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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CUX1-CDK14 (FusionGDB2 ID:HG1523TG5218)

Fusion Gene Summary for CUX1-CDK14

check button Fusion gene summary
Fusion gene informationFusion gene name: CUX1-CDK14
Fusion gene ID: hg1523tg5218
HgeneTgene
Gene symbol

CUX1

CDK14

Gene ID

1523

5218

Gene namecut like homeobox 1cyclin dependent kinase 14
SynonymsCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75PFTAIRE1|PFTK1
Cytomap('CUX1')('CDK14')

7q22.1

7q21.13

Type of geneprotein-codingprotein-coding
Descriptionprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000560541, ENST00000292535, 
ENST00000292538, ENST00000360264, 
ENST00000393824, ENST00000425244, 
ENST00000437600, ENST00000546411, 
ENST00000547394, ENST00000549414, 
ENST00000550008, ENST00000556210, 
Fusion gene scores* DoF score32 X 26 X 13=1081622 X 24 X 12=6336
# samples 3732
** MAII scorelog2(37/10816*10)=-4.86949797576587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(32/6336*10)=-4.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUX1 [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCUX1(101758553)-CDK14(90376996), # samples:1
Anticipated loss of major functional domain due to fusion event.CUX1-CDK14 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CUX1-CDK14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CUX1-CDK14 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CUX1-CDK14 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CUX1-CDK14 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CUX1-CDK14 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-A4BH-01ACUX1chr7

101758553

-CDK14chr7

90376996

+


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Fusion Gene ORF analysis for CUX1-CDK14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000560541ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
3UTR-3CDSENST00000560541ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
3UTR-3CDSENST00000560541ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
3UTR-intronENST00000560541ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
3UTR-intronENST00000560541ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000292535ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000292535ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000292538ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000292538ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000360264ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000360264ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000393824ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000393824ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000425244ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000425244ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000437600ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000437600ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000546411ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000546411ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000547394ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000547394ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000549414ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000549414ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000550008ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000550008ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000556210ENST00000436577CUX1chr7

101758553

-CDK14chr7

90376996

+
5CDS-intronENST00000556210ENST00000496279CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292535ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292535ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292535ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292538ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292538ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000292538ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000360264ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000360264ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000360264ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000393824ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000393824ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000393824ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000425244ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000425244ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000425244ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000437600ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000437600ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000437600ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000546411ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000546411ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000546411ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000547394ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000547394ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000547394ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000549414ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000549414ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000549414ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000550008ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000550008ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000550008ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000556210ENST00000265741CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000556210ENST00000380050CUX1chr7

101758553

-CDK14chr7

90376996

+
Frame-shiftENST00000556210ENST00000406263CUX1chr7

101758553

-CDK14chr7

90376996

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CUX1-CDK14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CUX1-CDK14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:101758553/:90376996)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CUX1-CDK14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CUX1-CDK14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CUX1-CDK14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CUX1-CDK14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUX1C0041696Unipolar Depression3PSYGENET
HgeneCUX1C1269683Major Depressive Disorder3PSYGENET
HgeneCUX1C0596263Carcinogenesis1CTD_human
TgeneC2239176Liver carcinoma1CTD_human