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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DBI-UBB (FusionGDB2 ID:HG1622TG7314)

Fusion Gene Summary for DBI-UBB

check button Fusion gene summary
Fusion gene informationFusion gene name: DBI-UBB
Fusion gene ID: hg1622tg7314
HgeneTgene
Gene symbol

DBI

UBB

Gene ID

1622

7314

Gene namediazepam binding inhibitor, acyl-CoA binding proteinubiquitin B
SynonymsACBD1|ACBP|CCK-RP|EPHEL-S-50
Cytomap('DBI')('UBB')

2q14.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionacyl-CoA-binding proteinGABA receptor modulatoracyl coenzyme A binding proteinacyl-Coenzyme A binding domain containing 1cholecystokinin-releasing peptide, trypsin-sensitivediazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding proteinpolyubiquitin-Bepididymis secretory protein Li 50polyubiquitin B
Modification date2020032020200313
UniProtAcc

P07108

.
Ensembl transtripts involved in fusion geneENST00000311521, ENST00000355857, 
ENST00000535617, ENST00000535757, 
ENST00000542275, ENST00000393103, 
ENST00000409094, ENST00000460901, 
Fusion gene scores* DoF score12 X 6 X 1=7234 X 9 X 11=3366
# samples 1234
** MAII scorelog2(12/72*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(34/3366*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DBI [Title/Abstract] AND UBB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDBI(120130114)-UBB(16285804), # samples:1
Anticipated loss of major functional domain due to fusion event.DBI-UBB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DBI-UBB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDBI

GO:0036151

phosphatidylcholine acyl-chain remodeling

21079819

HgeneDBI

GO:1903060

negative regulation of protein lipidation

21079819

HgeneDBI

GO:1905920

positive regulation of CoA-transferase activity

21079819

HgeneDBI

GO:2001140

positive regulation of phospholipid transport

21079819

TgeneUBB

GO:0031398

positive regulation of protein ubiquitination

24660806

TgeneUBB

GO:0047497

mitochondrion transport along microtubule

17571083

TgeneUBB

GO:0051881

regulation of mitochondrial membrane potential

17571083

TgeneUBB

GO:0061136

regulation of proteasomal protein catabolic process

17571083

TgeneUBB

GO:1901214

regulation of neuron death

17571083

TgeneUBB

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

17571083



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for DBI-UBB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DBI-UBB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for DBI-UBB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:120130114/:16285804)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DBI

P07108

.
FUNCTION: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DBI-UBB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DBI-UBB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DBI-UBB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DBI-UBB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDBIC0007097Carcinoma1CTD_human
HgeneDBIC0024667Animal Mammary Neoplasms1CTD_human
HgeneDBIC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneDBIC0205696Anaplastic carcinoma1CTD_human
HgeneDBIC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneDBIC0205698Undifferentiated carcinoma1CTD_human
HgeneDBIC0205699Carcinomatosis1CTD_human
HgeneDBIC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC0266122Cleft uvula1ORPHANET
TgeneC0432090Cleft of hard palate1ORPHANET
TgeneC0432098Cleft Soft Palate1ORPHANET
TgeneC0432103Submucous cleft of hard palate1ORPHANET
TgeneC4551487Submucous cleft palate1ORPHANET