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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNND1-SLC22A10 (FusionGDB2 ID:HG1500TG387775)

Fusion Gene Summary for CTNND1-SLC22A10

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1-SLC22A10
Fusion gene ID: hg1500tg387775
HgeneTgene
Gene symbol

CTNND1

SLC22A10

Gene ID

1500

387775

Gene namecatenin delta 1solute carrier family 22 member 10
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)OAT5|hOAT5
Cytomap('CTNND1')('SLC22A10')

11q12.1

11q12.3

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninsolute carrier family 22 member 10organic anion transporter 5solute carrier family 22 (organic anion/cation transporter), member 10
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358694, ENST00000360682, 
ENST00000361332, ENST00000361391, 
ENST00000361796, ENST00000399050, 
ENST00000415361, ENST00000426142, 
ENST00000428599, ENST00000525902, 
ENST00000526357, ENST00000526772, 
ENST00000526938, ENST00000527467, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529986, ENST00000530094, 
ENST00000530748, ENST00000531014, 
ENST00000532245, ENST00000532463, 
ENST00000532649, ENST00000532787, 
ENST00000532844, ENST00000533667, 
ENST00000534579, ENST00000399039, 
ENST00000524630, ENST00000529919, 
Fusion gene scores* DoF score29 X 18 X 15=78306 X 6 X 5=180
# samples 356
** MAII scorelog2(35/7830*10)=-4.48358548034607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND SLC22A10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND1(57529518)-SLC22A10(62934335), # samples:1
CTNND1(57529518)-SLC22A10(62934337), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNND1

GO:0099072

regulation of postsynaptic membrane neurotransmitter receptor levels

18602475



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-MU-A51Y-01ACTNND1chr11

57529518

+SLC22A10chr11

62934335

+
ChimerDB4CESCTCGA-MU-A51Y-01ACTNND1chr11

57529518

-SLC22A10chr11

62934337

+


Top

Fusion Gene ORF analysis for CTNND1-SLC22A10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000358694ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000358694ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000360682ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000360682ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000361332ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000361332ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000361391ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000361391ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000361796ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000361796ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000399050ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000399050ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000415361ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000415361ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000426142ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000426142ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000428599ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000428599ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000525902ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000525902ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000526357ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000526357ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000526772ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000526772ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000526938ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000526938ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000527467ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000527467ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000528232ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000528232ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000528621ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000528621ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000529526ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000529526ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000529873ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000529873ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000529986ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000529986ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000530094ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000530094ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000530748ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000530748ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000531014ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000531014ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000532245ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000532245ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000532463ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000532463ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000532649ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000532649ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000532787ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000532787ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000532844ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000532844ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000533667ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000533667ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-3UTRENST00000534579ENST00000525620CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-3UTRENST00000534579ENST00000525620CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000358694ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000358694ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000360682ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000360682ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000361332ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000361332ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000361391ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000361391ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000361796ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000361796ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000399050ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000399050ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000415361ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000415361ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000426142ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000426142ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000428599ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000428599ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000525902ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000525902ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000526357ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000526357ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000526772ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000526772ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000526938ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000526938ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000527467ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000527467ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000528232ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000528232ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000528621ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000528621ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000529526ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000529526ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000529873ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000529873ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000529986ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000529986ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000530094ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000530094ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000530748ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000530748ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000531014ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000531014ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000532245ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000532245ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000532463ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000532463ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000532649ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000532649ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000532787ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000532787ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000532844ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000532844ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000533667ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000533667ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-5UTRENST00000534579ENST00000535888CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-5UTRENST00000534579ENST00000535888CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000358694ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000358694ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000358694ENST00000526800CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000358694ENST00000526800CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000358694ENST00000544661CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000358694ENST00000544661CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000360682ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000360682ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000360682ENST00000526800CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000360682ENST00000526800CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000360682ENST00000544661CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000360682ENST00000544661CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361332ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361332ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361332ENST00000526800CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361332ENST00000526800CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361332ENST00000544661CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361332ENST00000544661CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361391ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361391ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361391ENST00000526800CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361391ENST00000526800CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361391ENST00000544661CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361391ENST00000544661CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361796ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
5UTR-intronENST00000361796ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
5UTR-intronENST00000361796ENST00000526800CTNND1chr11

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62934337

+
intron-intronENST00000529919ENST00000332793CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
intron-intronENST00000529919ENST00000332793CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
intron-intronENST00000529919ENST00000526800CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
intron-intronENST00000529919ENST00000526800CTNND1chr11

57529518

-SLC22A10chr11

62934337

+
intron-intronENST00000529919ENST00000544661CTNND1chr11

57529518

+SLC22A10chr11

62934335

+
intron-intronENST00000529919ENST00000544661CTNND1chr11

57529518

-SLC22A10chr11

62934337

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CTNND1-SLC22A10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNND1chr1157529518+SLC22A10chr1162934336+4.26E-060.9999957
CTNND1chr1157529518+SLC22A10chr1162934336+4.26E-060.9999957


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTNND1-SLC22A10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57529518/:62934335)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CTNND1-SLC22A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CTNND1-SLC22A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNND1-SLC22A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNND1-SLC22A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND1C0008925Cleft Palate1GENOMICS_ENGLAND
HgeneCTNND1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human