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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNND1-DOCK8 (FusionGDB2 ID:HG1500TG81704)

Fusion Gene Summary for CTNND1-DOCK8

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1-DOCK8
Fusion gene ID: hg1500tg81704
HgeneTgene
Gene symbol

CTNND1

DOCK8

Gene ID

1500

81704

Gene namecatenin delta 1dedicator of cytokinesis 8
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)HEL-205|MRD2|ZIR8
Cytomap('CTNND1')('DOCK8')

11q12.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenindedicator of cytokinesis protein 81200017A24Rikepididymis luminal protein 205
Modification date2020032720200327
UniProtAcc.

Q8NF50

Ensembl transtripts involved in fusion geneENST00000358694, ENST00000360682, 
ENST00000361332, ENST00000361391, 
ENST00000361796, ENST00000399039, 
ENST00000399050, ENST00000415361, 
ENST00000426142, ENST00000428599, 
ENST00000524630, ENST00000525902, 
ENST00000526357, ENST00000526772, 
ENST00000526938, ENST00000527467, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529919, ENST00000529986, 
ENST00000530094, ENST00000530748, 
ENST00000531014, ENST00000532245, 
ENST00000532463, ENST00000532649, 
ENST00000532787, ENST00000532844, 
ENST00000533667, ENST00000534579, 
Fusion gene scores* DoF score29 X 18 X 15=78309 X 14 X 10=1260
# samples 3516
** MAII scorelog2(35/7830*10)=-4.48358548034607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND DOCK8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND1(57574455)-DOCK8(304581), # samples:3
Anticipated loss of major functional domain due to fusion event.CTNND1-DOCK8 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CTNND1-DOCK8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNND1

GO:0099072

regulation of postsynaptic membrane neurotransmitter receptor levels

18602475

TgeneDOCK8

GO:0043547

positive regulation of GTPase activity

28028151



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-83-5908-01ACTNND1chr11

57574455

-DOCK8chr9

304581

+
ChimerDB4LUADTCGA-83-5908-01ACTNND1chr11

57574455

+DOCK8chr9

304581

+


Top

Fusion Gene ORF analysis for CTNND1-DOCK8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358694ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000358694ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000358694ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000358694ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000358694ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000358694ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000360682ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000360682ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000360682ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361332ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361332ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361332ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361391ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361391ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361391ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361796ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361796ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000361796ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399039ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399039ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399039ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399050ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399050ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000399050ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000415361ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000415361ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000415361ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000426142ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000426142ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000426142ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000428599ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000428599ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000428599ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000524630ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000524630ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000524630ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000525902ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000525902ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000525902ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526357ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526357ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526357ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526772ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526772ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526772ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526938ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526938ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000526938ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000527467ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000527467ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000527467ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528232ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528232ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528232ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528621ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528621ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000528621ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529526ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529526ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529526ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529873ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529873ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529873ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529919ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529919ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529919ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529986ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529986ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000529986ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530094ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530094ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530094ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530748ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530748ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000530748ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000531014ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000531014ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000531014ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532245ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532245ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532245ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532463ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532463ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532463ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532649ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532649ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532649ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532787ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532787ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532787ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532844ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532844ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000532844ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000533667ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000533667ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000533667ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000534579ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000534579ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shiftENST00000534579ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CTNND1-DOCK8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNND1chr1157574455+DOCK8chr9304580+0.0001728170.9998272
CTNND1chr1157574455+DOCK8chr9304580+0.0001728170.9998272


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTNND1-DOCK8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57574455/:304581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK8

Q8NF50

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CTNND1-DOCK8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CTNND1-DOCK8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNND1-DOCK8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNND1-DOCK8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND1C0008925Cleft Palate1GENOMICS_ENGLAND
HgeneCTNND1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET
TgeneC1968689Hyper-Immunoglobulin E Syndrome, Autosomal Recessive2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4722305HYPER-IgE RECURRENT INFECTION SYNDROME 2, AUTOSOMAL RECESSIVE2GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0008073Developmental Disabilities1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0027819Neuroblastoma1CTD_human
TgeneC0085996Child Development Deviations1CTD_human
TgeneC0085997Child Development Disorders, Specific1CTD_human
TgeneC0494261Combined immunodeficiency1GENOMICS_ENGLAND
TgeneC0917816Mental deficiency1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC2936739Hyper-Immunoglobulin E Syndrome, Autosomal Dominant1CTD_human;GENOMICS_ENGLAND
TgeneC3714756Intellectual Disability1CTD_human