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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCP2-TBCA (FusionGDB2 ID:HG167227TG6902)

Fusion Gene Summary for DCP2-TBCA

check button Fusion gene summary
Fusion gene informationFusion gene name: DCP2-TBCA
Fusion gene ID: hg167227tg6902
HgeneTgene
Gene symbol

DCP2

TBCA

Gene ID

167227

6902

Gene namedecapping mRNA 2tubulin folding cofactor A
SynonymsNUDT20-
Cytomap('DCP2')('TBCA')

5q22.2

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionm7GpppN-mRNA hydrolaseDCP2 decapping enzyme homologhDpcmRNA-decapping enzyme 2nudix (nucleoside diphosphate linked moiety X)-type motif 20tubulin-specific chaperone ACFATCP1-chaperonin cofactor Achaperonin cofactor Aepididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000504961, ENST00000389063, 
ENST00000515408, ENST00000543319, 
Fusion gene scores* DoF score10 X 8 X 6=48011 X 5 X 6=330
# samples 1312
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/330*10)=-1.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCP2 [Title/Abstract] AND TBCA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCP2(112312683)-TBCA(77004172), # samples:2
Anticipated loss of major functional domain due to fusion event.DCP2-TBCA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCP2-TBCA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCP2

GO:0006402

mRNA catabolic process

21070968|28002401

HgeneDCP2

GO:0043488

regulation of mRNA stability

28002401


check buttonFusion gene breakpoints across DCP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TBCA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3JW-01ADCP2chr5

112312683

+TBCAchr5

77004172

-


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Fusion Gene ORF analysis for DCP2-TBCA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000504961ENST00000306388DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-3CDSENST00000504961ENST00000380377DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-3CDSENST00000504961ENST00000518338DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-3CDSENST00000504961ENST00000520361DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-5UTRENST00000504961ENST00000522370DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-intronENST00000504961ENST00000517679DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-intronENST00000504961ENST00000517881DCP2chr5

112312683

+TBCAchr5

77004172

-
3UTR-intronENST00000504961ENST00000520039DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-5UTRENST00000389063ENST00000522370DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-5UTRENST00000515408ENST00000522370DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000389063ENST00000517679DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000389063ENST00000517881DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000389063ENST00000520039DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000515408ENST00000517679DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000515408ENST00000517881DCP2chr5

112312683

+TBCAchr5

77004172

-
5CDS-intronENST00000515408ENST00000520039DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-3CDSENST00000543319ENST00000306388DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-3CDSENST00000543319ENST00000380377DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-3CDSENST00000543319ENST00000518338DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-3CDSENST00000543319ENST00000520361DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-5UTRENST00000543319ENST00000522370DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-intronENST00000543319ENST00000517679DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-intronENST00000543319ENST00000517881DCP2chr5

112312683

+TBCAchr5

77004172

-
5UTR-intronENST00000543319ENST00000520039DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000389063ENST00000306388DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000389063ENST00000380377DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000389063ENST00000518338DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000389063ENST00000520361DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000515408ENST00000306388DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000515408ENST00000380377DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000515408ENST00000518338DCP2chr5

112312683

+TBCAchr5

77004172

-
In-frameENST00000515408ENST00000520361DCP2chr5

112312683

+TBCAchr5

77004172

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000515408DCP2chr5112312683+ENST00000380377TBCAchr577004172-811285106558150
ENST00000515408DCP2chr5112312683+ENST00000306388TBCAchr577004172-2503285106621171
ENST00000515408DCP2chr5112312683+ENST00000520361TBCAchr577004172-642285106471121
ENST00000515408DCP2chr5112312683+ENST00000518338TBCAchr577004172-779285106627173
ENST00000389063DCP2chr5112312683+ENST00000380377TBCAchr577004172-77725172524150
ENST00000389063DCP2chr5112312683+ENST00000306388TBCAchr577004172-246925172587171
ENST00000389063DCP2chr5112312683+ENST00000520361TBCAchr577004172-60825172437121
ENST00000389063DCP2chr5112312683+ENST00000518338TBCAchr577004172-74525172593173

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000515408ENST00000380377DCP2chr5112312683+TBCAchr577004172-0.0052561450.9947438
ENST00000515408ENST00000306388DCP2chr5112312683+TBCAchr577004172-0.0073709310.99262905
ENST00000515408ENST00000520361DCP2chr5112312683+TBCAchr577004172-0.0108309680.989169
ENST00000515408ENST00000518338DCP2chr5112312683+TBCAchr577004172-0.0034536610.9965463
ENST00000389063ENST00000380377DCP2chr5112312683+TBCAchr577004172-0.0046782640.9953217
ENST00000389063ENST00000306388DCP2chr5112312683+TBCAchr577004172-0.005666320.99433374
ENST00000389063ENST00000520361DCP2chr5112312683+TBCAchr577004172-0.0108229860.98917705
ENST00000389063ENST00000518338DCP2chr5112312683+TBCAchr577004172-0.0037339780.99626607

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Fusion Genomic Features for DCP2-TBCA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DCP2-TBCA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:112312683/chr5:77004172)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCP2chr5:112312683chr5:77004172ENST00000389063+11195_22617421.0DomainNudix hydrolase
HgeneDCP2chr5:112312683chr5:77004172ENST00000515408+11095_22617386.0DomainNudix hydrolase
HgeneDCP2chr5:112312683chr5:77004172ENST00000389063+111129_15017421.0MotifNote=Nudix box
HgeneDCP2chr5:112312683chr5:77004172ENST00000515408+110129_15017386.0MotifNote=Nudix box


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Fusion Gene Sequence for DCP2-TBCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21652_21652_1_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000306388_length(transcript)=2469nt_BP=251nt
AGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTTCCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCG
CGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCAGTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTC
CTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTG
ATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGAAGACGGTGAAAATTATGACATTAAAAAGCAGGCA
GAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGTAAGC
AAAGACTTCTGTGTCATGTTTAAATTTTTTTTTTCAATCCAATACATGGAAAGCCAAAAGTTTAAATATTTAACACTGAGAACTAGTTGG
CAGTATTTCTTATTCACTTGCCCTTTATACCGCTATATTTTAAAATAATTAATGGAGTTTAAATTGTGTTTTGAATTATGCCTCCAGTAA
AAGTACTGTTTTCTAGCATGTTTGTTCAGTTTATTAAAATTTAGCTAGTTAAATTTATTTAAGTTATGATAGTACCAGTATTGTCCAGCA
ATGTCTTGATTATTTGGTTTTCATACATAAAGATCTTTTGAGACATTGAGGATGAGTTGACTGATTAAAATTTTAAAAGATCTAATGTTT
CAAAAGAATTTGGGATCTTATTAAAAGGATCTTGAATTCTTTCACATTCAAACCTAGATCAGTTTGAGAGGGGGAAAAAACCTGGTAATC
TATGTAGTCCCCTCATACTAACTTGGAGCTGAATAACACTTATACTTGCTGGTATAAATGCCTTGTGATACAGAAGGTAGATAAAGCAGG
AAATAATAACTGTTAAAATACTATCTAAGACAGGAAGCATCATTTGTATTTCTTGACAGTTTAAATGCTTTTTTCTCTCATGAATCTAGT
AGCTGAGAAAGTAATAGAAATTGCTTGGAAAAAAATAATGTTGGCCGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAG
GCTGAGGTGGGTGGATCACGAGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAATCCTGTCTCTACTAAAAATACCAAAATAATA
ATAATAATAATAATGTATTTGGATGATATATTTGTATGTGAAGATGTATTCAACAATATCTCTGCCCTTGAAGAGCTTGTATTTACTAAC
AGAGAACAAAGATGTGTTTAAGGTATAACATGGAGGTTTAAGAAATTCTTACGTATAGTTTGAGCTAAGCAAATTCTCAGTCGTTTTGCT
TTCAGTTTTCATATTAAATACACACATACTTTATTTCCTCTACTGTTTGTATATCTCCATCTTTTATTGACCTGACATAAATTGCTAACC
ATAGCTTCATTTAAAAATCAAACAAAATTTCCTGTGTACTTTAGATAATATTATTTCATTTGTCTGTTATCATTACAATATATTAGTAAA
AGTTGCCTGTATATCAGTATTATGGAAAAACTCAATCTTTAAATATCAGAAAATGAAAGATGTATTTTGTTTCCTTTAGTGTAGGGTATG
TAATACCCATTAGCAAGCAGGCAATTCATTTGTTTAATTCAAAGATTATATTTAACTCTGTTGTGACATCAGAAGCCTTCTTTGTCATTG
TGAATAGTCAGTGGATTATTTTGGCCTGAATGCTGTCATATATGTAACATGTTAGTAAATCTTCCTTTTTACTTTTCTCTTTTGTATGAT
GATGATGGGTCAACAAAATGAGAATAAACTTTTTCTGAGGTTTTTATTTAATTAATGCTGGTAGCTTTAGAAGACTGTTATTCACTTATT
TTATGAGAATATATACAGTGAAACAAAACCACCAGTTATTTCTTCCTTTCCTTGTAAAGAAGGAACAGAATGTGGGAAACCTGTGGAATT
ACAATATATTTAGATGAGGCTTGGGATTTTTTACTTTTAATTTTTTAGTTATTAACATTAATGGTTTGTAATATTTGAGTAAATAACAAA
GTACTGAAACTTGAAAAGGATAAACTTAATTTTTATTGTATTTCATTTTAGGAAAATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAA
GAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATT
TTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATATATATTTCTTTGTC
TAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAA

>21652_21652_1_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000306388_length(amino acids)=171AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILVSKDFCVMFKFFFSIQYMESQKFKYLTLRTSWQYFLFTCPLYRYILK

--------------------------------------------------------------
>21652_21652_2_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000380377_length(transcript)=777nt_BP=251nt
AGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTTCCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCG
CGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCAGTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTC
CTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTG
ATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGAAGACGGTGAAAATTATGACATTAAAAAGCAGGCA
GAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAAT
GAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATG
GGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATT
GTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTT
ACAAAATTTTTAAATTAACCTTTTATCATTAAACCACATAGACTTTATGACAGAGAA

>21652_21652_2_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000380377_length(amino acids)=150AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------
>21652_21652_3_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000518338_length(transcript)=745nt_BP=251nt
AGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTTCCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCG
CGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCAGTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTC
CTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTG
ATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGAAGACGGTGAAAATTATGACATTAAAAAGCAGGCT
GGTCTTCAACTCCTGGCCTCCAGTGATCCTCCCACCCCAGCCTCTCAGAGTCCTGGGATGATAAGCGCAGAGATCCTACAAGAATCCAGG
ATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAAGACTTGGAAGAAGCT
GAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAATC
CTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATATA
TATTTCTTTGTCTAATTTAATATGT

>21652_21652_3_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000518338_length(amino acids)=173AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAGLQLLASSDPPTPASQSPGMISAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------
>21652_21652_4_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000520361_length(transcript)=608nt_BP=251nt
AGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTTCCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCG
CGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCAGTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTC
CTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTG
ATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGAAGACGGTGAAAATTATGACATTAAAAAGCAGGAA
AATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGT
ATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTG
ATTGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCT

>21652_21652_4_DCP2-TBCA_DCP2_chr5_112312683_ENST00000389063_TBCA_chr5_77004172_ENST00000520361_length(amino acids)=121AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------
>21652_21652_5_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000306388_length(transcript)=2503nt_BP=285nt
GTGACTCCGGGGGCTCCGCCCCGAGCCTTGGCCCAGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTT
CCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCGCGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCA
GTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTCCTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCT
GGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTGATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGA
AGACGGTGAAAATTATGACATTAAAAAGCAGGCAGAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGC
CGCATATTTGGATCTTCAACGGATACTAGTAAGCAAAGACTTCTGTGTCATGTTTAAATTTTTTTTTTCAATCCAATACATGGAAAGCCA
AAAGTTTAAATATTTAACACTGAGAACTAGTTGGCAGTATTTCTTATTCACTTGCCCTTTATACCGCTATATTTTAAAATAATTAATGGA
GTTTAAATTGTGTTTTGAATTATGCCTCCAGTAAAAGTACTGTTTTCTAGCATGTTTGTTCAGTTTATTAAAATTTAGCTAGTTAAATTT
ATTTAAGTTATGATAGTACCAGTATTGTCCAGCAATGTCTTGATTATTTGGTTTTCATACATAAAGATCTTTTGAGACATTGAGGATGAG
TTGACTGATTAAAATTTTAAAAGATCTAATGTTTCAAAAGAATTTGGGATCTTATTAAAAGGATCTTGAATTCTTTCACATTCAAACCTA
GATCAGTTTGAGAGGGGGAAAAAACCTGGTAATCTATGTAGTCCCCTCATACTAACTTGGAGCTGAATAACACTTATACTTGCTGGTATA
AATGCCTTGTGATACAGAAGGTAGATAAAGCAGGAAATAATAACTGTTAAAATACTATCTAAGACAGGAAGCATCATTTGTATTTCTTGA
CAGTTTAAATGCTTTTTTCTCTCATGAATCTAGTAGCTGAGAAAGTAATAGAAATTGCTTGGAAAAAAATAATGTTGGCCGCCAGGTGCA
GTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACGAGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTG
AAATCCTGTCTCTACTAAAAATACCAAAATAATAATAATAATAATAATGTATTTGGATGATATATTTGTATGTGAAGATGTATTCAACAA
TATCTCTGCCCTTGAAGAGCTTGTATTTACTAACAGAGAACAAAGATGTGTTTAAGGTATAACATGGAGGTTTAAGAAATTCTTACGTAT
AGTTTGAGCTAAGCAAATTCTCAGTCGTTTTGCTTTCAGTTTTCATATTAAATACACACATACTTTATTTCCTCTACTGTTTGTATATCT
CCATCTTTTATTGACCTGACATAAATTGCTAACCATAGCTTCATTTAAAAATCAAACAAAATTTCCTGTGTACTTTAGATAATATTATTT
CATTTGTCTGTTATCATTACAATATATTAGTAAAAGTTGCCTGTATATCAGTATTATGGAAAAACTCAATCTTTAAATATCAGAAAATGA
AAGATGTATTTTGTTTCCTTTAGTGTAGGGTATGTAATACCCATTAGCAAGCAGGCAATTCATTTGTTTAATTCAAAGATTATATTTAAC
TCTGTTGTGACATCAGAAGCCTTCTTTGTCATTGTGAATAGTCAGTGGATTATTTTGGCCTGAATGCTGTCATATATGTAACATGTTAGT
AAATCTTCCTTTTTACTTTTCTCTTTTGTATGATGATGATGGGTCAACAAAATGAGAATAAACTTTTTCTGAGGTTTTTATTTAATTAAT
GCTGGTAGCTTTAGAAGACTGTTATTCACTTATTTTATGAGAATATATACAGTGAAACAAAACCACCAGTTATTTCTTCCTTTCCTTGTA
AAGAAGGAACAGAATGTGGGAAACCTGTGGAATTACAATATATTTAGATGAGGCTTGGGATTTTTTACTTTTAATTTTTTAGTTATTAAC
ATTAATGGTTTGTAATATTTGAGTAAATAACAAAGTACTGAAACTTGAAAAGGATAAACTTAATTTTTATTGTATTTCATTTTAGGAAAA
TGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTAT
GGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGAT
TGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAA

>21652_21652_5_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000306388_length(amino acids)=171AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILVSKDFCVMFKFFFSIQYMESQKFKYLTLRTSWQYFLFTCPLYRYILK

--------------------------------------------------------------
>21652_21652_6_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000380377_length(transcript)=811nt_BP=285nt
GTGACTCCGGGGGCTCCGCCCCGAGCCTTGGCCCAGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTT
CCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCGCGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCA
GTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTCCTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCT
GGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTGATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGA
AGACGGTGAAAATTATGACATTAAAAAGCAGGCAGAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGC
CGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTC
AGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCA
CTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATG
AGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAATTTTTAAATTAACCTTTTATCATTAAACCACATAGACTTTATGACAGAGA
A

>21652_21652_6_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000380377_length(amino acids)=150AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------
>21652_21652_7_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000518338_length(transcript)=779nt_BP=285nt
GTGACTCCGGGGGCTCCGCCCCGAGCCTTGGCCCAGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTT
CCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCGCGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCA
GTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTCCTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCT
GGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTGATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGA
AGACGGTGAAAATTATGACATTAAAAAGCAGGCTGGTCTTCAACTCCTGGCCTCCAGTGATCCTCCCACCCCAGCCTCTCAGAGTCCTGG
GATGATAAGCGCAGAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACG
GATACTAGAAAATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAA
CTTTTCTCGTATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTA
TGAGAATGTGATTGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGT

>21652_21652_7_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000518338_length(amino acids)=173AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQAGLQLLASSDPPTPASQSPGMISAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------
>21652_21652_8_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000520361_length(transcript)=642nt_BP=285nt
GTGACTCCGGGGGCTCCGCCCCGAGCCTTGGCCCAGTCTTGGGGTCCAAGGCTGAGGGAGCGGGACGGAAGTGAGCGGGTCCCGCCCCTT
CCCCTTCTCGTCTCCGTTGGAGTCGTCTCTGCCGCGGCTTCCTCGGCTGCCAGCTCTCCGGCGAGCCGGAGTCCTAGTGCCGTACCGTCA
GTCCCCGGCCGCGCGGAGCCGGGATGCACTGTTCCTGCTGTGGGTCCTCATCATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCT
GGACGATTTCTGCAGGTTGGTCAAAGAAAAAGTGATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGA
AGACGGTGAAAATTATGACATTAAAAAGCAGGAAAATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGA
TTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGA
CCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAA
ATGAGTTCATCT

>21652_21652_8_DCP2-TBCA_DCP2_chr5_112312683_ENST00000515408_TBCA_chr5_77004172_ENST00000520361_length(amino acids)=121AA_BP=57
MESSLPRLPRLPALRRAGVLVPYRQSPAARSRDALFLLWVLIMETKRVEIPGSVLDDFCRLVKEKVMYEKEAKQQEEKIEKMRAEDGENY
DIKKQENEKDLEEAEEYKEARLVLDSVKLEA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCP2-TBCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCP2-TBCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCP2-TBCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneC4551472Hypertrophic obstructive cardiomyopathy1CTD_human