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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AP2A2-EPS8L2 (FusionGDB2 ID:HG161TG64787) |
Fusion Gene Summary for AP2A2-EPS8L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP2A2-EPS8L2 | Fusion gene ID: hg161tg64787 | Hgene | Tgene | Gene symbol | AP2A2 | EPS8L2 | Gene ID | 161 | 64787 |
| Gene name | adaptor related protein complex 2 subunit alpha 2 | EPS8 like 2 | |
| Synonyms | ADTAB|CLAPA2|HIP-9|HIP9|HYPJ | DFNB106|EPS8R2 | |
| Cytomap | ('AP2A2')('EPS8L2') 11p15.5 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin as | epidermal growth factor receptor kinase substrate 8-like protein 2EPS8-related protein 2epidermal growth factor receptor pathway substrate 8-related protein 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000332231, ENST00000448903, ENST00000525891, ENST00000534328, | ||
| Fusion gene scores | * DoF score | 13 X 10 X 12=1560 | 9 X 7 X 8=504 |
| # samples | 22 | 15 | |
| ** MAII score | log2(22/1560*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/504*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AP2A2 [Title/Abstract] AND EPS8L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AP2A2(994245)-EPS8L2(720062), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | AP2A2-EPS8L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP2A2-EPS8L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP2A2-EPS8L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP2A2-EPS8L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AP2A2 | GO:0072583 | clathrin-dependent endocytosis | 23676497 |
| Tgene | EPS8L2 | GO:0007266 | Rho protein signal transduction | 14565974 |
| Tgene | EPS8L2 | GO:0035023 | regulation of Rho protein signal transduction | 14565974 |
| Fusion gene breakpoints across AP2A2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EPS8L2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-21-1071-01A | AP2A2 | chr11 | 994245 | - | EPS8L2 | chr11 | 720062 | + |
| ChimerDB4 | LUSC | TCGA-21-1071-01A | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| ChimerDB4 | LUSC | TCGA-21-1071 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
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Fusion Gene ORF analysis for AP2A2-EPS8L2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000332231 | ENST00000534449 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| 5CDS-intron | ENST00000448903 | ENST00000534449 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000332231 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000332231 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000332231 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000332231 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000448903 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000448903 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000448903 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| In-frame | ENST00000448903 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000525891 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000525891 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000525891 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000525891 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000534328 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000534328 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000534328 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-3CDS | ENST00000534328 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-intron | ENST00000525891 | ENST00000534449 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| intron-intron | ENST00000534328 | ENST00000534449 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000332231 | AP2A2 | chr11 | 994245 | + | ENST00000318562 | EPS8L2 | chr11 | 720062 | + | 4829 | 2100 | 141 | 4082 | 1313 |
| ENST00000332231 | AP2A2 | chr11 | 994245 | + | ENST00000533256 | EPS8L2 | chr11 | 720062 | + | 4826 | 2100 | 141 | 4082 | 1313 |
| ENST00000332231 | AP2A2 | chr11 | 994245 | + | ENST00000530636 | EPS8L2 | chr11 | 720062 | + | 4153 | 2100 | 141 | 4082 | 1313 |
| ENST00000332231 | AP2A2 | chr11 | 994245 | + | ENST00000526198 | EPS8L2 | chr11 | 720062 | + | 4184 | 2100 | 141 | 4130 | 1329 |
| ENST00000448903 | AP2A2 | chr11 | 994245 | + | ENST00000318562 | EPS8L2 | chr11 | 720062 | + | 4826 | 2097 | 141 | 4079 | 1312 |
| ENST00000448903 | AP2A2 | chr11 | 994245 | + | ENST00000533256 | EPS8L2 | chr11 | 720062 | + | 4823 | 2097 | 141 | 4079 | 1312 |
| ENST00000448903 | AP2A2 | chr11 | 994245 | + | ENST00000530636 | EPS8L2 | chr11 | 720062 | + | 4150 | 2097 | 141 | 4079 | 1312 |
| ENST00000448903 | AP2A2 | chr11 | 994245 | + | ENST00000526198 | EPS8L2 | chr11 | 720062 | + | 4181 | 2097 | 141 | 4127 | 1328 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000332231 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.003650809 | 0.9963492 |
| ENST00000332231 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.003642894 | 0.996357 |
| ENST00000332231 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.00572386 | 0.9942761 |
| ENST00000332231 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.005512554 | 0.99448746 |
| ENST00000448903 | ENST00000318562 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.003624168 | 0.99637586 |
| ENST00000448903 | ENST00000533256 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.003616297 | 0.99638367 |
| ENST00000448903 | ENST00000530636 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.005676464 | 0.9943236 |
| ENST00000448903 | ENST00000526198 | AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720062 | + | 0.005467582 | 0.99453235 |
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Fusion Genomic Features for AP2A2-EPS8L2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720061 | + | 5.32E-11 | 1 |
| AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720061 | + | 5.32E-11 | 1 |
| AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720061 | + | 5.32E-11 | 1 |
| AP2A2 | chr11 | 994245 | + | EPS8L2 | chr11 | 720061 | + | 5.32E-11 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AP2A2-EPS8L2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:994245/chr11:720062) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000332231 | + | 14 | 22 | 11_12 | 653 | 941.0 | Region | Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000332231 | + | 14 | 22 | 57_61 | 653 | 941.0 | Region | Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000332231 | + | 14 | 22 | 5_80 | 653 | 941.0 | Region | Note=Lipid-binding |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000448903 | + | 14 | 22 | 11_12 | 652 | 940.0 | Region | Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000448903 | + | 14 | 22 | 57_61 | 652 | 940.0 | Region | Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
| Hgene | AP2A2 | chr11:994245 | chr11:720062 | ENST00000448903 | + | 14 | 22 | 5_80 | 652 | 940.0 | Region | Note=Lipid-binding |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000318562 | 3 | 21 | 492_551 | 55 | 716.0 | Domain | SH3 | |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000530636 | 3 | 21 | 492_551 | 55 | 716.0 | Domain | SH3 | |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000533256 | 4 | 22 | 492_551 | 55 | 716.0 | Domain | SH3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000318562 | 3 | 21 | 46_202 | 55 | 716.0 | Domain | PID | |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000530636 | 3 | 21 | 46_202 | 55 | 716.0 | Domain | PID | |
| Tgene | EPS8L2 | chr11:994245 | chr11:720062 | ENST00000533256 | 4 | 22 | 46_202 | 55 | 716.0 | Domain | PID |
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Fusion Gene Sequence for AP2A2-EPS8L2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5226_5226_1_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000318562_length(transcript)=4829nt_BP=2100nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG TATTATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACA ACGCCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCC TTGTCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCT GTGATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACA CACGCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACAC ACACTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAG CTTTCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTAC >5226_5226_1_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000318562_length(amino acids)=1313AA_BP=646 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN -------------------------------------------------------------- >5226_5226_2_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000526198_length(transcript)=4184nt_BP=2100nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC ATCGAGTCACAGAGTGCCCAGACCCCGGGTGCGAGTCGTGTCCGCGCGATGTACCCGCAGGAGGAGCTGGAAGACTTCCCGCTGCCCACG GTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGAT GTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAG ATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCC TTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAG TCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTT GTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAG GGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCA AAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGT GGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATG TCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTC CACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGT CCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGC TCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAAC GAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGG TACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCC AGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGG AAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGT CCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTC TCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAG AAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTG >5226_5226_2_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000526198_length(amino acids)=1329AA_BP=646 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQSAQTPGASRVRAM YPQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQ SILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQR KKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDA VDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTS EPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGA PFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRI -------------------------------------------------------------- >5226_5226_3_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000530636_length(transcript)=4153nt_BP=2100nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG >5226_5226_3_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000530636_length(amino acids)=1313AA_BP=646 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN -------------------------------------------------------------- >5226_5226_4_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000533256_length(transcript)=4826nt_BP=2100nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGAAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGC CTGGAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCC ATCAGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACC AACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTC ATCAACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCA CAGATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAG AAGTACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTAC CGAGTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCAC GAGAACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTC CACCTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCG GAGGTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTAC CTGCGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTG GCAAAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCT GAGCCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATC CGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGAC ATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTG CTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAG GACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGG CAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGC CCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAG ACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAG CGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATC GACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCAC TTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGAT GCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAG TGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGG GAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACT TCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAG TACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGC CGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGC GCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAG CTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAG CGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGG ATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTC CGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCAT TCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAG TATTATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACA ACGCCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCC TTGTCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCT GTGATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACA CACGCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACAC ACACTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAG CTTTCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTAC >5226_5226_4_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000332231_EPS8L2_chr11_720062_ENST00000533256_length(amino acids)=1313AA_BP=646 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRAL LLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLED TKRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQR SQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQH RGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVL TLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLW ESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPH THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPT HKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN -------------------------------------------------------------- >5226_5226_5_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000318562_length(transcript)=4826nt_BP=2097nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT TATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACAACG CCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCCTTG TCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCTGTG ATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACACAC GCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACACACA CTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAGCTT TCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTACAGA >5226_5226_5_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000318562_length(amino acids)=1312AA_BP=645 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK -------------------------------------------------------------- >5226_5226_6_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000526198_length(transcript)=4181nt_BP=2097nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC GAGTCACAGAGTGCCCAGACCCCGGGTGCGAGTCGTGTCCGCGCGATGTACCCGCAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTG CAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTC CACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATG CGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTC CAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCG CAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTG GCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGC GTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAG CTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGC CCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCG CTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCAC AGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCA GTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCC CCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAG CTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGGCAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTAC GTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCCCCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGC CCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTCATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAA ATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGCAGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCG GACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATCGTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCC CTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGCGTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAG CAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCCATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCT >5226_5226_6_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000526198_length(amino acids)=1328AA_BP=645 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQSAQTPGASRVRAMY PQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQS ILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRK KGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAV DFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSE PTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAP FEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIV -------------------------------------------------------------- >5226_5226_7_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000530636_length(transcript)=4150nt_BP=2097nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT >5226_5226_7_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000530636_length(amino acids)=1312AA_BP=645 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK -------------------------------------------------------------- >5226_5226_8_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000533256_length(transcript)=4823nt_BP=2097nt CTGGGACCCTGAGGCGGCCGTGGTTAGGCGGCTCCCCGGCGGCTCCTCCGCGGCGGTGACGGCGACCGCACTCCCCGCTTCCCGCTCCCC GCGCTCCTCCGCCCGGGTCCGCCAGCCGAGGCCGCTCCCGAGCGTCGGAAGATGCCGGCCGTGTCCAAGGGGGACGGGATGCGGGGCCTG GCGGTCTTCATCTCGGATATCCGCAACTGTAAAAGTAAAGAAGCAGAAATAAAAAGGATAAACAAGGAACTGGCAAATATCAGATCAAAA TTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAAAAAGTACGTCTGCAAGTTGCTCTTCATCTTTCTCCTTGGTCATGACATTGAC TTTGGACACATGGAGGCTGTGAACCTGCTGAGTTCAAACAGATACACGGAAAAGCAGATCGGCTACCTTTTCATCTCTGTGTTGGTGAAC TCAAACAGTGAGCTGATCCGCCTGATCAACAACGCCATCAAGAATGACCTGGCCAGCCGCAACCCCACCTTCATGGGCCTGGCCCTGCAC TGCATCGCCAGCGTGGGCAGCCGGGAGATGGCCGAGGCCTTCGCCGGGGAGATCCCTAAGGTCCTCGTAGCCGGAGACACTATGGACAGC GTGAAGCAGAGCGCGGCCCTGTGCTTGCTGCGCCTGTACAGGACGTCCCCCGATCTTGTCCCCATGGGCGACTGGACATCCCGAGTGGTG CACCTGCTCAATGACCAGCACTTGGGTGTGGTAACTGCAGCCACAAGTCTGATCACCACTTTAGCACAGAAGAACCCAGAAGAGTTTAAA ACCTCCGTGTCTCTGGCTGTCTCTAGGCTAAGCAGAATCGTGACGTCTGCATCCACAGATCTCCAGGATTACACTTACTATTTTGTCCCG GCTCCCTGGCTGTCTGTCAAACTGCTGAGACTGCTGCAGTGCTACCCACCCCCAGACCCTGCAGTGCGAGGCCGCCTGACTGAGTGCCTG GAGACCATCCTGAACAAAGCCCAAGAACCGCCCAAGTCGAAGAAGGTCCAGCACTCCAACGCGAAGAATGCCGTGCTCTTCGAGGCCATC AGCTTAATCATTCACCATGACAGTGAGCCGAACCTGCTCGTCCGTGCCTGCAACCAGTTGGGCCAGTTTCTGCAGCACCGCGAGACCAAC CTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCTGAGTTCTCCCATGAGGCTGTCAAGACGCACATCGAGACGGTCATC AACGCCCTGAAGACTGAGCGGGACGTGAGCGTGCGGCAGCGGGCCGTGGACCTCCTCTACGCCATGTGCGACCGCAGCAACGCCCCACAG ATCGTGGCCGAGATGCTGAGCTATCTGGAGACAGCTGACTACTCCATCCGAGAAGAGATTGTGCTGAAGGTCGCCATCCTGGCTGAGAAG TACGCGGTGGACTACACCTGGTATGTGGATACCATCTTGAACTTGATCCGAATTGCTGGTGATTACGTGAGTGAAGAGGTGTGGTACCGA GTCATTCAGATCGTCATCAACCGGGACGACGTGCAGGGCTACGCGGCCAAGACTGTGTTCGAGGCTCTTCAGGCTCCCGCGTGCCACGAG AACCTGGTCAAAGTGGGCGGCTACATCCTGGGGGAGTTTGGAAACTTGATAGCTGGAGACCCGAGATCCAGCCCGCTGATCCAGTTCCAC CTGCTGCACTCCAAGTTCCACCTGTGCAGCGTCCCCACCCGCGCGCTGCTCCTGTCCACCTACATCAAGTTCGTGAACCTCTTCCCGGAG GTGAAGCCCACCATCCAGGACGTGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTG CGGCTCAGCACCGTGGCCAGCACCGACATTCTGGCGACCGTGCTGGAGGAGATGCCCCCATTCCCGGAGCGGGAGTCCTCCATCTTGGCA AAGCTCAAGAAGAAGAAGGGCCCCAGCACGGTGACAGACCTGGAGGACACCAAGCGGGACAGGAGTGTGGACGTGAACGGGGGTCCTGAG CCTGCCCCAGCCAGTACCAGCGCCGTGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGG AAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATC GAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTG CTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGAC ATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAG TCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCG CAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACG CAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGG AAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGAC TGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTC CTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCC GTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGG CCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAG GTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCA GAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTAC GTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGGTGCTGGAGGACGGCCGG CAGTGGTGGAAGCTGCGCAGCCGCAGCGGCCAGGCGGGGTACGTGCCCTGCAACATCCTAGGCGAGGCGCGACCGGAGGACGCCGGCGCC CCGTTCGAGCAGGCCGGTCAGAAGTACTGGGGCCCCGCCAGCCCGACCCACAAGCTACCCCCAAGCTTCCCGGGGAACAAAGACGAGCTC ATGCAGCACATGGACGAGGTCAACGACGAGCTCATCCGGAAAATCAGCAACATCAGGGCGCAGCCACAGAGGCACTTCCGCGTGGAGCGC AGCCAGCCCGTGAGCCAGCCGCTCACCTACGAGTCGGGTCCGGACGAGGTCCGCGCCTGGCTGGAAGCCAAGGCCTTCAGCCCGCGGATC GTGGAGAACCTGGGCATCCTGACCGGGCCGCAGCTCTTCTCCCTCAACAAGGAGGAGCTGAAGAAAGTGTGCGGCGAGGAGGGCGTCCGC GTGTACAGCCAGCTCACCATGCAGAAGGCCTTCCTGGAGAAGCAGCAAAGTGGGTCGGAGCTGGAAGAACTCATGAACAAGTTTCATTCC ATGAATCAGAGGAGGGGGGAGGACAGCTAGGCCCAGCTGCCTTGGGCTGGGGCCTGCGGAGGGGAAGCCCACCCACAATGCATGGAGTAT TATTTTTATATGTGTATGTATTTTGTATCAAGGACACGGAGGGGGTGTGGTGCTGGCTAGAGGTCCCTGCCCCTGTCTGGAGGCACAACG CCCATCCTTAGGCCAAACAGTACCCAAGGCCTCAGCCCACACCAAGACTAATCTCAGCCAAACCTGCTGCTTGGTGGTGCCAGCCCCTTG TCCACCTTCTCTTGAGGCCACAGAACTCCCTGGGGCTGGGGCCTCTTTCTCTGGCCTCCCCTGTGCACCTGGGGGGTCCTGGCCCCTGTG ATGCTCCCCCATCCCCACCCACTTCTACATCCATCCACACCCCAGGGTGAGCTGGAGCTCCAGGCTGGCCAGGCTGAACCTCGCACACAC GCAGAGTTCTGCTCCCTGAGGGGGGCCCGGGAGGGGCTCCAGCAGGAGGCCGTGGGTGCCATTCGGGGGAAAGTGGGGGAACGACACACA CTTCACCTGCAAGGGCCGACAACGCAGGGGACACCGTGCCGGCTTCAGACACTCCCAGCGCCCACTCTTACAGGCCCAGGACTGGAGCTT TCTCTGGCCAAGTTTCAGGCCAATGATCCCCGCATGGTGTTGGGGGTGCTGGTGTGTCTTGGTGCCTGGACTTGAGTCTCACCCTACAGA >5226_5226_8_AP2A2-EPS8L2_AP2A2_chr11_994245_ENST00000448903_EPS8L2_chr11_720062_ENST00000533256_length(amino acids)=1312AA_BP=645 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPP PDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF SHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDT KRDRSVDVNGGPEPAPASTSAVHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRS QTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHR GGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWE SLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTH KLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNK 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Fusion Gene PPI Analysis for AP2A2-EPS8L2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AP2A2-EPS8L2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AP2A2-EPS8L2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C3711374 | Nonsyndromic Deafness | 3 | CLINGEN | |
| Tgene | C4539954 | DEAFNESS, AUTOSOMAL RECESSIVE 106 | 1 | GENOMICS_ENGLAND |
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