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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNND2-BTF3 (FusionGDB2 ID:HG1501TG689)

Fusion Gene Summary for CTNND2-BTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND2-BTF3
Fusion gene ID: hg1501tg689
HgeneTgene
Gene symbol

CTNND2

BTF3

Gene ID

1501

689

Gene namecatenin delta 2basic transcription factor 3
SynonymsGT24|NPRAPBETA-NAC|BTF3a|BTF3b|NACB
Cytomap('CTNND2')('BTF3')

5p15.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungintranscription factor BTF3NAC-betaRNA polymerase B transcription factor 3nascent polypeptide-associated complex subunit betanascent-polypeptide-associated complex beta polypeptide
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304623, ENST00000359640, 
ENST00000458100, ENST00000503622, 
ENST00000511377, ENST00000495388, 
Fusion gene scores* DoF score14 X 13 X 7=12749 X 7 X 6=378
# samples 1511
** MAII scorelog2(15/1274*10)=-3.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/378*10)=-1.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND2 [Title/Abstract] AND BTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND2(11117562)-BTF3(72798313), # samples:1
Anticipated loss of major functional domain due to fusion event.CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-0821-01ACTNND2chr5

11117562

-BTF3chr5

72798313

+


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Fusion Gene ORF analysis for CTNND2-BTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000304623ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000304623ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000359640ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000359640ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000458100ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000458100ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000503622ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000503622ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000511377ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5CDS-3UTRENST00000511377ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
5UTR-3CDSENST00000495388ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+
5UTR-3UTRENST00000495388ENST00000380591CTNND2chr5

11117562

-BTF3chr5

72798313

+
5UTR-3UTRENST00000495388ENST00000514505CTNND2chr5

11117562

-BTF3chr5

72798313

+
Frame-shiftENST00000458100ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+
Frame-shiftENST00000503622ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+
Frame-shiftENST00000511377ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+
In-frameENST00000304623ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+
In-frameENST00000359640ENST00000335895CTNND2chr5

11117562

-BTF3chr5

72798313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000304623CTNND2chr511117562-ENST00000335895BTF3chr572798313+314424671902886898
ENST00000359640CTNND2chr511117562-ENST00000335895BTF3chr572798313+309924221452841898

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304623ENST00000335895CTNND2chr511117562-BTF3chr572798313+0.0073098850.99269015
ENST00000359640ENST00000335895CTNND2chr511117562-BTF3chr572798313+0.0070995810.9929005

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Fusion Genomic Features for CTNND2-BTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNND2chr511117561-BTF3chr572798312+0.0002392080.9997608
CTNND2chr511117561-BTF3chr572798312+0.0002392080.9997608

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTNND2-BTF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11117562/chr5:72798313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-132249_847591226.0Coiled coilOntology_term=ECO:0000255
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-132149_847591168.0Coiled coilOntology_term=ECO:0000255
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322216_2267591226.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321216_2267591168.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322394_4387591226.0RepeatNote=ARM 1
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322540_5797591226.0RepeatNote=ARM 2
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322582_6217591226.0RepeatNote=ARM 3
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322626_6667591226.0RepeatNote=ARM 4
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322682_7247591226.0RepeatNote=ARM 5
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321394_4387591168.0RepeatNote=ARM 1
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321540_5797591168.0RepeatNote=ARM 2
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321582_6217591168.0RepeatNote=ARM 3
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321626_6667591168.0RepeatNote=ARM 4
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321682_7247591168.0RepeatNote=ARM 5
TgeneBTF3chr5:11117562chr5:72798313ENST0000033589516185_18823163.0Compositional biasNote=Poly-Asp
TgeneBTF3chr5:11117562chr5:72798313ENST0000038059116185_18867207.0Compositional biasNote=Poly-Asp
TgeneBTF3chr5:11117562chr5:72798313ENST000003358951682_14723163.0DomainNAC-A/B
TgeneBTF3chr5:11117562chr5:72798313ENST000003805911682_14767207.0DomainNAC-A/B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322811_8177591226.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321811_8177591168.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322728_7737591226.0RepeatNote=ARM 6
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322835_8757591226.0RepeatNote=ARM 7
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322882_9217591226.0RepeatNote=ARM 8
HgeneCTNND2chr5:11117562chr5:72798313ENST00000304623-1322975_10187591226.0RepeatNote=ARM 9
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321728_7737591168.0RepeatNote=ARM 6
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321835_8757591168.0RepeatNote=ARM 7
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321882_9217591168.0RepeatNote=ARM 8
HgeneCTNND2chr5:11117562chr5:72798313ENST00000359640-1321975_10187591168.0RepeatNote=ARM 9


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Fusion Gene Sequence for CTNND2-BTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20388_20388_1_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000304623_BTF3_chr5_72798313_ENST00000335895_length(transcript)=3144nt_BP=2467nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGAACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATC
CGAGACTGGCAGCATGAGCAGCATGAGTTCAGCAGAAGAGCAGTTTCAGTGGCAGTCACAAGATGGTCAAAAAGATATCGAAGATGAGCT
TACAACAGGTCTCGAGCTGGTGGACTCCTGTATTAGGTCACTACAGGAATCAGGAATACTTGACCCACAGGATTATTCTACAGGTGAAAG
GCCCAGCCTGCTCTCCCAGAGTGCACTTCAGCTCAATTCCAAACCTGAAGGGTCTTTCCAGTATCCGGCCAGCTACCATAGCAACCAGAC
CCTGGCCCTGGGGGAAACCACCCCTTCACAGCTCCCGGCCCGAGGCACACAAGCCCGAGCTACGGGCCAGAGCTTCAGCCAGGGCACGAC
CAGCCGCGCCGGCCACCTGGCGGGGCCCGAGCCCGCGCCGCCGCCGCCGCCGCCGCCGCGGGAGCCGTTCGCGCCCAGCCTGGGCAGCGC
CTTCCACCTGCCCGACGCGCCGCCCGCCGCCGCCGCCGCCGCGCTCTACTACTCCAGCTCCACGCTGCCCGCGCCGCCGCGCGGGGGCTC
CCCGCTGGCCGCGCCCCAGGGCGGTTCGCCCACCAAGCTGCAGCGCGGCGGCTCGGCCCCCGAGGGCGCCACCTACGCCGCGCCGCGCGG
CTCCTCGCCCAAGCAGTCGCCCAGCCGCCTGGCCAAGTCCTACAGCACCAGCTCGCCCATCAACATCGTCGTGTCCTCGGCCGGCCTGTC
CCCGATCCGCGTGACCTCGCCCCCCACCGTGCAGTCCACCATCTCCTCCTCGCCCATCCACCAGCTGAGCTCCACCATCGGCACGTACGC
CACCCTGTCGCCCACCAAGCGCCTGGTCCACGCGTCCGAGCAGTACAGCAAGCACTCGCAGGAGCTGTATGCCACGGCCACCCTCCAGAG
GCCGGGCAGCCTGGCAGCTGGTTCCCGAGCCTCATACAGCAGCCAGCATGGGCACCTGGGCCCAGAGTTGCGGGCCCTGCAGTCCCCAGA
ACACCACATAGATCCCATCTATGAAGACCGCGTCTATCAGAAGCCCCCTATGAGGAGTCTCAGCCAGAGCCAGGGGGACCCTCTGCCGCC
AGCACACACCGGCACCTACCGCACGAGCACAGCCCCATCTTCCCCTGGTGTCGACTCCGTCCCCTTGCAGCGCACAGGCAGCCAGCACGG
CCCACAGAATGCCGCCGCGGCCACCTTCCAGAGGGCCAGCTATGCCGCCGGCCCAGCCTCCAATTACGCGGACCCCTACCGACAGCTGCA
GTATTGTCCCTCTGTTGAGTCTCCATACAGCAAATCCGGCCCTGCTCTCCCGCCTGAAGGCACCTTGGCCAGGTCCCCGTCCATTGATAG
CATTCAGAAAGATCCCAGAGAATTTGGATGGAGAGACCCGGAACTGCCGGAAGTGATTCAGATGTTGCAGCACCAGTTTCCCTCGGTCCA
GTCTAACGCGGCAGCCTACTTGCAACACCTCTGTTTTGGAGACAACAAAATTAAAGCCGAGATAAGGAGACAAGGAGGCATCCAGCTCCT
GGTGGACCTGTTGGATCATCGGATGACCGAAGTCCACCGTAGTGCCTGTGGAGCTCTGAGAAACCTGGTGTATGGGAAGGCCAACGATGA
TAACAAAATTGCCCTGAAAAACTGTGGTGGCATCCCAGCACTGGTGAGGTTACTCCGCAAGACGACTGACCTGGAGATCCGGGAGCTGGT
CACAGGAGTCCTTTGGAACCTCTCCTCATGCGATGCACTCAAAATGCCAATCATCCAGGATGCCCTAGCAGTACTGACCAACGCGGTGAT
TATCCCCCACTCAGGCTGGGAAAATTCGCCTCTTCAGGATGATCGGAAAATACAGCTGCATTCATCACAGGTGCTGCGTAACGCCACCGG
GTGCCTAAGGAATGTTAGTTCGGCCGGAGAGGAGGCCCGCAGAAGGATGAGAGAGTGTGATGGGCTTACGGATGCCTTGCTGTACGTGAT
CCAGTCTGCGCTGGGGAGCAGTGAGATCGATAGCAAGGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGA
CAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGT
GATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGA
AATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGA
TGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGC
AAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTT
TGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACA

>20388_20388_1_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000304623_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=898AA_BP=759
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETG
SMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLAL
GETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLA
APQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLS
PTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT
GTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQK
DPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKI
ALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR
NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHF

--------------------------------------------------------------
>20388_20388_2_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000359640_BTF3_chr5_72798313_ENST00000335895_length(transcript)=3099nt_BP=2422nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGA
ACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATCCGAGACTGGCAGCATGAGCAGCATGAGTTCAGCAGAAGAGCAGTT
TCAGTGGCAGTCACAAGATGGTCAAAAAGATATCGAAGATGAGCTTACAACAGGTCTCGAGCTGGTGGACTCCTGTATTAGGTCACTACA
GGAATCAGGAATACTTGACCCACAGGATTATTCTACAGGTGAAAGGCCCAGCCTGCTCTCCCAGAGTGCACTTCAGCTCAATTCCAAACC
TGAAGGGTCTTTCCAGTATCCGGCCAGCTACCATAGCAACCAGACCCTGGCCCTGGGGGAAACCACCCCTTCACAGCTCCCGGCCCGAGG
CACACAAGCCCGAGCTACGGGCCAGAGCTTCAGCCAGGGCACGACCAGCCGCGCCGGCCACCTGGCGGGGCCCGAGCCCGCGCCGCCGCC
GCCGCCGCCGCCGCGGGAGCCGTTCGCGCCCAGCCTGGGCAGCGCCTTCCACCTGCCCGACGCGCCGCCCGCCGCCGCCGCCGCCGCGCT
CTACTACTCCAGCTCCACGCTGCCCGCGCCGCCGCGCGGGGGCTCCCCGCTGGCCGCGCCCCAGGGCGGTTCGCCCACCAAGCTGCAGCG
CGGCGGCTCGGCCCCCGAGGGCGCCACCTACGCCGCGCCGCGCGGCTCCTCGCCCAAGCAGTCGCCCAGCCGCCTGGCCAAGTCCTACAG
CACCAGCTCGCCCATCAACATCGTCGTGTCCTCGGCCGGCCTGTCCCCGATCCGCGTGACCTCGCCCCCCACCGTGCAGTCCACCATCTC
CTCCTCGCCCATCCACCAGCTGAGCTCCACCATCGGCACGTACGCCACCCTGTCGCCCACCAAGCGCCTGGTCCACGCGTCCGAGCAGTA
CAGCAAGCACTCGCAGGAGCTGTATGCCACGGCCACCCTCCAGAGGCCGGGCAGCCTGGCAGCTGGTTCCCGAGCCTCATACAGCAGCCA
GCATGGGCACCTGGGCCCAGAGTTGCGGGCCCTGCAGTCCCCAGAACACCACATAGATCCCATCTATGAAGACCGCGTCTATCAGAAGCC
CCCTATGAGGAGTCTCAGCCAGAGCCAGGGGGACCCTCTGCCGCCAGCACACACCGGCACCTACCGCACGAGCACAGCCCCATCTTCCCC
TGGTGTCGACTCCGTCCCCTTGCAGCGCACAGGCAGCCAGCACGGCCCACAGAATGCCGCCGCGGCCACCTTCCAGAGGGCCAGCTATGC
CGCCGGCCCAGCCTCCAATTACGCGGACCCCTACCGACAGCTGCAGTATTGTCCCTCTGTTGAGTCTCCATACAGCAAATCCGGCCCTGC
TCTCCCGCCTGAAGGCACCTTGGCCAGGTCCCCGTCCATTGATAGCATTCAGAAAGATCCCAGAGAATTTGGATGGAGAGACCCGGAACT
GCCGGAAGTGATTCAGATGTTGCAGCACCAGTTTCCCTCGGTCCAGTCTAACGCGGCAGCCTACTTGCAACACCTCTGTTTTGGAGACAA
CAAAATTAAAGCCGAGATAAGGAGACAAGGAGGCATCCAGCTCCTGGTGGACCTGTTGGATCATCGGATGACCGAAGTCCACCGTAGTGC
CTGTGGAGCTCTGAGAAACCTGGTGTATGGGAAGGCCAACGATGATAACAAAATTGCCCTGAAAAACTGTGGTGGCATCCCAGCACTGGT
GAGGTTACTCCGCAAGACGACTGACCTGGAGATCCGGGAGCTGGTCACAGGAGTCCTTTGGAACCTCTCCTCATGCGATGCACTCAAAAT
GCCAATCATCCAGGATGCCCTAGCAGTACTGACCAACGCGGTGATTATCCCCCACTCAGGCTGGGAAAATTCGCCTCTTCAGGATGATCG
GAAAATACAGCTGCATTCATCACAGGTGCTGCGTAACGCCACCGGGTGCCTAAGGAATGTTAGTTCGGCCGGAGAGGAGGCCCGCAGAAG
GATGAGAGAGTGTGATGGGCTTACGGATGCCTTGCTGTACGTGATCCAGTCTGCGCTGGGGAGCAGTGAGATCGATAGCAAGGGAACTGC
TCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATAT
CTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAA
CACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGAC
TAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGT
TCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTA
CTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCC
CAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATC

>20388_20388_2_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000359640_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=898AA_BP=759
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETG
SMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLAL
GETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLA
APQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLS
PTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT
GTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQK
DPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKI
ALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR
NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHF

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Fusion Gene PPI Analysis for CTNND2-BTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNND2-BTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNND2-BTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCTNND2C0017636Glioblastoma1CTD_human
HgeneCTNND2C0036341Schizophrenia1PSYGENET
HgeneCTNND2C0041696Unipolar Depression1PSYGENET
HgeneCTNND2C0334588Giant Cell Glioblastoma1CTD_human
HgeneCTNND2C1269683Major Depressive Disorder1PSYGENET
HgeneCTNND2C1621958Glioblastoma Multiforme1CTD_human
HgeneCTNND2C1832841EPILEPSY, FAMILIAL ADULT MYOCLONIC, 11ORPHANET
HgeneCTNND2C3495676Anorectal Malformations1GENOMICS_ENGLAND