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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS17-CERS3 (FusionGDB2 ID:HG170691TG204219)

Fusion Gene Summary for ADAMTS17-CERS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS17-CERS3
Fusion gene ID: hg170691tg204219
HgeneTgene
Gene symbol

ADAMTS17

CERS3

Gene ID

170691

204219

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 17ceramide synthase 3
SynonymsWMS4ARCI9|LASS3
Cytomap('ADAMTS17')('CERS3')

15q26.3

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 17a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
Modification date2020031320200313
UniProtAcc

Q8TE56

.
Ensembl transtripts involved in fusion geneENST00000268070, ENST00000559976, 
Fusion gene scores* DoF score24 X 8 X 8=15368 X 7 X 7=392
# samples 1411
** MAII scorelog2(14/1536*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS17 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS17(100692817)-CERS3(100943070), # samples:2
ADAMTS17(100692817)-CERS3(100996251), # samples:2
Anticipated loss of major functional domain due to fusion event.ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCERS3

GO:0046513

ceramide biosynthetic process

17977534|22038835


check buttonFusion gene breakpoints across ADAMTS17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-33-4532-01AADAMTS17chr15

100692817

-CERS3chr15

100943070

-
ChimerDB4LUSCTCGA-33-4532-01AADAMTS17chr15

100692817

-CERS3chr15

100996251

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
ChimerDB4LUSCTCGA-56-6545-01AADAMTS17chr15

100794341

-CERS3chr15

100943070

-


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Fusion Gene ORF analysis for ADAMTS17-CERS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000268070ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
5CDS-5UTRENST00000268070ENST00000560944ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
5CDS-intronENST00000268070ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
5CDS-intronENST00000268070ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
5UTR-3CDSENST00000559976ENST00000284382ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
5UTR-3CDSENST00000559976ENST00000394113ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
5UTR-3CDSENST00000559976ENST00000538112ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
5UTR-5UTRENST00000559976ENST00000560944ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
Frame-shiftENST00000268070ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
Frame-shiftENST00000268070ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
Frame-shiftENST00000268070ENST00000284382ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
Frame-shiftENST00000268070ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
Frame-shiftENST00000268070ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
Frame-shiftENST00000268070ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
Frame-shiftENST00000268070ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
Frame-shiftENST00000268070ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
Frame-shiftENST00000268070ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
Frame-shiftENST00000268070ENST00000538112ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
In-frameENST00000268070ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
In-frameENST00000268070ENST00000394113ADAMTS17chr15

100794341

-CERS3chr15

100943070

-
intron-3CDSENST00000559976ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
intron-3CDSENST00000559976ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
intron-3CDSENST00000559976ENST00000284382ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
intron-3CDSENST00000559976ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
intron-3CDSENST00000559976ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
intron-3CDSENST00000559976ENST00000394113ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
intron-3CDSENST00000559976ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
intron-3CDSENST00000559976ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
intron-3CDSENST00000559976ENST00000538112ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
intron-5UTRENST00000559976ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
intron-intronENST00000559976ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
intron-intronENST00000559976ENST00000560944ADAMTS17chr15

100692817

-CERS3chr15

100996251

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268070ADAMTS17chr15100692817-ENST00000284382CERS3chr15100943070-40501579371731564
ENST00000268070ADAMTS17chr15100794341-ENST00000394113CERS3chr15100943070-15361181371203388

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268070ENST00000284382ADAMTS17chr15100692817-CERS3chr15100943070-0.0071074940.9928925
ENST00000268070ENST00000394113ADAMTS17chr15100794341-CERS3chr15100943070-0.0612790470.938721

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Fusion Genomic Features for ADAMTS17-CERS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADAMTS17-CERS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:100692817/chr15:100943070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS17

Q8TE56

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-102260_1204911096.0Compositional biasNote=Arg-rich
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-72260_1203581096.0Compositional biasNote=Arg-rich
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022232_4524911096.0DomainPeptidase M12B
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022199_2064911096.0MotifCysteine switch
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722199_2063581096.0MotifCysteine switch
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113346_355333384.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022599_7014911096.0Compositional biasNote=Cys-rich
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722599_7013581096.0Compositional biasNote=Cys-rich
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-10221045_10844911096.0DomainPLAC
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022453_5424911096.0DomainNote=Disintegrin
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022543_5984911096.0DomainTSP type-1 1
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022800_8604911096.0DomainTSP type-1 2
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022861_9224911096.0DomainTSP type-1 3
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022925_9684911096.0DomainTSP type-1 4
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022972_10294911096.0DomainTSP type-1 5
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-7221045_10843581096.0DomainPLAC
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722232_4523581096.0DomainPeptidase M12B
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722453_5423581096.0DomainNote=Disintegrin
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722543_5983581096.0DomainTSP type-1 1
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722800_8603581096.0DomainTSP type-1 2
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722861_9223581096.0DomainTSP type-1 3
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722925_9683581096.0DomainTSP type-1 4
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722972_10293581096.0DomainTSP type-1 5
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022702_7794911096.0RegionNote=Spacer
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722702_7793581096.0RegionNote=Spacer
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113130_331333384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214130_331333384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113130_331333384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113130_331333384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214130_331333384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113130_331333384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST00000284382111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST00000394113121466_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST00000538112111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000284382111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000394113121466_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000538112111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000284382111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000394113121432_52333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000538112111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000284382111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000394113121432_52333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000538112111332_52333384.0TransmembraneHelical


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Fusion Gene Sequence for ADAMTS17-CERS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2055_2055_1_ADAMTS17-CERS3_ADAMTS17_chr15_100692817_ENST00000268070_CERS3_chr15_100943070_ENST00000284382_length(transcript)=4050nt_BP=1579nt
AATTACTTTTTCCAAAGGCTGGAGGGCTTCACTCCGGCTGGCGCCGCCGCCTAGCGCGCTCCTGCTTCGCCGCCACGGTCCGGGGGGGCT
GCCGGTCCCGGGTACCATGTGTGACGGCGCCCTGCTGCCTCCGCTCGTCCTGCCCGTGCTGCTGCTGCTGGTTTGGGGACTGGACCCGGG
CACAGCTGTCGGCGACGCGGCGGCCGACGTGGAGGTGGTGCTCCCGTGGCGGGTGCGCCCCGACGACGTGCACCTGCCGCCGCTGCCCGC
AGCCCCCGGGCCCCGACGGCGGCGACGCCCCCGCACGCCCCCAGCCGCCCCGCGCGCCCGGCCCGGAGAGCGCGCCCTGCTGCTGCACCT
GCCGGCCTTCGGGCGCGACCTGTACCTTCAGCTGCGCCGCGACCTGCGCTTCCTGTCCCGAGGCTTCGAGGTGGAGGAGGCGGGCGCGGC
CCGGCGCCGCGGCCGCCCCGCCGAGCTGTGCTTCTACTCGGGCCGTGTGCTCGGCCACCCCGGCTCCCTCGTCTCGCTCAGCGCCTGCGG
CGCCGCCGGCGGCCTGGTTGGCCTCATTCAGCTTGGGCAGGAGCAGGTGCTAATCCAGCCCCTCAACAACTCCCAGGGCCCATTCAGTGG
ACGAGAACATCTGATCAGGCGCAAATGGTCCTTGACCCCCAGCCCTTCTGCTGAGGCCCAGAGACCTGAGCAGCTCTGCAAGGTTCTAAC
AGAAAAGAAGAAGCCGACGTGGGGCAGGCCTTCGCGGGACTGGCGGGAGCGGAGGAACGCTATCCGGCTCACCAGCGAGCACACGGTGGA
GACCCTGGTGGTGGCCGACGCCGACATGGTGCAGTACCACGGGGCCGAGGCCGCCCAGAGGTTCATCCTGACCGTCATGAACATGGTATA
CAATATGTTTCAGCACCAGAGCCTGGGGATTAAAATTAACATTCAAGTGACCAAGCTTGTCCTGCTACGACAACGTCCCGCTAAGTTGTC
CATTGGGCACCATGGTGAGCGGTCCCTGGAGAGCTTCTGTCACTGGCAGAACGAGGAGTATGGAGGAGCGCGATACCTCGGCAATAACCA
GGTTCCCGGCGGGAAGGACGACCCGCCCCTGGTGGATGCTGCCGTGTTTGTGACCAGGACAGATTTCTGTGTACACAAGGATGAACCGTG
TGACACTGTTGGAATTGCTTACTTAGGAGGTGTGTGCAGTGCTAAGAGGAAGTGTGTGCTTGCCGAAGACAATGGTCTCAATTTGGCCTT
TACCATCGCCCATGAGCTGGGCCACAACTTGGGCATGAACCACGACGATGACCACTCATCTTGCGCTGGCAGGTCCCACATCATGTCAGG
AGAGTGGGTGAAAGGCCGGAACCCAAGTGACCTCTCTTGGTCCTCCTGCAGCCGAGATGACCTTGAAAACTTCCTCAAGTCAAAAGTCAG
CACCTGCTTGCTAGTCACGGACCCCAGAAGCCAGCACACAGTACGCCTCCCGCACAAGCTGCCGGGCATGCACTACAGTGCCAACGAGCA
GTGCCAGATCCTGTTTGGCATGAATGCCACCTTCTGCAGAAACATGGAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGA
GGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCC
CAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCC
CCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTG
TGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAA
CCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTG
TCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTA
GAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCA
GTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTG
AACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAA
TTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCC
CCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCC
TTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGG
GACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTA
CACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAA
CACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATA
GGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCC
TTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGG
CCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCC
TATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGC
CCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAA
AAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAA
CATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGC
TATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTA
TGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAG
TTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAA
GAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAG
GATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAACAGTAATGACTACAATAAAGCCAAAAGTCCAGTGTA

>2055_2055_1_ADAMTS17-CERS3_ADAMTS17_chr15_100692817_ENST00000268070_CERS3_chr15_100943070_ENST00000284382_length(amino acids)=564AA_BP=514
MAPPPSALLLRRHGPGGLPVPGTMCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT
PPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLG
QEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY
HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVD
AAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLS
WSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMESIQDVRSDDEDYEEEEEEEEEEATKG

--------------------------------------------------------------
>2055_2055_2_ADAMTS17-CERS3_ADAMTS17_chr15_100794341_ENST00000268070_CERS3_chr15_100943070_ENST00000394113_length(transcript)=1536nt_BP=1181nt
AATTACTTTTTCCAAAGGCTGGAGGGCTTCACTCCGGCTGGCGCCGCCGCCTAGCGCGCTCCTGCTTCGCCGCCACGGTCCGGGGGGGCT
GCCGGTCCCGGGTACCATGTGTGACGGCGCCCTGCTGCCTCCGCTCGTCCTGCCCGTGCTGCTGCTGCTGGTTTGGGGACTGGACCCGGG
CACAGCTGTCGGCGACGCGGCGGCCGACGTGGAGGTGGTGCTCCCGTGGCGGGTGCGCCCCGACGACGTGCACCTGCCGCCGCTGCCCGC
AGCCCCCGGGCCCCGACGGCGGCGACGCCCCCGCACGCCCCCAGCCGCCCCGCGCGCCCGGCCCGGAGAGCGCGCCCTGCTGCTGCACCT
GCCGGCCTTCGGGCGCGACCTGTACCTTCAGCTGCGCCGCGACCTGCGCTTCCTGTCCCGAGGCTTCGAGGTGGAGGAGGCGGGCGCGGC
CCGGCGCCGCGGCCGCCCCGCCGAGCTGTGCTTCTACTCGGGCCGTGTGCTCGGCCACCCCGGCTCCCTCGTCTCGCTCAGCGCCTGCGG
CGCCGCCGGCGGCCTGGTTGGCCTCATTCAGCTTGGGCAGGAGCAGGTGCTAATCCAGCCCCTCAACAACTCCCAGGGCCCATTCAGTGG
ACGAGAACATCTGATCAGGCGCAAATGGTCCTTGACCCCCAGCCCTTCTGCTGAGGCCCAGAGACCTGAGCAGCTCTGCAAGGTTCTAAC
AGAAAAGAAGAAGCCGACGTGGGGCAGGCCTTCGCGGGACTGGCGGGAGCGGAGGAACGCTATCCGGCTCACCAGCGAGCACACGGTGGA
GACCCTGGTGGTGGCCGACGCCGACATGGTGCAGTACCACGGGGCCGAGGCCGCCCAGAGGTTCATCCTGACCGTCATGAACATGGTATA
CAATATGTTTCAGCACCAGAGCCTGGGGATTAAAATTAACATTCAAGTGACCAAGCTTGTCCTGCTACGACAACGTCCCGCTAAGTTGTC
CATTGGGCACCATGGTGAGCGGTCCCTGGAGAGCTTCTGTCACTGGCAGAACGAGGAGTATGGAGGAGCGCGATACCTCGGCAATAACCA
GGTTCCCGGCGGGAAGGACGACCCGCCCCTGGTGGATGCTGCCGTGTTTGTGACCAGGACAGATTTCTGTGTACACAAGGATGAACCGTG
TGACACTGTTGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCA
AAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGA
CTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCA
CCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTT

>2055_2055_2_ADAMTS17-CERS3_ADAMTS17_chr15_100794341_ENST00000268070_CERS3_chr15_100943070_ENST00000394113_length(amino acids)=388AA_BP=
MAPPPSALLLRRHGPGGLPVPGTMCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT
PPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLG
QEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY
HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAMTS17-CERS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS17-CERS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS17-CERS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS17C2750787Weill-Marchesani-Like Syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneADAMTS17C0023903Liver neoplasms1CTD_human
HgeneADAMTS17C0345904Malignant neoplasm of liver1CTD_human
TgeneC3554349ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 92CTD_human;GENOMICS_ENGLAND
TgeneC0079154Congenital Nonbullous Ichthyosiform Erythroderma1ORPHANET
TgeneC2750787Weill-Marchesani-Like Syndrome1ORPHANET