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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DECR1-STAU2 (FusionGDB2 ID:HG1666TG27067)

Fusion Gene Summary for DECR1-STAU2

check button Fusion gene summary
Fusion gene informationFusion gene name: DECR1-STAU2
Fusion gene ID: hg1666tg27067
HgeneTgene
Gene symbol

DECR1

STAU2

Gene ID

1666

27067

Gene name2,4-dienoyl-CoA reductase 1staufen double-stranded RNA binding protein 2
SynonymsDECR|NADPH|SDR18C139K2|39K3
Cytomap('DECR1')('STAU2')

8q21.3

8q21.11

Type of geneprotein-codingprotein-coding
Description2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1double-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000519007, ENST00000220764, 
ENST00000522161, 
Fusion gene scores* DoF score7 X 4 X 6=16821 X 18 X 11=4158
# samples 729
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(29/4158*10)=-3.84176495284344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DECR1 [Title/Abstract] AND STAU2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDECR1(91013789)-STAU2(74464554), # samples:5
Anticipated loss of major functional domain due to fusion event.DECR1-STAU2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DECR1-STAU2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DECR1-STAU2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DECR1-STAU2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDECR1

GO:0006635

fatty acid beta-oxidation

15531764


check buttonFusion gene breakpoints across DECR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across STAU2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GG-01ADECR1chr8

91013789

-STAU2chr8

74464554

-
ChimerDB4ESCATCGA-2H-A9GG-01ADECR1chr8

91013789

+STAU2chr8

74464554

-
ChimerDB4ESCATCGA-2H-A9GGDECR1chr8

91013789

+STAU2chr8

74464554

-


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Fusion Gene ORF analysis for DECR1-STAU2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000519007ENST00000355780DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000517542DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000519961DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000521210DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000521451DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000521727DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000522509DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000522695DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000523558DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-3CDSENST00000519007ENST00000524300DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-intronENST00000519007ENST00000521419DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-intronENST00000519007ENST00000522962DECR1chr8

91013789

+STAU2chr8

74464554

-
3UTR-intronENST00000519007ENST00000524104DECR1chr8

91013789

+STAU2chr8

74464554

-
5CDS-intronENST00000220764ENST00000521419DECR1chr8

91013789

+STAU2chr8

74464554

-
5CDS-intronENST00000220764ENST00000522962DECR1chr8

91013789

+STAU2chr8

74464554

-
5CDS-intronENST00000220764ENST00000524104DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000355780DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000517542DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000519961DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000521210DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000521451DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000521727DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000522509DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000522695DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000523558DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-3CDSENST00000522161ENST00000524300DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-intronENST00000522161ENST00000521419DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-intronENST00000522161ENST00000522962DECR1chr8

91013789

+STAU2chr8

74464554

-
5UTR-intronENST00000522161ENST00000524104DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000521210DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000521451DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000521727DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000522509DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000522695DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000523558DECR1chr8

91013789

+STAU2chr8

74464554

-
Frame-shiftENST00000220764ENST00000524300DECR1chr8

91013789

+STAU2chr8

74464554

-
In-frameENST00000220764ENST00000355780DECR1chr8

91013789

+STAU2chr8

74464554

-
In-frameENST00000220764ENST00000517542DECR1chr8

91013789

+STAU2chr8

74464554

-
In-frameENST00000220764ENST00000519961DECR1chr8

91013789

+STAU2chr8

74464554

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000220764DECR1chr891013789+ENST00000355780STAU2chr874464554-287315751470139
ENST00000220764DECR1chr891013789+ENST00000519961STAU2chr874464554-278515751470139
ENST00000220764DECR1chr891013789+ENST00000517542STAU2chr874464554-64715751470139

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220764ENST00000355780DECR1chr891013789+STAU2chr874464554-0.095880220.9041198
ENST00000220764ENST00000519961DECR1chr891013789+STAU2chr874464554-0.132771220.8672288
ENST00000220764ENST00000517542DECR1chr891013789+STAU2chr874464554-0.0363497470.9636502

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Fusion Genomic Features for DECR1-STAU2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DECR1-STAU2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:91013789/chr8:74464554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAU2chr8:91013789chr8:74464554ENST0000052410406207_2740106.0DomainDRBM 3
TgeneSTAU2chr8:91013789chr8:74464554ENST0000052410406307_3750106.0DomainDRBM 4
TgeneSTAU2chr8:91013789chr8:74464554ENST00000524104068_750106.0DomainDRBM 1
TgeneSTAU2chr8:91013789chr8:74464554ENST000005241040695_1810106.0DomainDRBM 2
TgeneSTAU2chr8:91013789chr8:74464554ENST0000052410406273_2910106.0MotifNuclear localization signal 1
TgeneSTAU2chr8:91013789chr8:74464554ENST0000052410406373_4120106.0MotifNuclear localization signal 2
TgeneSTAU2chr8:91013789chr8:74464554ENST0000052410406381_5700106.0RegionRequired for dendritic transport

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDECR1chr8:91013789chr8:74464554ENST00000220764+110240_24323336.0Nucleotide bindingNADP
HgeneDECR1chr8:91013789chr8:74464554ENST00000220764+11066_7123336.0Nucleotide bindingNADP


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Fusion Gene Sequence for DECR1-STAU2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22136_22136_1_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000355780_length(transcript)=2873nt_BP=157nt
TCCAGCCCCGAGAACTTTGTTCTTTTTGTCCCGCCCCCTGCGCCCAACCGCCTGCGCCGCCTTCCGGCCCGAGTTCTGGAGACTCAACAT
GAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCTCCTCGGAGGCTCCAAAAGGAATTCTTCATTTG
TCTCCTGATGTTTATCAAGAGATGGAAGCCAGCCGCCACAAAGTAATCTCTGGCACTACTCTAGGCTATTTGTCACCCAAAGATATGAAC
CAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAATAGTTCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCT
ACAGCTGAAGCCATAGGTTTAAAAGGAAGTTCTCCTACTCCCCCTTGTTCTCCAGTACAACCTTCAAAACAACTGGAATATTTAGCAAGG
ATTCAAGGCTTTCAGGTATGAATTAAAAGCAAAAACAAAAAACAAAACAATTCATTAGCCTCAGATTCTTCATCTGTATACATCACAAGG
CTCATTCTTGCCTGCTAGTATGGCCTACATGCCACTTACGTTTTAAGTTATTTAGGAACACAAAGGACAGACAAAAAAGCCATATGCACA
TGCCTCATTTTCTCTTATTTTTGATCTATCTAGTAATTCTTTTGCTGCCTGTCTCTTCTCCATTTTCCTTCTTCTTTTTTAAGCATTTTT
CATATTCTTCACTGTCTTCTATTTGGTCTTGATTAGGTGCATCTATCTCTTCGCTCTGTCTTCCACAAACAAAAATTCTGCCTTCAGACA
TTTGGTGTTAGTATTTCACACTCAGTTCTCCCTTTTTTTACATAAGGATTGAGTTTCTTTTTATGATGATTTTACCTTTATAGCAATTTT
GAATTTTGCATTCTATTGCTAGTATTGATTCAGGTACACCATTAAGATACAACATTCTAGAAGTCTATTACCTTAGGAGTTAATTAAACA
TGATATTTGAAGAATAATGAAATGCTTTATAGTTGTTTGAGGCATAACAATGTGTATTTGTTTTACTGGATCATGTTTTGAACTGACTAG
GGAGGGTAGCACCTGCCTCAGATAGTACCAACAATTCTGTTTCACTGGGTAGTCTAAAACTAGCTTATAGTTTAACTTAACTTGTTGTGT
ATGTGAATTTAGGGATGGAAACTTTTTTTCCCCTATTTATTCTTTGTTTCCTTCTGGGAAAAAACCCCACAAAAATCAGCACTCCTTTAT
GGATACATTGGAGCTTTTGAAAGAATTGTAAACTCTAGGAAGGGGAAATATCTGTGTCTTGATTTCTTAGTTGCCTTGAAAATCATGTAC
TGAACTGTAACCGCTAACTTGACTGGATGAACTAGTTTGCTTGTGTGTAGAGAGTGTATTGCTTCCTCAGATTTCACTGTTTTCATCTCC
TTTTCCATCTTAGTCTTTATTCCTTAAGACCAAAAACTGTAATATCCTTTAGAAATGCTCTAGAAGATCTGTATTGTGTAGAATGATCAT
GTATTTATAAATATTTTACAAGTTTAGATTATAAAATGAAAAAGAAGGTCATGTGTTTTGGGGGGTATTTTGCATGTTCGGATTTTTTTT
TCACTTCACCGAACCCTTCTGATTCTTTCAAACTATTGCCAGGTAGTTGTTAGTGTTTCTAATTGGACTCTTAATATGAACTTCAAGAAG
CTGTTACCAGTTATCGGCTCTGTCATCTGAAATTTTAACCACTTAATTTAAAGTTACAATTTTAGAATTTGTTTTTGTTGTTTTACCTTA
AGAAACACAATAAATCACTGTTTAAAAAAGATCTCAATTTATATAAAGTACTGGAAAAAAGCTAAGTAATTTTTAGTTCTATCTATAATC
TCCGTAGGATGAATTAGAAATAAATTGTGATGAAAAGAAATTAACTGCTTATTTATGAATCTAATCATTTAGAAATGTCTGAGAGTAACA
CTGCATTCTTATAGAAACAAAGCACAAATTGCATTCAAGCTCTGAATTGATTTTTTGCTTGGAGCTGTTGTTACAGTAGCTGTAATTTTG
CTACCAGAATGTCTTAATTTTTTAAATTTGTTTTTATTTCTAAGCTCTTGGCAATGACAATAATTATAATTTTAACATATCTTCACTGTA
GTCAACATGTAGAGTCTGCTTCCCTCATTATTGCATTGCTAAGGCCTTTTTAAAAAGCTTATGCTTACATAATATACTCTTTTTTATGGA
CACGTTATATGTTTCCAAATCTGTGTATTGTGATTTTTACATACTAATGAATATAAACAGGTGATTTTAAAATATTACTGTGCTTCTTTG
GTTGAATGAGCTGGTATTGATGTAAAATACTCTGTCATTGATGGACCACTACCTGCAGCTAAGCAGTGAGCAGAATCTCCGGGAAATGAC
TTAGTCTGGCCACATGCATAGCCCATCTTCATAATGTCGCAGCAGAAGGTTCTTTGTGGTTAAAAGTTTTAAAGCCTATTTCTTTATAGG
TAACCCTCTCAGGTATATTTACCTGGTAGAAAAACATGTAGATTGTTTCTATTACTTAAATGTTTTAATTGGACTGTAGTTTAGAAATTA
CAGGACCAGCTTGTTACAGATTATACACTATTCTGTTACTTTTATTTCTGAAACTTAAAAACAATAAATTCTTTTTCTGTGTTTCTAGGT
TAGAACTTTTTTATTTTATTGCACACTGAACAGATACTGTTGCTTATTGAATATTGTGTAAACCCTTCTTTGGCTTTCCTTGCCCATTGC

>22136_22136_1_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000355780_length(amino acids)=139AA_BP=35
MRRLPARVLETQHEATGQGFLYSGVPAALWPRSSEAPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSA

--------------------------------------------------------------
>22136_22136_2_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000517542_length(transcript)=647nt_BP=157nt
TCCAGCCCCGAGAACTTTGTTCTTTTTGTCCCGCCCCCTGCGCCCAACCGCCTGCGCCGCCTTCCGGCCCGAGTTCTGGAGACTCAACAT
GAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCTCCTCGGAGGCTCCAAAAGGAATTCTTCATTTG
TCTCCTGATGTTTATCAAGAGATGGAAGCCAGCCGCCACAAAGTAATCTCTGGCACTACTCTAGGCTATTTGTCACCCAAAGATATGAAC
CAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAATAGTTCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCT
ACAGCTGAAGCCATAGGTTTAAAAGGAAGTTCTCCTACTCCCCCTTGTTCTCCAGTACAACCTTCAAAACAACTGGAATATTTAGCAAGG
ATTCAAGGCTTTCAGGTATGAATTAAAAGCAAAAACAAAAAACAAAACAATTCATTAGCCTCAGATTCTTCATCTGTATACATCACAAGG
CTCATTCTTGCCTGCTAGTATGGCCTACATGCCACTTACGTTTTAAGTTATTTAGGAACACAAAGGACAGACAAAAAAGCCATATGCACA

>22136_22136_2_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000517542_length(amino acids)=139AA_BP=35
MRRLPARVLETQHEATGQGFLYSGVPAALWPRSSEAPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSA

--------------------------------------------------------------
>22136_22136_3_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000519961_length(transcript)=2785nt_BP=157nt
TCCAGCCCCGAGAACTTTGTTCTTTTTGTCCCGCCCCCTGCGCCCAACCGCCTGCGCCGCCTTCCGGCCCGAGTTCTGGAGACTCAACAT
GAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCTCCTCGGAGGCTCCAAAAGGAATTCTTCATTTG
TCTCCTGATGTTTATCAAGAGATGGAAGCCAGCCGCCACAAAGTAATCTCTGGCACTACTCTAGGCTATTTGTCACCCAAAGATATGAAC
CAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAATAGTTCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCT
ACAGCTGAAGCCATAGGTTTAAAAGGAAGTTCTCCTACTCCCCCTTGTTCTCCAGTACAACCTTCAAAACAACTGGAATATTTAGCAAGG
ATTCAAGGCTTTCAGGTATGAATTAAAAGCAAAAACAAAAAACAAAACAATTCATTAGCCTCAGATTCTTCATCTGTATACATCACAAGG
CTCATTCTTGCCTGCTAGTATGGCCTACATGCCACTTACGTTTTAAGTTATTTAGGAACACAAAGGACAGACAAAAAAGCCATATGCACA
TGCCTCATTTTCTCTTATTTTTGATCTATCTAGTAATTCTTTTGCTGCCTGTCTCTTCTCCATTTTCCTTCTTCTTTTTTAAGCATTTTT
CATATTCTTCACTGTCTTCTATTTGGTCTTGATTAGGTGCATCTATCTCTTCGCTCTGTCTTCCACAAACAAAAATTCTGCCTTCAGACA
TTTGGTGTTAGTATTTCACACTCAGTTCTCCCTTTTTTTACATAAGGATTGAGTTTCTTTTTATGATGATTTTACCTTTATAGCAATTTT
GAATTTTGCATTCTATTGCTAGTATTGATTCAGGTACACCATTAAGATACAACATTCTAGAAGTCTATTACCTTAGGAGTTAATTAAACA
TGATATTTGAAGAATAATGAAATGCTTTATAGTTGTTTGAGGCATAACAATGTGTATTTGTTTTACTGGATCATGTTTTGAACTGACTAG
GGAGGGTAGCACCTGCCTCAGATAGTACCAACAATTCTGTTTCACTGGGTAGTCTAAAACTAGCTTATAGTTTAACTTAACTTGTTGTGT
ATGTGAATTTAGGGATGGAAACTTTTTTTCCCCTATTTATTCTTTGTTTCCTTCTGGGAAAAAACCCCACAAAAATCAGCACTCCTTTAT
GGATACATTGGAGCTTTTGAAAGAATTGTAAACTCTAGGAAGGGGAAATATCTGTGTCTTGATTTCTTAGTTGCCTTGAAAATCATGTAC
TGAACTGTAACCGCTAACTTGACTGGATGAACTAGTTTGCTTGTGTGTAGAGAGTGTATTGCTTCCTCAGATTTCACTGTTTTCATCTCC
TTTTCCATCTTAGTCTTTATTCCTTAAGACCAAAAACTGTAATATCCTTTAGAAATGCTCTAGAAGATCTGTATTGTGTAGAATGATCAT
GTATTTATAAATATTTTACAAGTTTAGATTATAAAATGAAAAAGAAGGTCATGTGTTTTGGGGGGTATTTTGCATGTTCGGATTTTTTTT
TCACTTCACCGAACCCTTCTGATTCTTTCAAACTATTGCCAGGTAGTTGTTAGTGTTTCTAATTGGACTCTTAATATGAACTTCAAGAAG
CTGTTACCAGTTATCGGCTCTGTCATCTGAAATTTTAACCACTTAATTTAAAGTTACAATTTTAGAATTTGTTTTTGTTGTTTTACCTTA
AGAAACACAATAAATCACTGTTTAAAAAAGATCTCAATTTATATAAAGTACTGGAAAAAAGCTAAGTAATTTTTAGTTCTATCTATAATC
TCCGTAGGATGAATTAGAAATAAATTGTGATGAAAAGAAATTAACTGCTTATTTATGAATCTAATCATTTAGAAATGTCTGAGAGTAACA
CTGCATTCTTATAGAAACAAAGCACAAATTGCATTCAAGCTCTGAATTGATTTTTTGCTTGGAGCTGTTGTTACAGTAGCTGTAATTTTG
CTACCAGAATGTCTTAATTTTTTAAATTTGTTTTTATTTCTAAGCTCTTGGCAATGACAATAATTATAATTTTAACATATCTTCACTGTA
GTCAACATGTAGAGTCTGCTTCCCTCATTATTGCATTGCTAAGGCCTTTTTAAAAAGCTTATGCTTACATAATATACTCTTTTTTATGGA
CACGTTATATGTTTCCAAATCTGTGTATTGTGATTTTTACATACTAATGAATATAAACAGGTGATTTTAAAATATTACTGTGCTTCTTTG
GTTGAATGAGCTGGTATTGATGTAAAATACTCTGTCATTGATGGACCACTACCTGCAGCTAAGCAGTGAGCAGAATCTCCGGGAAATGAC
TTAGTCTGGCCACATGCATAGCCCATCTTCATAATGTCGCAGCAGAAGGTTCTTTGTGGTTAAAAGTTTTAAAGCCTATTTCTTTATAGG
TAACCCTCTCAGGTATATTTACCTGGTAGAAAAACATGTAGATTGTTTCTATTACTTAAATGTTTTAATTGGACTGTAGTTTAGAAATTA
CAGGACCAGCTTGTTACAGATTATACACTATTCTGTTACTTTTATTTCTGAAACTTAAAAACAATAAATTCTTTTTCTGTGTTTCTAGGT

>22136_22136_3_DECR1-STAU2_DECR1_chr8_91013789_ENST00000220764_STAU2_chr8_74464554_ENST00000519961_length(amino acids)=139AA_BP=35
MRRLPARVLETQHEATGQGFLYSGVPAALWPRSSEAPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSA

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Fusion Gene PPI Analysis for DECR1-STAU2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DECR1-STAU2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DECR1-STAU2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDECR1C18572522,4-Dienoyl-CoA Reductase Deficiency2CTD_human;GENOMICS_ENGLAND
HgeneDECR1C0009171Cocaine Abuse1PSYGENET
HgeneDECR1C0023772Lipid Metabolism, Inborn Errors1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human