr6	30113771	+	1723	368	134	799	221
ENST00000394106	CMTM4	chr16	66730243	-	ENST00000396581	TRIM40	chr6	30113771	+	1723	368	134	799	221

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000330687	ENST00000396581	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	0.002206428	0.99779356
ENST00000394106	ENST00000396581	CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	0.002206428	0.99779356
ENST00000330687	ENST00000396581	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+	0.002206428	0.99779356
ENST00000394106	ENST00000396581	CMTM4	chr16	66730243	-	TRIM40	chr6	30113771	+	0.002206428	0.99779356

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Fusion Genomic Features for CMTM4-TRIM40

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	2.91E-12	1
CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	2.91E-12	1
CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	2.91E-12	1
CMTM4	chr16	66730242	-	TRIM40	chr6	30113770	+	2.91E-12	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CMTM4-TRIM40

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:66730243/chr6:30113771)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000383610

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000400651

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000421981

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000429471

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000433713

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000434151

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000436951

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000437563

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000547289

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000549728

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000552119

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000383610

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000400651

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000421981

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000429471

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000433713

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000434151

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000436951

107_159

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000437563

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000547289

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000549728

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000552119

107_159

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000383610

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000383610

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000400651

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000400651

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000421981

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000421981

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000429471

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000429471

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000433713

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000433713

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000434151

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000434151

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000436951

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000436951

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000437563

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000437563

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000547289

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000547289

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000549728

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000549728

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000552119

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000552119

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000383610

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000383610

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000400651

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000400651

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000421981

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000421981

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000429471

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000429471

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000433713

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000433713

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000434151

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000434151

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000436951

14_56

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000436951

66_107

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000437563

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000437563

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000547289

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000547289

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000549728

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000549728

66_107

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000552119

14_56

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000552119

66_107

259.0

Zinc finger

B box-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000330687

49_176

235.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000394106

49_176

209.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000563952

49_176

180.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000330687

49_176

235.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000394106

49_176

209.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000563952

49_176

180.0

Domain

MARVEL

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000330687

123_143

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000330687

151_171

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000330687

59_79

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000330687

85_105

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000394106

123_143

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000394106

151_171

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000394106

59_79

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000394106

85_105

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000563952

123_143

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000563952

151_171

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000563952

59_79

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730242

chr6:30113770

ENST00000563952

85_105

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000330687

123_143

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000330687

151_171

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000330687

59_79

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000330687

85_105

235.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000394106

123_143

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000394106

151_171

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000394106

59_79

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000394106

85_105

209.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000563952

123_143

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000563952

151_171

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000563952

59_79

180.0

Transmembrane

Helical

Hgene

CMTM4

chr16:66730243

chr6:30113771

ENST00000563952

85_105

180.0

Transmembrane

Helical

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000307859

107_159

115

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000376724

107_159

115

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000396581

107_159

115

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000307859

107_159

115

230.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000376724

107_159

115

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000396581

107_159

115

259.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000307859

14_56

115

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000307859

66_107

115

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000376724

14_56

115

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000376724

66_107

115

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000396581

14_56

115

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730242

chr6:30113770

ENST00000396581

66_107

115

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000307859

14_56

115

230.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000307859

66_107

115

230.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000376724

14_56

115

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000376724

66_107

115

259.0

Zinc finger

B box-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000396581

14_56

115

259.0

Zinc finger

RING-type

Tgene

TRIM40

chr16:66730243

chr6:30113771

ENST00000396581

66_107

115

259.0

Zinc finger

B box-type

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Fusion Gene Sequence for CMTM4-TRIM40

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17571_17571_1_CMTM4-TRIM40_CMTM4_chr16_66730242_ENST00000330687_TRIM40_chr6_30113770_ENST00000396581_length(transcript)=1723nt_BP=368nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT

>17571_17571_1_CMTM4-TRIM40_CMTM4_chr16_66730242_ENST00000330687_TRIM40_chr6_30113770_ENST00000396581_length(amino acids)=221AA_BP=78
MAPGASRARRPGPGGSMRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRK
DIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELD

--------------------------------------------------------------
>17571_17571_2_CMTM4-TRIM40_CMTM4_chr16_66730242_ENST00000394106_TRIM40_chr6_30113770_ENST00000396581_length(transcript)=1723nt_BP=368nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT

>17571_17571_2_CMTM4-TRIM40_CMTM4_chr16_66730242_ENST00000394106_TRIM40_chr6_30113770_ENST00000396581_length(amino acids)=221AA_BP=78
MAPGASRARRPGPGGSMRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRK
DIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELD

--------------------------------------------------------------
>17571_17571_3_CMTM4-TRIM40_CMTM4_chr16_66730243_ENST00000330687_TRIM40_chr6_30113771_ENST00000396581_length(transcript)=1723nt_BP=368nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT

>17571_17571_3_CMTM4-TRIM40_CMTM4_chr16_66730243_ENST00000330687_TRIM40_chr6_30113771_ENST00000396581_length(amino acids)=221AA_BP=78
MAPGASRARRPGPGGSMRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRK
DIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELD

--------------------------------------------------------------
>17571_17571_4_CMTM4-TRIM40_CMTM4_chr16_66730243_ENST00000394106_TRIM40_chr6_30113771_ENST00000396581_length(transcript)=1723nt_BP=368nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT

>17571_17571_4_CMTM4-TRIM40_CMTM4_chr16_66730243_ENST00000394106_TRIM40_chr6_30113771_ENST00000396581_length(amino acids)=221AA_BP=78
MAPGASRARRPGPGGSMRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRK
DIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CMTM4-TRIM40

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CMTM4-TRIM40

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CMTM4-TRIM40

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0162823	Dermatitis, Irritant	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CMTM4-TRIM40 (FusionGDB2 ID:HG146223TG135644)

Fusion Gene Summary for CMTM4-TRIM40

Fusion Gene ORF analysis for CMTM4-TRIM40

Fusion Genomic Features for CMTM4-TRIM40

Fusion Protein Features for CMTM4-TRIM40

Fusion Gene Sequence for CMTM4-TRIM40

Fusion Gene PPI Analysis for CMTM4-TRIM40

Related Drugs for CMTM4-TRIM40

Related Diseases for CMTM4-TRIM40

Fusion Gene Studies
in Kim Lab