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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf25-CTDSP2 (FusionGDB2 ID:HG148223TG10106)

Fusion Gene Summary for C19orf25-CTDSP2

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf25-CTDSP2
Fusion gene ID: hg148223tg10106
HgeneTgene
Gene symbol

C19orf25

CTDSP2

Gene ID

148223

10106

Gene namechromosome 19 open reading frame 25CTD small phosphatase 2
Synonyms-OS4|PSR2|SCP2
Cytomap('C19orf25')('CTDSP2')

19p13.3

12q14.1

Type of geneprotein-codingprotein-coding
DescriptionUPF0449 protein C19orf25carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-intera
Modification date2020031320200313
UniProtAcc

Q9UFG5

.
Ensembl transtripts involved in fusion geneENST00000427685, ENST00000436106, 
ENST00000585675, ENST00000586564, 
ENST00000588427, ENST00000588849, 
ENST00000588871, ENST00000591027, 
ENST00000592872, 
Fusion gene scores* DoF score10 X 4 X 9=36012 X 10 X 7=840
# samples 1213
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/840*10)=-2.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf25 [Title/Abstract] AND CTDSP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf25(1478653)-CTDSP2(58223379), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf25-CTDSP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C19orf25-CTDSP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTDSP2

GO:0006470

protein dephosphorylation

12721286



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01AC19orf25chr19

1478653

-CTDSP2chr12

58223379

-


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Fusion Gene ORF analysis for C19orf25-CTDSP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000427685ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
Frame-shiftENST00000427685ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
Frame-shiftENST00000427685ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000436106ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000436106ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000585675ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000585675ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000586564ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000586564ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588427ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588427ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588849ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588849ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588871ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000588871ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000591027ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000591027ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000592872ENST00000398073C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-3CDSENST00000592872ENST00000548823C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000436106ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000585675ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000586564ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000588427ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000588849ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000588871ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000591027ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-
intron-5UTRENST00000592872ENST00000547701C19orf25chr19

1478653

-CTDSP2chr12

58223379

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for C19orf25-CTDSP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for C19orf25-CTDSP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1478653/:58223379)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C19orf25

Q9UFG5

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C19orf25-CTDSP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C19orf25-CTDSP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf25-CTDSP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf25-CTDSP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource