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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ADAMTS16-ETV6 (FusionGDB2 ID:HG170690TG2120) |
Fusion Gene Summary for ADAMTS16-ETV6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS16-ETV6 | Fusion gene ID: hg170690tg2120 | Hgene | Tgene | Gene symbol | ADAMTS16 | ETV6 | Gene ID | 170690 | 2120 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 16 | ETS variant transcription factor 6 | |
| Synonyms | ADAMTS16s | TEL|TEL/ABL|THC5 | |
| Cytomap | ('ADAMTS16')('ETV6') 5p15.32 | 12p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 | transcription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P41212 | |
| Ensembl transtripts involved in fusion gene | ENST00000274181, ENST00000511368, ENST00000513709, | ||
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 21 X 24 X 6=3024 |
| # samples | 3 | 19 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/3024*10)=-3.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS16 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADAMTS16(5209359)-ETV6(11905384), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ADAMTS16-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS16-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS16-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS16-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Fusion gene breakpoints across ADAMTS16 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ETV6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A7-A4SD-01A | ADAMTS16 | chr5 | 5209359 | - | ETV6 | chr12 | 11905384 | + |
| ChimerDB4 | BRCA | TCGA-A7-A4SD-01A | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
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Fusion Gene ORF analysis for ADAMTS16-ETV6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000274181 | ENST00000544715 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| 5CDS-3UTR | ENST00000511368 | ENST00000544715 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| In-frame | ENST00000274181 | ENST00000396373 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| In-frame | ENST00000511368 | ENST00000396373 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| intron-3CDS | ENST00000513709 | ENST00000396373 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| intron-3UTR | ENST00000513709 | ENST00000544715 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000274181 | ADAMTS16 | chr5 | 5209359 | + | ENST00000396373 | ETV6 | chr12 | 11905384 | + | 7425 | 1743 | 30 | 3068 | 1012 |
| ENST00000511368 | ADAMTS16 | chr5 | 5209359 | + | ENST00000396373 | ETV6 | chr12 | 11905384 | + | 7425 | 1743 | 30 | 3068 | 1012 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000274181 | ENST00000396373 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + | 0.000467665 | 0.99953234 |
| ENST00000511368 | ENST00000396373 | ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905384 | + | 0.000467665 | 0.99953234 |
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Fusion Genomic Features for ADAMTS16-ETV6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905383 | + | 0.003816997 | 0.996183 |
| ADAMTS16 | chr5 | 5209359 | + | ETV6 | chr12 | 11905383 | + | 0.003816997 | 0.996183 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ADAMTS16-ETV6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:5209359/chr12:11905384) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ETV6 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 290_495 | 535 | 1225.0 | Domain | Peptidase M12B |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 247_254 | 535 | 1225.0 | Motif | Cysteine switch |
| Tgene | ETV6 | chr5:5209359 | chr12:11905384 | ENST00000396373 | 0 | 8 | 339_420 | 11 | 453.0 | DNA binding | ETS | |
| Tgene | ETV6 | chr5:5209359 | chr12:11905384 | ENST00000396373 | 0 | 8 | 40_124 | 11 | 453.0 | Domain | PNT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 642_746 | 535 | 1225.0 | Compositional bias | Note=Cys-rich |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 1051_1115 | 535 | 1225.0 | Domain | TSP type-1 5 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 1127_1181 | 535 | 1225.0 | Domain | TSP type-1 6 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 1186_1223 | 535 | 1225.0 | Domain | PLAC |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 496_585 | 535 | 1225.0 | Domain | Note=Disintegrin |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 586_641 | 535 | 1225.0 | Domain | TSP type-1 1 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 874_922 | 535 | 1225.0 | Domain | TSP type-1 2 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 927_987 | 535 | 1225.0 | Domain | TSP type-1 3 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 988_1048 | 535 | 1225.0 | Domain | TSP type-1 4 |
| Hgene | ADAMTS16 | chr5:5209359 | chr12:11905384 | ENST00000274181 | + | 10 | 23 | 747_873 | 535 | 1225.0 | Region | Note=Spacer |
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Fusion Gene Sequence for ADAMTS16-ETV6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >2051_2051_1_ADAMTS16-ETV6_ADAMTS16_chr5_5209359_ENST00000274181_ETV6_chr12_11905384_ENST00000396373_length(transcript)=7425nt_BP=1743nt AGTAATAACCCCGGCGCGGCGGCGGAGTCGCTGTGGGGAATCCTCCCGCGCTCTGCCTGGGTCGGGTCCTCCCTGCCCGCTCGCACGCTG CCGGCCGGGGACCCTCCGGTGGCCCCTAGCCCCTCGGAGCGCTCCTGGATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTG TGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATGGGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGT CCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATATGACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTAC GTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCCGTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCC AGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCTCCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAG TCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCTTTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGC CAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCT GCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGG ACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAA TACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCC CATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTAC GTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTT CTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGG AAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTT GCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAG TCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGA CGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAG CCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAG AAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG CCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGG GAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACC TATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATG AAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGAT GAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAG GCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGAC AAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTC CATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGAC TCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACA AAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTC CTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCT GTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTT GGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCAC CCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTG AGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGC AGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTT CCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACC TGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGA TCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCAT AGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTC TTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCC AATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTT GGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCA GCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCT AGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTT ATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACC TTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCAT TCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATT GTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATG TTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATT ATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGC CACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTA AAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTC TTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATAT GAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATAT ATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCT GGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGT TCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACC TTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCC ACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTG CCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGA AAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGG CATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCA GTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGT GACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCC CTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGA TCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGT TTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGA AGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACA CTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACC AGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAA TCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGC >2051_2051_1_ADAMTS16-ETV6_ADAMTS16_chr5_5209359_ENST00000274181_ETV6_chr12_11905384_ENST00000396373_length(amino acids)=1012AA_BP=571 MWGILPRSAWVGSSLPARTLPAGDPPVAPSPSERSWMKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGW MEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDF CFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLH SSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSA LFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKY RSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYP EKLPGELYDANTQCKWQFGEKAKLCMLDFKKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWL KWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQR TPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRL LWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGR -------------------------------------------------------------- >2051_2051_2_ADAMTS16-ETV6_ADAMTS16_chr5_5209359_ENST00000511368_ETV6_chr12_11905384_ENST00000396373_length(transcript)=7425nt_BP=1743nt AGTAATAACCCCGGCGCGGCGGCGGAGTCGCTGTGGGGAATCCTCCCGCGCTCTGCCTGGGTCGGGTCCTCCCTGCCCGCTCGCACGCTG CCGGCCGGGGACCCTCCGGTGGCCCCTAGCCCCTCGGAGCGCTCCTGGATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTG TGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATGGGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGT CCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATATGACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTAC GTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCCGTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCC AGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCTCCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAG TCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCTTTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGC CAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCT GCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGG ACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAA TACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCC CATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTAC GTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTT CTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGG AAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTT GCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAG TCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGA CGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAG CCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAG AAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG CCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGG GAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACC TATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATG AAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGAT GAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAG GCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGAC AAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTC CATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGAC TCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACA AAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTC CTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCT GTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTT GGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCAC CCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTG AGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGC AGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTT CCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACC TGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGA TCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCAT AGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTC TTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCC AATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTT GGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCA GCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCT AGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTT ATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACC TTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCAT TCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATT GTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATG TTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATT ATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGC CACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTA AAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTC TTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATAT GAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATAT ATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCT GGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGT TCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACC TTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCC ACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTG CCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGA AAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGG CATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCA GTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGT GACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCC CTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGA TCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGT TTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGA AGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACA CTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACC AGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAA TCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGC >2051_2051_2_ADAMTS16-ETV6_ADAMTS16_chr5_5209359_ENST00000511368_ETV6_chr12_11905384_ENST00000396373_length(amino acids)=1012AA_BP=571 MWGILPRSAWVGSSLPARTLPAGDPPVAPSPSERSWMKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGW MEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDF CFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLH SSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSA LFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKY RSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYP EKLPGELYDANTQCKWQFGEKAKLCMLDFKKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWL KWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQR TPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRL LWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADAMTS16-ETV6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAMTS16-ETV6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAMTS16-ETV6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C4015537 | THROMBOCYTOPENIA 5 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 3 | CTD_human | |
| Tgene | C0040034 | Thrombocytopenia | 3 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C0023480 | Leukemia, Myelomonocytic, Chronic | 2 | ORPHANET | |
| Tgene | C1332965 | Congenital Mesoblastic Nephroma | 2 | ORPHANET | |
| Tgene | C0006413 | Burkitt Lymphoma | 1 | ORPHANET | |
| Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
| Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
| Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
| Tgene | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human | |
| Tgene | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human | |
| Tgene | C0023467 | Leukemia, Myelocytic, Acute | 1 | CGI;CTD_human;GENOMICS_ENGLAND | |
| Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
| Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
| Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
| Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
| Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
| Tgene | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET | |
| Tgene | C0376544 | Hematopoietic Neoplasms | 1 | CTD_human | |
| Tgene | C0376545 | Hematologic Neoplasms | 1 | CTD_human | |
| Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
| Tgene | C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | ORPHANET | |
| Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
| Tgene | C1832388 | Platelet Disorder, Familial, with Associated Myeloid Malignancy | 1 | ORPHANET | |
| Tgene | C1838656 | Macrocytosis, Familial | 1 | CTD_human | |
| Tgene | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human | |
| Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
| Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
| Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human | |
| Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
| Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
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