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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAB2IP-ATXN1 (FusionGDB2 ID:HG153090TG6310)

Fusion Gene Summary for DAB2IP-ATXN1

check button Fusion gene summary
Fusion gene informationFusion gene name: DAB2IP-ATXN1
Fusion gene ID: hg153090tg6310
HgeneTgene
Gene symbol

DAB2IP

ATXN1

Gene ID

153090

6310

Gene nameDAB2 interacting proteinataxin 1
SynonymsAF9Q34|AIP-1|AIP1|DIP1/2ATX1|D6S504E|SCA1
Cytomap('DAB2IP')('ATXN1')

9q33.2

6p22.3

Type of geneprotein-codingprotein-coding
Descriptiondisabled homolog 2-interacting proteinASK-interacting protein 1ASK1-interacting protein 1DAB2 interaction proteinDOC-2/DAB2 interactive proteinnGAP-like proteinataxin-1alternative ataxin1spinocerebellar ataxia type 1 protein
Modification date2020031320200313
UniProtAcc

Q5VWQ8

.
Ensembl transtripts involved in fusion geneENST00000259371, ENST00000408936, 
ENST00000309989, ENST00000487716, 
Fusion gene scores* DoF score12 X 10 X 8=96011 X 13 X 4=572
# samples 1212
** MAII scorelog2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/572*10)=-2.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAB2IP [Title/Abstract] AND ATXN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAB2IP(124461737)-ATXN1(16307090), # samples:1
Anticipated loss of major functional domain due to fusion event.DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DAB2IP-ATXN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAB2IP

GO:0000122

negative regulation of transcription by RNA polymerase II

15310755

HgeneDAB2IP

GO:0000185

activation of MAPKKK activity

19903888

HgeneDAB2IP

GO:0007257

activation of JUN kinase activity

12813029

HgeneDAB2IP

GO:0008285

negative regulation of cell proliferation

19903888

HgeneDAB2IP

GO:0010719

negative regulation of epithelial to mesenchymal transition

20154697

HgeneDAB2IP

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

19903888

HgeneDAB2IP

GO:0016525

negative regulation of angiogenesis

19033661

HgeneDAB2IP

GO:0031334

positive regulation of protein complex assembly

18281285

HgeneDAB2IP

GO:0034144

negative regulation of toll-like receptor 4 signaling pathway

19948740

HgeneDAB2IP

GO:0035924

cellular response to vascular endothelial growth factor stimulus

19033661

HgeneDAB2IP

GO:0043065

positive regulation of apoptotic process

17389591|19903888

HgeneDAB2IP

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

15310755|17389591

HgeneDAB2IP

GO:0043254

regulation of protein complex assembly

19948740

HgeneDAB2IP

GO:0043407

negative regulation of MAP kinase activity

12813029

HgeneDAB2IP

GO:0043410

positive regulation of MAPK cascade

19903888

HgeneDAB2IP

GO:0043507

positive regulation of JUN kinase activity

15310755

HgeneDAB2IP

GO:0043553

negative regulation of phosphatidylinositol 3-kinase activity

19903888

HgeneDAB2IP

GO:0044257

cellular protein catabolic process

17389591

HgeneDAB2IP

GO:0045944

positive regulation of transcription by RNA polymerase II

15310755|17389591

HgeneDAB2IP

GO:0046330

positive regulation of JNK cascade

17389591|19903888

HgeneDAB2IP

GO:0070317

negative regulation of G0 to G1 transition

19903888

HgeneDAB2IP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

19903888

HgeneDAB2IP

GO:0071158

positive regulation of cell cycle arrest

19903888

HgeneDAB2IP

GO:0071222

cellular response to lipopolysaccharide

19948740

HgeneDAB2IP

GO:0071347

cellular response to interleukin-1

19948740

HgeneDAB2IP

GO:0071356

cellular response to tumor necrosis factor

12813029|15310755|17389591

HgeneDAB2IP

GO:0071901

negative regulation of protein serine/threonine kinase activity

19903888

HgeneDAB2IP

GO:0071902

positive regulation of protein serine/threonine kinase activity

19903888

HgeneDAB2IP

GO:1903363

negative regulation of cellular protein catabolic process

19903888

HgeneDAB2IP

GO:2001235

positive regulation of apoptotic signaling pathway

19903888

TgeneATXN1

GO:0045892

negative regulation of transcription, DNA-templated

15016912

TgeneATXN1

GO:0051168

nuclear export

15615787


check buttonFusion gene breakpoints across DAB2IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATXN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerSPNT_276DAB2IPchr9

124461737

+ATXN1chr6

16307090

-


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Fusion Gene ORF analysis for DAB2IP-ATXN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000259371ENST00000467008DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
5CDS-intronENST00000408936ENST00000467008DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
Frame-shiftENST00000259371ENST00000436367DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
Frame-shiftENST00000408936ENST00000436367DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
In-frameENST00000259371ENST00000244769DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
In-frameENST00000408936ENST00000244769DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-3CDSENST00000309989ENST00000244769DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-3CDSENST00000309989ENST00000436367DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-3CDSENST00000487716ENST00000244769DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-3CDSENST00000487716ENST00000436367DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-intronENST00000309989ENST00000467008DAB2IPchr9

124461737

+ATXN1chr6

16307090

-
intron-intronENST00000487716ENST00000467008DAB2IPchr9

124461737

+ATXN1chr6

16307090

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259371DAB2IPchr9124461737+ENST00000244769ATXN1chr616307090-809534742903706194
ENST00000408936DAB2IPchr9124461737+ENST00000244769ATXN1chr616307090-829254444873903194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAB2IP-ATXN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DAB2IP-ATXN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:124461737/chr6:16307090)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAB2IP

Q5VWQ8

.
FUNCTION: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+3178_52921133.0Compositional biasNote=Arg-rich
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316112_1171201190.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+3168_521201190.0Compositional biasNote=Arg-rich
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979794_797639816.0MotifNuclear localization signal
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768794_797639816.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+3171026_1159921133.0Coiled coilOntology_term=ECO:0000255
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+1141026_115901066.0Coiled coilOntology_term=ECO:0000255
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+3161026_11591201190.0Coiled coilOntology_term=ECO:0000255
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317112_117921133.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317867_870921133.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317903_948921133.0Compositional biasNote=Pro-rich
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114112_11701066.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114867_87001066.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+1148_5201066.0Compositional biasNote=Arg-rich
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114903_94801066.0Compositional biasNote=Pro-rich
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316867_8701201190.0Compositional biasNote=Poly-Ala
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316903_9481201190.0Compositional biasNote=Pro-rich
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317101_202921133.0DomainPH
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317193_311921133.0DomainC2
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000259371+317371_563921133.0DomainRas-GAP
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114101_20201066.0DomainPH
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114193_31101066.0DomainC2
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000309989+114371_56301066.0DomainRas-GAP
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316101_2021201190.0DomainPH
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316193_3111201190.0DomainC2
HgeneDAB2IPchr9:124461737chr6:16307090ENST00000408936+316371_5631201190.0DomainRas-GAP
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979197_225639816.0Compositional biasNote=Poly-Gln
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768197_225639816.0Compositional biasNote=Poly-Gln
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979562_693639816.0DomainAXH
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768562_693639816.0DomainAXH
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979494_604639816.0RegionSelf-association
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979540_766639816.0RegionRNA-binding
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768494_604639816.0RegionSelf-association
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768540_766639816.0RegionRNA-binding


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Fusion Gene Sequence for DAB2IP-ATXN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21229_21229_1_DAB2IP-ATXN1_DAB2IP_chr9_124461737_ENST00000259371_ATXN1_chr6_16307090_ENST00000244769_length(transcript)=8095nt_BP=347nt
CCCAGACGCTCATGGAGACAGCCTCGGTTCATAAATCAGGTGGGGCCAGGGGCTGGGGGCCCACACGCCATGGAGCCCGACTCCCTTCTG
GACCAAGACGACTCCTACGAGTCGCCTCAAGAAAGGCCGGGCTCTCGGCGCAGCCTGCCTGGCAGCCTTTCCGAGAAGAGCCCCAGCATG
GAGCCCTCGGCCGCCACGCCGTTCCGGGTCACGGGCTTCCTCAGCCGCCGCCTCAAGGGCTCCATCAAGCGCACCAAGAGCCAGCCCAAG
CTGGACCGCAACCACAGCTTCCGCCACATCCTGCCGGGGTTCCGGAGCGCCGCCGCCGCCGCCGCGGACAATGAGAGGTCAGCGTTGAAG
TTTTGGTAGAGTATCCTTTTTTTGTGTTTGGACAGGGCTGGTCATCCTGCTGTCCGGAGAGAACCAGCCAGCTCTTTGATTTGCCGTGTT
CCAAACTCTCAGTTGGGGATGTCTGCATCTCGCTTACCCTCAAGAACCTGAAGAACGGCTCTGTTAAAAAGGGCCAGCCCGTGGATCCCG
CCAGCGTCCTGCTGAAGCACTCAAAGGCCGACGGCCTGGCGGGCAGCAGACACAGGTATGCCGAGCAGGAAAACGGAATCAACCAGGGGA
GTGCCCAGATGCTCTCTGAGAATGGCGAACTGAAGTTTCCAGAGAAAATGGGATTGCCTGCAGCGCCCTTCCTCACCAAAATAGAACCCA
GCAAGCCCGCGGCAACGAGGAAGAGGAGGTGGTCGGCGCCAGAGAGCCGCAAACTGGAGAAGTCAGAAGACGAACCACCTTTGACTCTTC
CTAAGCCTTCTCTAATTCCTCAGGAGGTTAAGATTTGCATTGAAGGCCGGTCTAATGTAGGCAAGTAGAGGCAGCGTGGGGGAAAGGAAA
CGTGGCTCTCCCTTATCATTTGTATCCAGATTACTGTACTGTAGGCTAAAATAACACAGTATTTACATGTTATCTTCTTAATTTTAGGTT
TCTGTTCTAACCTTGTCATTAGAGTTACAGCAGGTGTGTCGCAGGAGACTGGTGCATATGCTTTTTCCACGAGTGTCTGTCAGTGAGCGG
GCGGGAGGAAGGGCACAGCAGGAGCGGTCAGGGCTCCAGGCATCCCCGGGGAAGAAAGGAACGGGGCTTCACAGTGCCTGCCTTCTCTAG
CGGCACAGAAGCAGCCGGGGGCGCTGACTCCCGCTAGTGTCAGGAGAAAAGTCCCGTGGGAAGGGTCCTGCAGGGGTGCAGGGTTGCACG
CATGTGGGGGTGCACAGGCGCTGTGGCGGCGAGTGAGGGTCTCTTTTTCTCTGCCTCCCTCTGCCTCACTCTCTTGCTATCGGCATGGGC
CGGGGGGGTTCAGAGCAGTGTCCTCCTGGGGTTCCCACGTGCAAAATCAACATCAGGAACCCAGCTTCAGGGCATCGCGGAGACGCGTCA
GATGGCAGATTTGGAAAGTTAACCATTTAAAAGAACATTTTTCTCTCCAACATATTTTACAATAAAAGCAACTTTTAATTGTATAGATAT
ATATTTCCCCCTATGGGGCCTGACTGCACTGATATATATTTTTTTTAAAGAGCAACTGCCACATGCGGGATTTCATTTCTGCTTTTTACT
AGTGCAGCGATGTCACCAGGGTGTTGTGGTGGACAGGGAAGCCCCTGCTGTCATGGCCCCACATGGGGTAAGGGGGGTTGGGGGTGGGGG
AGAGGGAGAGAGCGAACACCCACGCTGGTTTCTGTGCAGTGTTAGGAAAACCAATCAGGTTATTGCATTGACTTCACTCCCAAGAGGTAG
ATGCAAACTGCCCTTCAGTGAGAGCAACAGAAGCTCTTCACGTTGAGTTTGCGAAATCTTTTTGTCTTTGAACTCTAGTACTGTTTATAG
TTCATGACTATGGACAACTCGGGTGCCACTTTTTTTTTTTTTCAGATTCCAGTGTGACATGAGGAATTAGATTTTGAAGATGAGCATATA
TTACTATCTTTAAGCATTTAAAAATACTGTTCACACTTTATTACCAAGCATCTTGGTCTCTCATTCAACAAGTACTGTATCTCACTTTAA
ACTCTTTGGGGAAAAAACAAAAACAAAAAAAACTAAGTTGCTTTCTTTTTTTCAACACTGTAACTACATTTCAGCTCTGCAGAATTGCTG
AAGAGCAAGATATTGAAAGTTTCAATGTGGTTTAAAGGGATGAATGTGAATTATGAACTAGTATGTGACAATAAATGACCACCAAGTACT
ACCTGACGGGAGGCACTTTTCACTTTGATGTCTGAGAATCAGTTCAAGGCATATGCAGAGTTGGCAGAGAAACTGAGAGAAAAGGGATGG
AGAAGAGAATACTCATTTTTGTCCAGTGTTTTTCTTTTTAAGATGAACTTTTAAAGAACCTTGCGATTTGCACATATTGAGTTTATAACT
TGTGTGATATTCCTGCAGTTTTTATCCAATAACATTGTGGGAAAGGTTTGGGGGACTGAACGAGCATAAATAAATGTAGCAAAATTTCTT
TCTAACCTGCCTAAACTCTAGGCCATTTTATAAGGTTATGTTCCTTTGAAAATTCATTTTGGTCTTTTTACCACATCTGTCACAAAAAGC
CAGGTCTTAGCGGGCTCTTAGAAACTCTGAGAATTTTCTTCAGATTCATTGAGAGAGTTTTCCATAAAGACATTTATATATGTGAGCAAG
ATTTTTTTTAAACAATTACTTTATTATTGTTGTTATTAATGTTATTTTCAGAATGGCTTTTTTTTTTCTATTCAAAATCAAATCGAGATT
TAATGTTTGGTACAAACCCAGAAAGGGTATTTCATAGTTTTTAAACCTTTCATTCCCAGAGATCCGAAATATCATTTGTGGGTTTTGAAT
GCATCTTTAAAGTGCTTTAAAAAAAAGTTTTATAAGTAGGGAGAAATTTTTAAATATTCTTACTTGGATGGCTGCAACTAAACTGAACAA
ATACCTGACTTTTCTTTTACCCCATTGAAAATAGTACTTTCTTCGTTTCACAAATTAAAAAAAAAATCTGGTATCAACCCACATTTTGGC
TGTCTAGTATTCATTTACATTTAGGGTTCACCAGGACTAATGATTTTTATAAACCGTTTTCTGGGGTGTACCAAAAACATTTGAATAGGT
TTAGAATAGCTAGAATAGTTCCTTGACTTTCCTCGAATTTCATTACCCTCTCAGCATGCTTGCAGAGAGCTGGGTGGGCTCATTCTTGCA
GTCATACTGCTTATTTAGTGCTGTATTTTTTAAACGTTTCTGTTCAGAGAACTTGCTTAATCTTCCATATATTCTGCTCAGGGCACTTGC
AATTATTAGGTTTTGTTTTTCTTTTTGTTTTTTAGCCTTTGATGGTAAGAGGAATACGGGCTGCCACATAGACTTTGTTCTCATTAATAT
CACTATTTACAACTCATGTGGACTCAGAAAAACACACACCACCTTTTGGCTTACTTCGAGTATTGAATTGACTGGATCCACTAAACCAAC
ACTAAGATGGGAAAACACACATGGTTTGGAGCAATAGGAACATCATCATAATTTTTGTGGTTCTATTTCAGGTATAGGAATTATAAAATA
ATTGGTTCTTTCTAAACACTTGTCCCATTTCATTCTCTTGCTTTTTTAGCATGTGCAATACTTTCTGTGCCAATAGAGTCTGACCAGTGT
GCTATATAGTTAAAGCTCATTCCCTTTTGGCTTTTTCCTTGTTTGGTTGATCTTCCCCATTCTGGCCAGAGCAGGGCTGGAGGGAAGGAG
CCAGGAGGGAGAGAGCCTCCCACCTTTCCCCTGCTGCGGATGCTGAGTGCTGGGGCGGGGAGCCTTCAGGAGCCCCGTGCGTCTGCCGCC
ACGTTGCAGAAAGAGCCAGCCAAGGAGACCCGGGGGAGGAACCGCAGTGTCCCCTGTCACCACACGGAATAGTGAATGTGGAGTGTGGAG
AGGAAGGAGGCAGATTCATTTCTAAGACGCACTCTGGAGCCATGTAGCCTGGAGTCAACCCATTTTCCACGGTCTTTTCTGCAAGTGGGC
AGGCCCCTCCTCGGGGTCTGTGTCCTTGAGACTTGGAGCCCTGCCTCTGAGCCTGGACGGGAAGTGTGGCCTGTTGTGTGTGTGCGTTCT
GAGCGTGTTGGCCAGTGGCTGTGGAGGGGACCACCTGCCACCCACGGTCACCACTCCCTTGTGGCAGCTTTCTCTTCAAATAGGAAGAAC
GCACAGAGGGCAGGAGCCTCCTGTTTGCAGACGTTGGCGGGCCCCGAGGCTCCCAGAGCAGCCTCTGTCACCGCTTCTGTGTAGCAAACA
TTAACGATGACAGGGGTAGAAATTCTTCGGTGCCGTTCAGCTTACAAGGATCAGCCATGTGCCTCTGTACTATGTCCACTTTGCAATATT
TACCGACAGCCGTCTTTTGTTCTTTCTTTCCTGTTTTCCATTTTTAAACTAGTAACAGCAGGCCTTTTGCGTTTACAATGGAACACAATC
ACCAAGAAATTAGTCAGGGCGAAAAGAAAAAAATAATACTATTAATAAGAAACCAACAAACAAGAACCTCTCTTTCTAGGGATTTCTAAA
TATATAAAATGACTGTTCCTTAGAATGTTTAACTTAAGAATTATTTCAGTTTGTCTGGGCCACACTGGGGCAGAGGGGGGAGGGAGGGAT
ACAGAGATGGATGCCACTTACCTCAGATCTTTTAAAGTGGAAATCCAAATTGAATTTTCATTTGGACTTTCAGGATAATTTTCTATGTTG
GTCAACTTTTCGTTTTCCCTAACTCACCCAGTTTAGTTTGGGATGATTTGATTTCTGTTGTTGTTGATCCCATTTCTAACTTGGAATTGT
GAGCCTCTATGTTTTCTGTTAGGTGAGTGTGTTGGGTTTTTTCCCCCCACCAGGAAGTGGCAGCATCCCTCCTTCTCCCCTAAAGGGACT
CTGCGGAACCTTTCACACCTCTTTCTCAGGGACGGGGCAGGTGTGTGTGTGGTACACTGACGTGTCCAGAAGCAGCACTTTGACTGCTCT
GGAGTAGGGTTGTACAATTTCAAGGAATGTTTGGATTTCCTGCATCTTGTGGATTACTCCTTAGATACCGCATAGATTGCAATATAATGC
TGCATGTTCAAGATGAACAGTAGCTCCTAGTAATCATAAAATCCACTCTTTGCACAGTTTGATCTTTACTGAAATATGTTGCCAAAATTT
ATTTTTGTTGTTGTAGCTCTGGATTTTGTTTTGTTTTGTTTTTTAAGGAAACGATTGACAATACCCTTTAACATCTGTGACTACTAAGGA
AACCTATTTCTTTCATAGAGAGAAAAATCTCCAATGCTTTTGAAGACACTAATACCGTGCTATTTCAGATATGGGTGAGGAAGCAGAGCT
CTCGGTACCGAAGGCCGGGCTTCTTGAGCTGTGTTGGTTGTCATGGCTACTGTTTCATGAACCACAAGCAGCTCAACAGACTGGTCTGTT
GCCTTCTGAAACCCTTTGCACTTCAATTTGCACCAGGTGAAAACAGGGCCAGCAGACTCCATGGCCCAATTCGGTTTCTTCGGTGGTGAT
GTGAAAGGAGAGAATTACACTTTTTTTTTTTTTAAGTGGCGTGGAGGCCTTTGCTTCCACATTTGTTTTTAACCCAGAATTTCTGAAATA
GAGAATTTAAGAACACATCAAGTAATAAATATACAGAGAATATACTTTTTTATAAAGCACATGCATCTGCTATTGTGTTGGGTTGGTTTC
CTCTCTTTTCCACGGACAGTGTTGTGTTTCTGGCATAGGGAAACTCCAAACAACTTGCACACCTCTACTCCGGAGCTGAGATTTCTTTTA
CATAGATGACCTCGCTTCAAATACGTTACCTTACTGATGATAGGATCTTTTCTTGTAGCACTATACCTTGTGGGAATTTTTTTTTAAATG
TACACCTGATTTGAGAAGCTGAAGAAAACAAAATTTTGAAGCACTCACTTTGAGGAGTACAGGTAATGTTTTAAAAAATTGCACAAAAGA
AAAATGAATGTCGAAATGATTCATTCAGTGTTTGAAAGATATGGCTCTGTTGAAACAATGAGTTTCATACTTTGTTTGTAAAAAAAAAAA
AGCAGAGAAGGGTTGAAAGTTACATGTTTTTTTGTATATAGAAATTTGTCATGTCTAAATGATCAGATTTGTATGGTTATGGCCTGGAAG
AATTACTACGTAAAAGGCTCTTAAACTATACCTATGCTTATTGTTATTTTTGTTACATATAGCCCTCGTCTGAGGGAGGGGAACTCGGTA
TTCTGCGATTTGAGAATACTGTTCATTCCTATGCTGAAAGTACTTCTCTGAGCTCCCTTCTTAGTCTAAACTCTTAAGCCATTGCAACTT
CTTTTTCTTCAGAGATGATGTTTGACATTTTCAGCACTTCCTGTTCCTATAAACCCAAAGAATATAATCTTGAACACGAAGTGTTTGTAA
CAAGGGATCCAGGCTACCAATCAAACAGGACTCATTATGGGGACAAAAAAAAAAATTATTTCACCTTCTTTCCCCCCACACCTCATTTAA
ATGGGGGGAGTAAAAACATGATTTCAATGTAAATGCCTCATTTTATTTTAGTTTTATTTTGATTTTTATTTAATATAAAGAGGCCAGAAT
AAATACGGAGCATCTTCTCAGAATAGTATTCCTGTCCAAAAATCAAGCCGGACAGTGGAAACTGGACAGCTGTGGGGATATTAAGCACCC
CCACTTACAATTCTTAAATTCAGAATCTCGTCCCCTCCCTTCTCGTTGAAGGCAACTGTTCTGGTAGCTAACTTTCTCCTGTGTAATGGC
GGGAGGGAACACCGGCTTCAGTTTTTCATGTCCCCATGACTTGCATACAAATGGTTCAACTGTATTAAAATTAAGTGCATTTGGCCAATA
GGTAGTATCTATACAATAACAACAATCTCTAAGAATTTCCATAACTTTTCTTATCTGAAAGGACTCAAGTCTTCCACTGCAGATACATTG
GAGGCTTCACCCACGTTTTCTTTCCCTTTAGTTTGTTTGCTGTCTGGATGGCCAATGAGCCTGTCTCCTTTTCTGTGGCCAATCTGAAGG
CCTTCGTTGGAAGTGTTGTTTACAGTAATCCTTACCAAGATAACATACTGTCCTCCAGAATACCAAGTATTAGGTGACACTAGCTCAAGC
TGTTGTCTTCAGAGCAGTTACCAAGAAGCTCGGTGCACAGGTTTTCTCTGGTTCTTACAGGAACCACCTACTCTTTCAGTTTTCTGGCCC
AGGAGTGGGGTAAATCCTTTAGTTAGTGCATTTGAACTTGATACCTGTGCATTCAGTTCTGTGAATACTGCCCTTTTTGGCGGGGTTTCC
TCATCTCCCCAGCCTGAACTGCTCAACTCTAAACCCAAATTAGTGTCAGCCGAAAGGAGGTTTCAAGATAGTCCTGTCAGTATTTGTGGT
GACCTTCAGATTAGACAGTCTTCATTTCCAGCCAGTGGAGTCCTGGCTCCAGAGCCATCTCTGAGACTCGTACTACTGGATGTTTTAATA
TCAGATCATTACCCACCATATGCCTCCCACAGGCCAAGGGAAAACAGACACCAGAACTTGGGTTGAGGGCACTACCAGACTGACATGGCC
AGTACAGAGGAGAACTAGGGAAGGAATGATGTTTTGCACCTTATTGAAAAGAAAATTTTAAGTGCATACATAATAGTTAAGAGCTTTTAT
TGTGACAGGAGAACTTTTTTCCATATGCGTGCATACTCTCTGTAATTCCAGTGTAAAATATTGTACTTGCACTAGCTTTTTTAAACAAAT
ATTAAAAAATGGAAGAATTCATATTCTATTTTCTAATCGTGGTGTGTCTATTTGTAGGATACACTCGAGTCTGTTTATTGAATTTTATGG
TCCCTTTCTTTGATGGTGCTTGCAGGTTTTCTAGGTAGAAATTATTTCATTATTATAATAAAACAATGTTTGATTCAAAATTTGAACAAA

>21229_21229_1_DAB2IP-ATXN1_DAB2IP_chr9_124461737_ENST00000259371_ATXN1_chr6_16307090_ENST00000244769_length(amino acids)=194AA_BP=
MLWEPRGPPTSANRRLLPSVRSSYLKRKLPQGSGDRGWQVVPSTATGQHAQNAHTQQATLPVQAQRQGSKSQGHRPRGGACPLAEKTVEN
GLTPGYMAPECVLEMNLPPSSPHSTFTIPCGDRGHCGSSPGSPWLALSATWRQTHGAPEGSPPQHSASAAGERWEALSLLAPSLQPCSGQ

--------------------------------------------------------------
>21229_21229_2_DAB2IP-ATXN1_DAB2IP_chr9_124461737_ENST00000408936_ATXN1_chr6_16307090_ENST00000244769_length(transcript)=8292nt_BP=544nt
GGGAGCGGGAGGGGGCAGGAGGCGGAGGAGGAGTTTGAGCGACTTTGTGGGGCAGCCAGGGCCTCGGCGGCCGCTCGGGCGAGCGCGGGA
GAACGCGTGGGCGCCCGCCGGGCTGTCCGGAGCGGCCGATGGGGCCCGTGTGAGCGCGCCCAGGCCCGGCCCGGTGCCCGGCGGGCGGCA
GCATGTCCGCGGGCGGCAGCGCCAGGAAGAGCACCGGGAGGTCCTCCTACTACTACCGGCTGCTGAGGCGGCCCCGGCTGCAGCGACAGA
GGAGCCGCTCCCGCAGCCGGACCCGGCCTGCCAGGGAGTCGCCTCAAGAAAGGCCGGGCTCTCGGCGCAGCCTGCCTGGCAGCCTTTCCG
AGAAGAGCCCCAGCATGGAGCCCTCGGCCGCCACGCCGTTCCGGGTCACGGGCTTCCTCAGCCGCCGCCTCAAGGGCTCCATCAAGCGCA
CCAAGAGCCAGCCCAAGCTGGACCGCAACCACAGCTTCCGCCACATCCTGCCGGGGTTCCGGAGCGCCGCCGCCGCCGCCGCGGACAATG
AGAGGTCAGCGTTGAAGTTTTGGTAGAGTATCCTTTTTTTGTGTTTGGACAGGGCTGGTCATCCTGCTGTCCGGAGAGAACCAGCCAGCT
CTTTGATTTGCCGTGTTCCAAACTCTCAGTTGGGGATGTCTGCATCTCGCTTACCCTCAAGAACCTGAAGAACGGCTCTGTTAAAAAGGG
CCAGCCCGTGGATCCCGCCAGCGTCCTGCTGAAGCACTCAAAGGCCGACGGCCTGGCGGGCAGCAGACACAGGTATGCCGAGCAGGAAAA
CGGAATCAACCAGGGGAGTGCCCAGATGCTCTCTGAGAATGGCGAACTGAAGTTTCCAGAGAAAATGGGATTGCCTGCAGCGCCCTTCCT
CACCAAAATAGAACCCAGCAAGCCCGCGGCAACGAGGAAGAGGAGGTGGTCGGCGCCAGAGAGCCGCAAACTGGAGAAGTCAGAAGACGA
ACCACCTTTGACTCTTCCTAAGCCTTCTCTAATTCCTCAGGAGGTTAAGATTTGCATTGAAGGCCGGTCTAATGTAGGCAAGTAGAGGCA
GCGTGGGGGAAAGGAAACGTGGCTCTCCCTTATCATTTGTATCCAGATTACTGTACTGTAGGCTAAAATAACACAGTATTTACATGTTAT
CTTCTTAATTTTAGGTTTCTGTTCTAACCTTGTCATTAGAGTTACAGCAGGTGTGTCGCAGGAGACTGGTGCATATGCTTTTTCCACGAG
TGTCTGTCAGTGAGCGGGCGGGAGGAAGGGCACAGCAGGAGCGGTCAGGGCTCCAGGCATCCCCGGGGAAGAAAGGAACGGGGCTTCACA
GTGCCTGCCTTCTCTAGCGGCACAGAAGCAGCCGGGGGCGCTGACTCCCGCTAGTGTCAGGAGAAAAGTCCCGTGGGAAGGGTCCTGCAG
GGGTGCAGGGTTGCACGCATGTGGGGGTGCACAGGCGCTGTGGCGGCGAGTGAGGGTCTCTTTTTCTCTGCCTCCCTCTGCCTCACTCTC
TTGCTATCGGCATGGGCCGGGGGGGTTCAGAGCAGTGTCCTCCTGGGGTTCCCACGTGCAAAATCAACATCAGGAACCCAGCTTCAGGGC
ATCGCGGAGACGCGTCAGATGGCAGATTTGGAAAGTTAACCATTTAAAAGAACATTTTTCTCTCCAACATATTTTACAATAAAAGCAACT
TTTAATTGTATAGATATATATTTCCCCCTATGGGGCCTGACTGCACTGATATATATTTTTTTTAAAGAGCAACTGCCACATGCGGGATTT
CATTTCTGCTTTTTACTAGTGCAGCGATGTCACCAGGGTGTTGTGGTGGACAGGGAAGCCCCTGCTGTCATGGCCCCACATGGGGTAAGG
GGGGTTGGGGGTGGGGGAGAGGGAGAGAGCGAACACCCACGCTGGTTTCTGTGCAGTGTTAGGAAAACCAATCAGGTTATTGCATTGACT
TCACTCCCAAGAGGTAGATGCAAACTGCCCTTCAGTGAGAGCAACAGAAGCTCTTCACGTTGAGTTTGCGAAATCTTTTTGTCTTTGAAC
TCTAGTACTGTTTATAGTTCATGACTATGGACAACTCGGGTGCCACTTTTTTTTTTTTTCAGATTCCAGTGTGACATGAGGAATTAGATT
TTGAAGATGAGCATATATTACTATCTTTAAGCATTTAAAAATACTGTTCACACTTTATTACCAAGCATCTTGGTCTCTCATTCAACAAGT
ACTGTATCTCACTTTAAACTCTTTGGGGAAAAAACAAAAACAAAAAAAACTAAGTTGCTTTCTTTTTTTCAACACTGTAACTACATTTCA
GCTCTGCAGAATTGCTGAAGAGCAAGATATTGAAAGTTTCAATGTGGTTTAAAGGGATGAATGTGAATTATGAACTAGTATGTGACAATA
AATGACCACCAAGTACTACCTGACGGGAGGCACTTTTCACTTTGATGTCTGAGAATCAGTTCAAGGCATATGCAGAGTTGGCAGAGAAAC
TGAGAGAAAAGGGATGGAGAAGAGAATACTCATTTTTGTCCAGTGTTTTTCTTTTTAAGATGAACTTTTAAAGAACCTTGCGATTTGCAC
ATATTGAGTTTATAACTTGTGTGATATTCCTGCAGTTTTTATCCAATAACATTGTGGGAAAGGTTTGGGGGACTGAACGAGCATAAATAA
ATGTAGCAAAATTTCTTTCTAACCTGCCTAAACTCTAGGCCATTTTATAAGGTTATGTTCCTTTGAAAATTCATTTTGGTCTTTTTACCA
CATCTGTCACAAAAAGCCAGGTCTTAGCGGGCTCTTAGAAACTCTGAGAATTTTCTTCAGATTCATTGAGAGAGTTTTCCATAAAGACAT
TTATATATGTGAGCAAGATTTTTTTTAAACAATTACTTTATTATTGTTGTTATTAATGTTATTTTCAGAATGGCTTTTTTTTTTCTATTC
AAAATCAAATCGAGATTTAATGTTTGGTACAAACCCAGAAAGGGTATTTCATAGTTTTTAAACCTTTCATTCCCAGAGATCCGAAATATC
ATTTGTGGGTTTTGAATGCATCTTTAAAGTGCTTTAAAAAAAAGTTTTATAAGTAGGGAGAAATTTTTAAATATTCTTACTTGGATGGCT
GCAACTAAACTGAACAAATACCTGACTTTTCTTTTACCCCATTGAAAATAGTACTTTCTTCGTTTCACAAATTAAAAAAAAAATCTGGTA
TCAACCCACATTTTGGCTGTCTAGTATTCATTTACATTTAGGGTTCACCAGGACTAATGATTTTTATAAACCGTTTTCTGGGGTGTACCA
AAAACATTTGAATAGGTTTAGAATAGCTAGAATAGTTCCTTGACTTTCCTCGAATTTCATTACCCTCTCAGCATGCTTGCAGAGAGCTGG
GTGGGCTCATTCTTGCAGTCATACTGCTTATTTAGTGCTGTATTTTTTAAACGTTTCTGTTCAGAGAACTTGCTTAATCTTCCATATATT
CTGCTCAGGGCACTTGCAATTATTAGGTTTTGTTTTTCTTTTTGTTTTTTAGCCTTTGATGGTAAGAGGAATACGGGCTGCCACATAGAC
TTTGTTCTCATTAATATCACTATTTACAACTCATGTGGACTCAGAAAAACACACACCACCTTTTGGCTTACTTCGAGTATTGAATTGACT
GGATCCACTAAACCAACACTAAGATGGGAAAACACACATGGTTTGGAGCAATAGGAACATCATCATAATTTTTGTGGTTCTATTTCAGGT
ATAGGAATTATAAAATAATTGGTTCTTTCTAAACACTTGTCCCATTTCATTCTCTTGCTTTTTTAGCATGTGCAATACTTTCTGTGCCAA
TAGAGTCTGACCAGTGTGCTATATAGTTAAAGCTCATTCCCTTTTGGCTTTTTCCTTGTTTGGTTGATCTTCCCCATTCTGGCCAGAGCA
GGGCTGGAGGGAAGGAGCCAGGAGGGAGAGAGCCTCCCACCTTTCCCCTGCTGCGGATGCTGAGTGCTGGGGCGGGGAGCCTTCAGGAGC
CCCGTGCGTCTGCCGCCACGTTGCAGAAAGAGCCAGCCAAGGAGACCCGGGGGAGGAACCGCAGTGTCCCCTGTCACCACACGGAATAGT
GAATGTGGAGTGTGGAGAGGAAGGAGGCAGATTCATTTCTAAGACGCACTCTGGAGCCATGTAGCCTGGAGTCAACCCATTTTCCACGGT
CTTTTCTGCAAGTGGGCAGGCCCCTCCTCGGGGTCTGTGTCCTTGAGACTTGGAGCCCTGCCTCTGAGCCTGGACGGGAAGTGTGGCCTG
TTGTGTGTGTGCGTTCTGAGCGTGTTGGCCAGTGGCTGTGGAGGGGACCACCTGCCACCCACGGTCACCACTCCCTTGTGGCAGCTTTCT
CTTCAAATAGGAAGAACGCACAGAGGGCAGGAGCCTCCTGTTTGCAGACGTTGGCGGGCCCCGAGGCTCCCAGAGCAGCCTCTGTCACCG
CTTCTGTGTAGCAAACATTAACGATGACAGGGGTAGAAATTCTTCGGTGCCGTTCAGCTTACAAGGATCAGCCATGTGCCTCTGTACTAT
GTCCACTTTGCAATATTTACCGACAGCCGTCTTTTGTTCTTTCTTTCCTGTTTTCCATTTTTAAACTAGTAACAGCAGGCCTTTTGCGTT
TACAATGGAACACAATCACCAAGAAATTAGTCAGGGCGAAAAGAAAAAAATAATACTATTAATAAGAAACCAACAAACAAGAACCTCTCT
TTCTAGGGATTTCTAAATATATAAAATGACTGTTCCTTAGAATGTTTAACTTAAGAATTATTTCAGTTTGTCTGGGCCACACTGGGGCAG
AGGGGGGAGGGAGGGATACAGAGATGGATGCCACTTACCTCAGATCTTTTAAAGTGGAAATCCAAATTGAATTTTCATTTGGACTTTCAG
GATAATTTTCTATGTTGGTCAACTTTTCGTTTTCCCTAACTCACCCAGTTTAGTTTGGGATGATTTGATTTCTGTTGTTGTTGATCCCAT
TTCTAACTTGGAATTGTGAGCCTCTATGTTTTCTGTTAGGTGAGTGTGTTGGGTTTTTTCCCCCCACCAGGAAGTGGCAGCATCCCTCCT
TCTCCCCTAAAGGGACTCTGCGGAACCTTTCACACCTCTTTCTCAGGGACGGGGCAGGTGTGTGTGTGGTACACTGACGTGTCCAGAAGC
AGCACTTTGACTGCTCTGGAGTAGGGTTGTACAATTTCAAGGAATGTTTGGATTTCCTGCATCTTGTGGATTACTCCTTAGATACCGCAT
AGATTGCAATATAATGCTGCATGTTCAAGATGAACAGTAGCTCCTAGTAATCATAAAATCCACTCTTTGCACAGTTTGATCTTTACTGAA
ATATGTTGCCAAAATTTATTTTTGTTGTTGTAGCTCTGGATTTTGTTTTGTTTTGTTTTTTAAGGAAACGATTGACAATACCCTTTAACA
TCTGTGACTACTAAGGAAACCTATTTCTTTCATAGAGAGAAAAATCTCCAATGCTTTTGAAGACACTAATACCGTGCTATTTCAGATATG
GGTGAGGAAGCAGAGCTCTCGGTACCGAAGGCCGGGCTTCTTGAGCTGTGTTGGTTGTCATGGCTACTGTTTCATGAACCACAAGCAGCT
CAACAGACTGGTCTGTTGCCTTCTGAAACCCTTTGCACTTCAATTTGCACCAGGTGAAAACAGGGCCAGCAGACTCCATGGCCCAATTCG
GTTTCTTCGGTGGTGATGTGAAAGGAGAGAATTACACTTTTTTTTTTTTTAAGTGGCGTGGAGGCCTTTGCTTCCACATTTGTTTTTAAC
CCAGAATTTCTGAAATAGAGAATTTAAGAACACATCAAGTAATAAATATACAGAGAATATACTTTTTTATAAAGCACATGCATCTGCTAT
TGTGTTGGGTTGGTTTCCTCTCTTTTCCACGGACAGTGTTGTGTTTCTGGCATAGGGAAACTCCAAACAACTTGCACACCTCTACTCCGG
AGCTGAGATTTCTTTTACATAGATGACCTCGCTTCAAATACGTTACCTTACTGATGATAGGATCTTTTCTTGTAGCACTATACCTTGTGG
GAATTTTTTTTTAAATGTACACCTGATTTGAGAAGCTGAAGAAAACAAAATTTTGAAGCACTCACTTTGAGGAGTACAGGTAATGTTTTA
AAAAATTGCACAAAAGAAAAATGAATGTCGAAATGATTCATTCAGTGTTTGAAAGATATGGCTCTGTTGAAACAATGAGTTTCATACTTT
GTTTGTAAAAAAAAAAAAGCAGAGAAGGGTTGAAAGTTACATGTTTTTTTGTATATAGAAATTTGTCATGTCTAAATGATCAGATTTGTA
TGGTTATGGCCTGGAAGAATTACTACGTAAAAGGCTCTTAAACTATACCTATGCTTATTGTTATTTTTGTTACATATAGCCCTCGTCTGA
GGGAGGGGAACTCGGTATTCTGCGATTTGAGAATACTGTTCATTCCTATGCTGAAAGTACTTCTCTGAGCTCCCTTCTTAGTCTAAACTC
TTAAGCCATTGCAACTTCTTTTTCTTCAGAGATGATGTTTGACATTTTCAGCACTTCCTGTTCCTATAAACCCAAAGAATATAATCTTGA
ACACGAAGTGTTTGTAACAAGGGATCCAGGCTACCAATCAAACAGGACTCATTATGGGGACAAAAAAAAAAATTATTTCACCTTCTTTCC
CCCCACACCTCATTTAAATGGGGGGAGTAAAAACATGATTTCAATGTAAATGCCTCATTTTATTTTAGTTTTATTTTGATTTTTATTTAA
TATAAAGAGGCCAGAATAAATACGGAGCATCTTCTCAGAATAGTATTCCTGTCCAAAAATCAAGCCGGACAGTGGAAACTGGACAGCTGT
GGGGATATTAAGCACCCCCACTTACAATTCTTAAATTCAGAATCTCGTCCCCTCCCTTCTCGTTGAAGGCAACTGTTCTGGTAGCTAACT
TTCTCCTGTGTAATGGCGGGAGGGAACACCGGCTTCAGTTTTTCATGTCCCCATGACTTGCATACAAATGGTTCAACTGTATTAAAATTA
AGTGCATTTGGCCAATAGGTAGTATCTATACAATAACAACAATCTCTAAGAATTTCCATAACTTTTCTTATCTGAAAGGACTCAAGTCTT
CCACTGCAGATACATTGGAGGCTTCACCCACGTTTTCTTTCCCTTTAGTTTGTTTGCTGTCTGGATGGCCAATGAGCCTGTCTCCTTTTC
TGTGGCCAATCTGAAGGCCTTCGTTGGAAGTGTTGTTTACAGTAATCCTTACCAAGATAACATACTGTCCTCCAGAATACCAAGTATTAG
GTGACACTAGCTCAAGCTGTTGTCTTCAGAGCAGTTACCAAGAAGCTCGGTGCACAGGTTTTCTCTGGTTCTTACAGGAACCACCTACTC
TTTCAGTTTTCTGGCCCAGGAGTGGGGTAAATCCTTTAGTTAGTGCATTTGAACTTGATACCTGTGCATTCAGTTCTGTGAATACTGCCC
TTTTTGGCGGGGTTTCCTCATCTCCCCAGCCTGAACTGCTCAACTCTAAACCCAAATTAGTGTCAGCCGAAAGGAGGTTTCAAGATAGTC
CTGTCAGTATTTGTGGTGACCTTCAGATTAGACAGTCTTCATTTCCAGCCAGTGGAGTCCTGGCTCCAGAGCCATCTCTGAGACTCGTAC
TACTGGATGTTTTAATATCAGATCATTACCCACCATATGCCTCCCACAGGCCAAGGGAAAACAGACACCAGAACTTGGGTTGAGGGCACT
ACCAGACTGACATGGCCAGTACAGAGGAGAACTAGGGAAGGAATGATGTTTTGCACCTTATTGAAAAGAAAATTTTAAGTGCATACATAA
TAGTTAAGAGCTTTTATTGTGACAGGAGAACTTTTTTCCATATGCGTGCATACTCTCTGTAATTCCAGTGTAAAATATTGTACTTGCACT
AGCTTTTTTAAACAAATATTAAAAAATGGAAGAATTCATATTCTATTTTCTAATCGTGGTGTGTCTATTTGTAGGATACACTCGAGTCTG
TTTATTGAATTTTATGGTCCCTTTCTTTGATGGTGCTTGCAGGTTTTCTAGGTAGAAATTATTTCATTATTATAATAAAACAATGTTTGA
TTCAAAATTTGAACAAAATTGTTTTAAATAAATTGTCTGTATACCAGTACAAGTTTATTGTTTCAGTATACTCGTACTAATAAAATAACA

>21229_21229_2_DAB2IP-ATXN1_DAB2IP_chr9_124461737_ENST00000408936_ATXN1_chr6_16307090_ENST00000244769_length(amino acids)=194AA_BP=
MLWEPRGPPTSANRRLLPSVRSSYLKRKLPQGSGDRGWQVVPSTATGQHAQNAHTQQATLPVQAQRQGSKSQGHRPRGGACPLAEKTVEN
GLTPGYMAPECVLEMNLPPSSPHSTFTIPCGDRGHCGSSPGSPWLALSATWRQTHGAPEGSPPQHSASAAGERWEALSLLAPSLQPCSGQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DAB2IP-ATXN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneATXN1chr9:124461737chr6:16307090ENST0000024476979538_815639.0816.0USP7
TgeneATXN1chr9:124461737chr6:16307090ENST0000043636768538_815639.0816.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAB2IP-ATXN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAB2IP-ATXN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAB2IPC0024121Lung Neoplasms1CTD_human
HgeneDAB2IPC0027051Myocardial Infarction1CTD_human
HgeneDAB2IPC0033578Prostatic Neoplasms1CTD_human
HgeneDAB2IPC0034065Pulmonary Embolism1CTD_human
HgeneDAB2IPC0085096Peripheral Vascular Diseases1CTD_human
HgeneDAB2IPC0162871Aortic Aneurysm, Abdominal1CTD_human
HgeneDAB2IPC0242379Malignant neoplasm of lung1CTD_human
HgeneDAB2IPC0376358Malignant neoplasm of prostate1CTD_human
HgeneDAB2IPC0524702Pulmonary Thromboembolisms1CTD_human
TgeneC0752120Spinocerebellar Ataxia Type 15CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0087012Ataxia, Spinocerebellar4CTD_human
TgeneC0752121Spinocerebellar Ataxia Type 24CTD_human
TgeneC0752122Spinocerebellar Ataxia Type 44CTD_human
TgeneC0752123Spinocerebellar Ataxia Type 54CTD_human
TgeneC0752124Spinocerebellar Ataxia Type 6 (disorder)4CTD_human
TgeneC0752125Spinocerebellar Ataxia Type 74CTD_human
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC0035309Retinal Diseases1CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneC0524851Neurodegenerative Disorders1CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneC2362914clinical depression1PSYGENET