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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CYBA-CYBA (FusionGDB2 ID:HG1535TG1535) |
Fusion Gene Summary for CYBA-CYBA |
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Fusion gene information | Fusion gene name: CYBA-CYBA | Fusion gene ID: hg1535tg1535 | Hgene | Tgene | Gene symbol | CYBA | CYBA | Gene ID | 1535 | 1535 |
Gene name | cytochrome b-245 alpha chain | cytochrome b-245 alpha chain | |
Synonyms | p22-PHOX | p22-PHOX | |
Cytomap | ('CYBA')('CYBA') 16q24.2 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptiden | cytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptiden | |
Modification date | 20200329 | 20200329 | |
UniProtAcc | P13498 | P13498 | |
Ensembl transtripts involved in fusion gene | ENST00000261623, ENST00000561972, ENST00000567174, ENST00000569359, | ENST00000261623, ENST00000567174, ENST00000569359, ENST00000561972, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 5=125 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CYBA [Title/Abstract] AND CYBA [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CYBA(88712577)-CYBA(88713562), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CYBA | GO:0017004 | cytochrome complex assembly | 7938008 |
Hgene | CYBA | GO:0032755 | positive regulation of interleukin-6 production | 22423966 |
Hgene | CYBA | GO:0032760 | positive regulation of tumor necrosis factor production | 22423966 |
Hgene | CYBA | GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway | 22423966 |
Hgene | CYBA | GO:0050766 | positive regulation of phagocytosis | 22423966 |
Hgene | CYBA | GO:1900426 | positive regulation of defense response to bacterium | 22423966 |
Hgene | CYBA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 22423966 |
Tgene | CYBA | GO:0017004 | cytochrome complex assembly | 7938008 |
Tgene | CYBA | GO:0032755 | positive regulation of interleukin-6 production | 22423966 |
Tgene | CYBA | GO:0032760 | positive regulation of tumor necrosis factor production | 22423966 |
Tgene | CYBA | GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway | 22423966 |
Tgene | CYBA | GO:0050766 | positive regulation of phagocytosis | 22423966 |
Tgene | CYBA | GO:1900426 | positive regulation of defense response to bacterium | 22423966 |
Tgene | CYBA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 22423966 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CYBA-CYBA |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CYBA-CYBA |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CYBA-CYBA |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:88712577/:88713562) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CYBA | CYBA |
FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}. | FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CYBA-CYBA |
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Fusion Gene PPI Analysis for CYBA-CYBA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CYBA-CYBA |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CYBA-CYBA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CYBA | C1856255 | Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative | 11 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CYBA | C0020538 | Hypertensive disease | 3 | CTD_human |
Hgene | CYBA | C0002152 | Alloxan Diabetes | 2 | CTD_human |
Hgene | CYBA | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
Hgene | CYBA | C0038433 | Streptozotocin Diabetes | 2 | CTD_human |
Hgene | CYBA | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | CYBA | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | CYBA | C0018203 | Chronic granulomatous disease | 1 | CTD_human |
Hgene | CYBA | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | CYBA | C0019209 | Hepatomegaly | 1 | CTD_human |
Hgene | CYBA | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | CYBA | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | CYBA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CYBA | C0035078 | Kidney Failure | 1 | CTD_human |
Hgene | CYBA | C0239946 | Fibrosis, Liver | 1 | CTD_human |
Hgene | CYBA | C1563937 | Atherogenesis | 1 | CTD_human |
Hgene | CYBA | C1565489 | Renal Insufficiency | 1 | CTD_human |
Hgene | CYBA | C1844376 | Granulomatous Disease, Chronic, X-Linked | 1 | CTD_human |
Hgene | CYBA | C3661525 | Autosomal Recessive Chronic Granulomatous Disease | 1 | CTD_human |
Tgene | C1856255 | Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative | 11 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0020538 | Hypertensive disease | 3 | CTD_human | |
Tgene | C0002152 | Alloxan Diabetes | 2 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 2 | CTD_human | |
Tgene | C0004153 | Atherosclerosis | 1 | CTD_human | |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human | |
Tgene | C0018203 | Chronic granulomatous disease | 1 | CTD_human | |
Tgene | C0018799 | Heart Diseases | 1 | CTD_human | |
Tgene | C0019209 | Hepatomegaly | 1 | CTD_human | |
Tgene | C0022661 | Kidney Failure, Chronic | 1 | CTD_human | |
Tgene | C0023890 | Liver Cirrhosis | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0035078 | Kidney Failure | 1 | CTD_human | |
Tgene | C0239946 | Fibrosis, Liver | 1 | CTD_human | |
Tgene | C1563937 | Atherogenesis | 1 | CTD_human | |
Tgene | C1565489 | Renal Insufficiency | 1 | CTD_human | |
Tgene | C1844376 | Granulomatous Disease, Chronic, X-Linked | 1 | CTD_human | |
Tgene | C3661525 | Autosomal Recessive Chronic Granulomatous Disease | 1 | CTD_human |