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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DACH1-KLF12 (FusionGDB2 ID:HG1602TG11278)

Fusion Gene Summary for DACH1-KLF12

check button Fusion gene summary
Fusion gene informationFusion gene name: DACH1-KLF12
Fusion gene ID: hg1602tg11278
HgeneTgene
Gene symbol

DACH1

KLF12

Gene ID

1602

11278

Gene namedachshund family transcription factor 1Kruppel like factor 12
SynonymsDACHAP-2rep|AP2REP|HSPC122
Cytomap('DACH1')('KLF12')

13q21.33

13q22.1

Type of geneprotein-codingprotein-coding
Descriptiondachshund homolog 1dac homologKrueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000305425, ENST00000313174, 
ENST00000354591, ENST00000359684, 
Fusion gene scores* DoF score8 X 7 X 4=22413 X 13 X 6=1014
# samples 816
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1014*10)=-2.66391384211598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DACH1 [Title/Abstract] AND KLF12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDACH1(72440054)-KLF12(74269808), # samples:3
Anticipated loss of major functional domain due to fusion event.DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DACH1-KLF12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DACH1-KLF12 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDACH1

GO:0000122

negative regulation of transcription by RNA polymerase II

20956529

HgeneDACH1

GO:0030336

negative regulation of cell migration

20956529

HgeneDACH1

GO:2000279

negative regulation of DNA biosynthetic process

16980615

TgeneKLF12

GO:0000122

negative regulation of transcription by RNA polymerase II

16615998


check buttonFusion gene breakpoints across DACH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KLF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-XP-A8T8-01ADACH1chr13

72440054

-KLF12chr13

74269808

-
ChimerDB4ESCATCGA-XP-A8T8DACH1chr13

72440054

-KLF12chr13

74269808

-


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Fusion Gene ORF analysis for DACH1-KLF12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000305425ENST00000472022DACH1chr13

72440054

-KLF12chr13

74269808

-
5CDS-intronENST00000313174ENST00000472022DACH1chr13

72440054

-KLF12chr13

74269808

-
5CDS-intronENST00000354591ENST00000472022DACH1chr13

72440054

-KLF12chr13

74269808

-
5CDS-intronENST00000359684ENST00000472022DACH1chr13

72440054

-KLF12chr13

74269808

-
Frame-shiftENST00000305425ENST00000377669DACH1chr13

72440054

-KLF12chr13

74269808

-
Frame-shiftENST00000313174ENST00000377669DACH1chr13

72440054

-KLF12chr13

74269808

-
Frame-shiftENST00000354591ENST00000377669DACH1chr13

72440054

-KLF12chr13

74269808

-
Frame-shiftENST00000359684ENST00000377669DACH1chr13

72440054

-KLF12chr13

74269808

-
In-frameENST00000305425ENST00000377666DACH1chr13

72440054

-KLF12chr13

74269808

-
In-frameENST00000313174ENST00000377666DACH1chr13

72440054

-KLF12chr13

74269808

-
In-frameENST00000354591ENST00000377666DACH1chr13

72440054

-KLF12chr13

74269808

-
In-frameENST00000359684ENST00000377666DACH1chr13

72440054

-KLF12chr13

74269808

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313174DACH1chr1372440054-ENST00000377666KLF12chr1374269808-155012771801337385
ENST00000305425DACH1chr1372440054-ENST00000377666KLF12chr1374269808-155012771801337385
ENST00000354591DACH1chr1372440054-ENST00000377666KLF12chr1374269808-155012771801337385
ENST00000359684DACH1chr1372440054-ENST00000377666KLF12chr1374269808-11278540914304

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313174ENST00000377666DACH1chr1372440054-KLF12chr1374269808-0.0174665770.9825334
ENST00000305425ENST00000377666DACH1chr1372440054-KLF12chr1374269808-0.0174665770.9825334
ENST00000354591ENST00000377666DACH1chr1372440054-KLF12chr1374269808-0.0174665770.9825334
ENST00000359684ENST00000377666DACH1chr1372440054-KLF12chr1374269808-0.0057970090.99420303

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Fusion Genomic Features for DACH1-KLF12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DACH1-KLF12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:72440054/chr13:74269808)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111114_121284709.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111140_163284709.0Compositional biasNote=Poly-Ser
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-11161_68284709.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-11174_87284709.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-11190_101284709.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18114_121284561.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18140_163284561.0Compositional biasNote=Poly-Ser
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-1861_68284561.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-1874_87284561.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-1890_101284561.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17114_121284507.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17140_163284507.0Compositional biasNote=Poly-Ser
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-1761_68284507.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-1774_87284507.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-1790_101284507.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112114_121284761.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112140_163284761.0Compositional biasNote=Poly-Ser
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-11261_68284761.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-11274_87284761.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-11290_101284761.0Compositional biasNote=Poly-Gly
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111189_275284709.0RegionNote=DACHbox-N
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18189_275284561.0RegionNote=DACHbox-N
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17189_275284507.0RegionNote=DACHbox-N
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112189_275284761.0RegionNote=DACHbox-N
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766668347_371342403.0Zinc fingerC2H2-type 2
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766668377_399342403.0Zinc fingerC2H2-type 3
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766957347_371342403.0Zinc fingerC2H2-type 2
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766957377_399342403.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111630_718284709.0Coiled coilOntology_term=ECO:0000255
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18630_718284561.0Coiled coilOntology_term=ECO:0000255
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17630_718284507.0Coiled coilOntology_term=ECO:0000255
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112630_718284761.0Coiled coilOntology_term=ECO:0000255
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111325_333284709.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111467_470284709.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18325_333284561.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18467_470284561.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17325_333284507.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17467_470284507.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112325_333284761.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112467_470284761.0Compositional biasNote=Poly-Ala
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111616_696284709.0RegionNote=DACHbox-C
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18616_696284561.0RegionNote=DACHbox-C
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17616_696284507.0RegionNote=DACHbox-C
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112616_696284761.0RegionNote=DACHbox-C
TgeneKLF12chr13:72440054chr13:74269808ENST000003776666880_88342403.0Motif9aaTAD%3B inactive
TgeneKLF12chr13:72440054chr13:74269808ENST000003776695780_88342403.0Motif9aaTAD%3B inactive
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766668317_341342403.0Zinc fingerC2H2-type 1
TgeneKLF12chr13:72440054chr13:74269808ENST0000037766957317_341342403.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for DACH1-KLF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21250_21250_1_DACH1-KLF12_DACH1_chr13_72440054_ENST00000305425_KLF12_chr13_74269808_ENST00000377666_length(transcript)=1550nt_BP=1277nt
ATCTTTGATCAATGTACTTGCCAGGGAGAGCCCAAGTCCTTCAAACCTCCTCCTTTTCACCTTCATCCTTAACTTTGTGCTAGAGCGAGA
CCCACACAACAACAGCCGACCCTCCCCGCCCCACCCCCACCCCCAAACCAGCCCTCGATCCCAGCCCCCGGAGAGGACTCGCATTTCGAC
TTGCGGGACACTTTTGTGCGTTCCTCTCCAGAGCGCCTCTCGTGCTCGCCCCTCTTGCGCTCGCTCTTTATTACCTTCACCTCCTTTTCT
CCCCCTTCTCTCCCTTTCTCCTTCTCGTTCTCTCCCGGAGTTGTTGTTGCCCCCCTCGCTCCTTCTCCCCCCTTTTTTCCCCTTCCCCTC
CCGGGGGTGTGTGGCAACTTTTCCTCTCGCTTCTCCTCCGTCTGTTTCCCCTTATATGTGACCATGGCAGTGCCGGCGGCTTTGATCCCT
CCGACCCAGCTGGTCCCCCCTCAACCCCCAATCTCCACGTCTGCTTCCTCCTCTGGCACCACCACCTCCACCTCTTCGGCGACTTCGTCT
CCGGCTCCTTCCATCGGACCCCCGGCGTCCTCTGGGCCAACTCTGTTCCGCCCGGAGCCCATCGCTTCGGCGGCGGCGGCGGCGGCCACA
GTCACCTCTACCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGAGGCGGCGGCGGCAGCAGCGGCAACGGAGGCGGCGGTGGCGGC
GGCGGCGGTGGCAGCAACTGCAACCCCAACCTGGCGGCCGCGAGCAACGGCAGCGGCGGCGGCGGCGGCGGCATCAGCGCTGGCGGCGGC
GTCGCTTCCAGCACCCCCATCAACGCCAGCACCGGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGTAGTAGCAGCAGC
AGCAGTAGCAGCAGCAGCTGCGGCCCCCTCCCCGGGAAACCCGTGTACTCAACCCCGTCCCCAGTGGAAAACACCCCTCAGAATAATGAG
TGCAAAATGGTGGATCTGAGGGGGGCCAAAGTGGCTTCCTTCACGGTGGAGGGCTGCGAGCTGATCTGCCTGCCCCAGGCTTTCGACCTG
TTCCTGAAGCACTTGGTGGGGGGCTTGCATACGGTCTACACCAAGCTGAAGCGGCTGGAGATCACGCCGGTGGTGTGCAATGTGGAACAA
GTTCGCATCCTGAGGGGACTGGGCGCCATCCAGCCAGGAGTGAACCGCTGCAAACTCATCTCCAGGAAGGACTTCGAGACCCTCTACAAT
GACTGCACCAACGCAAGGAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCA
TTACCGCAAACATACGGGAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCG
GAGGCATATGTTGGTGTGAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATC

>21250_21250_1_DACH1-KLF12_DACH1_chr13_72440054_ENST00000305425_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------
>21250_21250_2_DACH1-KLF12_DACH1_chr13_72440054_ENST00000313174_KLF12_chr13_74269808_ENST00000377666_length(transcript)=1550nt_BP=1277nt
ATCTTTGATCAATGTACTTGCCAGGGAGAGCCCAAGTCCTTCAAACCTCCTCCTTTTCACCTTCATCCTTAACTTTGTGCTAGAGCGAGA
CCCACACAACAACAGCCGACCCTCCCCGCCCCACCCCCACCCCCAAACCAGCCCTCGATCCCAGCCCCCGGAGAGGACTCGCATTTCGAC
TTGCGGGACACTTTTGTGCGTTCCTCTCCAGAGCGCCTCTCGTGCTCGCCCCTCTTGCGCTCGCTCTTTATTACCTTCACCTCCTTTTCT
CCCCCTTCTCTCCCTTTCTCCTTCTCGTTCTCTCCCGGAGTTGTTGTTGCCCCCCTCGCTCCTTCTCCCCCCTTTTTTCCCCTTCCCCTC
CCGGGGGTGTGTGGCAACTTTTCCTCTCGCTTCTCCTCCGTCTGTTTCCCCTTATATGTGACCATGGCAGTGCCGGCGGCTTTGATCCCT
CCGACCCAGCTGGTCCCCCCTCAACCCCCAATCTCCACGTCTGCTTCCTCCTCTGGCACCACCACCTCCACCTCTTCGGCGACTTCGTCT
CCGGCTCCTTCCATCGGACCCCCGGCGTCCTCTGGGCCAACTCTGTTCCGCCCGGAGCCCATCGCTTCGGCGGCGGCGGCGGCGGCCACA
GTCACCTCTACCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGAGGCGGCGGCGGCAGCAGCGGCAACGGAGGCGGCGGTGGCGGC
GGCGGCGGTGGCAGCAACTGCAACCCCAACCTGGCGGCCGCGAGCAACGGCAGCGGCGGCGGCGGCGGCGGCATCAGCGCTGGCGGCGGC
GTCGCTTCCAGCACCCCCATCAACGCCAGCACCGGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGTAGTAGCAGCAGC
AGCAGTAGCAGCAGCAGCTGCGGCCCCCTCCCCGGGAAACCCGTGTACTCAACCCCGTCCCCAGTGGAAAACACCCCTCAGAATAATGAG
TGCAAAATGGTGGATCTGAGGGGGGCCAAAGTGGCTTCCTTCACGGTGGAGGGCTGCGAGCTGATCTGCCTGCCCCAGGCTTTCGACCTG
TTCCTGAAGCACTTGGTGGGGGGCTTGCATACGGTCTACACCAAGCTGAAGCGGCTGGAGATCACGCCGGTGGTGTGCAATGTGGAACAA
GTTCGCATCCTGAGGGGACTGGGCGCCATCCAGCCAGGAGTGAACCGCTGCAAACTCATCTCCAGGAAGGACTTCGAGACCCTCTACAAT
GACTGCACCAACGCAAGGAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCA
TTACCGCAAACATACGGGAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCG
GAGGCATATGTTGGTGTGAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATC

>21250_21250_2_DACH1-KLF12_DACH1_chr13_72440054_ENST00000313174_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------
>21250_21250_3_DACH1-KLF12_DACH1_chr13_72440054_ENST00000354591_KLF12_chr13_74269808_ENST00000377666_length(transcript)=1550nt_BP=1277nt
ATCTTTGATCAATGTACTTGCCAGGGAGAGCCCAAGTCCTTCAAACCTCCTCCTTTTCACCTTCATCCTTAACTTTGTGCTAGAGCGAGA
CCCACACAACAACAGCCGACCCTCCCCGCCCCACCCCCACCCCCAAACCAGCCCTCGATCCCAGCCCCCGGAGAGGACTCGCATTTCGAC
TTGCGGGACACTTTTGTGCGTTCCTCTCCAGAGCGCCTCTCGTGCTCGCCCCTCTTGCGCTCGCTCTTTATTACCTTCACCTCCTTTTCT
CCCCCTTCTCTCCCTTTCTCCTTCTCGTTCTCTCCCGGAGTTGTTGTTGCCCCCCTCGCTCCTTCTCCCCCCTTTTTTCCCCTTCCCCTC
CCGGGGGTGTGTGGCAACTTTTCCTCTCGCTTCTCCTCCGTCTGTTTCCCCTTATATGTGACCATGGCAGTGCCGGCGGCTTTGATCCCT
CCGACCCAGCTGGTCCCCCCTCAACCCCCAATCTCCACGTCTGCTTCCTCCTCTGGCACCACCACCTCCACCTCTTCGGCGACTTCGTCT
CCGGCTCCTTCCATCGGACCCCCGGCGTCCTCTGGGCCAACTCTGTTCCGCCCGGAGCCCATCGCTTCGGCGGCGGCGGCGGCGGCCACA
GTCACCTCTACCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGAGGCGGCGGCGGCAGCAGCGGCAACGGAGGCGGCGGTGGCGGC
GGCGGCGGTGGCAGCAACTGCAACCCCAACCTGGCGGCCGCGAGCAACGGCAGCGGCGGCGGCGGCGGCGGCATCAGCGCTGGCGGCGGC
GTCGCTTCCAGCACCCCCATCAACGCCAGCACCGGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGTAGTAGCAGCAGC
AGCAGTAGCAGCAGCAGCTGCGGCCCCCTCCCCGGGAAACCCGTGTACTCAACCCCGTCCCCAGTGGAAAACACCCCTCAGAATAATGAG
TGCAAAATGGTGGATCTGAGGGGGGCCAAAGTGGCTTCCTTCACGGTGGAGGGCTGCGAGCTGATCTGCCTGCCCCAGGCTTTCGACCTG
TTCCTGAAGCACTTGGTGGGGGGCTTGCATACGGTCTACACCAAGCTGAAGCGGCTGGAGATCACGCCGGTGGTGTGCAATGTGGAACAA
GTTCGCATCCTGAGGGGACTGGGCGCCATCCAGCCAGGAGTGAACCGCTGCAAACTCATCTCCAGGAAGGACTTCGAGACCCTCTACAAT
GACTGCACCAACGCAAGGAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCA
TTACCGCAAACATACGGGAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCG
GAGGCATATGTTGGTGTGAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATC

>21250_21250_3_DACH1-KLF12_DACH1_chr13_72440054_ENST00000354591_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------
>21250_21250_4_DACH1-KLF12_DACH1_chr13_72440054_ENST00000359684_KLF12_chr13_74269808_ENST00000377666_length(transcript)=1127nt_BP=854nt
ATGGCAGTGCCGGCGGCTTTGATCCCTCCGACCCAGCTGGTCCCCCCTCAACCCCCAATCTCCACGTCTGCTTCCTCCTCTGGCACCACC
ACCTCCACCTCTTCGGCGACTTCGTCTCCGGCTCCTTCCATCGGACCCCCGGCGTCCTCTGGGCCAACTCTGTTCCGCCCGGAGCCCATC
GCTTCGGCGGCGGCGGCGGCGGCCACAGTCACCTCTACCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGAGGCGGCGGCGGCAGC
AGCGGCAACGGAGGCGGCGGTGGCGGCGGCGGCGGTGGCAGCAACTGCAACCCCAACCTGGCGGCCGCGAGCAACGGCAGCGGCGGCGGC
GGCGGCGGCATCAGCGCTGGCGGCGGCGTCGCTTCCAGCACCCCCATCAACGCCAGCACCGGCAGCAGCAGCAGCAGCAGTAGCAGCAGC
AGCAGCAGCAGCAGTAGTAGCAGCAGCAGCAGTAGCAGCAGCAGCTGCGGCCCCCTCCCCGGGAAACCCGTGTACTCAACCCCGTCCCCA
GTGGAAAACACCCCTCAGAATAATGAGTGCAAAATGGTGGATCTGAGGGGGGCCAAAGTGGCTTCCTTCACGGTGGAGGGCTGCGAGCTG
ATCTGCCTGCCCCAGGCTTTCGACCTGTTCCTGAAGCACTTGGTGGGGGGCTTGCATACGGTCTACACCAAGCTGAAGCGGCTGGAGATC
ACGCCGGTGGTGTGCAATGTGGAACAAGTTCGCATCCTGAGGGGACTGGGCGCCATCCAGCCAGGAGTGAACCGCTGCAAACTCATCTCC
AGGAAGGACTTCGAGACCCTCTACAATGACTGCACCAACGCAAGGAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTT
CGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGGGAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCG
GTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGTGAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAG

>21250_21250_4_DACH1-KLF12_DACH1_chr13_72440054_ENST00000359684_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=304AA_BP=284
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGS
SGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSP
VENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DACH1-KLF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111627_706284.6666666666667709.0SIN3A
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18627_706284.6666666666667561.0SIN3A
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17627_706284.6666666666667507.0SIN3A
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112627_706284.6666666666667761.0SIN3A
HgeneDACH1chr13:72440054chr13:74269808ENST00000305425-111189_384284.6666666666667709.0SIX6 and HDAC3
HgeneDACH1chr13:72440054chr13:74269808ENST00000313174-18189_384284.6666666666667561.0SIX6 and HDAC3
HgeneDACH1chr13:72440054chr13:74269808ENST00000354591-17189_384284.6666666666667507.0SIX6 and HDAC3
HgeneDACH1chr13:72440054chr13:74269808ENST00000359684-112189_384284.6666666666667761.0SIX6 and HDAC3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DACH1-KLF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DACH1-KLF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human