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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ASXL1-LFNG (FusionGDB2 ID:HG171023TG3955)

Fusion Gene Summary for ASXL1-LFNG

Fusion gene summary

Fusion gene information	Fusion gene name: ASXL1-LFNG
	Fusion gene ID: hg171023tg3955
		Hgene	Tgene
	Gene symbol	ASXL1	LFNG
	Gene ID	171023	3955
	Gene name	ASXL transcriptional regulator 1	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
	Synonyms	BOPS\|MDS	SCDO3
	Cytomap	('ASXL1')('LFNG') 20q11.21	7p22.3
	Type of gene	protein-coding	protein-coding
	Description	polycomb group protein ASXL1additional sex combs like 1, transcriptional regulatoradditional sex combs like transcriptional regulator 1putative Polycomb group protein ASXL1	beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
	Modification date	20200313	20200313
	UniProtAcc	.	Q8NES3
	Ensembl transtripts involved in fusion gene	ENST00000470145, ENST00000306058, ENST00000375687, ENST00000375689, ENST00000542461,
Fusion gene scores	* DoF score	16 X 10 X 8=1280	2 X 2 X 2=8
	# samples	21	2
	** MAII score	log2(21/1280*10)=-2.60768257722124 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: ASXL1 [Title/Abstract] AND LFNG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ASXL1(30956926)-LFNG(2566780), # samples:1
Anticipated loss of major functional domain due to fusion event.	ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. ASXL1-LFNG seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASXL1	GO:0035522	monoubiquitinated histone H2A deubiquitination	20436459

Fusion gene breakpoints across ASXL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LFNG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A486-01A	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+

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Fusion Gene ORF analysis for ASXL1-LFNG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000470145	ENST00000222725	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
3UTR-3CDS	ENST00000470145	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
3UTR-3CDS	ENST00000470145	ENST00000402045	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
3UTR-3CDS	ENST00000470145	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
3UTR-intron	ENST00000470145	ENST00000359574	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
5CDS-intron	ENST00000306058	ENST00000359574	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
5CDS-intron	ENST00000375687	ENST00000359574	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
5CDS-intron	ENST00000375689	ENST00000359574	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
5CDS-intron	ENST00000542461	ENST00000359574	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000306058	ENST00000222725	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000306058	ENST00000402045	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000375687	ENST00000222725	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000375687	ENST00000402045	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000375689	ENST00000222725	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000375689	ENST00000402045	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000542461	ENST00000222725	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
Frame-shift	ENST00000542461	ENST00000402045	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000306058	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000306058	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000375687	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000375687	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000375689	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000375689	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000542461	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+
In-frame	ENST00000542461	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375687	ASXL1	chr20	30956926	+	ENST00000402506	LFNG	chr7	2566780	+	1958	676	178	1047	289
ENST00000375687	ASXL1	chr20	30956926	+	ENST00000338732	LFNG	chr7	2566780	+	1958	676	178	1047	289
ENST00000542461	ASXL1	chr20	30956926	+	ENST00000402506	LFNG	chr7	2566780	+	1948	666	171	1037	288
ENST00000542461	ASXL1	chr20	30956926	+	ENST00000338732	LFNG	chr7	2566780	+	1948	666	171	1037	288
ENST00000375689	ASXL1	chr20	30956926	+	ENST00000402506	LFNG	chr7	2566780	+	1704	422	1208	417	263
ENST00000375689	ASXL1	chr20	30956926	+	ENST00000338732	LFNG	chr7	2566780	+	1704	422	1208	417	263
ENST00000306058	ASXL1	chr20	30956926	+	ENST00000402506	LFNG	chr7	2566780	+	1519	237	1023	232	263
ENST00000306058	ASXL1	chr20	30956926	+	ENST00000338732	LFNG	chr7	2566780	+	1519	237	1023	232	263

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375687	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.38267726	0.6173228
ENST00000375687	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.38267726	0.6173228
ENST00000542461	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.37410083	0.62589914
ENST00000542461	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.37410083	0.62589914
ENST00000375689	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.57594824	0.4240518
ENST00000375689	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.57594824	0.4240518
ENST00000306058	ENST00000402506	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.62265104	0.37734893
ENST00000306058	ENST00000338732	ASXL1	chr20	30956926	+	LFNG	chr7	2566780	+	0.62265104	0.37734893

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Fusion Genomic Features for ASXL1-LFNG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ASXL1	chr20	30956926	+	LFNG	chr7	2566779	+	0.9987079	0.001292145
ASXL1	chr20	30956926	+	LFNG	chr7	2566779	+	0.9987079	0.001292145

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASXL1-LFNG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30956926/chr7:2566780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LFNG Q8NES3
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250\|UniProtKB:O09010, ECO:0000269\|PubMed:11346656}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

2_9

1542.0

Compositional bias

Note=Poly-Lys

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

11_86

1542.0

Domain

HTH HARE-type

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000359574

1_8

362.0

Topological domain

Cytoplasmic

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000359574

30_379

362.0

Topological domain

Lumenal

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000359574

9_29

362.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

1457_1460

1542.0

Compositional bias

Note=Poly-Ser

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

199_209

1542.0

Compositional bias

Note=Poly-Ser

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

641_684

1542.0

Compositional bias

Note=Gly-rich

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

255_364

1542.0

Domain

DEUBAD

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

160_164

1542.0

Motif

Nuclear localization signal 1

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

284_288

1542.0

Motif

Note=LXXLL motif

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

409_413

1542.0

Motif

Nuclear localization signal 2

Hgene

ASXL1

chr20:30956926

chr7:2566780

ENST00000375687

1503_1540

1542.0

Zinc finger

Note=PHD-type%3B atypical

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000222725

1_8

357

380.0

Topological domain

Cytoplasmic

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000222725

30_379

357

380.0

Topological domain

Lumenal

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000338732

1_8

228

251.0

Topological domain

Cytoplasmic

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000338732

30_379

228

251.0

Topological domain

Lumenal

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402045

1_8

228

251.0

Topological domain

Cytoplasmic

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402045

30_379

228

251.0

Topological domain

Lumenal

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402506

1_8

286

309.0

Topological domain

Cytoplasmic

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402506

30_379

286

309.0

Topological domain

Lumenal

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000222725

9_29

357

380.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000338732

9_29

228

251.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402045

9_29

228

251.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

LFNG

chr20:30956926

chr7:2566780

ENST00000402506

9_29

286

309.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for ASXL1-LFNG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7296_7296_1_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000306058_LFNG_chr7_2566780_ENST00000338732_length(transcript)=1519nt_BP=237nt
ATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATT
CTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGA
GGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGA
CACACCCTGGTGTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGA
CCCTGTTGCGCTGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGC
ATGCCCACCCGGGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCA
GTGGGCTGCAGGGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAG
CTACGGGGCTCCGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGT
GCCCTGAAGTCCTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTG
ACCCAATCCCCTTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGT
GGCTGGCTGTCCAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTG
CCTCCCCAGGACAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAAT
ATTGTGACAGTATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGG
GGTGGGGGAGGGTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGA
AGTGGGACTGTCTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCC
CGCTGGGCCCAGCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATA

>7296_7296_1_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000306058_LFNG_chr7_2566780_ENST00000338732_length(amino acids)=263AA_BP=0
MLSSDSPCPGEAKGRPLRRPGRLPTQKSWEGCHCLPSWTASHWGLRGATGTGRWLLLLLSHSVQARRKGIGSRTPRPSLPCNEHGSVSRT
WGYDTGARTSGHRYPQHRACGQQEEKGTYASHPCKVARSPVAVERSKNPNRIALGVASDTQILPPSRPCSPLALGAEAHKWRWCPPLHRA

--------------------------------------------------------------
>7296_7296_2_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000306058_LFNG_chr7_2566780_ENST00000402506_length(transcript)=1519nt_BP=237nt
ATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATT
CTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGA
GGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGA
CACACCCTGGTGTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGA
CCCTGTTGCGCTGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGC
ATGCCCACCCGGGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCA
GTGGGCTGCAGGGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAG
CTACGGGGCTCCGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGT
GCCCTGAAGTCCTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTG
ACCCAATCCCCTTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGT
GGCTGGCTGTCCAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTG
CCTCCCCAGGACAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAAT
ATTGTGACAGTATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGG
GGTGGGGGAGGGTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGA
AGTGGGACTGTCTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCC
CGCTGGGCCCAGCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATA

>7296_7296_2_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000306058_LFNG_chr7_2566780_ENST00000402506_length(amino acids)=263AA_BP=0
MLSSDSPCPGEAKGRPLRRPGRLPTQKSWEGCHCLPSWTASHWGLRGATGTGRWLLLLLSHSVQARRKGIGSRTPRPSLPCNEHGSVSRT
WGYDTGARTSGHRYPQHRACGQQEEKGTYASHPCKVARSPVAVERSKNPNRIALGVASDTQILPPSRPCSPLALGAEAHKWRWCPPLHRA

--------------------------------------------------------------
>7296_7296_3_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375687_LFNG_chr7_2566780_ENST00000338732_length(transcript)=1958nt_BP=676nt
CGGCAGACACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGA
GCGGGAAAGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCT
GCCGCCGTGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTG
CCCGCCCCTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGC
CACCGCCCCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAA
GGAGCGCACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGA
GGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGG
GTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGACACACCCTGGT
GTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGACCCTGTTGCGC
TGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGCATGCCCACCCG
GGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCAGTGGGCTGCAG
GGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAGCTACGGGGCTC
CGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGTGCCCTGAAGTC
CTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTGACCCAATCCCC
TTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGTGGCTGGCTGTC
CAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTGCCTCCCCAGGA
CAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAATATTGTGACAGT
ATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGGGGTGGGGGAGG
GTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGAAGTGGGACTGT
CTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCCCGCTGGGCCCA
GCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATAAGGGAAAAGTT

>7296_7296_3_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375687_LFNG_chr7_2566780_ENST00000338732_length(amino acids)=289AA_BP=8
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKVPLHPLPPVPGHTL
VSPHCHLLVAMAETQSLGAPGIQRAQGPCCAALASAFEAPLGPCLCVCVCVCVCVYCMPTRVAGCWAVLLCGGAGTSATYVPLLRGPVGC

--------------------------------------------------------------
>7296_7296_4_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375687_LFNG_chr7_2566780_ENST00000402506_length(transcript)=1958nt_BP=676nt
CGGCAGACACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGA
GCGGGAAAGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCT
GCCGCCGTGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTG
CCCGCCCCTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGC
CACCGCCCCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAA
GGAGCGCACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGA
GGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGG
GTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGACACACCCTGGT
GTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGACCCTGTTGCGC
TGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGCATGCCCACCCG
GGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCAGTGGGCTGCAG
GGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAGCTACGGGGCTC
CGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGTGCCCTGAAGTC
CTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTGACCCAATCCCC
TTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGTGGCTGGCTGTC
CAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTGCCTCCCCAGGA
CAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAATATTGTGACAGT
ATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGGGGTGGGGGAGG
GTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGAAGTGGGACTGT
CTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCCCGCTGGGCCCA
GCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATAAGGGAAAAGTT

>7296_7296_4_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375687_LFNG_chr7_2566780_ENST00000402506_length(amino acids)=289AA_BP=8
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKVPLHPLPPVPGHTL
VSPHCHLLVAMAETQSLGAPGIQRAQGPCCAALASAFEAPLGPCLCVCVCVCVCVYCMPTRVAGCWAVLLCGGAGTSATYVPLLRGPVGC

--------------------------------------------------------------
>7296_7296_5_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375689_LFNG_chr7_2566780_ENST00000338732_length(transcript)=1704nt_BP=422nt
CAGACTGGGCTGTTTGCCTTCAGAAGCTGGACTGGAAATTGGTATTTTGAGGAGAACTGAATCCACTTTGCAAAGAATGTATGTTGGACA
AAGACAAAGTATCTCTGTTGGGAGACGTTGTTCACTGAGGATTTAGCAAGGGAGAGCGTAACTTGAGTGTTTGAAGCCGTCTCGTTCAAC
CGATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGA
TTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATT
CAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTAC
CCGGACACACCCTGGTGTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCC
AGGGACCCTGTTGCGCTGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGT
ACTGCATGCCCACCCGGGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAG
GGCCAGTGGGCTGCAGGGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTC
TACAGCTACGGGGCTCCGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTA
CCTGTGCCCTGAAGTCCTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGT
GCGTGACCCAATCCCCTTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCC
CCAGTGGCTGGCTGTCCAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCC
CTTTGCCTCCCCAGGACAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTG
TAAATATTGTGACAGTATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGG
GTGGGGGTGGGGGAGGGTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAA
GCTGAAGTGGGACTGTCTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCAC
CTCCCCGCTGGGCCCAGCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAA

>7296_7296_5_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375689_LFNG_chr7_2566780_ENST00000338732_length(amino acids)=263AA_BP=0
MLSSDSPCPGEAKGRPLRRPGRLPTQKSWEGCHCLPSWTASHWGLRGATGTGRWLLLLLSHSVQARRKGIGSRTPRPSLPCNEHGSVSRT
WGYDTGARTSGHRYPQHRACGQQEEKGTYASHPCKVARSPVAVERSKNPNRIALGVASDTQILPPSRPCSPLALGAEAHKWRWCPPLHRA

--------------------------------------------------------------
>7296_7296_6_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375689_LFNG_chr7_2566780_ENST00000402506_length(transcript)=1704nt_BP=422nt
CAGACTGGGCTGTTTGCCTTCAGAAGCTGGACTGGAAATTGGTATTTTGAGGAGAACTGAATCCACTTTGCAAAGAATGTATGTTGGACA
AAGACAAAGTATCTCTGTTGGGAGACGTTGTTCACTGAGGATTTAGCAAGGGAGAGCGTAACTTGAGTGTTTGAAGCCGTCTCGTTCAAC
CGATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGA
TTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATT
CAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTAC
CCGGACACACCCTGGTGTCCCCGCACTGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCC
AGGGACCCTGTTGCGCTGCCCTGGCCTCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGT
ACTGCATGCCCACCCGGGTAGCAGGCTGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAG
GGCCAGTGGGCTGCAGGGCCTGCTTGGAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTC
TACAGCTACGGGGCTCCGGGCTACTTTGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTA
CCTGTGCCCTGAAGTCCTGGCCCCTGTGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGT
GCGTGACCCAATCCCCTTCCTCCTGGCCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCC
CCAGTGGCTGGCTGTCCAGCTGGGCAAACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCC
CTTTGCCTCCCCAGGACAGGGTGAGTCAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTG
TAAATATTGTGACAGTATTTTTTTACTGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGG
GTGGGGGTGGGGGAGGGTCTTATTTTATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAA
GCTGAAGTGGGACTGTCTGGCACTCTGTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCAC
CTCCCCGCTGGGCCCAGCATGGCTCACCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAA

>7296_7296_6_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000375689_LFNG_chr7_2566780_ENST00000402506_length(amino acids)=263AA_BP=0
MLSSDSPCPGEAKGRPLRRPGRLPTQKSWEGCHCLPSWTASHWGLRGATGTGRWLLLLLSHSVQARRKGIGSRTPRPSLPCNEHGSVSRT
WGYDTGARTSGHRYPQHRACGQQEEKGTYASHPCKVARSPVAVERSKNPNRIALGVASDTQILPPSRPCSPLALGAEAHKWRWCPPLHRA

--------------------------------------------------------------
>7296_7296_7_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000542461_LFNG_chr7_2566780_ENST00000338732_length(transcript)=1948nt_BP=666nt
CACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGAGCGGGAA
AGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCTGCCGCCG
TGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTGCCCGCCC
CTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGCCACCGCC
CCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAAGGAGCGC
ACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAA
GGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTAT
AAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGACACACCCTGGTGTCCCCGCAC
TGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGACCCTGTTGCGCTGCCCTGGCC
TCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGCATGCCCACCCGGGTAGCAGGC
TGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCAGTGGGCTGCAGGGCCTGCTTG
GAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAGCTACGGGGCTCCGGGCTACTT
TGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGTGCCCTGAAGTCCTGGCCCCTG
TGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTGACCCAATCCCCTTCCTCCTGG
CCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGTGGCTGGCTGTCCAGCTGGGCA
AACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTGCCTCCCCAGGACAGGGTGAGT
CAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAATATTGTGACAGTATTTTTTTAC
TGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGGGGTGGGGGAGGGTCTTATTTT
ATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGAAGTGGGACTGTCTGGCACTCT
GTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCCCGCTGGGCCCAGCATGGCTCA
CCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATAAGGGAAAAGTTCTCAGGGAAT

>7296_7296_7_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000542461_LFNG_chr7_2566780_ENST00000338732_length(amino acids)=288AA_BP=8
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKVPLHPLPPVPGHTLV
SPHCHLLVAMAETQSLGAPGIQRAQGPCCAALASAFEAPLGPCLCVCVCVCVCVYCMPTRVAGCWAVLLCGGAGTSATYVPLLRGPVGCR

--------------------------------------------------------------
>7296_7296_8_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000542461_LFNG_chr7_2566780_ENST00000402506_length(transcript)=1948nt_BP=666nt
CACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGAGCGGGAA
AGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCTGCCGCCG
TGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTGCCCGCCC
CTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGCCACCGCC
CCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAAGGAGCGC
ACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAA
GGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTAT
AAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGGTTCCGCTCCATCCACTGCCACCTGTACCCGGACACACCCTGGTGTCCCCGCAC
TGCCATCTTCTAGTGGCCATGGCTGAGACCCAATCCCTGGGCGCCCCTGGTATCCAAAGGGCCCAGGGACCCTGTTGCGCTGCCCTGGCC
TCGGCATTCGAGGCTCCCCTAGGGCCGTGCCTGTGCGTGTGCGTGTGCGTGTGTGTGTGTGTGTACTGCATGCCCACCCGGGTAGCAGGC
TGCTGGGCAGTTCTGCTCTGTGGAGGGGCGGGCACCAGCGCCACTTATGTGCCTCTGCTCCGAGGGCCAGTGGGCTGCAGGGCCTGCTTG
GAGGAAGGATTTGTGTGTCGGAGGCCACTCCGAGGGCAATTCTGTTAGGATTTTTGGATCTTTCTACAGCTACGGGGCTCCGGGCTACTT
TGCAGGGATGCGATGCGTAGGTGCCTTTCTCTTCCTGCTGACCACAAGCTCTGTGCTGGGGGTACCTGTGCCCTGAAGTCCTGGCCCCTG
TGTCATAGCCCCAAGTACGACTCACTGAGCCATGCTCATTGCAGGGGAGGCTGGGTCTGGGGGTGCGTGACCCAATCCCCTTCCTCCTGG
CCTGGACGCTGTGGCTTAAGAGTAACAGCAGCCACCGCCCAGTTCCAGTGGCCCCACGAAGCCCCCAGTGGCTGGCTGTCCAGCTGGGCA
AACAGTGGCACCCCTCCCAGCTCTTCTGAGTGGGGAGTCTTCCAGGCCTCCTCAGAGGTCTTCCCTTTGCCTCCCCAGGACAGGGTGAGT
CAGAGCTCAGCATTTAATCTCCTCTCCAAAGTAGAGAGCAAGTCGCCCACAGTGGGCGTGTCTGTAAATATTGTGACAGTATTTTTTTAC
TGTGCTGTTTTTTTTGAAAGGGGATGGGTAAAAAGTAGGGTGTTCTTGTTTTTTGCTTGGGAGGGTGGGGGTGGGGGAGGGTCTTATTTT
ATCTTATCTTTTCTGTGGATCAGAAAAAACAGAAGCCAAACTCGGGGTCATCTTTGTTTTTAAAGCTGAAGTGGGACTGTCTGGCACTCT
GTGTATTTATGCGTTCCAGCATCTGGAACCTCCCATCCCTGCCCTCCTCCTGTGTAGCTGCCACCTCCCCGCTGGGCCCAGCATGGCTCA
CCTGTCCCGTGGGCTGTGTTTCTTGTTGTTTTTCTCTTTGCAAAGACATAGCTAGGAAAGCGAATGATAAGGGAAAAGTTCTCAGGGAAT

>7296_7296_8_ASXL1-LFNG_ASXL1_chr20_30956926_ENST00000542461_LFNG_chr7_2566780_ENST00000402506_length(amino acids)=288AA_BP=8
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKVPLHPLPPVPGHTLV
SPHCHLLVAMAETQSLGAPGIQRAQGPCCAALASAFEAPLGPCLCVCVCVCVCVYCMPTRVAGCWAVLLCGGAGTSATYVPLLRGPVGCR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASXL1-LFNG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ASXL1	chr20:30956926	chr7:2566780	ENST00000375687	+	4	13	300_658	84.0	1542.0	NCOA1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ASXL1-LFNG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ASXL1-LFNG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ASXL1	C0796232	Bohring syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	ASXL1	C0349639	Juvenile Myelomonocytic Leukemia	2	CTD_human;GENOMICS_ENGLAND
Hgene	ASXL1	C3463824	MYELODYSPLASTIC SYNDROME	2	CGI;CTD_human;GENOMICS_ENGLAND
Hgene	ASXL1	C0023487	Acute Promyelocytic Leukemia	1	CTD_human
Hgene	ASXL1	C0027643	Neoplasm Recurrence, Local	1	CTD_human
Hgene	ASXL1	C0027708	Nephroblastoma	1	CTD_human
Hgene	ASXL1	C1301365	Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease	1	ORPHANET
Hgene	ASXL1	C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Hgene	ASXL1	C2930471	Bilateral Wilms Tumor	1	CTD_human
Tgene		C1853296	SPONDYLOCOSTAL DYSOSTOSIS, AUTOSOMAL RECESSIVE 3	2	CTD_human;GENOMICS_ENGLAND;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:ASXL1-LFNG (FusionGDB2 ID:HG171023TG3955)

Fusion Gene Summary for ASXL1-LFNG

Fusion Gene ORF analysis for ASXL1-LFNG

Fusion Genomic Features for ASXL1-LFNG

Fusion Protein Features for ASXL1-LFNG

Fusion Gene Sequence for ASXL1-LFNG

Fusion Gene PPI Analysis for ASXL1-LFNG

Related Drugs for ASXL1-LFNG

Related Diseases for ASXL1-LFNG

Fusion Gene Studies
in Kim Lab