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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AAMP-ANKZF1 (FusionGDB2 ID:HG14TG55139)

Fusion Gene Summary for AAMP-ANKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: AAMP-ANKZF1
Fusion gene ID: hg14tg55139
HgeneTgene
Gene symbol

AAMP

ANKZF1

Gene ID

14

55139

Gene nameangio associated migratory cell proteinankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
Synonyms-Vms1|ZNF744
Cytomap('AAMP')('ANKZF1')

2q35

2q35

Type of geneprotein-codingprotein-coding
Descriptionangio-associated migratory cell proteinankyrin repeat and zinc finger domain-containing protein 1ankyrin repeat and zinc finger domain containing 1zinc finger protein 744
Modification date2020032020200313
UniProtAcc

Q13685

.
Ensembl transtripts involved in fusion geneENST00000248450, ENST00000420660, 
ENST00000444053, 
Fusion gene scores* DoF score2 X 1 X 2=44 X 4 X 3=48
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAMP [Title/Abstract] AND ANKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAAMP(219134105)-ANKZF1(220096650), # samples:1
Anticipated loss of major functional domain due to fusion event.AAMP-ANKZF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AAMP-ANKZF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AAMP-ANKZF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AAMP-ANKZF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
AAMP-ANKZF1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AAMP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANKZF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AAAMPchr2

219134105

-ANKZF1chr2

220096650

+


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Fusion Gene ORF analysis for AAMP-ANKZF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000248450ENST00000409849AAMPchr2

219134105

-ANKZF1chr2

220096650

+
5CDS-intronENST00000248450ENST00000410034AAMPchr2

219134105

-ANKZF1chr2

220096650

+
5CDS-intronENST00000420660ENST00000409849AAMPchr2

219134105

-ANKZF1chr2

220096650

+
5CDS-intronENST00000420660ENST00000410034AAMPchr2

219134105

-ANKZF1chr2

220096650

+
5CDS-intronENST00000444053ENST00000409849AAMPchr2

219134105

-ANKZF1chr2

220096650

+
5CDS-intronENST00000444053ENST00000410034AAMPchr2

219134105

-ANKZF1chr2

220096650

+
Frame-shiftENST00000420660ENST00000323348AAMPchr2

219134105

-ANKZF1chr2

220096650

+
In-frameENST00000248450ENST00000323348AAMPchr2

219134105

-ANKZF1chr2

220096650

+
In-frameENST00000444053ENST00000323348AAMPchr2

219134105

-ANKZF1chr2

220096650

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000248450AAMPchr2219134105-ENST00000323348ANKZF1chr2220096650+2702445242477817
ENST00000444053AAMPchr2219134105-ENST00000323348ANKZF1chr2220096650+2626369562401781

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248450ENST00000323348AAMPchr2219134105-ANKZF1chr2220096650+0.007826480.99217355
ENST00000444053ENST00000323348AAMPchr2219134105-ANKZF1chr2220096650+0.0130217040.9869783

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Fusion Genomic Features for AAMP-ANKZF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AAMPchr2219134104-ANKZF1chr2220096649+7.63E-060.9999924
AAMPchr2219134104-ANKZF1chr2220096649+7.63E-060.9999924

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AAMP-ANKZF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:219134105/chr2:220096650)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAMP

Q13685

.
FUNCTION: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-21153_5991435.0Compositional biasNote=Poly-Glu
TgeneANKZF1chr2:219134105chr2:220096650ENST00000323348114609_65949727.0Coiled coilOntology_term=ECO:0000255
TgeneANKZF1chr2:219134105chr2:220096650ENST00000410034114609_65949727.0Coiled coilOntology_term=ECO:0000255
TgeneANKZF1chr2:219134105chr2:220096650ENST00000323348114654_66649727.0RegionVCP/p97-interacting motif (VIM)
TgeneANKZF1chr2:219134105chr2:220096650ENST00000410034114654_66649727.0RegionVCP/p97-interacting motif (VIM)
TgeneANKZF1chr2:219134105chr2:220096650ENST00000323348114493_52649727.0RepeatNote=ANK 1
TgeneANKZF1chr2:219134105chr2:220096650ENST00000323348114534_56349727.0RepeatNote=ANK 2
TgeneANKZF1chr2:219134105chr2:220096650ENST00000410034114493_52649727.0RepeatNote=ANK 1
TgeneANKZF1chr2:219134105chr2:220096650ENST00000410034114534_56349727.0RepeatNote=ANK 2
TgeneANKZF1chr2:219134105chr2:220096650ENST0000032334811472_9649727.0Zinc fingerNote=C2H2-type
TgeneANKZF1chr2:219134105chr2:220096650ENST0000041003411472_9649727.0Zinc fingerNote=C2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211132_17191435.0RepeatNote=WD 2
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211173_21291435.0RepeatNote=WD 3
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211214_25491435.0RepeatNote=WD 4
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211258_29991435.0RepeatNote=WD 5
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211315_35491435.0RepeatNote=WD 6
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211356_39591435.0RepeatNote=WD 7
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-211398_43391435.0RepeatNote=WD 8
HgeneAAMPchr2:219134105chr2:220096650ENST00000248450-21189_12991435.0RepeatNote=WD 1


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Fusion Gene Sequence for AAMP-ANKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77_77_1_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000248450_ANKZF1_chr2_220096650_ENST00000323348_length(transcript)=2702nt_BP=445nt
GCGGCCAGCCAACCTTCGTAGCTATTGGCCGAACGGCCGTCGCTCTTCCTGCTGGGGAGTCGCCTACGCCTACTTCCTGCCGGGAGGAGG
GGCTCGAGTTCCGCGTCGTCGCGCAGAGCTGACTCTGGGAGGCGTTTGGGCCCAGAGAAGTGGATCCGCCGCTTGCGCCGCATGGAGTCC
GAATCGGAAAGCGGGGCTGCTGCTGACACCCCCCCACTGGAGACCCTAAGCTTCCATGGTGATGAAGAGATTATCGAGGTGGTAGAACTT
GATCCCGGTCCGCCGGACCCAGATGACCTGGCCCAGGAGATGGAAGATGTGGACTTTGAGGAAGAAGAGGAGGAAGAGGGCAACGAAGAG
GGCTGGGTTCTAGAACCCCAGGAAGGGGTGGTCGGCAGCATGGAGGGCCCCGACGATAGCGAGGTCACCTTTGCATTGCACTCAGGCTCA
GGGGAGAGAGAAAGCCCAGAAAGAAAGCTACTCCAGGGTCCTATGGATATTTCAGAGAAGTTATTTTGTTCAACTTGTGACCAGACCTTC
CAGAACCACCAAGAACAGAGGGAACATTATAAGCTTGACTGGCATCGGTTTAACCTAAAGCAACGTCTCAAGGACAAGCCTCTCCTGTCT
GCCCTGGACTTTGAAAAGCAGAGCTCCACAGGAGATCTTTCCAGCATCTCGGGATCAGAAGACTCAGACTCAGCCAGTGAGGAGGACTTG
CAGACACTGGATCGGGAGAGGGCTACATTTGAGAAGTTGAGCCGACCCCCAGGCTTTTACCCTCATCGAGTTCTTTTCCAGAATGCCCAG
GGCCAGTTTCTTTATGCCTACCGCTGTGTCCTAGGCCCTCATCAGGATCCCCCAGAAGAGGCAGAACTGCTGCTACAGAACCTGCAAAGT
AGAGGTCCCAGAGACTGCGTGGTGCTCATGGCTGCAGCTGGGCACTTTGCTGGTGCTATATTTCAAGGAAGAGAAGTGGTGACACACAAA
ACTTTTCACCGCTATACGGTTCGGGCCAAGCGGGGCACAGCCCAGGGGCTTCGGGATGCCCGAGGTGGGCCATCACACTCTGCTGGAGCC
AACCTGAGGCGCTACAATGAAGCCACACTATATAAGGATGTTCGTGACCTGCTGGCAGGGCCAAGCTGGGCTAAGGCGCTGGAGGAGGCT
GGTACAATACTGTTGCGTGCTCCCCGCTCTGGCCGGTCTTTGTTCTTTGGAGGCAAGGGAGCACCCCTGCAAAGGGGGGATCCCCGACTT
TGGGATATCCCCCTCGCCACCCGCAGACCCACCTTCCAAGAGCTACAGCGTGTGCTCCATAAGCTGACCACTTTGCATGTCTATGAAGAA
GACCCTCGGGAAGCAGTCAGACTGCACTCACCTCAGACACACTGGAAAACAGTAAGAGAGGAGAGAAAGAAGCCTACTGAGGAAGAAATA
AGAAAGATCTGCAGGGATGAAAAGGAAGCGCTGGGGCAGAATGAGGAATCTCCCAAACAGGGTTCAGGGTCGGAGGGAGAAGATGGCTTT
CAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGG
AATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCA
TCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCT
TGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTG
GGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCC
ACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAAT
CCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAG
AAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCC
CTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCA
ATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACA
CGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAG
GGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGG
CAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGCAAGGAATGTGTACTTGTACTTA

>77_77_1_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000248450_ANKZF1_chr2_220096650_ENST00000323348_length(amino acids)=817AA_BP=140
MAERPSLFLLGSRLRLLPAGRRGSSSASSRRADSGRRLGPEKWIRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPD
DLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQRE
HYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYR
CVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEA
TLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRL
HSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD
QEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLL
HAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQRE
EQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRR

--------------------------------------------------------------
>77_77_2_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000444053_ANKZF1_chr2_220096650_ENST00000323348_length(transcript)=2626nt_BP=369nt
CCGGGAGGAGGGGCTCGAGTTCCGCGTCGTCGCGCAGAGCTGACTCTGGGAGGCGTTTGGGCCCAGAGAAGTGGATCCGCCGCTTGCGCC
GCATGGAGTCCGAATCGGAAAGCGGGGCTGCTGCTGACACCCCCCCACTGGAGACCCTAAGCTTCCATGGTGATGAAGAGATTATCGAGG
TGGTAGAACTTGATCCCGGTCCGCCGGACCCAGCAGATGACCTGGCCCAGGAGATGGAAGATGTGGACTTTGAGGAAGAAGAGGAGGAAG
AGGGCAACGAAGAGGGCTGGGTTCTAGAACCCCAGGAAGGGGTGGTCGGCAGCATGGAGGGCCCCGACGATAGCGAGGTCACCTTTGCAT
TGCACTCAGGCTCAGGGGAGAGAGAAAGCCCAGAAAGAAAGCTACTCCAGGGTCCTATGGATATTTCAGAGAAGTTATTTTGTTCAACTT
GTGACCAGACCTTCCAGAACCACCAAGAACAGAGGGAACATTATAAGCTTGACTGGCATCGGTTTAACCTAAAGCAACGTCTCAAGGACA
AGCCTCTCCTGTCTGCCCTGGACTTTGAAAAGCAGAGCTCCACAGGAGATCTTTCCAGCATCTCGGGATCAGAAGACTCAGACTCAGCCA
GTGAGGAGGACTTGCAGACACTGGATCGGGAGAGGGCTACATTTGAGAAGTTGAGCCGACCCCCAGGCTTTTACCCTCATCGAGTTCTTT
TCCAGAATGCCCAGGGCCAGTTTCTTTATGCCTACCGCTGTGTCCTAGGCCCTCATCAGGATCCCCCAGAAGAGGCAGAACTGCTGCTAC
AGAACCTGCAAAGTAGAGGTCCCAGAGACTGCGTGGTGCTCATGGCTGCAGCTGGGCACTTTGCTGGTGCTATATTTCAAGGAAGAGAAG
TGGTGACACACAAAACTTTTCACCGCTATACGGTTCGGGCCAAGCGGGGCACAGCCCAGGGGCTTCGGGATGCCCGAGGTGGGCCATCAC
ACTCTGCTGGAGCCAACCTGAGGCGCTACAATGAAGCCACACTATATAAGGATGTTCGTGACCTGCTGGCAGGGCCAAGCTGGGCTAAGG
CGCTGGAGGAGGCTGGTACAATACTGTTGCGTGCTCCCCGCTCTGGCCGGTCTTTGTTCTTTGGAGGCAAGGGAGCACCCCTGCAAAGGG
GGGATCCCCGACTTTGGGATATCCCCCTCGCCACCCGCAGACCCACCTTCCAAGAGCTACAGCGTGTGCTCCATAAGCTGACCACTTTGC
ATGTCTATGAAGAAGACCCTCGGGAAGCAGTCAGACTGCACTCACCTCAGACACACTGGAAAACAGTAAGAGAGGAGAGAAAGAAGCCTA
CTGAGGAAGAAATAAGAAAGATCTGCAGGGATGAAAAGGAAGCGCTGGGGCAGAATGAGGAATCTCCCAAACAGGGTTCAGGGTCGGAGG
GAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGA
GGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGC
CTTCCACACAGTCATCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATG
CACTGCTTGCTGCTTGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGC
TCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAG
CAGGTGCTGACCCCACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGT
TCATGGAGAAGAATCCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACAC
GGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGC
GGCGATTTGCCGCCCTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAA
TCCCTGACTCTGCAATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCT
CTTTCTGCTCCACACGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACT
CAGGGACCTGAGAGGGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACA
CTCGGGAACTAGGGCAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGCAAGGAATG

>77_77_2_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000444053_ANKZF1_chr2_220096650_ENST00000323348_length(amino acids)=781AA_BP=104
MGPEKWIRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPADDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSM
EGPDDSEVTFALHSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLS
SISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAG
HFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSL
FFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQN
EESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDE
AKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA
ADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR

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Fusion Gene PPI Analysis for AAMP-ANKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AAMP-ANKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AAMP-ANKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource